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Interfacial modifications between perovskite and charge transport layers based on physical adsorption are susceptible to detachment. Here, authors report a chemical modification with in-situ crosslinking reaction in the modifiers, achieving certified efficiency of over 25% in perovskite solar cells.

Developing high-current-density catalysts is key to efficient water splitting. Here, the authors report a single-atom Ru-doped amorphous Ni–Mo oxide that dynamically self-reconstructs to retain high activity at industrial current densities in an anion-exchange membrane water electrolyzer.

Stretchable elastic materials with high strength, toughness, and good ionic conductivity are desirable for flexible electronics but attaining all of these properties simultaneously remains challenging. Here, the authors report a family of ionically conductive elastomers without compromise between mechanical properties and ionic conductivity by introducing a multiple network elastomer architecture into a low T_g polymer.

The use of donor-derived CAR-NK cells is limited by CD8 T cell-mediated allorejection. Here, the authors describe a one-step approach, based on selective HLA knockdown and overexpression of PD-L1, that allows allogeneic modified CAR-NK cells to escape rejection by the host immune system while exhibiting enhanced anti-tumor activity and safety in preclinical mouse models.

A subthermionic organic thin-film tunnel transistor can offer a subthreshold swing of 24.2 ± 5.6 mV dec⁻¹ and a signal amplification efficiency of 101.2 ± 28.3 S A⁻¹.

Literature mining, such as systematic review and meta-analysis, is crucial for discovering, integrating, and interpreting emerging research. This study presents a specialized large language model for literature that outperforms six general LLMs and helps clinicians in study selection and data extraction tasks.

Radiation-induced malignantly transformed cells undergo multi-scale 3D genome reorganization. TP63 acts as a key mediator, creating accessible chromatin sites that form tumour-specific loops activating the MYC oncogene during malignant transformation.

Precise separation of ions with similar valence and size is critical. Here, authors designed a selective membrane that precisely extract Li+ from Na+ and Ca²⁺ interferences. The high selectivity and permeability enable energy-efficient, precise, and chemical-free lithium extraction using the electrodialysis process.

The use of bulky protein tags and the limited positions available for probe introduction restrict current methods for studying protein microenvironments at high spatial resolution. Here the authors genetically incorporate small environment-sensitive fluorescent amino acids to visualize real-time microenvironmental changes at specific protein substructures.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Achieving long-term stability in halide perovskite solar cells remains challenging due to their susceptibility to environmental degradation. Here, the authors fabricate antimony and sulfur-alloyed perovskite films via a sequential ambient-air process, achieving maximum device efficiency of 25.07%.

Recent studies have traced haematopoiesis at the clonal level but lack a way to extract dynamical information. Here, authors develop CLADES, a tool to estimate cellular kinetics and the number of divisions to produce mature cells for each clone, in human cord blood and adult mouse haematopoiesis.

Nuclear morphology plays a critical role in regulating gene expression and cell function. Here, Wang et al. report that topography-induced nuclear deformation enhances the secretome of hMSCs, promoting extracellular matrix (ECM) organization and facilitating bone regeneration through matricrine effects.

The authors find low-energy magnetic excitations and a flat band near the Fermi level in kagome metal superconductor CsCr3Sb5 by angle-resolved photoemission and resonant inelastic X-ray scattering. They suggest that the flat band plays a role in the emergence of charge/magnetic order at low temperatures.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Inspired by the regenerative capacity of deer antlers, Hao and colleagues report that antler blastema progenitor cell-derived extracellular vesicle treatment counteracts bone loss and epigenetic aging and is neuroprotective in mice and macaques.

Live-cell imaging and proximity labeling face limits in tracking protein dynamics. Here, the authors present SeeID, a NIR-activated method using SiR as a photocatalyst, enabling precise intracellular labeling, organelle- and disease-relevant interactome mapping, and deep-tissue studies in vivo.

Computer algorithms for contrast and resolution enhancement of microscopic images can become derailed. The authors here provide proof is offered that the Richardson-Lucy algorithm turns out to amplify noise in the initial data, wrecking the final outcome.

Convective flow can enhance solar evaporation performance but requires external components and power input. Here, authors develop a Dyson sphere-like evaporator capable of self-generating internal convection to significantly improve evaporation rates. Energy allocation for direct water evaporation and vapor removal is investigated.

