Clinical Sciences articles for China

Time frame: 1 May 2025 - 30 April 2026

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Count: 1674

Article ‘Count’ for Clinical Sciences.

Journal Count Share
83 81.96
Chemotherapeutic Agent-Loaded Nanoparticles Synergizing with X-ray Irradiation to Regulate Fibroblast-like Synoviocytes for Rheumatoid Arthritis Treatment 1.00
A Bispecific Nanovehicle Disarms a Biofilm Amyloid Shield for Implant-Related Osteomyelitis Therapy 1.00
Exosome-Mitochondrial Hybrid Membrane with Targeted Delivery of CO Prevents Mitochondrial Dysfunction and Pyroptosis against Myocardial Ischemia-Reperfusion Injury 1.00
A Self-Alarming Nanoantidote for Early Urinary Diagnosis and Antioxidative Therapy of Drug-Induced Acute Kidney Injury 1.00
DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles 0.93
Combination mRNA Vaccine Adjuvanted with CpG Oligodeoxynucleotides Enhances Protection against Respiratory Virus Infection 1.00
Simultaneous Monitoring of Cytochrome c and Caspase-3 Dynamics Using a Dual-Channel Nanoprobe for Deciphering Single-Cell Apoptosis 1.00
An Engineered Triple-Functional Nanoplatform for Effective Sepsis Therapy via Macrophage-Targeted Polo-like Kinase 1 Inhibition 1.00
Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical 3D Printing 1.00
An Acidosis-Activatable Nanocomposite for Synergistic Microenvironment Remodeling and Reprogramming of Innate–Adaptive Immune Crosstalk in Rheumatoid Arthritis 1.00
Predicting Plaque Vulnerability Using Machine Learning-Enabled Nanoagents Sensitized Molecular High-Resolution Magnetic Resonance Imaging Data 1.00
Ultrasmall Platinum Nanoclusters Modulating Dysregulated Reactive Oxide Species and Immunity for Psoriasis Therapy and Prevention 0.91
Engineering Bacteriophage Cocktail with Mutually Promoted Chemodynamic–Photodynamic Activity for Targeted and Synergistic Biofilm Eradication 1.00
Dynamic Simulation Assists Insights into the Deafness Prevention of a Self-Assembly Pd Nanozyme with Intrinsic Targeting 1.00
Diagnostic-Mediated Interactive Superlattices Engineering for Threshold-Saltatory Visual Assessment of Tuberculous Meningitis 1.00
HA/CD44–SS31 Mitochondrial Targeting of Manganese Oxide Nanozymes for Ischemia-Reperfusion-Induced Acute Kidney Injury Therapy 1.00
Disrupting the Senescence-Associated Secretory Phenotype–M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis 1.00
A First-Aid Nanomedicine Endowed with Microenvironment Self-Adaptive Regulation Ability to Facilitate Acute Liver Failure Prophylaxis and Therapy 1.00
Heterogeneous Magnetic Resonance Nanoprobe for Assisting Liver Fibrosis Three-Dimensional Reconstruction and Cascaded Therapy 0.83
A Sonopiezoelectric Z-Scheme Nanoplatform Synergizing Trace Ag+ for Eradicating Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia 1.00
Smart Nanoplatform with Self-Stimulation Strategy for Dynamic Regulation and In Situ Visual Imaging of Histamine Activities in Allergic Rhinitis 1.00
TA-Zr/Ce Nanozyme-Mediated Lipopolysaccharide Dephosphorylation: A Targeted Strategy for Sepsis Treatment with Hemoperfusion Applications 1.00
Chemical Gambit in Bone Microenvironment: pH-Responsive Cu–Mn Nanoplatform Breaks the Inflammation-Osteoclast Vicious Cycle in Prosthesis-Associated Osteolysis 1.00
Bone-Targeted Platinum Nanoframework Prevents Postmenopausal Osteoporosis via Transmembrane Protein 16A Channel Blockade and Reactive Oxygen Species Scavenging 1.00
Effective Osteoporosis Treatment by Polypeptosome-Mediated Neutralization of Acid Bone Microenvironment 1.00
An Ultralong-Circulating Tantalum-Based Computed Tomography Contrast Agent for Vascular Imaging in Large Animals 0.91
Membrane-Targeting Poly(Amino Acids) with a Phage-Like Action Process for Antifungal Therapy 0.88
Sequential Mitochondrial Transplantation for Myocardial Ischemia-Reperfusion Injury Treatment 1.00
Mitochondria-Targeting Polymeric Micelles for Intervertebral Disc Degeneration Alleviation via Coordinated Cascade Energetic Intervention 1.00
In Situ Supply and Anchoring of Glycosaminoglycan by Dual-Modified Hydrogel Loaded with Glycoengineered Stem Cells for Attenuating Disc Degeneration 1.00
A Diselenide-Linkage Self-Assembled Nanoprodrug for Enhanced Osteoarthritis Treatment 1.00
A Multifunctional MOF Heterojunction for Combating Antibiotic Resistance and Promoting Regenerative Immunity 1.00
Oral Bacterial Predator with “Catch-and-Kill” Functionality for Bacterial Enteritis via Selective Pathogen Capture and Sonodynamic Elimination 1.00
Neutrophil Granule-Mimetic Emulsion Inducing Gastrointestinal Immunity against Helicobacter pylori via Subcutaneous Vaccination 1.00
On-Demand Collaborative Delivery for Remodeling the Senescent Microenvironment in Intervertebral Disc Degeneration 1.00
Self-Reinforcing Nanosonosensitizer Boosts Cascade Immune Activation for Refractory Osteomyelitis Treatment and Recurrence Prevention 1.00
Oral Multi-Enzymatic Manganese–Carbon Dots Alleviate Sepsis-Associated Lung Injury via the Gut–Lung Axis 1.00
Aggregation-Induced Emission-Based Nanoparticles for Synergistic Photothermal Antibacterial Therapy and Anti-Inflammatory Regulation in Periodontal Infections 1.00
Artificial Intelligence-Assisted Low-Dose High Atomic Number Contrast Agent for Ultrahigh-Resolution Computed Tomography Angiography 1.00
N-Acetylcysteine-Capped TLQP21-Containing Au Nanocages Alleviate Depression in Mice 1.00
Dendritic Cell-Inspired Triple-Functional Biocatalysts with Atomic Iron Sites To Eradicate Drug-Resistant Bacteria and Biofilms 0.92
A Therapeutic System Regulating Iron Metabolism in CD63+ Macrophage Subsets Activates Anti-tumor Immunity for Bone Metastasis Therapy 1.00
Cell Wall-Binding Proteins-Armed Controlled-Release Nanodelivery System Enhances Nisin’s Efficacy against Streptococcus pneumoniae Infections 1.00
Nano-Self-Assembled Particles Loaded with Aldehyde Dehydrogenase 2 Agonist Inhibit Ischemia-Reperfusion Injury of Transplanted Kidneys 1.00
A Near-Infrared-II Molecular Probe for Early Diagnosis of Acute Kidney Injury Induced by Diverse Etiologies 1.00
Autoinducing Peptide-Mediated Bacterial Keratitis Therapy by Camouflaged Staphylococcus aureus 1.00
Injectable Plant Phosphate Coordination Compound-Based Adhesive Hydrogel Accelerates Osteoporotic Fracture Healing by Restoring Osteoclast/Osteoblast Imbalance 1.00
Light-Driven Double-Layer Polydopamine-Coated Flexible Metal–Organic Frameworks: Balancing Antibacterial and Regenerative Functions 0.83
Metal–Organic Framework-Integrated Nanoplatform Orchestrates Osteochondral-Synovial Homeostasis for Osteoarthritis Therapy 1.00
An Activated Gasdermin Mimicking Polymer for Antitumor Immunity 1.00
Hybrid Spike-Facilitated Capture and Biofilm Destruction Co-Enhances Ultrasound-Mediated Bactericidal Therapy 1.00
Biofilm-Responsive Nano-Antibiotics for Degradation of Extracellular Polymeric Substance Matrix and Reduction of Pathogenicity against Drug-Resistant Bacterial Infections 1.00
Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of Roseburia intestinalis 0.93
Conformational versus Configurational Entropy: Deciphering the Alkyl Chain-Dependent Membrane Attack Mechanism of Ionic Liquid Derivatives 1.00
Hydrogen Therapy and Lipopolysaccharide Trapping with MgB2@Inulin Gel for Reversing Colitis and Its Associated Psychiatric Complications via the Gut–Brain Axis 1.00
A Droplet Microfluidic-Derived Pathological Microenvironment-Activated Spore Nanozyme Device for the Precise Regulation and Treatment of Colitis 1.00
Dual-Pronged Attack: Biomimetic Multi-Functional MOFs for Rheumatoid Arthritis Therapy via Inhibiting Synovial Hyperplasia and Improving Immune Microenvironment 1.00
Hierarchical Micro–Nano Porous Structure of Diatom Biosilica Induces Selective Absorption and Protease Inhibition for Bleeding Control 1.00
Selenium Nanoplatform Engages Tranexamic Acid to Alleviate Ultraviolet B-Induced Skin Pigmentation via Inflammatory Response 1.00
Lysosome-Targeting Nanochimeras Attenuating Liver Fibrosis by Interconnected Transforming Growth Factor-β Reduction and Activin Receptor-Like Kinase 5 Degradation 1.00
Oral Nanoarmored Live Bacterial Biotherapeutics Bearing Polyphenol-Based Supraparticles Enhance Chemotherapy via Reestablishing Immuno-Oncology-Microbiome Axis 0.97
Nanoparticle–Protein Corona Boosted Cancer Diagnosis with Proteomic Transfer Learning 1.00
Defective RuO2 Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway 1.00
Photoactivatable Exosenolytics Activate Natural Killer Cells for Delaying Osteoarthritis 1.00
Microenvironment-Activatable Long-Wavelength NIR-II Visualization and Synergistic Treatment of Pulmonary Embolism 1.00
Simultaneous Visualization of Anatomical Structure and Molecular Pathology Variation in Vascular Inflammation with Informationized Serum Albumin 1.00
An Intein-Spliced Nipah G Protein Ferritin Nanoparticle Vaccine Provides Complete Protection against Lethal Nipah Virus Challenge 1.00
Biosynthesis of Melanin with Engineered Probiotics for Oral Treatment of Ulcerative Colitis 1.00
Valence Electron Fluctuation in a High-Entropy Oxide Heterojunction Enables Collaborative Photodynamic and Mild-Thermal Therapy for Cutaneous Biofilm Infections 0.85
Defect-Boosted Piezoelectric and Nanozymatic Synergetic Catalysis for Deep Bacterial Abscess Therapy 1.00
Monitoring Abundance and Activity of Electrochemically Inactive Protein in a Single Cell by an Atomically Precise Metal Cluster-Based Electrochemical Sensor 1.00
Epitope-Optimized Influenza Hemagglutinin Nanoparticle Vaccine Provides Broad Cross-Reactive Immunity against H9N2 Influenza Virus 1.00
MXene-Based Cartilage-Adhesive Microspheres for Photothermal-Controlled Hydrophobic Drug Release and Mesenchymal Stem Cell Delivery in Osteoarthritis 1.00
Capillary Force-Driven Capture of Magnetic Nanoparticles in Calcium Phosphate Hollow-Tube Whisker Scaffolds for Osteonecrosis of the Femoral Head 1.00
Functional Amyloid Phenol-Soluble Modulin α1-Targeting Photothermal Nanoplatform for Effective Elimination of Biofilm-Associated Infections 1.00
High-Sensitivity Cell-Based Plasmonic Biolayer Interferometry with a Two-Tiered Enhancement for Clinical Autoimmunity Surveillance of Pemphigus Vulgaris 1.00
A Precision-Guided “Trojan Horse” for Tissue-Cell-Bacteria Targeted Therapy of iSalmonella/i Intestinal Infections 1.00
Oxygen-Independent Sulfate Radical and Fe2+-Modified Implants for Fast Sterilization and Osseointegration of Infectious Bone Defects 1.00
Antibacterial Peptides-Produced Cell Hydrogel Eliminates Intracellular Pathogens and Remodels Immune Microenvironment for Osteomyelitis Therapy 1.00
In Situ Generation of Pyroptosis Inducer Mediated by Intracellular Labile Copper Pool for Safe and Robust Antitumor Immunotherapy 1.00
Selenium-Doped Carbon Dots as a Multipronged Nanoplatform to Alleviate Oxidative Stress and Ferroptosis for the Reversal of Acute Kidney Injury 1.00
Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis 1.00
Acid-Triggered Charge-Switchable Antibacterial Hydrogel for Accelerated Healing of Gastric Mucosal Wounds 1.00
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Biomaterial-mediated scavenging of extracellular thrombospondin-1 in peripheral vessels mitigates intestinal ischemia-reperfusion injury 1.00
Hyaluronic Acid–Phosphatidylcholine Complexes as Reductionist Mimics of Extracellular Vesicle–Mediated Boundary Lubrication in Synovial Joints 0.10
Polypyrrole nanozymes with cell-free DNA scavenging and ferroptosis inhibition capabilities for the treatment of acetaminophen-induced acute liver injury 1.00
Phagocyte-Inspired Supramolecular Self-Assembly Design of Abiotic Cell-Mimics for Pathogen Recognition and Eradication 0.85
Thermosensitive hydrogel delivers nanoparticles for the modulation of immune homeostasis for salpingitis therapy 1.00
Bioinspired and Absorbable Self-Gelling Powder with Anti-Polyelectrolyte Effect for Effective Hemostasis and Tissue Adhesion Prevention of Non-Compressible Wounds 1.00
An amyloid-based hydrogel with remineralizing and antibacterial properties for interrupting dental caries 1.00
Synergistic therapy with cerium-based nanozymes and mitochondrial RNA polymerase inhibition combats mitochondrial double-stranded RNA-mediated inflammation in osteoarthritis 1.00
Multilayer Lipid Vesicles Loaded with Deoxyribonuclease 1 for the Degradation of Neutrophil Extracellular Traps in Rheumatoid Arthritis 1.00
M2 macrophage-derived exosome nanoplatform for targeted H2S delivery to alleviate hepatic ischemia–reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects 0.93
Self-Assembled Polymeric Nanoparticles for Redox- and Gene-Regulated Osteoarthritis Therapy 1.00
Oxygen-Self-Supplying Biomimetic Nanozymes Synergize with Methotrexate to Reprogram Macrophage Polarization for Rheumatoid Arthritis Therapy 1.00
A Physiological Oxygen Gradient Liver-Zonation-on-a-Chip Reveals HIF-2α Intervention in Hepatic Lipotoxicity 0.86
Metal Ion-Protein-Based Liquid Hemostatic Foam for Prehospital Emergency Treatment of Incompressible Hemorrhage 1.00
Breast Implant microbiome profile correlates with foreign body response severity 0.03
Angiogenesis-Driven Hybrid Hydrogel with pH/ROS-Activated Anti-infection and Enhanced Cellular Metabolism for Efficient MRSA-Impaired Wound Repair 1.00
A multifunctional self-gelling hemostatic powder based on synergistic non-covalent interactions for rapid hemostasis and infected wound healing 0.90
Post-yield Behavior and Failure Mechanisms of Murine Cortical Bone at the Microscale across Different Ages Depend on Alterations in Mineralized Collagen Fibrils’ Arrangement 1.00
Broad-spectrum Antibacterial Peptidopolysaccharides for Targeted Therapy of a Drug-resistant Bacterial Liver Abscess 0.85
An engineering-reinforced hypoxia-preconditioned exosome-integrated hydrogel delays intervertebral disc degeneration via the PPARγ-autophagy axis 1.00
Ultrasound-activated directional and controllable nitric oxide therapy for vascular calcification repair through the modulation of eNOS/iNOS homeostasis 1.00
Macrophage membrane-camouflaged dual drug-based biomimetic pH-responsive nanomedicine for synergistic antifungal-antioxidant therapy in oral candidiasis 1.00
Biofilm-triggered interfacial assembly of dual-porphyrin heterojunctions for chemo-/sonodynamic treatment of pyomyositis 1.00
A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration 1.00
A Supramolecular Photopyroptosis Nanoinducer with Acidity-Activatable Immunomodulation for Potentiating Cancer immunotherapy 1.00
Biofilm penetrating and disrupting polymers to effectively treat endotracheal-tube-associated biofilm infections 1.00
Tailored “Three-stage booster” nano-extinguisher for synergistic treatment of severe acute pancreatitis by rectifying mitochondrial dysfunction and inhibiting pancreatic autodigestion 1.00
Sonosensitizer-doped framework theranostic nanoprobe for enhanced spatiotemporal eradication of helicobacter pylori with photoacoustic imaging guidance 1.00
Synergistic reversal of inflammation-mediated degeneration in intervertebral discs: Phenylboric acid-grafted hyaluronic acid hydrogel as an anti-oxidative vehicle for Timp-3 delivery and promotion of extracellular matrix synthesis 1.00
Collagen glycation-mediated mechanical stress aggravates ischemia-reperfusion injury 1.00
CD4+ T cell membrane-based nanocomposites for enhanced dual epigenetic therapy in psoriasis 1.00
Liposomic lubricants suppress acute inflammatory gene regulation in the joint in vivo 0.04
Esterase-responsive kartogenin composite hydrogel microspheres boost nucleus pulposus regeneration in intervertebral disc degeneration 1.00
Drug-loaded microneedle patches containing regulatory T cell-derived exosomes for psoriasis treatment 1.00
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Near‑Infrared Driven Renal Nanomotors for Oxidative‑Stress Relief and Stone Prevention 1.00
Gene‐Engineered Nucleus Pulposus‐Mimetic Microspheres Reshaping the Hydration Microenvironment to Delay Intervertebral Disc Degeneration 1.00
Ternary Synergy in an Atomically Precise Alloy Nanocluster: Precision Engineering of a ROS-Scavenging Nanozyme for Effective Psoriasis Therapy 1.00
Sequential Physical Disruption and Metabolic Interference via a Photothermal Nanozyme Integrated Platform for Eradicating Biofilm Associated Infections and Promoting Tissue Regeneration 1.00
Microenvironment-Adaptive, Size-Transformable Self-Assembling Peptide Nanoassemblies for Targeted Delivery and Synergistic Combat Biofilm and Deep Tissue Associated Infections 1.00
A Sonosensitizer-Cationic Polypeptide Conjugate Potentiates Sonodynamic Therapy for Mature Biofilm Eradication and Periodontitis Treatment 1.00
Polydopamine‐Mediated Thermotherapy Hydrogel for Disc Degeneration Inhibition via Modulating Inflammation and Extracellular Matrix Metabolism 1.00
Rational Design of Pentamethine Cyanine With Enhanced NIR-II Fluorescence and Photothermal Conversion Efficiency for Gram-Selective Antibacterial Applications 1.00
Reversing Pro‐adhesive Niche Through Manipulating Aggregative Behaviors of Immune Cell Subsets With a Lubricous Janus Spray Gel for Enhancing Colorectal Cancer Postoperative Adjuvant Immunotherapy 1.00
Zwitterionic Polymer-Functionalized Carbon Quantum Dots as High-Performance Nanolubricants for Potential Osteoarthritis Treatment 1.00
Closed-Loop Control of Cerebral ATP Transients by an Optogenetic Nanosensor for Alleviation of Depressive-Like Symptoms 1.00
NIR‐II‐Triggered Cascade Nanoplatform Combats Biofilms Through CO Release and Macrophage Reprogramming 1.00
Lesion-Localized Lubricating Microspheres Loaded with Highly Permeable Spermidine-Derived Carbon Quantum Dots Attenuate Post-Traumatic Ankle Osteoarthritis 1.00
Eradicating Helicobacter Pylori with a Multifunctional Trojan Horse Nanoplatform Armored with β-Cyclodextrin 1.00
Kidney-Targeted Nanoparticles with ROS Scavenging and STING Inhibition for the Treatment of Acute Kidney Injury 1.00
Spatiotemporally Controllable In Situ Hydrogels Enabled by Nanobottle‐Mediated Encapsulation Technology for Stage‐Specific Synergistic Therapy of Osteoarthritis 1.00
Domain Confined Fluid-Solid-Piezoelectricity Interaction Triggered Thrombogenesis by Directional Scalariform Meta-Aerogel for Rapid Hemostasis 1.00
Interface-Engineered C3N4/TiN Heterostructures for Synergistic Photocatalytic-Nanozyme ROS Generation and Anti-Infective Therapy 0.75
NIR‐Triggered Hydrogen‐Thermotherapy Regulates Inflammatory Circuits Between Macrophages and Synovial Fibroblasts in Rheumatoid Arthritis 1.00
A Novel NIR‐II Organic Fluorescent Small Molecule for the Early Diagnosis of Fat Embolism Syndrome 1.00
Ultrasound‐Triggered Diselenide Bonds Scission for On‐Demand Drug Release in Osteoarthritis Therapy 1.00
Iterative‐Designed Multifunctional Carbon Dots Nanodrug for Celastrol Loading, Targeting Delivery, and Combination Therapy of Kidney Stones 1.00
Discovery of a Novel Nephroprotective Drug Leveraging a Customized Photoacoustic Imaging Nanoprobe 1.00
Preferential Drug Loading into Platelet α Granules Boosts Inflammation‐Targeted Delivery in Rheumatoid Arthritis 1.00
Inhalable Microenvironment‐Responsive and Self‐Adaptive AuCu Bimetallic Clusterzyme‐Based Microgel for Spatiotemporally Precise Therapy of Bacterial Pneumonia 0.89
Biochemically Responsive Bacterial Codes Enabled by Photodynamic AIE Nanoparticles for Advanced Information Encryption 1.00
Charge-Guided Deep Cartilage Targeting Carriers for Nav1.7-Mediated Osteoarthritis Treatment via Simultaneous Pain Management and Cartilage Protection 1.00
Self-Propelled Janus Micromotors with Cascade Microenvironments-Responsiveness for Hydrogen-Actuated Whole-Stage Symptomatic Therapy of Helicobacter Pylori-Associated Gastritis 1.00
Cascade‐Amplified Light‐Free Singlet Oxygen Generation: A Biomimetic‐Targeted Nanogenerator for Precision Rheumatoid Arthritis Therapy 1.00
Breaking the ΔEST Barrier: Triazole-AIE Nanoplatforms with Near-Degenerate Excited States for Combating Drug-Resistant Bacteria 1.00
Mechanically Robust Super-Lubrication Polycarbonate-Polyurethane (PCU) Enabled by Design of Dynamic Mechanics Network and Manufacture of Constrained Hydrogel Coating 1.00
ROS-Scavenging Hydrogel Microneedles Reverse Intervertebral Disc Degeneration via Combined Mild Photothermal and NO Gas Therapy 1.00
An AB-Type Hydrogel CT Contrast Agent for Precise Localization of Intra-Abdominal Hemorrhage 1.00
Engineered NK Exosomes for Tumor Immunotherapy via a Positive Feedback Loop-Mediated Efficient Pyroptosis 1.00
Barnacle‐Inspired Nanocomposite Paste with Enhanced Toughness and Crack Blunting for Rapid Hemostasis 1.00
ROS‐Responsive Nanoplatforms for Atherosclerosis Photoacoustic Diagnosis and Endothelial Cell‐Macrophage Crosstalk Regulation 1.00
Robust Superlubricity in Artificial Cartilage Hydrogels via Gradient Stress Dissipation and Comb-Like Polymer Structures 1.00
TMEM16A Channel Blockade and Strontium/ROS Regulation by Carrier‐Free Nanoprodrug to Reconstruct Bone Homeostasis for Enhanced Osteoporosis Prevention and Treatment 1.00
Rapid Shape Recovery Sponge with Reinforced Skeletons Prepared by Centrifugation‐Assisted Mechanochemical Crosslinking Strategy for Noncompressible Hemostasis 1.00
AIE-Powered Nanosoldiers for Precision Disruption of Biofilm's Extracellular Defense in Infection Treatment 1.00
Wide-Gamut and Reversible Phosphorescence Tuning From Green to NIR in Carbon Dots via Acid-Responsive Protonation-Assembly Strategy 1.00
Lubrication on Demand: A Stress‐Adaptive and Self‐Repairing Material 1.00
Bioinspired Wavy Self‐Secretion Surface for Anti‐Encrustation 1.00
Flexible Wireless Electrical Stimulator Based on Liquid Metal High‐Density Coils for Chronic Pain Therapy 1.00
X‐Ray‐Activated ROS Storm: A Multimechanistic SAO25‐AO@Gel Platform for Deep‐Tissue Bacterial Eradication 1.00
Engineered Nanosponge Platform Corrects TLR7-Related Efferocytosis and Platelet-Activation for Treatment of Different Systemic Lupus Erythematosus Stages 1.00
Highly Efficient Photocatalytic Elimination of Bacteria and Antibiotic Resistance Genes via a Strong Oxidation Surface in Donor-Acceptor SA-PDI@C60 1.00
Extracellular Vesicle–Based Biohybrid Enabling Synergistic Anti‐Oxidative Stress and Anti‐Inflammation for Targeted Therapy of Acute Kidney Injury 1.00
An MSR1‐Targeting Glycolipid Platform for Imaging the Changes of Phagocytic Macrophages in the Progression of Atherosclerotic Plaque 0.96
Rapid Self‐Gelling Powder Forms Dual‐Crosslinked Hydrogel for Robust Tissue Adhesion and Non‐Compressible Hemorrhage Control 1.00
Mild Hyperthermia‐Assisted Coaxial Electrospun Nanofiber Patches for Epicutaneous Allergen‐Specific Immunotherapy 1.00
Design and Development of Fiber Patch to Prevent Reperfusion Injury and Provide Thermal Stimulation for Treating Severe Frostbite 1.00
MnO2–Pd/PAAS Hydrogels With OXD-Like and SOD-Like Dual Enzymatic Activities Accelerate Infected Wound Healing by Inhibiting Bacterial Growth and Mitigating Oxidative Stress 1.00
Orchestration of Pathological Osteoclast‐Chondrocyte Communication via Acid‐Responsive Nanotherapeutics for Articular Cartilage Regeneration 1.00
Phage-Inspired Nanomotor Synergized with Sono-Sensitive Antibiotics for Treating Multidrug-Resistant Klebsiella pneumoniae Lung Infection 1.00
Hydration-Lubricated, Cartilage-Targeted, and Anti-Inflammatory Triple-Functional Nanospheres for the Treatment of Osteoarthritis 1.00
Lubrication Barriers Hydrogel Microspheres Improve Dynamic Tissue Repair via the Blockade of Inflammatory Communication 1.00
Spatiotemporal Regulation of Oxidative Stress by Redox Relays for Ischemia‐Reperfusion Injury Rescue 0.98
Au-Modified SrTiO3 Nanoarray Featuring Enhanced Ultrasound-Responsive Mott–Schottky Heterojunction Speeds Bone Regeneration Through Sonodynamic Antibacterial and Inflammatory Management 1.00
Polymeric Skin Booster with Moderate Collagen Regeneration 1.00
An In Situ Transformable Orally Administrated System for Targeted Intestinal Barrier Protection and Inflammatory Microenvironment Modulation in Sepsis Therapy 1.00
Self‐Propelled Lung‐Targeting Nanovaccine Modulates Iron Homeostasis‐Immune Crosstalk for Therapeutic‐Prophylactic Intervention in Bacterial Pneumonia 1.00
Oxygen‐Immunomodulated Nanocatalysts Enhance Anti‐Infection by Trained Immunity 1.00
“Precision-Guided Killer” Engineered Phage for Combating Carbapenem-Resistant Klebsiella Pneumoniae Induced Inflammatory Bowel Disease 1.00
Polyphenol‐Driven Modular Self‐Assembled Nano‐Antibiotic for Inflammation Control via Bacterial Infection Clearance and Pyroptosis Inhibition 1.00
Biomimetic Hydrogen‐Generating Piezoelectric Hydrogel for Dual Glucose Regulation and Mitophagy Activation in Diabetes‐Induced IVDD 1.00
Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism 1.00
Enhanced Sonodynamic Bacterial Elimination and Wound Healing Therapy Based on Lanthanide Ion Doped Bisub2/subWOsub6/sub Nanosheets and Hydrogel Platform 1.00
Pollen‐Inspired Aptamer Delivery System for Multi‐Target Therapy in Rheumatoid Arthritis 1.00
Ferroelectric Heterojunction Membrane with Rapid Disinfection Through Coupling Piezoelectric and Pyroelectric Catalysis for Wound Regeneration 0.89
Toxin‐Responsive Antigen Reservoir Nanovaccines for In Situ Vaccination Against Bacterial Infection Recurrence 0.74
Surface-Bound Gene-Functionalized Injectable Short Fibers via Reversing Collagen Aging for Inhibiting Intervertebral Disc Degeneration 1.00
Montmorillonite Modulates Manganese d-Band Center to Enhance Cascade Reaction Activity Against Inflammatory Bowel Disease 1.00
Precise Synthesis of Tri‐Pyrroles for Combating Drug‐Resistant Bacteria 1.00
Cellular Capsule Delivery Bioink with Punicalagin-Loaded Chondrocyte Membrane Vesicles for Tissue Engineering Therapy 1.00
Activatable Near-Infrared IIb Rare-Earth Nanoprobe for Early Monitoring Chemotherapy-Induced Liver Injury 1.00
A Printed Polarization-Sensitive Biochip for Rapid and Accurate Detection of Respiratory Infections 0.89
Dual-Nanoparticle Engineered Hydrogel Reverses Bicellular Oxidative Stress to Accelerate Diabetic Fracture Healing 1.00
Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation 0.97
Self-Assembled Poly(sarcosine) Functionalized Host Defense Peptide-Mimicking Poly-β-Peptides for Combating Drug-Resistant Fungal Infection 1.00
Advanced Injectable Microgels: Porous, Small-Sized, and Lubricated Systems for Targeted Synergistic Therapy in Osteoarthritis 1.00
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Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD+ Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection 1.00
Selective Induction of Cancer Cell Pyroptosis by Erbium Nanotuner Enhances Potent Anti‐Cancer Immunity 0.92
Immune and Stem Cell-Mediated Bactericidal Amplification and Bone Remodeling for Infection Clearance and Osteointegration 1.00
Coagulation-Independent Hemostasis Through Architecturally Programmed Chitosan Aerogels with Dual-Crosslinked Networks 1.00
A Nanochiral Biosensor Enables Clinical Anesthesia Monitoring 1.00
Multifunctional Self-Assembling Peptide System for Preventing Noise-Induced Hearing Loss 1.00
High-Efficiency Targeted Mitochondrial Transfer and AUTAC4-Enhanced Dual Renewal Strategy for Rheumatoid Arthritis 0.94
Intercellular Communication‐Driven Mitochondrial Transfer via CXCR4‐Engineered Macrophages Reprograms Bone Marrow Metabolism for Osteoporosis Therapy 1.00
Sheath‐Inspired Durable Semi‐Convertible Hydrogel Enabled Controllable Lubrication and Contractibility 0.92
Polysaccharide Engineered Nanozymes Target Inflammation for Alleviating Colitis‐Associated Mental Disorders via Microbiome‐Gut–Brain Axis 1.00
Bubble Evolution-Guided Interconnected Hierarchical Macroporous Sponges for Non-Compressible Hemostasis in Preclinical Models 1.00
Novel Antimicrobial Nano Bacteriocin: Lactic Acid Bacteria-Derived, Self-Assembled, and Enhanced for Superior Antimicrobial Activity 1.00
Enhanced Biofilm Infiltration by Drug-laden Coacervate for Treating Refractory Infections 1.00
Magnetic Mesoporous Nanoparticles Loaded with Lycium barbarum Glycopeptide for Targeted Therapy of Noise-Triggered Auditory Dysfunction 1.00
Poly(Ionic Liquid) Nanofibers Suppress S. aureus Membrane Vesicle-Induced NETosis to Mitigate Wound and Lung Damage 1.00