This study presents LiteLoc, a lightweight and scalable AI model for efficient and accurate single molecule localization microscopy data analysis, bringing real-time deep-learning-based analysis to the era of high throughput super resolution imaging.

The specific circuits mediating opioid-induced itch remain not fully understood. Here, authors reveal that morphine suppresses spinal NPY⁺ inhibitory neurons via μ-opioid receptors, which disinhibit GRP-GRPR circuits to trigger itching in mice.

Ym1, encoding a CC-NBS-LRR type resistance protein, confers defense to wheat yellow mosaic virus (WYMV) infection in roots. Ym1’s function in preventing viral invasion is dependent on its interaction with WYMV coat protein and followed by induction of cell death.

The relationship between pancreatic β-cell dysfunction and autoinflammation in T2DM is unclear. Here, the authors show the key role of a UCP2/mtDNA/STING axis in the IL-1β induced autoinflammation cycle in T2DM and develop Mito-G, a highly efficient mitochondria targeting nanodrug to treat T2DM.

Subtle changes in solvent composition control peptide crystal polymorphism, enabling the formation of distinct structures and offering new insights for designing advanced bio-inspired materials.

A self-transmissible CRISPR-associated transposase system encodes a nanobody payload to treat Shiga toxin infections.

In this Review, Nicholas Chew and colleagues use epidemiological data on the cardiovascular–liver–metabolic disease syndemic to illustrate current and future projections on the burden of these diseases and their risk factors, and propose a unified framework for integrating and implementing effective multisystem interventions to tackle key components of this syndemic.

This work introduces roll-to-roll fluidics, a method that enhances reagent efficiency and reduces turnaround time, enabling rapid and economical next-generation sequencing.

Photonic memristor arrays fabricated from hexagonal boron nitride/silicon heterostructures provide a scalable, silicon-compatible solution for artificial vision systems, featuring broad spectral reconfigurability and promising performance characteristics.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

Holographic transcranial ultrasound cortical stimulation achieves single or multiple adjacently grouped high-resolution foci.

Biological wastewater treatment is greatly challenging in cold environments as low temperatures inhibit enzyme activity in microbial metabolism. This work presents a strategy that integrates biological wastewater treatment with photothermal technology to improve its resilience to low temperatures.

Wu et al. show that glucosamine acts as a P-glycoprotein activator, rapidly enhancing intestinal drug efflux and reducing drug absorption. The authors propose this as a detox strategy to improve survival outcomes following paraquat exposure.

This study reveals that Holocene drying-induced woody plant expansion in peatlands suppresses microbial heterotrophic activity and enhances organic matter stability, creating a natural buffer for carbon storage under climatic stress.

Zhang et al. show that YAP binds to TDP-43 to promote TDP-43 multimerization and phase separation. YAP and TDP-43 may co-localize in multiple cell types in oxidative stress and in brain samples from individuals with amyotrophic lateral sclerosis.

This study identifies FOXN3 as a suppressor of pulmonary fibrosis by inhibiting Smad signaling. FOXN3 facilitates Smad4 ubiquitination, disrupting the Smad complex’s association with target elements and abolishing its transcriptional activity.

Dopaminergic dysfunction is a key of Alzheimer’s disease pathogenesis. Here, the authors developed a multifunctional neural interface that simultaneously monitors dopamine dynamics and neural activity while delivering 40 Hz stimulation to rescue cognitive deficits in APP/PS1 mice.

C(sp³)–H fluoroalkylation of bioactive molecules is a challenge. Now, a scalable and site-selective allylic fluoroalkylation of terpenes and olefins has been developed using a cobaloxime catalyst. Mechanistic studies reveal the process probably proceeds through halogen-atom transfer and hydrogen-atom transfer steps.

The authors present a 3D map of nearly all cells in C. elegans embryos, revealing how cell shape, size, and fate change over time. They show how Notch and Wnt signaling, along with mechanical forces, influence development, including organ formation.

A severe acute respiratory syndrome coronavirus 2 Omicron subvariant, BA.2.86, was found to be no more resistant to human sera than the currently dominant XBB.1.5 and EG.5.1, but it had a remarkably higher receptor affinity.