Fluoropolymer-Mediated Delivery of a Dual TSHR/IGF1R-Targeting CRISPR-Cas9 System for Localized Therapy in Thyroid-Associated Ophthalmopathy 1.00
Chiral Single-Atom Nanozymes-Enabled ROS Catalysis and Metal Transport Regulation Cooperatively Induce Ferroptosis to Treat Bacterial Infections 1.00
Selectively Breaking Bicontinuous Microphase Confinement for Sustainable and Unprecedented Superlubricating Hydrogels 1.00
Lattice‐Reconstructed Ru‐Clusters on FeOOH‐Based Self‐Adaptive Artificial Peroxisome with Programmed ROS Regulation for Infectious and Inflammatory Chronic Wounds 0.90
Disrupting Complement‐Inflammation Positive Feedback Circuit via Oligonucleotide Hydrogel Microspheres for Reversing Joint Inflammation 0.63
LPS-Binding Hydrogel for TLR4-Mediated Microbiota-Immune Modulation 0.94
A Single-Cell-Inspired Self-Enrichment Therapeutic Strategy Delays Intervertebral Disc Degeneration by Inhibiting Pyroptosis 1.00
Bio‐Orthogonally Labeled Orbitals‐Hybridizing Nanozymes Induce Tissue‐Resident NK Cells for Enhanced Photo‐Immunologic Therapy of Biofilms and Preventing Secondary Infection 1.00
Mitochondria Rewiring by Polyphenol-Copper Nanodots to Truncate Mitochondrial-Endoplasmic Reticulum Crosstalk for Acute Kidney Injury Therapy 1.00
Fully Biocompatible Tantalum-Based Antioxidant Nanoshields for Proximal Tubule Epithelial Cells-Targeted Mitochondrial Holistic Protection in Acute Kidney Injury 1.00
Janus Graphene Oxide Nanoplatform with Oppositely Functionalized Adhesion and Lubrication Enables Local Sustained Fenofibrate Release to Synergistically Halt Osteoarthritis 1.00
Engineered Apoptotic Extracellular Vesicles for Programmable Regulation of Neutrophil-Macrophage-ROS Pathogenic Axis to Reconstruct Rheumatoid Arthritis Microenvironment 1.00
Flexible Photovoltaic Neurostimulator for Analgesia 1.00
Oral Covalent Organic Frameworks as Dysbiosis‐Mitigating Oxalate Sequestrants for Crystalline Nephropathy 1.00
Push–Pull Electronic Effect and D‐Band Center Bi‐Modulated Bio‐Heterojunction Enzyme Enables All‐Stage Infected Wound Healing 0.86
3D Acoustic Imaging Hitting the Diffraction Limit via Fully Parameter‐Optimized Meta‐Lens and Frequency‐Domain Reconstruction 1.00
Photosensitive Biomimetic Nanomedicine‐Mediated Recombination of Adipose Microenvironments for Antiobesity Therapy 1.00
Biomimetic Engineering of Robust Gradient Antibacterial Coatings using Hollow Nanoframes of Prussian Blue Analogues 0.77
Dendritic Cell‐Based Biohybrid Immunomodulator Alleviates Intestinal Inflammatory Disease 1.00
Spatiotemporal Charging Single‐Atom Nanozymes Activated Pyroptosis for Antitumor Immunotherapy via Bioorthogonal Disruption of Succination and Reinvigorating T Lymphocytes 1.00
Bioinspired Smart Nanogels for Rapid Blue Laser‐Activated Hemostasis in Gastrointestinal Bleeding 0.77
DNA‐Engineered Modular Nanovaccines Featuring Precise Topology for Enhanced Immunogenicity 0.93
7 5.14
Is light-to-moderate alcohol drinking associated with the onset of metabolic dysfunction-associated steatotic liver disease in a Chinese cohort? 1.00
Ultra-processed food consumption and incident autoimmune-related hypothyroidism: A sex-stratified prospective analysis from the UK Biobank 1.00
Novel protein targets for type 2 diabetes prevention and their mediating role in the diet–disease relationship: evidence from 2 population-based cohorts and a Mendelian randomization analysis 0.06
Weight-adjusted-waist index, estimated glucose disposal rate, C-reactive protein, and mortality risks among individuals with type 2 diabetes: two prospective cohort studies in China and the UK 0.90
The effect of muscle quality index on the risk of adverse health outcomes: a prospective cohort study of 355,209 adults 1.00
Association of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study 1.00
Empirical Dietary Index for Lower Urate Levels and Risk of Gout: Evidence From Cohort Studies 0.18
4 3.67
The prognostic and clinical significance of cervical stromal invasion in endometrial cancer: a multicenter retrospective study 1.00
Semi-supervised deep learning for uterus and bladder segmentation on female pelvic floor MRI with limited labeled data 0.67
Whole-Genome Sequencing for the Prenatal Evaluation of Fetal Structural Anomalies: A prospective multicenter study 1.00
Expanded Non-Invasive Prenatal Screening for Dominant Single-Gene Disorders: Proof-of-concept, Performance, and Challenges 1.00
13 8.92
Cuproptosis Is Induced in Drug-Induced Liver Injury by Oxidative Stress–Mediated Copper Overload 1.00
Notch1-Gli1 Axis Reprograms Macrophage Polarization and Promotes Hepatic Inflammation and Fibrosis in Metabolic Dysfunction–Associated Steatohepatitis 1.00
Semaphorin 3C/Plexin D1 Interaction Regulates Collagen Metabolism in Keloid Fibroblasts via the Transforming Growth Factor-β1 Signaling Pathway 1.00
Pseudogene-derived long non-coding RNAs GSM3P1/Gstm2-ps1 exacerbate sepsis-associated acute kidney injury by suppressing their parent gene translation 0.17
Deletion of megalin in kidney tubular epithelium upregulates TGFβ1 signaling, aggravates ischemia/reperfusion kidney injury and accelerates the progression to CKD 0.06
Necroptosis Inhibition Preserves Diaphragm Function in Experimental Sepsis 1.00
Liver macrophage changes during early adaptation to alcohol exposure 0.09
Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia 0.08
Growth differentiation factor 11 attenuates photoaging through ferroptosis pathway in SZ95 sebocytes 0.86
Aldehyde dehydrogenase 2 deficiency impairs liver progenitor cell proliferation in alcohol-fed mice 1.00
The Long Noncoding RNA TUG1 Is Down-Regulated in Osteonecrosis of the Femoral Head and Enhances the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Stimulating the Wnt/β-Catenin Pathway 1.00
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus 1.00
Peroxisome Proliferator-activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis 0.67
5 1.96
A large-scale single-cell atlas reveals the pulmonary immune panorama in adult patients with influenza 0.97
Electrical impedance tomography-guided PEEP and mortality of patients with the acute respiratory distress syndrome: The EITVent randomized clinical trial 0.89
Early mechanical reperfusion in high-risk pulmonary embolism supported by V-A ECMO: a multicenter international cohort study 0.02
The Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis. 0.05
Physiological Consequences of Breathing Effort According to the Mode of Ventilation During Acute Hypoxemic Respiratory Failure. 0.03
49 47.95
Elucidation of the Relationship between Hydrogen Peroxide and Pyroptosis by a Superior near-Infrared Fluorescent Probe 1.00
Engineering an Activatable Near-Infrared Fluorogenic Probe for Hypochlorous Acid in Keloid Diagnosis and Therapeutic Evaluation 1.00
Unlocking Spatiotemporal Dynamics: Precise Dual-Modal Bioimaging of Endogenous c-MYC mRNA in Tumors via a CHA-Activated Ratiometric Nanoplatform 1.00
Tandem Mass Spectrometry Fingerprint Tags (TMSFT) Applied for Early Gestation Noninvasive Prenatal Detection of Single-Gene Disorders 1.00
Hypoxia-Responsive Artificial Urinary Biomarker Probe for Early Detection of Drug-Induced Acute Kidney Injury 1.00
Construction of a Renal-Clearable NIR Fluorescent Probe with Sequential Response to Peroxynitrite/Hypochlorous Acid for Visualizing Autophagy Progression in Cisplatin-Induced Acute Kidney Injury 1.00
Rapid Identification of Yeasts in Foods Based on Thermal-Scanning Fluorescence Spectroscopy 1.00
Rapid and Accurate Quantification of Viable Bacteria in Reproducibly Generated Bioaerosols with a Certified Microbial Reference Material 1.00
The Noninvasive Diagnosis of Central Nervous System Leukemia by Specifically Enhanced Magnetic Resonance Imaging 1.00
Mass Spectrometric Analysis of Exercise-Induced Breath Metabolites, Lipids, and Proteins Using Wearable Cold-Mask Sampling 1.00
A Membrane-Impermeable Near-Infrared Probe Enables High-Fidelity Tracking of Foam Cell Progression 1.00
A Visible/NIR-II Dual-Channel Fluorescent Probe for Investigating the Roles of NLRP3 Inflammasome and Ferroptosis during Hepatic Ischemia-Reperfusion Injury 1.00
Preclinical Evaluation of Rationally Designed Peptide-NIRF Probe for c-Met Positive Liver Cancer Imaging-Guided Surgery 1.00
Single-Molecule Analysis of Glycopeptide Antibiotic–Target Interactions Using Nanopore-Based Biomimetic Probes 0.83
A Deep Multimodal Fusion Framework Integrating SERS, Clinical Data, and Metabolomics for Noninvasive MASH Diagnosis 1.00
Label-Free SERS Strategy for Simultaneous Detection of Triplex Renal Biomarkers in Serum toward Precise Renal Function Evaluation 1.00
Integrating AI-assisted SERS Biosensing and Photoactivated Antibacterial Therapy in Au@Cu2–xSe for Combating Multidrug-Resistant Bacteria 1.00
Enhanced Integrative Diagnosis and Therapeutic Strategy for Hepatic Ischemia-Reperfusion Injury through HOCl-Sensitive Cysteine Delivery System for Targeted Antioxidant Modulation 1.00
ZNGEA: ZINB-NMF Integrated Graph Embedding Autoencoder for Metabolite-Disease Association Identification 1.00
A Novel Lithium Ion-Assisted TPP Approach for Enhanced Target Discovery 1.00
Dipeptidyl Peptidase IV Activated Near-Infrared Fluorescent Probe for Visually Evaluating Diabetes Models under Microplastic Exposure 1.00
Highly Specific Targeting of Tumor Extracellular Matrix by a Sharply pH-Activated Single-Chain Collagen Mimetic Peptide Probe 1.00
Dual Targeting and Cascaded Aggregation of Luminogen for Washing-Free and Enhanced Fluorescence Imaging of Intracellular Bacteria 1.00
Rambutan-Like Magnetic Nanozyme Modified with Wheat Germ Agglutinin Enhances Lateral Flow Immunoassay for Ultrasensitive and Broad-Spectrum Detection of Respiratory Microorganisms 1.00
The Burst Enhancement of MRI Using Magnetic Resonance Tuning Based Contrast Agents 1.00
A Target-Induced In Situ J-Aggregation Coupling Cascade Catalyzing Reactive Oxygen Species Clearance Strategy for 3D NIR-II Photoacoustic Imaging Diagnosis and Smart Therapy of Acute Kidney Injury 1.00
Tracking Mutual Interactions of Mitochondria/Lysosomes/Lipid Droplets in DILI and NAFLD with a Viscosity and Peroxynitrite-Sensitive Single Fluorescent Probe 0.75
Deep Learning-Assisted Lens-Free Holography Integrated Pd Nanozyme-Armed Phages for the Rapid and Extraction-Free Detection of Viable Bacteria 1.00
A Highly Efficient Pyroptosis Activator for Three-Photon Fluorescence Imaging-Guided Phototherapy and Hypoxia Tumor Immunotherapy 1.00
A Structure-Guided Bifunctional Aptamer Mitigates Pseudomonas aeruginosa Virulence and Biofilms by Disrupting las and rhl Quorum Sensing Systems 1.00
Rational Design of a Novel Dual-Functional Fluorescent Probe for Simultaneous Monitoring and Imaging of Mitochondrial CO and ATP Fluctuations during Drug-Induced Liver Injury without Spectral Crosstalk 1.00
Cholesterol-Anchored AND-Logic NIR-II Probe for Triple-Responsive Atherosclerosis Imaging 1.00
Apoptotic Body-Hitchhiked Manganese-Based Biomimetic Nanoprobe for Sensitive Magnetic Resonance Imaging of Bacteria Triggering Peritoneal Dialysis-Associated Peritonitis In Vivo 1.00
Multifunctional Co3O4@PDA Nanocomposite-Based Sensitive Dual-Mode Lateral Flow Immunoassay for the Simultaneous Detection of Two Antibodies against Respiratory Tract Pathogens 1.00
A Recyclable Affinity Chromatographic Device for Rapid Colorimetry of Bacteria Using Phage-Derived Cell Wall Binding Domains As Recognition Ligands 1.00
Knitting Organic Cage into Hyper Cross-Linked Polymers for the Efficient Capture of Fluoroquinolones in Pork Samples 1.00
Development of SPQC Biosensor for iStreptococcus pneumoniae/i Detection Based on IscB Nuclease Recognition 1.00
Reversible NIR Ratiometric Probe for Monitoring Redox Homeostasis in Lipid Droplets during Ferroptosis-Driven Liver Injury 1.00
Aptamer-Functionalized Granzyme B-Responsive Nanoprobe for Immunotherapy Assessment: Real-Time Monitoring of Cytotoxic T Lymphocyte Activation Cleavage 1.00
Phage Cell Wall Binding Domain for Gram-Negative Bacteria and Its Application in Detection of Acinetobacter baumannii 1.00
Intratumoral Bacterial-Targeted Cascade-Responsive Sonoafterglow Nanoprobes for Immune Reprogramming and Visualization in Glioblastoma 1.00
Rational Design and Synthesis of Peptide-Based Probes for Fibroblast Activation Protein-Targeted Magnetic Resonance and NIR-I/II Fluorescence Imaging of Cancer-Associated Fibroblasts 0.90
Construction of Flexible Electrochemical Sensing Interfaces Based on Paper/PEDOT:PSS for the Detection of Cystatin C 0.57
A Bienzyme-Locked Activatable Photoacoustic Probe for Precise in Vivo Imaging of Drug-Induced Liver Injury 1.00
Interaction of Single E. coli Bacteria and Phage Revealed and Quantified by Electrochemical Collision Technique 1.00
An NAG-Activatable Glow-Type Chemiluminescent Probe for Sensitive and Early Diagnosis of Acute Kidney Injury through Urinalysis 1.00
An Efficient Electrochemiluminescence Biosensor Based on Ru(bpy)32+@AuNPs@SWCNTs for miRNAs Detection Using a Dual Engine-Triggered DNA Walker 1.00
A Facile Workflow for Sebum Fatty Acids and Squalene Identification via Advanced Lipidomic Methodologies 1.00
Synergistic Integration of Aggregation-Induced Emission and FRET Mechanisms in Conjugated Polymers via Molecular Engineering for Ultrasensitive, Rapid, and Discriminative Detection of Perfluoroalkyl Substances 0.90
20 17.38
Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: a Multicenter, Randomized, Single-blind, Non-inferiority, Phase 3 trial. 1.00
Multi-Planar Ultrasonographic Assessment of Gastric Volume: A Prospective Observational Study. 1.00
Perspectives of children, parents and health care providers on outcomes following anesthesia for surgery:: An international mixed methods stakeholder engagement study from the Pediatric Perioperative Outcomes Group. 0.13
Association of Peripheral Nerve Block with Postoperative Myocardial Injury in High-Risk Cardiac Older Adults Undergoing Hip Fracture Surgery: A Two-Center Retrospective Cohort Study. 0.95
The role of the dorsomedial periaqueductal gray glutamatergic neurons in promoting arousal under multiple general anesthetics in mice. 1.00
Saccade tasks: A non-invasive approach for predicting postoperative delirium in elderly arthroplasty patients. 1.00
Critical Closing and Tissue Perfusion Pressures in Sepsis-Implications for Risk Stratification: A Retrospective Cohort Study. 1.00
Changes in intraoperative rocuronium dosing following the introduction of sugammadex and association with postoperative respiratory complications: A retrospective cohort study. 0.02
Discordances Between Preoperative Creatinine- and Cystatin C-Based Estimated Glomerular Filtration Rate and Outcomes After Noncardiac Surgery: An Observational Study. 0.93
Ultrasound-guided external oblique intercostal plane block with ropivacaine for analgesia after open hepatectomy- a randomized controlled study. 1.00
Sex-specific effects of acute stress on emergence from isoflurane anesthesia via brainstem circuitry in mice. 1.00
Effect of S-Ketamine on Postoperative Delirium in Elderly Patients Undergoing Arthroplasty: A Randomized Controlled Trial. 1.00
Bispectral Index-Guided Anesthesia for Older Patients Having Non-Cardiac Surgery: A Randomized Multicenter Trial. 0.97
The GABAergic Parafacial Zone: Integrating Consciousness and Respiratory Control in Sevoflurane Anesthesia. 1.00
Cognitive decline and dementia in chronic widespread pain: A longitudinal population-based study. 0.44
Effect of urine-guided intraoperative hydration on incidence of acute kidney injury after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei: a randomized trial. 0.94
Effect of Intravenous, Inhalational, or Combined Anesthesia Maintenance on Postoperative Respiratory Adverse Events in Children Undergoing Adenotonsillectomy (AmPRAEC): A Multicenter Randomized Clinical Trial. 1.00
Associations between SNAP-25 gene polymorphism, autonomic nervous system activity and recovery of consciousness from propofol anesthesia. 1.00
The role of the supramammillary nucleus-medial septum glutamatergic pathway in mediating the effects of isoflurane anesthesia. 1.00
Association of Intraoperative Hypotension with Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery: A Secondary Analysis of a Randomized Trial 1.00
22 18.15
Bio-Propelled Stomatocyte Nanomotors with Glutathione-Responsiveness for Osteoarthritis Treatment 0.31
Self‐Assembling Nano‐Antimicrobial Oligopeptides With Dual Offense–Defense Functions for Synchronously Achieving High Activity and Biosafety 0.89
Aggregation‐State Dynamics Drive Double Cooperativity Between Antimicrobial Peptides LL‐37 and HNP1 0.10
Enhancing Superlubricity and Wear Resistance in Mechanically Robust Hydrogel via Microliter‐Scale Subsurface‐Initiated Polymer Brush Grafting 1.00
Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease 1.00
Dual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation 1.00
Real‐Time Super‐Resolution Tracking of mtDNA Remodeling and Inflammatory Release with a Selective Fluorescent Probe 0.45
A Smart Self‐Immobilization Magnetic Resonance Contrast Agent for Delayed Tumor Imaging In Vivo 1.00
C─H Amination of Polypropylene with Sodium N-Chloro-Amides 1.00
Discovery of Antivirulence ClpP Inhibitors by Self‐Resistance Gene‐Guided Mining Coupled with Dual Functional Screening 1.00
Molecular Rotor‐Based NIR‐II TICTgens for Mitochondria‐Targeted Pyroptosis Induction and Multi‐Model Monitoring of Cancer Immunotherapy 0.88
Molecular-Level Design of Polymeric Semiconductor Nanomotors with Multichannel Sensitive 3D Motion for Microorganism Inactivation 0.94
Exercise Modulates Exocytosis: Chemical Insights from the Intracellular Vesicle Perspective 1.00
Precision Screening and Surgical Resection of Pan‐Cancer Using a Tandem‐Locked NIR‐II Fluorescent Probe with Optimized Activation Efficiency 1.00
A “Cocktail” Fluorescent Probe for Multi‐ROS Imaging Unveils Ferroptosis‐Driven Liver Fibrosis Development 1.00
Covalent Organic Framework Nanohydrogel‐Based Oxidase‐Mimicking Nanozyme for Photocatalytic Antibacterial Therapy 1.00
Dynamic Photoacoustic Imaging of Mobile Cu(II) in Vivo via Catalytic Radical Cation Formation 0.88
Host–Guest Antimicrobial Based on Conjugated Oligoelectrolyte and Cyclodextrin 0.93
Heavy‐Atom‐Free Supramolecular Photosensitizers Derived from Conventional Fluorophores 1.00
pH‐Responsive AIE Photosensitizers for Enhanced Antibacterial Therapy 0.67
Modular Synthesis of Dendritic Oligo‐Glycerol Cationic Surfactants for Enhanced Antibacterial Efficacy 0.11
Self‐Assembly of Short Peptides Activates Specific ER‐Phagy and Induces Pyroptosis for Enhanced Tumor Immunotherapy 1.00
1 0.06
Tranexamic Acid Timing and Mortality Impact After Trauma 0.06
2 1.02
Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery. 0.02
Thyroid Function Reference Intervals by Age, Sex, and Race : A Cross-Sectional Study. 1.00
6 4.26
Impact of Dexamethasone-Enriched Tumescent Anesthesia for Radiofrequency Ablation of GSV insufficiency: A Double-Blind Randomized Clinical Trial. 1.00
Long-Term Survival on Extent of Lymphadenectomy for Right-Sided Colon Cancer: Five-Year Follow-up Results of a Randomized Controlled Trial (RELARC Trial). 1.00
In vivo Hypothermic Perfusion Intestinal Auto-transplantation for Patients With Tumors Invading the Mesenteric Root Vascular System: An Unusual Consecutive 19-case Series (with video). 1.00
Comparative outcomes of Single and Dual Proglide Strategies in Endovascular Aortic Repair: A Multi-center Cohort Study. 1.00
Defining Global Benchmarks for Robotic Liver Resections: An International Multicenter Study. 0.15
Novel Benchmark for Robotic Liver Resection - Bridging Tradition with Innovation. 0.11
24 15.35
Human hypofunctional NCF1 variant aggravates salivary gland immunopathology in Sjögren’s disease by promoting switched memory B-cell recruitment and long-lived plasma cell differentiation 0.63
Musculoskeletal ultrasound findings in people with asymptomatic hyperuricemia: baseline analysis from the Transitions in Gout Research (TIGER) study using the OMERACT gout ultrasound semiquantitative scoring system 0.08
Transmembrane TNF-α signalling of macrophages drives pathological osteogenesis in radiographic axial spondyloarthritis 1.00
Psoriatic arthritis monocyte DNA methylomes bridge joint and skin inflammatory pathways across rheumatoid arthritis and psoriasis 0.04
Differentiation of physiological from pathological bone erosions in rheumatoid arthritis: an 8-year HR-pQCT study of the second metacarpal head 1.00
Frequency and characteristics of axial involvement in psoriatic arthritis: results from the International Multicentre AXIS Study 0.02
Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis 0.02
Inhibition of the type I interferon receptor pathway protects against muscle weakness induced by dermatomyositis serum 0.04
Efficacy and safety of mufemilast in patients with Behçet’s syndrome: a phase 2 randomised clinical trial 1.00
A brain-driven neural circuit contributes to tissue regeneration in joint cartilage 0.93
Shared and unique molecular signatures across different autoantibody groups in systemic sclerosis: a multiomics analysis 1.00
Low-dose belimumab reduced risk of flares in patients with systemic lupus erythematosus: a multicentre, randomised, double-blind, placebo-controlled trial 1.00
Difficult-to-treat rheumatoid arthritis (part 1): systematic review and meta-analysis on global prevalence 1.00
Deconstruction of tophi and synovium defines SPP1+ macrophages involved in extracellular matrix remodelling in gout 0.90
Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in lupus nephritis 0.91
The impact of population ageing on musculoskeletal disorders in 204 countries and territories, 1990-2021: global burden and healthcare costs 1.00
Multiomics analysis uncovers subtype-specific mechanisms and biomarkers in idiopathic inflammatory myopathies 1.00
Mycophenolate mofetil plus methotrexate versus cyclophosphamide with sequential azathioprine for treatment of Takayasu arteritis 0.95
Autoantibody reactome analysis reveals diagnostic biomarkers and molecular classification for relapsing polychondritis 1.00
Development of an MHC imputation panel highlights independent contributions of HLA amino acid residues and C4 copy number variations to SLE risk 0.18
Spatiotemporal distributions and regional disparities of rheumatoid arthritis in 953 global to local locations, 1980-2040, with deep learning-empowered forecasts and evaluation of interventional policies’ benefits 0.97
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue 0.14
Spatial multiomics decipher fibroblast–macrophage dynamics in systemic sclerosis 0.53
Epitopes targeted by autoantibodies in presymptomatic individuals predict early rheumatoid arthritis 0.02
2 2.00
Integrated ultraviolet photoacoustic and spectroscopic autofluorescence microscopy for label-free histological and molecular imaging 1.00
Noninvasive in vivo imaging of brain specific absorption rate using thermoacoustic tomography 1.00
8 8.00
Effect of Extracorporeal Shock Wave Therapy Combined With Kinesio Taping on Shoulder Function in Patients With Long-Head Biceps Tendinopathy: A Randomized Controlled Trial 1.00
Plantar Pressure–Paraspinal Surface Electromyography Associations and Within-Participant Surface Electromyography Changes Under Orthotic Insoles in Idiopathic Scoliosis: A Pilot Study 1.00
Tailored Physical Activity Patterns Reduce Poststroke Cognitive Impairment Risk and Improve Long-Term Cognitive Trajectories: Evidence From the Decade-Long CHARLS Cohort 1.00
Association between healthy lifestyle index trajectories and functional disability in middle-aged and older adults: a longitudinal cohort study 1.00
Association Between Sitting Time and Physical Activity with Survival Among Stroke Survivors: A National Cohort Study 1.00
Cortical response and functional connectivity in subacute stroke patients during dual task: An fNIRS study 1.00
Insights into the Complex Relationship Between Domain-Specific Physical Activity, Sedentary Behavior and Mortality in Adults with Chest Pain in the US 1.00
Comparing the Effect of Intermittent Blood Flow Restriction Training and High-Load Resistance Training in Patients with Patellofemoral Pain: A Randomized Controlled Trial 1.00
35 27.97
Integrative Multi‐omics Approaches Identify Biomarkers Associated with Progression from Arthralgia to Rheumatoid Arthritis 0.96
Autoantibodies to Joint‐Related Peptides Are Associated with Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals 0.03
Landscape of Somatic Mutations in a Large Cohort of Chinese Patients With Immune Dysregulations 1.00
Toll‐like receptor 8 is a therapeutic target in rheumatoid arthritis 1.00
TWIST1-Mediated Induction of AEBP1 in Fibroblast-Like Synoviocytes Activates Transforming Growth Factor β Signaling to Drive Angiogenesis and Promote Rheumatoid Arthritis 1.00
ANK1 and EPB41 Variants and the Risk of Steroid-Induced Osteonecrosis 0.86
A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome 1.00
A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis 0.93
OGFRL1 Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor 1.00
TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays 0.92
XCR1+ Conventional Type 1 Dendritic Cells Exacerbate the Inflammation in Osteogenic Arthritis Through IL-17A+CD8+ T Cells 1.00
<atl>First‐Year scpIgG/scp Dynamics in scpIgG4/scp ‐Related Disease: A Critical Window for Predicting Long‐Term Outcomes</atl> 1.00
Deficiency of AP1M2 causes a new autoinflammatory disease with colitis 0.50
Tumor Necrosis Factor–Induced Neuropilin-2 in Fibroblast-Like Synoviocytes Exacerbates Rheumatoid Arthritis 1.00
Single‐Cell Profiling Reveals Divergent Mechanisms of Fibrosis in Localized Scleroderma and Systemic Sclerosis 1.00
Plasma Proteomics Identifies TAOK3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target 1.00
Autoantigen peptide-8-arm PEG-Dyes (APP-Dyes) specifically recognize antigen-specific B cells and improve the diagnosis of rheumatoid arthritis 0.98
Low‐Grade Proteinuria Does Not Predict Favorable Outcomes in Lupus Nephritis: A Longitudinal Cohort Study 1.00
The relation of colchicine to total joint arthroplasty among people with gout in a population‐based cohort study 0.08
The efficacy of Telitacicept in Childhood-onset Systemic Lupus Erythematosus: a prospective multi-center cohort study with IPTW-adjusted comparison to a historical control group treated with Belimumab 1.00
Telomere Length of Peripheral Blood Leukocytes Predicts Disease Severity and Worse Survival in Systemic Sclerosis 0.14
ZBTB20 Regulating Postnatal Articular Cartilage Development and Homeostasis: Implications for Early‐Onset Osteoarthritis 1.00
Chitinase 3‐Like 1 Promotes Endothelial‐to‐Mesenchymal Transition in Systemic Sclerosis via scpmTORC1/scp Signaling Pathway 1.00
Longitudinal Autoantibody and Proteomic Profiles Uncover Biomarkers and Mechanisms of Disease Progression in Systemic Sclerosis 0.97
Efficacy and Safety of Ivarmacitinib, a Selective JAK1 Inhibitor, in Patients With Active Ankylosing Spondylitis: Results From an Adaptive Seamless Phase 2/3 Trial 1.00
Antifibrotic effects of specific targeting of the 5-hydroxytryptamine 2B receptor (5-HT2BR) in murine models and ex vivo models of scleroderma skin 0.08
Risk of serious infection in patients with rheumatoid arthritis‐associated interstitial lung disease or bronchiectasis: A comparative cohort study 0.04
Serum urate levels alter the spatial distribution of urate crystals in synovium and correlate with synovitis and pain in non‐gout female patients with anteromedial knee osteoarthritis 1.00
Association of Abatacept with Lower Mortality Risk Compared to Rituximab in Rheumatoid Arthritis‐Associated Interstitial Lung Disease: An Emulated Target Trial 0.25
C3a‐C3aR1‐mediated interactions between fibroblast‐like synoviocytes and macrophages promote the progression of rheumatoid arthritis 1.00
Deficiency of cartilage‐specific Y‐box binding protein 1 represses NF‐κB signaling and alleviates osteoarthritis progression 0.83
scpEAT/scp‐lancet Diet Modifies the Risk of Rheumatoid Arthritis through Metabolomic Signature 1.00
Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China 0.85
Trio whole exome sequencing in Chinese childhood‐onset lupus reveals novel candidate genes 0.67
Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement 0.88
3 2.96
Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21 0.96
Heat stress activates the coagulation cascade through Z-DNA-binding protein 1–dependent necroptosis 1.00
Endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis 1.00
2 1.20
Angiogenic switching in cerebral cavernous malformations driven by MAP3K3–PIK3CA synergy 1.00
Treatment resistant recurrent unipolar and bipolar depression: associative learning abnormalities 0.20
1 1.00
Outcomes of endovascular aortic arch repair with an off-the-shelf modular inner branched stent-graft: an IDEAL 2a prospective multicentre trial 1.00
3 2.94
Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression 1.00
Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors 1.00
Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma 0.94
4 4.00
Intratumoral Lactobacillus johnsonii Enhances Sensitivity to PD-1 Blockade by Inducing CD8+ T-cell Expansion in Hepatocellular Carcinoma 1.00
Cis-Regulatory Alterations in iFOXP4/i Modulate Esophageal Cancer Susceptibility Induced by Chronic Alcohol Exposure 1.00
Multitask Deep Learning Based on Longitudinal CT Images Facilitates Prediction of Lymph Node Metastasis and Survival in Chemotherapy-Treated Gastric Cancer 1.00
Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer. 1.00
9 6.41
B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism 1.00
Structure of pancreatic hIAPP fibrils derived from patients with type 2 diabetes 1.00
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks 0.15
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration 1.00
Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition 0.94
Systematic profiling reveals betaine as an exercise mimetic for geroprotection 0.99
Dopamine encodes deep network teaching signals for individual learning trajectories 0.08
Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects 0.25
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity 1.00
13 10.51
Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments 0.91
Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury via the microbial-host isozyme DPP4 1.00
Discovery of human gut phage-encoded anti-CRISPR proteins unveils diverse mechanisms for phages to evade type II CRISPR immunity 1.00
Leveraging intratumoral probiotics for pancreatic cancer immunotherapy via xenophagy 1.00
Commensal enteric virome regulates intestinal carbohydrate digestion and absorption 1.00
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health 0.10
Rothia mucilaginosa membrane vesicles stabilize labile iron to alleviate UVB-induced ferroptosis 1.00
A gut-secreted histidine methyltransferase enforces cross-kingdom catalytic antifungal defense 1.00
Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite 0.31
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma 1.00
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy 1.00
Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease 0.19
Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury 1.00
10 8.68
Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia 1.00
The gut microbiota alleviates depression by remodeling gut-brain energy metabolism 1.00
Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling 1.00
Plasma proteomic signature of frailty in 50,506 adults 0.78
Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism 0.92
Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade 1.00
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender 1.00
Gut microbiome-adipose crosstalk modulates soluble IL-6 receptor influencing exercise responsiveness in glycemic control and insulin sensitivity 0.95
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression 1.00
FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression 0.03
5 5.00
Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis 1.00
Auditory activity sustains adult neurogenesis and cognition through the locus coeruleus-norepinephrine system 1.00
VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis 1.00
Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo 1.00
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease 1.00
7 7.00
The anion–π+ interaction strategy enhances the PDT antibacterial performance of AIE-active photosensitizers 1.00
Cationic donor–π–acceptor AIEgen enabling dual-mode reactive oxygen species generation for antibacterial photodynamic therapy 1.00
A light-activated nickel(ii)–antibiotic conjugate for synergistic antibacterial therapy 1.00
An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis 1.00
Core–shell covalent organic framework-copper nickel disulfide nanoreactors for the synergistic treatment of wound infections 1.00
Chain-engineered tetraphenylethylene derivatives for potent antimicrobial activity against pathogens 1.00
A sensitive 2D Cu-TCPP-based respiratory ammonia sensor for non-invasive and more accessible detection of Helicobacter pylori infection 1.00
8 7.88
An extrinsic enzyme-activatable fluorescent probe for high-contrast tumor imaging 1.00
Regulating the photoelectric properties of porphyrin-based COF nanozymes by pillararene with polyphenol structure for efficient photo-enhanced antibacterial effect 1.00
Macrocycle formation-mediated augmentation in reactive oxygen species production 1.00
Tri-specific molecularly imprinted lysosomal nanodegrader enables synergistic therapy of cytokine storm 0.88
Photothermal therapy for bacteria-infected wound healing via a cation–anion inverted antiperovskite with full-spectrum solar absorption 1.00
Bismuth drug eradicates multi-drug resistant Burkholderia cepacia complex via aerobic respiration 1.00
Targeted recognition, fluorescent tracking and augmented killing of multi-bacterial infections via synergizing a magnetic bead-armored phage cocktail with enzyme-activated AIE probes 1.00
Promotion or suppression of hydrogen evolution activity? The competition between sodium cations and quaternary ammonium ions at the metal/water interface 1.00
5 3.34
Prophylactic Hemostatic Treatment to Control Iatrogenic Bleeding During Endobronchial Biopsy (PROTECT Study) 0.91
Poor olfaction is associated with lower pulmonary function in older adults 0.05
Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients with Impaired Consciousness: A Multicenter Randomized Controlled Trial 0.98
Comparative Effectiveness of Tocilizumab Versus Rituximab in RA-ILD: A Emulated Target Trial 0.46
Medical Thoracoscopy with versus without Prior Artificial Pneumothorax for Patients with Minimal or Absent Pleural Effusion 0.94
7 5.34
Targeting E3 Ubiquitin Ligase Hrd1 Prevents Myocardial Ischemia-Reperfusion Injury Through Enhancing ALDH2 Enzymatic Activity. 1.00
The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis. 1.00
Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage. 0.09
Microvascular Endothelial Cells License APS Vasculopathy Through YAP1- and CCN2-Mediated Signaling. 0.25
Partnership Model of Regionalized Care for Congenital Heart Disease in Resource-Limited Settings: Results From the ASSIST Project 1.00
Intracellular L-PGDS-Derived 15d-PGJ2 Inhibits CaMKII Through Lipoxidation to Alleviate Cardiac Ischemia/Reperfusion Injury. 1.00
Dusp14-Mediated Dephosphorylation of MLKL Protects Against Cardiomyocyte Necroptosis in Hypothyroidism-Induced Heart Failure. 1.00
1 0.20
Mapping environmental determinants of aging in place through network analysis: insights from Taipei 0.20
4 3.98
Intrathecal Isoniazid and Dexamethasone Therapy May Improve Outcomes in Patients with Tuberculous Meningitis: A Two-Center Retrospective Cohort Study 1.00
Impact of different INSTIs on BMI among people living with HIV who newly started ART in Shenzhen, China: a real-world data analysis 0.98
Safety, feasibility and rifapentine plasma concentration in Chinese children with 1 month of daily rifapentine plus isoniazid for tuberculosis infection 1.00
A Short, All-Oral Regimen for Pre-Extensively Drug-Resistant Tuberculosis: A Multicenter Open-label Single-arm Study 1.00
6 4.85
Economic and Regional Disparities in Critical Care Ultrasound Training, Equipment Access, and Implementation Barriers in China: A Nationwide Cross-Sectional Survey. 0.94
Conversion From Venovenous to Venoarterial or Hybrid Extracorporeal Membrane Oxygenation: Analysis From the Extracorporeal Life Support Organization Registry. 0.04
Remimazolam Besylate Versus Dexmedetomidine As a Sedative in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-blinded, Randomized, Noninferiority Trial. 1.00
Phenylephrine Vs. Norepinephrine on the Renin-Angiotensin-Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial. 1.00
Association Between Mechanical Power During Prone Positioning and Mortality in Patients With Acute Respiratory Distress Syndrome. 1.00
Habitual Glucosamine Use and Risk of Sepsis: A 16-Year Follow-Up Study. 0.88
5 4.26
BAF60C links nucleolar stress to β cell dysfunction in type 2 diabetes through controlling Reg3b mRNA decay 0.90
Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID 1.00
Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction 1.00
A non-canonical immunometabolic function of BRD3 during sepsis 0.36
Lmo3-expressing peri-isthmus progenitor cells sustain renewal and repair of the mammalian intestinal telocyte niche 1.00
3 1.17
Young-Onset Hypertension Confers Higher Risk of Cardiovascular Disease, Kidney Disease, and All-Cause Mortality in Individuals With Type 2 Diabetes: A Propensity Score-Matched Cohort Analysis. 1.00
White Matter Hyperintensities Moderate the Association Between Diabetes and Non-AD Brain Atrophy. 0.10
Impact of Baseline GLP-1 Receptor Agonist Use on Albuminuria Reduction and Safety With Simultaneous Initiation of Finerenone and Empagliflozin in Type 2 Diabetes and Chronic Kidney Disease (CONFIDENCE Trial). 0.07
6 3.66
Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα 0.92
Mobilization of the Environmental Toxicant Chlorpyrifos during Weight Loss and Its Impact on Liver and Adipose Tissue Metabolism in Mice 0.97
Mobilization of the environmental toxicant chlorpyrifos during weight loss and its impact on liver and adipose tissue metabolism in mice. 0.97
Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics. 0.08
Estimation of Dermal Exposure to Volatile Organic Compounds (VOCs) from Feminine Hygiene Products: Integrating Measurement Data and Physiologically Based Toxicokinetic (PBTK) Model. 0.58
Effect modification of serum omega-3 fatty acids on the associations between urinary phthalate biomarkers mixture and pregnancy outcomes among women seeking fertility care. 0.14
65 64.12
Transcriptomics and single cell sequencing revealed the important role of PPAR signaling pathway in zebrafish liver fibrosis induced by thioacetamide 1.00
Profiling Hydrophobic Organic Pollutants in Serum from Vulnerable Populations in Dalian, China 1.00
Associations of urinary and follicular fluid phthalate exposure with salpingitis in women seeking fertility treatment 1.00
Nanoplastics Exacerbated Renal Injury amid Hypertension: Rethinking Health Hazards in Disease and Implication of Renal Senescence and EMT Associated with Sirt1 Downregulation 1.00
Toxic effects of bisphenol M, a bisphenol A substitute, on early developmental stages of marine medaka (Oryzias melastigma) 1.00
Parental DEHP exposure induces sex-specific reproductive toxicity in zebrafish and behavioral deficits in unexposed offspring 1.00
Dibutyl phthalate exposure-induced AhR activation drives ferroptosis and HMGB1/TLR4-mediated inflammatory liver injury via NRF2–HO-1 signaling 1.00
Occurrence and Transplacental Transfer of Benzotriazole Ultraviolet Stabilizers in Maternal-Cord Serum and Association with Birth Outcomes 1.00
Bisphenol analogs affected hepatic development and disrupted lipid homeostasis in zebrafish larvae 1.00
Associations of Environmental Phenols Exposure with Cognitive Function in Middle-Aged and Older Adults: A Nested Case-Control Study 1.00
Molecular and toxicological study of the plasticizers exposure-induced metabolic disorders 0.67
Urinary metabolomics reveals associations between benzophenone exposure and thyroid function in Children: A repeated-measures study 1.00
Binding Activities of Bisphenol Analogues toward TTR and TBG and Their Potential to Disrupt Thyroid Hormone Homeostasis 1.00
The Effects of Polystyrene Nanoplastic and Bisphenol A Exposure on the Thyroid Gland in Mice 1.00
Paternal BPA and BPS exposure induce testicular dysfunction in pubertal male offspring: roles of OCTN2 carnitine transporter disruption and exacerbated oxidative stress/apoptosis 0.82
Chlorpyrifos-induced autism and depression-like behaviors are ameliorated by trehalose: Integrating network pharmacology and toxicology analyses and animal experiments 1.00
Developmental and metabolic toxicity of diphenyl phosphate: insights from an integrative mechanistic framework in zebrafish embryos 1.00
Network toxicology and multi-omics analyses identify diagnostic genes and elucidate underlying mechanisms of 6PPDQ-induced hepatocellular carcinoma 1.00
Integrative Analysis of DEHP Exposure and Prostate Cancer: Mechanistic Insights and Predictive Modeling 1.00
Impairment of zebrafish (Danio rerio) oogenesis and F1 embryonic development by maternal methylparaben exposure: Insights from transcriptomic analysis 1.00
Nonylphenol Exposure and Cardiovascular Toxicity: Mechanistic Insights and Integrated Risk Assessment from Experimental Models 1.00
6-PPD quinone inhibits ammonia excretion to cause multiple aspects of toxicity in Caenorhabditis elegans by activating dual oxidase complex-SKN-1 axis 1.00
Is Reproductive Toxicity of Bisphenols an Adverse Outcome from Insulin Homeostasis Disruption in Fish? 1.00
Investigating the role and mechanism of methionine in different types of skeletal fluorosis based on Siglec-15 methylation 1.00
Bisphenol exposure during pregnancy and serum total bile acid levels across trimesters: single and combined effects in pregnant women from Guangxi Zhuang, China 1.00
Association between prenatal phthalate exposure and preschoolers’ blood pressure: Mediating role of DNA methylation in hypertension-related genes 1.00
Lipid metabolism disruption as a conserved early response to Benzophenone-1: Pathway sensitivity profiling via dose-dependent yeast functional genomics platform 1.00
Neurotoxic Effects of 4-Hydroxy-4'-Isopropoxydiphenylsulfone Exposure on Zebrafish Embryos 1.00
The Effects of Prenatal GenX (HFPO-DA) Exposure on Gut Microbiota and Metabolic Function in Pregnant Rats and Their Offspring 0.89
Unraveling the reproductive toxicity mechanisms of emerging environmental contaminants 6:2 and 8:2 diPAPs in male mice: an integrated transcriptome-metabolome investigation 0.80
Chronic DBP exposure may cause reduced fertility in female mice by interfering with the HPO axis 1.00
Synergistic Exposure to Endocrine-Disrupting Chemicals in Pediatric Lungs: Epidemiological Drivers and Disease-Associated Variations 1.00
School backpacks and commuter bags: A non-negligible source of human exposure to phthalate monoesters 1.00
Exploring the toxicological impact of 6PPDQ exposure on psoriasis through network toxicology, machine learning, and multidimensional bioinformatics analysis 1.00
The sanitation in restrooms to respiratory health: modelling concentration distribution changes of bioaerosols across buildings with/without semi-open settings 1.00
Associations of urinary biomarkers of exposure to drinking-water disinfection by-products with haematological parameters and systemic inflammation indices among women undergoing assisted reproductive technology treatment 1.00
Responses of zebrafish to phthalate exposure and recovery: Insights into transcriptome-based molecular mechanisms 1.00
Multi-omics analysis reveals fluorinated liquid crystal monomers BDPrB/EDPrB exposure disrupts the steroid biosynthesis function via inhibition of CYP17A1 1.00
Mycotoxin Alternariol exposure promotes endoplasmic reticulum stress-induced hepatotoxicity to exacerbate chronic liver injury 1.00
Insights into the occurrence of ten bisphenol analogues in tidal flat and deepwater sediments in the Pearl River Basin 1.00
Integrative Genetic, Single-Cell and Mechanistic Dissection Identifies Bisphenol A as a Causal Driver of Preeclampsia via Fibroblast-Derived IL-6/STAT3 Signaling 1.00
Perfluorooctane sulfonate exposure disrupts steroid hormone synthesis in rats via the gut-metabolism-testis axis 1.00
Diversity and functional roles of viral communities in gene transfer and antibiotic resistance in aquaculture waters and microplastic biofilms 1.00
Elucidating the mechanisms of environmental pollutant BPA inducing neurotoxicity through metabolomics and network toxicology strategy 1.00
Integrated physiological, transcriptomics, and metabolite analysis reveal photosynthetic toxicity related to the bisphenol A stress response mechanism in pepper (Capsicum annuum L.) 1.00
Exploring the toxicity of bisphenol A and its analogue bisphenol S-MPE to Escherichia coli K12 from integrated AutoQSAR and transcriptomics analysis 1.00
Investigating the biphasic impacts of dodecamethylcyclohexasiloxane on Caenorhabditis elegans: From reproductive and mitochondrial dysfunctions to biochemical and molecular responses 1.00
Environmental levels of bis(2-ethylhexyl)-tetrabromophthalate (TBPH) cause thyroid toxicity and early carcinogenic signals in juvenile fish 1.00
Co-exposure to bisphenol a and arsenic enhance hepatotoxicity in zebrafish by targeting the hypothalamic–pituitary–thyroid axis and PPAR pathway 1.00
Ferroptosis-driven neurobehavioral impairment in zebrafish embryos: Mechanistic links to developmental dibutyl phthalate exposure 1.00
Effects of BPAF exposure on endometrial remodeling: A focus on the homeostasis of the extracellular matrix and the immune status 1.00
Phenol exposure, polygenic risk score, and dyslexia in Chinese children: Gene-environment interaction 1.00
LCCPs exposure induces pulmonary inflammatory injury via AIM2 mediated pulmonary macrophage PANoptosis and M1 polarization 1.00
Phenanthrene Exposure Disrupts Puberty Onset in SD rats by Influencing Hypothalamic Neural Networks 1.00
Nano polystyrene accelerated the reproductive toxicity induced by the Tris(1,3-dichloro-2-propyl) phosphate via Nhr-69-PISD-Drp-1-mediated mitochondrial fragmentation in Caenorhabditis elegans 1.00
Prioritization of Legacy and Emerging Halogenated Organic Contaminants in Humpback Dolphins from Northern South China Sea 1.00
Postnatal exposure to various benzophenones at environmentally relevant levels enhances the susceptibility of mammalian testes to cyclophosphamide-induced spermatogenic stress in adulthood 1.00
Maternal exposure to tris (2-chloroethyl) phosphate during pregnancy and suckling period alters gut microbiota and SCFAs metabolism in offspring of rats 1.00
Environmental tobacco smoke exposure in pregnant women and thyroid hormone levels in newborn cord blood: A birth cohort in China 1.00
The association between maternal exposure to ten neonicotinoid insecticides and preterm birth in Guangxi, China 1.00
Association of Urinary Pesticide Metabolites and Iodine with Thyroid Volume in School-Aged Children 1.00
Bisphenol analogues in soils and lettuce (Lactuca sativa L.) around typical factories in eastern China: Occurrence, contamination characteristics, and health risks 1.00
Novel insights into DBP-induced zebrafish liver inflammatory damage: Ferroptosis activating the HMGB1-TLR4-NF-κB signaling pathway 0.95
Pentachlorophenol exposure, plasma metabolomic markers, and gestational diabetes mellitus: Association and potential mediation analyses 1.00
Promoting effects of lipophilic pollutants on the reproductive toxicity of proteinophilic pollutants to Daphnia magna under chronic exposure 1.00
31 28.77
Life-time levonorgestrel exposure causes intergenerational alterations of the thyroid-catecholaminergic–GABAergic functional network in zebrafish (Danio rerio) 1.00
Climate Change and Chronic Kidney Disease: A Global Analysis Integrating the Global Burden of Disease study 2021 with TerraClimate Data 1.00
Di-tert-Butylphenol (2,4-DTBP) and its analogs disrupt thyroid hormone signaling via activation of retinoid X receptor α 1.00
Disposable plastic-alcohol leachates as emerging Neurotoxicants: Evidence for the mir-330-3p/Acsl1 pathway in cognitive performance 0.91
Prenatal Exposure to Tire-Derived Chemical Mixtures and Childhood Neurodevelopment at 2 years: Integrating Mixture and Single-Pollutant Models 1.00
PFOS exposure at environmentally relevant concentrations promote papillary thyroid carcinoma progression through PI3K/AKT/mTOR-mediated epithelial-mesenchymal transition 1.00
Histone H3K27 acetylation of slc25a4 mediates triclocarban-induced transgenerational developmental toxicity in zebrafish (Danio rerio) at subthreshold exposure 1.00
Placental DNA Methylation at Thyroid Hormone-related Genes Mediates the Association between Prenatal Exposure to Bisphenol Analogues and Increased Offspring Obesity Risk 1.00
Prenatal PFHxS exposure alters ovarian development in female adolescent mice: Transcriptomic, hormonal, and structural evidence of disrupted steroidogenesis 1.00
Physical exercise mitigates the adverse effects of PM2.5 constituents on lung function: New evidence for inflammatory pathways from a crossover study 0.89
Associations of maternal exposure to nonylphenol and bisphenols with precocious puberty in girls: A nested case-control study 1.00
Association between flood exposure and chronic kidney disease: A nationwide cross-sectional study in China 1.00
Association of nitrogen dioxide with non-alcoholic fatty liver disease in Chinese rural older adults: The mediating role of fasting plasma glucose 1.00
Enhancing butyrate production from food waste fermentation: an overlooked role of fungal yeast 0.88
Prenatal organophosphate esters exposure impacts placental structure and inflammatory markers in a trimester-specific manner 1.00
Association of phthalate and substitute exposure with gestational liver function: A longitudinal cohort study 1.00
Acute effects of temperature fluctuations on skin health: A randomized, crossover trial 1.00
Associations of Urinary Environmental phenols with Obesity and Lipid Metabolism in Children and Adolescents: The Expanded Chinese National Human Biomonitoring (CNHBM) Project 1.00
Exposure to triclosan and triclocarban are associated with estrogen metabolism in Chinese pregnant women 0.94
Associations between emerging endocrine-disrupting chemicals and thyroid hormone homeostasis in pregnant women 1.00
Responses of marine pathogen Vibrio parahaemolyticus to 6:2 and 8:2 polyfluoroalkyl phosphate diesters at environmentally relevant concentrations: Concentration-dependent but not fluorocarbon chain length-dependent 1.00
Occurrence, Maternal Transfer, and Risk Implications of Parabens in Humpback Dolphins from the South China Sea 1.00
Dysregulation of gut barrier and microbiota in Asiatic hard clams (Meretrix petechialis) exposed to environmentally relevant bisphenol A 1.00
Association of urinary phthalate metabolite concentrations with inflammatory biomarker levels among pregnant women 0.09
Impact of human lifestyle on the pathogenic potential of urban wastewater 0.06
AO168=O at environmentally relevant concentrations induces reproductive toxicity by causing germline apoptosis and cell cycle arrest in Caenorhabditis elegans 1.00
2,4,6-Tri-tert-butylphenol Promoted Adipogenesis in 3T3-L1 Cells through a Retinoid X Receptor α-Dependent Mechanism 1.00
Assessment of human parabens exposure and health risk based on global biomonitoring data 1.00
Impact of the environmental endocrine disruptor 4-octylphenol on reproductive function in pubertal male mice 1.00
Response of life-history traits, population dynamics, offspring size of Brachionus plicatilis exposure to BTBPE 1.00
17β-Trenbolone modulates anxiety-related synaptic plasticity by affecting the interaction between hippocampal TACR3 and systemic testosterone in male mice 1.00
64 57.73
Systematic Revelation of the Metabolic Fate of Typical Quaternary Ammonium Compounds in Wheat Seedlings 0.92
miR-184/hamp-Mediated Cardiotoxicity and Hepatotoxicity in Offspring Zebrafish Following Paternal Exposure to Environmentally Relevant Concentrations of Tris(1,3-dichloro-2-propyl) Phosphate 1.00
Phage-Encoded Metabolic Bypass Drives Herbicide Resistance in Soil Microbiomes 1.00
Maternal Exposure to Bisphenol A Bis(diphenyl Phosphate) Induces Offspring Colitis through Disrupting the Gut Microbiome-Metabolite Axis 1.00
Gut Microbiota Mediates HFPO–DA-Induced Hepatotoxicity via Arginine Reprogramming in Lean NAFLD Mice 1.00
Synthetic Fiber Sanitary Napkins: Nonnegligible Exposure Source of Organophosphate Esters in Women 1.00
From Field Metagenomes to Mutant Genomes: Coevolution of Cyanophages and Synechococcus in Estuarine Ecosystems 1.00
Insights into the Arms Race between Prokaryotic Hosts and Their Viruses in Mangrove Ecosystem 1.00
Gestational Exposure to Tri-n-butyl Phosphate Induces Maternal Insulin Resistance and Glucose Intolerance by Antagonizing Estrogen Receptor Alpha 1.00
Is There an Optimal Wavelength for Germicidal Ultraviolet Air Disinfection? 0.08
Methylparaben Induces Gut Microbiota–Dependent Neurotoxicity in Zebrafish 0.89
AIE Gemini Surfactant-Enabled Janus Membrane for All-In-One “Sampling–Detection–Elimination” of Airborne Pathogens 1.00
Temporal (2012–2021), Age, and Sex Trends in Exposure to Bisphenols, Antimicrobials, and Parabens in the Australian General Population 0.08
Integrated Network Toxicology and Multiomics Analyses Reveal the Potential Hepatocarcinogenic Effect of BDE 47 and Its Underlying Mechanism 1.00
Prenatal Exposure to Primary Aromatic Amines: Structure-Dependent Transplacental Transfer Mechanism and Toxicity 0.83
Beyond Nephrotoxicity: Maternal–Fetal Transfer of Melamine and Potential Disruption of Placental Steroid Hormones 0.90
Exposure Profile and Combined Effects of Human PPARγ Agonists in Residential Indoor Dust from China 1.00
6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (6:2 Cl-PFAES), a PFOS Alternative, Impairs Testosterone Synthesis in Leydig Cells by Targeting Lipophagy via the SIRT1–FOXO1–RAB7 Axis: An In Vitro and In Vivo Study 1.00
Deglycosylation Enhances the Toxicity of Plant-Derived Glycosyl Bisphenol A during Gastrointestinal Digestion 0.94
Kidney Urate Underexcretion Mediates the Relationship between Per- and Polyfluoroalkyl Substances and their Alternatives and Uric Acid Levels: Evidence from a Case–Control Study and an Animal Study 0.68
Elemental Exposure and Attention-Deficit Hyperactivity Disorder Risk in Population Aged 6–16 Years: Associations and Potential Mediation by Oxylipins 1.00
Far-UVC (222 nm) Suppresses Bacterial UV Resistance and Repair through Inhibition of DNA Repair Pathways 0.91
Elevated Exposure to Pharmaceutical and Personal Care Products Increases Hyperlipidemia Risk: The Mediating Effect of Thyroid Hormones 1.00
Combining Suspect Screening with Large Language Model-Based Text Mining to Comprehensively Characterize Organic Compounds in Human Milk Associated with Pregnancy Complications 1.00
In-Depth Investigation into the Neurotoxic and Neuroglioma Risks of 6PPD Exposure in Zebrafish Larvae: Benchmark Dose Analysis, Molecular Mechanisms, and Adult Pathological Effects 1.00
Disruption of the Reproductive–Metabolic–Aging Signaling Cascade by Organophosphate Esters: Comparative Toxicity of Tris(1,3-dichloro-2-propyl) phosphate and Bis(1,3-dichloro-2-propyl) phosphate in Caenorhabditis elegans 0.61
Unraveling the Mechanisms of Osteoporosis Triggered by Methylparaben and Monomethyl Phthalate through Integrated Mendelian Randomization, In Silico Simulations, and Experimental Validation 1.00
Experimental Tracing and Modeling of Exogenous Microbe Dynamics in Home Environments 0.71
Tetrabromobisphenol S (TBBPS) Causes Non-Negligible and Multigenerational Reproductive Toxicity in Zebrafish 0.82
Food-Associated Phthalate Exposure and Health Risk: Insights from Urinary Biomonitoring and Dose–Response Modeling 1.00
Exposure to a GenX Homologue Results in Sexually Dimorphic Bile Acid Metabolism Disorders Mediated by Hepatic PPARα in Mice 1.00
Interfacial Stabilization of Cu(I) in Ultralow-Dose Cu2O/ZIF-8 Heterojunctions Enabling Rapid and Energy-Efficient Genomic Disruption of Pathogens 1.00
Bisphenol A Disrupts Spermatogenesis via Excessive Mitophagy-Driven Ferroptosis 1.00
Revealing Ferroptosis Induction by Bisphenol A and Bisphenol S through Distinct Protein Targets 1.00
Translocation and Tissue Distribution of Bisphenol AF and Its Transformation Products in Pumpkin Seedlings 1.00
Chain Length-Dependent Inhibition of Human and Rat Placental Aromatase by Benzalkonium Disinfectants: Experimental, Quantitative Structure–Activity Relationship, and In Silico Docking Insights 1.00
Toxic Switch and Key Effectors of Cu in Zebrafish Gills: Coupling Single-Cell RNA Sequencing and Redox Imaging 1.00
Placentation Disruption by Perfluorooctanoic Acid and Perfluorooctanesulfonate in Human Trophoblast Organoids 1.00
Hepatotoxicity of 8:2 Polyfluoroalkyl Phosphate Diesters Exposure via JAK2/STAT3 Pathway Activation and M1 Macrophage Polarization in Mice 1.00
Quantitative Toxicokinetic Investigation of Emerging Aryl Organophosphate Esters in Rats 1.00
Identifying Metabolic Signatures of Bisphenol Analog Exposure: Implication for Rapid Toxicity Screening of New Alternatives 1.00
Tetrabromobisphenol A Induces Neurotoxicity in Adult Zebrafish: Insights from the Gut Microbiota-Bile Acid-Brain Axis 1.00
Risk of Neurodevelopmental Disorders in Preschool Children Associated with the Longitudinal Trajectory of Phthalates during Pregnancy: Potential Mechanisms Based on Metabonomics of Cord Blood 1.00
Disrupted Cholesterol Homeostasis as a Mechanism of Pharmaceutical-Induced Neurodevelopmental Toxicity: A Transgenic Zebrafish Screening Model for abcg1 1.00
Unraveling the Link between Air Pollution and Psoriasis Subtypes: Genetic Architecture of Epigenetic Insights and Mediating Cytokines 0.82
Life-Cycle Benzo[a]pyrene Exposure Induces Sex-Specific Reproductive Impairment, Feminization, and Transgenerational Disruption in Marine Medaka (Oryzias melastigma) 1.00
Machine Learning-Based Screening of Cosmetic Ingredients Identifies Vat Blue 6 as a Thyroid Hormone Receptor β Disruptor 1.00
Molecular Mechanisms of Premature Hippocampal and Hypothalamic Senescence Induced by Maternal Exposure to DBP in Male Offspring Mice 1.00
High-Throughput Screening Identifies Bisphenol P as a Potent Cardiotoxin, Inducing Cardiotoxicity through Apoptosis and the NF-κB Pathway 0.86
Benzotriazoles and Benzothiazoles, Maternal and Neonatal Thyroid Hormones, and Childhood Growth: A Longitudinal Cohort Study 0.88
Typical Thermochromic Dye Crystal Violet Lactone Acts as an Endocrine Disruptor: Nontargeted Screening, Prioritization, and In Vivo Experimental Verification 1.00
Unveiling Hidden Health Risks: Machine Learning Enhanced Modeling of Plastic Additive Release Kinetics in Fresh Produce Packaging 1.00
Similar Prophage Induction but Divergent Antibiotic Resistance Gene Occurrence: Leachates and Free Radicals Drive Differential Activation Mechanisms in Aged Tire Crumb Rubber 1.00
Occurrence and Emission Evaluation of Oxypurinol and Metformin from Effluent in WWTPs across Australia 0.23
Microbial Dysbiosis in the Lung and Gut in Response to Inhalable Particulate Matters in Pneumoconiosis Patients and Animals 1.00
Gestation Exposure to Organophosphate Esters: Structure-Dependent Transplacental Transfer Patterns, Mechanisms, and Toxicity 1.00
Screening and Evaluation of Male Reproductive Effects of Isothiazolinones at Human-Relevant Levels in Mammals: Direct Impairments and Increased Susceptibility to Subsequent Spermatogenic Stress 1.00
Renal Dysfunction Induced by Sodium p-Perfluorous Nonenoxybenzenesulfonate in Mice: Insights from the Intrinsic Mechanisms of Proteinuria 1.00
Aryl Organophosphate Esters and Hemostatic Disruption: Identifying Risk through Machine Learning and Experimental Validation 1.00
Enhanced Phytopathogen Biofilm Control in the Soybean Phyllosphere by the Phoresy of Bacteriophages Hitchhiking on Biocontrol Bacteria 0.63
Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice 1.00
Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights 0.92
6PPD and 6PPD Quinone Induce Endometrial Cell Dysfunction via Activating ERα and GPER at Human-Relevant Levels 1.00
Trends of Organophosphate Ester Flame Retardant Metabolites in Age- and Sex-Stratified Pooled Australian Urine Samples from the Past Decade (2012–2023) 0.04
3 2.34
Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases 0.50
Urinary tract infection and continuation of sodium-glucose cotransporter-2 inhibitors in diabetic patients 0.88
Fractional flow reserve-guided renal artery stenting in atherosclerotic renovascular hypertension: the FAIR randomized trial 0.96
2 0.81
RESECT: A Randomised Controlled Trial of Audit and Feedback in Non–muscle-invasive Bladder Cancer Surgery 0.00
Flexible Ureteroscopy with a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2–3 cm Renal Stones: An International, Multicenter, Randomized, Noninferiority Trial 0.81
8 5.28
ENPP1-Regulated Extracellular Purine Metabolism Drives Pancreatitis-Mediated Pancreatic Cancer 1.00
Ganglioside-Mediated Neural-Acinar Crosstalk Facilitates Pancreatic Carcinogenesis via Metaplastic Niche Remodeling 1.00
Revealing the Antagonistic Interactions of Faecalibacterium prausnitzii and Bacteroides fragilis in Colorectal Cancer 1.00
Targeting APE1-Redox Function Reverses SOX9-mediated Chemoresistance in Esophageal Adenocarcinoma 0.05
The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis 0.06
Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis 1.00
Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation 0.18
Associations of alcohol consumption and genetic predisposition to hepatic steatosis with liver-related events: results from large population-based cohort studies 1.00
25 21.63
Metagenomic identification of gut microbiome signatures for accurate diagnosis and prognostic prediction of Epstein-Barr virus-associated nasopharyngeal carcinoma 1.00
Targeting PKM2-dependent glycolysis reprogrammes monocytes into Cadm1+ macrophages to promote mucosal repair and attenuate colitis progression 1.00
ifidobacterium catenulatum boosts anti-PD-1 efficacy in microsatellite stable colorectal cancer via activating CD8+ T cells 0.93
Token-guided multimodal prognosis in hepatocellular carcinoma: a framework steered by tumour–stroma ratio 0.95
Bacterial genomic structural variations in children with autism serve as diagnostic biomarkers 0.83
Endothelial RAP1A attenuates sinusoidal capillarisation and liver fibrosis by inhibiting RAF1-mediated Notch activation 1.00
Low-frequency repetitive transcranial magnetic stimulation attenuates visceral pain in IBS with diarrhoea via inhibition of the medial prefrontal cortex 1.00
Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes 0.42
Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity 0.86
<atl>Pueraria lobata-derived exosome-like nanovesicles alleviate rheumatoid arthritis via targeting iRuminococcus gnavus/i phenylethylamine production</atl> 1.00
Spatial transcriptomics defines the molecular progression, invasion and immune landscape of IPMN and IPMN-derived pancreatic cancer 0.79
Autophagy of Kupffer cells modulates CD8+ T cell activation in primary biliary cholangitis 0.89
Gut microbe alleviates stress-related cancer metastasis by oleic acid degradation 1.00
A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis 0.94
First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia 0.03
Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts 1.00
Single-cell analysis identifies RETNsup+/sup monocyte-derived Resistin as a therapeutic target in hepatitis B virus-related acute-on-chronic liver failure 1.00
Holdemanella biformis augments washed microbiota transplantation for the treatment of radiation enteritis 1.00
Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression 1.00
ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation 1.00
Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies 0.83
Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor 1.00
Rice-derived recombinant human serum albumin as an alternative to human plasma for patients with decompensated liver cirrhosis: a randomised, double-blind, positive-controlled and non-inferiority trial 1.00
Non-invasive risk-based surveillance of hepatocellular carcinoma in patients with metabolic dysfunction-associated steatotic liver disease 0.23
Commensal Bacteroides T6SS alleviate GI-aGVHD via mediating gut microbiota composition and bile acids metabolism 0.93
23 17.28
Toxic lipid-induced epigenetic activation of ICAM1 in liver sinusoidal endothelium regulates myeloid-driven fibro-inflammatory response in MASH. 0.03
Forkhead box protein M1 network induction and crosstalk drives the development of alcohol-associated liver disease. 0.18
Prospective head-to-head comparison of routine non-invasive scores for predicting severe cirrhosis-related morbidity in the general population. 1.00
Liver transcriptome sequencing contributes to the molecular diagnosis of genetic liver diseases. 1.00
ECM1 produced by hepatic stellate cells serves as a gatekeeper of liver homeostasis in hepatic fibrosis. 0.89
Head-to-head comparison between vibration-controlled transient elastography and histology in predicting liver-related events due to metabolic dysfunction-associated steatotic liver disease. 0.21
Myeloid CD36 deficiency alleviates hepatic fibrosis by promoting adaptive immunity of macrophage. 1.00
CXCR6 defines a distinct resident state in γδ T cells for protecting from liver cirrhosis. 1.00
HBV induces liver fibrosis through the generation of reactive oxygen species in a pyruvate-dependent manner. 0.69
Development and validation of a non-invasive score for at-risk metabolic dysfunction-associated steatohepatitis in individuals with obesity undergoing bariatric surgery. 1.00
Predictors of fibrosis, clinical events and mortality in MASLD: Data from the Global-MASLD study. 0.05
Decoding tumor heterogeneity with imaging biomarkers predicts response to TACE plus Immunotherapy and targeted therapy in HCC. 1.00
KLF9 drives intermittent hypoxia-induced NAFLD by suppressing the NR4A1-p38 MAPK hepatic metabolic axis. 1.00
Epigenetic repression of hepatocyte FoxO1 disrupts local immune homeostasis and promotes liver inflammation. 1.00
Global performance of non-invasive tests in MASLD: Insights from the G-MASLD study. 0.05
Association between longitudinal weight change and clinical outcome in individuals with MASLD. 0.21
Early on-treatment LSM reliably predicts liver-related events in CHB patients with significant fibrosis and cirrhosis. 1.00
Chiglitazar in MASLD with hypertriglyceridemia and insulin resistance: A phase II, randomized, double-blind, placebo-controlled study. 1.00
Biliary YB-1/GLI2 axis facilitates ductular reaction and promotes hepatic stellate cell activation via SPP1/Integrin αvβ1 signaling during liver fibrogenesis. 1.00
Dissecting liver inflammation ecosystem identifies annexin A1 as a pro-resolving target for liver failure. 0.96
ECM1 protects against liver steatosis through PCBP1-mediated iron homeostasis. 1.00
Hepatocyte-specific C-C motif chemokine ligand 9 signaling promotes liver fibrosis progression in mice. 1.00
Alcohol-induced disruption of hepatic m6A modification exacerbates alcohol-associated steatohepatitis by impairing liver immune microenvironment homeostasis. 1.00
2 2.00
DNAH14 deficiency disrupts sperm annulus positioning and compromises offspring postnatal development 1.00
Randomized controlled study on the use of virtual reality for pain relief in oocyte retrieval under transvaginal ultrasound guidance using paracervical block and conscious sedation 1.00
6 5.59
Unsupervised Liver Deformation Correction Network Using Optimal Transport for Image-Guided Liver Surgery 0.88
Label-supervised surgical instrument segmentation using temporal equivariance and semantic continuity 1.00
RoboNurse-VLA: Robotic Scrub Nurse System based on Vision-Language-Action Model 0.71
Deep Coarse-to-Fine Networks for Robust Segmentation and Pose Estimation of Surgical Suturing Threads 1.00
Visual Anomaly Detection for Reliable Robotic Implantation of Flexible Microelectrode Array 1.00
Learning to Perform Low-Contact Autonomous Nasotracheal Intubation by Recurrent Action-Confidence Chunking with Transformer 1.00
3 3.00
Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells 1.00
Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine 1.00
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo 1.00
1 0.20
Optimizing Intracellular Transport of Antimicrobial Metallohelices Delivers Selective Nanomolar Potency in E. coli 0.20
14 11.44
The effect of weight-loss surgery in patients with obesity on adipose tissue mesenchymal stem cells versus circulating endothelial progenitor cells 0.05
Association between metabolic signatures of predicted VAT mass and risk of MASLD and other chronic liver diseases 1.00
Exploring the interaction of obesity and allergy and the potential roles of gut microbiota in the development of this comorbidity in male mice 1.00
Estimating the effect of hypothetical dietary protein interventions on changes in body composition of postmenopausal women over 3 years using data from the Women’s Health Initiative (WHI) Study: an emulated target trial 0.04
Long-term impact of newly-proposed clinical obesity on autoimmune disease incidence: insights from the UK Biobank 0.67
Are reallocating time to moderate-to-vigorous physical activity associated with preschoolers’ body composition? 1.00
Dynapenic abdominal obesity is associated with long-term cognitive trajectories and mild cognitive impairment 1.00
A U-shaped relationship between body mass index and the risk of elevated liver stiffness in older people: evidence from the 5‐year retrospective cohort study 1.00
Diurnal timing and volume of physical activity in relation to metabolic syndrome in US adults: a population-based cohort study 1.00
Mortality risk associated with general and central obesity in inflammatory bowel disease patients: a long-term prospective cohort study 1.00
Age-specific childhood obesity and adult cholelithiasis: association and shared transcriptomic bases 1.00
Association between plasma proteomic dynamic changes and metabolic outcomes in patients undergoing bariatric surgery 0.93
Causal effects of body composition on lifespan: Mendelian randomization analysis 0.75
Evaluating the obesity paradox in patients with sepsis and cancer 1.00
2 1.01
Diacerein for Knee Osteoarthritis 0.06
Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis 0.94
5 4.49
Parent-Reported Chronic Pain in Children With and Without Developmental Disabilities 0.80
40-Hz Light Stimulation and Emergence Delirium Incidence After Sevoflurane Anesthesia in Children 0.91
Digital Health Interventions in Pediatric Perioperative Care 1.00
Acceptance and Commitment Therapy–Based Parenting Program in Children With Co-Occurring Asthma and ADHD 0.80
Tacrolimus or Mycophenolate Mofetil for Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome 0.98
4 1.53
Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis 0.82
Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks 0.57
Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence 0.06
Framework for Brain-Derived Dimensions of Psychopathology 0.09
4 3.23
Severe Splenic Injuries in Patients With Multiple Trauma 0.30
Intrathecal Morphine for Enhanced Recovery After Laparoscopic Colorectal Surgery 1.00
Parathyroidectomy and Risk of Incident Diabetes in Patients With Primary Hyperparathyroidism 0.93
Hemodynamic Impact of Cipepofol vs Propofol During Anesthesia Induction in Patients With Severe Aortic Stenosis 1.00
4 2.90
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score 0.01
A Fall Prevention Program Integrated in Primary Health Care for Older People in Rural China 0.89
Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma 1.00
Robotic vs Laparoscopic Surgery for Middle and Low Rectal Cancer 1.00
23 20.83
Caveolin-1 deficiency improved glucose metabolism via modulation of β-cell autophagy in high-fat diet-fed mice 1.00
Small RNA ASpks2 promotes Mycobacterium tuberculosis survival in macrophages via targeting polyketide synthase 2 1.00
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation 1.00
Aspartate treatment ameliorates metabolic dysfunction-associated fatty liver disease through upregulation of CBS and suppression of ferroptosis 1.00
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl− currents in the early distal convoluted tubule of the mouse kidney 1.00
CLDN5 as a novel modulator of podocyte adhesion to extracellular matrix via β1-integrin binding 1.00
Neurofascin stabilization by contactin-associated protein-like 2 and CTCF alleviates mitochondrial dysfunction in Schwann cells during facial nerve injury 1.00
Temperature downshifts induce biofilm formation in Pseudomonas aeruginosa through the SiaABCD signal and functional module 1.00
B3GNT8-Mediated Glycosylation Maintains Intestinal Homeostasis and Protects Against Colitis 1.00
EGFR-Targeted Gadolinium Contrast Agents for Enhanced Molecular Magnetic Resonance Imaging of Tumors 1.00
Rab2A modulates liver fibroblast growth factor 21 (FGF21) expression and systemic metabolism via apolipoprotein B-CREBH signaling 1.00
Metformin attenuates O-GlcNAc modification to improve renal function via AMPK/mTOR signaling in diabetic nephropathy 0.92
Acetoacetate ameliorates skin fibrosis by modulating TGF-β1–Smad2/3 signaling pathway 1.00
Long non-coding RNA enhances SARS-CoV-2-mediated apoptosis through epigenetic repression of angiotensin-converting enzyme 2 1.00
Compartmentalized thymidine phosphorylation by mitochondrial nucleotide kinases TK2 and CMPK2 0.07
Structure-based identification of salvianolic acid B as an inhibitor targeting Salmonella InvC ATPase 1.00
Dominant-negative NARS1 R534∗ mutation causes wild-type subunit poisoning and heterodimer predominance in cells 0.11
Phosphoglycerate dehydrogenase interacts with and inhibits the protein kinase TAK1 to mitigate septic shock 1.00
Sidt2 Inhibits Islet β-Cell Dedifferentiation by Regulating Insulin Secretion 1.00
Leber's hereditary optic neuropathy–associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis 0.93
Secreted EMC10 inhibits muscle GLUT4 activity and glucose uptake in mice 0.94
Mitochondrial tRNA processing defects reprogram mitochondrial and cellular homeostasis 0.86
High uric acid exacerbates nonalcoholic steatohepatitis through NLRP3 inflammasome and Gasdermin D-mediated pyroptosis 1.00
18 16.42
High-Grade 3-Column Osteotomies Are Not Interchangeable: Schwab-Grade-III PSO Versus Schwab-Grade-V VCR in Treating Severe Kyphoscoliosis with an Average 9-Year Follow-up. 1.00
Significant Anxiolytic Effect and Enhanced Recovery Benefits of Perioperative Low-Dose Olanzapine in Patients with Anxiety Undergoing THA: A Randomized Controlled Trial. 1.00
Mild Lateral Femoral Condyle Cartilage Damage Does Not Affect the Outcomes of Medial Unicompartmental Knee Arthroplasty: A Mean 6-Year Follow-up Study. 0.89
Increased Critical Shoulder Angle Impairs Tendon-Bone Healing in a Rat Model of Chronic Rotator Cuff Tears. 1.00
Impact of the Femoral Pin Tracker on Soft-Tissue Tension in Robotic-Assisted Total Knee Arthroplasty: A Prospective Randomized Controlled Trial. 1.00
AI-Driven CT-MRI Image Fusion and Segmentation for Automatic Preoperative Planning of ACL Reconstruction: Development and Application. 1.00
Effect of Tourniquet Use on 3D Cement Penetration and Mid-Term Implant Stability in Primary Total Knee Arthroplasty: A Randomized Controlled Trial. 1.00
Physical Activity and 4-Year Radiographic Medial Joint Space Loss in Knee Osteoarthritis: A Joint Model Analysis. 0.55
Clinical Application of an Ultrasonic Bone Scalpel in the Treatment of Osteoid Osteoma: A Single-Center Pilot Study. 1.00
The Impact of Cervical Multifidus Sarcopenia on Outcomes After Laminoplasty for Cervical Ossification of the Posterior Longitudinal Ligament. 1.00
Postoperative Abstinence Restores Osseointegration Impaired by Ethanol Consumption in a Murine Tibial Implant Model. 0.05
Congenital Cervical Scoliosis at the Craniovertebral Junction: Clinical Characteristics and Surgical Strategies in 27 Patients with Mid-Term Follow-up. 1.00
Efficacy and Safety of Tranexamic Acid Combined with Absorbable Hemostat in Reducing Perioperative Blood Loss in Total Knee Arthroplasty: A Prospective, Blinded, Randomized Controlled Trial. 1.00
The Smallest Worthwhile Effect as a Promising Alternative to the MCID in Estimating PROMs for Adult Idiopathic Scoliosis. 1.00
A Deep Learning-Based Clinical Classification System for the Differential Diagnosis of Hip Prosthesis Failures Using Radiographs: A Multicenter Study. 0.93
PGE2 Ameliorates Aging-Aggravated Rotator Cuff Muscle Atrophy. 1.00
Surgical Correction of Severe Scoliosis Leads to Changes in Central Airway Resistance Evaluated with CT-Based 3D Reconstruction and Impulse Oscillometry. 1.00
Intraoperative Direct Sonication Versus Conventional Sonication in the Diagnosis of Periprosthetic Joint Infection: Comparison of Diagnostic Accuracy and Time to Positivity of Fluid Culture. 1.00
6 5.90
Galaxolide triggers trophic cascades from microbes to fish: Community sensitivity and molecular insights reveal underestimated ecological risks 1.00
Effects of architectural spatial design on bacterial and fungal diversity and pathogenic potential in student dormitories under hot-humid climates 1.00
Cu-doped biomass-derived carbon quantum dot modified BiOBr/g-C3N4 photocatalyst to eliminate antibiotics, antibiotic resistant bacteria, and resistance genes 1.00
Research on the influence of dust collection pipeline and vacuum hood structure on the dust removal effect of polishing workshops 1.00
Experimental study of local exhaust dust control characteristics from partial enclosure during bulk material falling in an industrial building 1.00
Natural bio-photosensitizers in sludge: Extracellular polymeric substances (EPS)-driven persulfate activation for sustainable antibiotic degradation 0.90
14 10.01
International real-world study on osilodrostat efficacy and safety in adrenal Cushing syndrome 0.05
Impact of serum prolactin on cognitive function, brain structure, and function in type 2 diabetes mellitus 1.00
Handgrip Strength and Trajectories of Preclinical Obesity Progression: A Multistate Model Analysis Using the UK Biobank 0.67
Serum Minerals and Male Age-related Hypogonadism: Multimodal Evidence Decoding Associations and Intervention Strategies 1.00
Trends In Reported Outcomes for Growth Hormone Therapy In Children With Growth Hormone Deficiency 0.15
Integrative Machine Learning Approach for Predicting Resistance to First-Generation Receptor Ligands in Acromegaly 0.33
Defining puberty and spectrum of hypogonadism in Alström Syndrome 0.24
A missense mutation in close proximity of ALS-linked PFN1 mutations causes only early-onset Paget’s disease of bone 1.00
The USP8 Mutational Status in Combination With Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease 1.00
High-Throughput Proteomics and Immunohistochemistry of Orbital Connective Tissue in Graves’ Orbitopathy 0.68
Thyrotrophin Receptor Antibody: Objective and Quantitative Inflammatory Indicator in Patients With Thyroid Eye Disease 1.00
The Combination of Aromatase Inhibitors and GH Treatment for Idiopathic Short Stature in Male Adolescents 1.00
Optimal Levothyroxine Dosing Strategy for Immune Checkpoint Inhibitor-related Hypothyroidism: A Retrospective Study 1.00
Regional Brain Structure Alterations in Diabetes but Not Prediabetes: the Shanghai Changfeng Study 0.90
15 12.83
Epigenetically controlled endothelial promyelocytic leukemia drives liver inflammation and fibrosis 0.85
Chloride homeostasis dysfunction drives hyperactivation of corticotropin-releasing factor-expressing neurons in the amygdala in stress-induced hypertension 1.00
Estrogen deficiency and risk of hearing loss in pediatric Turner syndrome 1.00
Reduced glycoprotein hormone β-5 links male aging and testosterone decline to increased adiposity 1.00
A protein-based pneumococcal vaccine elicits broad immunity associated with multifunctional antibody responses in humans 1.00
A midbrain–cortical circuit mediated by claustrum neuronal ensemble orchestrates drug-paired context memory processing 0.86
Adipocyte-derived FABP4 promotes metabolism-associated steatotic liver–induced hepatocellular carcinoma by driving ITGB1-mediated β-catenin activation 1.00
Subcutaneous white adipose tissue–derived extracellular vesicles maintain intestinal homeostasis via IgA biosynthesis in aging mice 1.00
BAF60a-dependent chromatin remodeling preserves β-cell function and contributes to the therapeutic benefits of GLP-1R agonists 1.00
Urine proteins reveal distinct coagulation and complement cascades underlying acute versus chronic lupus nephritis 0.06
A noncanonical parasubthalamic nucleus–to–extended amygdala circuit converts chronic social stress into anxiety 1.00
Distinct nucleus accumbens neural pathways underlie separate behavioral features of chronic pain and comorbid depression 1.00
Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment 1.00
CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling 0.12
Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis 0.94
2 2.00
Fullerene for Reducing Acute Radiation Dermatitis in Patients Undergoing Radiotherapy for Head and Neck Cancer: A Phase II, Double-Blind, Randomized Controlled Trial. 1.00
Phase II Clinical Study of Adebrelimab and Bevacizumab Combined With Cisplatin/Carboplatin in Patients With Triple-Negative Breast Cancer With Brain Metastases (ABC Study). 1.00
1 1.00
Xbp1 controls the reparative function of intestinal ILC2s during colitis 1.00
7 4.44
Global epidemiology of bacterial infections in patients with cirrhosis: A systematic review and meta-analysis 0.89
Incidence and implications of abstinence-induced recompensation in alcohol-related cirrhosis 0.04
Microbial metabolism dysfunction induced by transarterial chemoembolization aggravates postprocedural liver injury in HCC 1.00
Alcohol activates ATF4/LPLA2-mediated BMP metabolism to enhance HBV-induced hepatocellular carcinogenesis 1.00
Effect of Hypertension on Long-term Adverse Clinical Outcomes and Liver Fibrosis Progression in MASLD 0.45
B cells drive CCR5+CD4+ tissue-resident memory T cell cytotoxicity via IL-15Rα-IL-15 signaling in primary biliary cholangitis 1.00
Impact of first and further decompensation in patients with compensated ACLD due to MASLD 0.06
22 12.63
<atl>Predicting risk of iPlasmodium vivax/i microscopy-detected episodes using serological markers in patients with iPlasmodium falciparum/i malaria: a multi-country diagnostic performance evaluation</atl> 0.02
Middle East Respiratory Syndrome Coronavirus–Specific T-Cell Responses in Dromedary Camel Abattoir Workers in Nigeria Suggests Frequent Zoonotic Spillover 0.78
Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia 0.02
RNA Polymerase III suppresses varicella zoster virus in human neurons 0.06
Repeat influenza vaccination effects in 2021/22 and 2022/23 in a community-based cohort in Hong Kong 0.85
Influenza vaccination effectiveness against influenza-associated hospitalization in children and the effects of repeated vaccination 0.90
Mzb1 Promotes Progression of Schistosomiasis by Inducing Endoplasmic Reticulum Stress 1.00
A monovalent SMAC mimetic as a potential host-directed therapy for tuberculosis 1.00
TRAF1 Inhibits Macrophage Killing of Sporothrix schenckii by Enhancing NOS2 Expression and Activity 1.00
Defining Severe Shigellosis in the Enterics for Global Health Study: A Comparison of Leading Diarrhea Severity Definitions Among Children With Shigella Diarrhea 0.02
Anti-neuraminidase antibody responses in older adults after consecutive vaccinations with enhanced influenza vaccines: a randomized controlled trial 0.71
Non-invasive detection of occult yet significant liver pathology in ALT-normal chronic hepatitis B: a multicenter study 1.00
Characteristics and Antiadhesion Activity of Chicken Single-Chain Fragment Variable Antibodies Against Helicobacter pylori Adhesin 1.00
Evaluating the impact of unadjusted confounding and study design on estimated pathogen-attributable diarrhea incidence among children in the MAL-ED cohort 0.20
Single-cell transcriptome profiling reveals the immune dysregulation characteristics of mice infected by iBrucella abortus/i 0.93
Emergence of Two New Lineages of the Cosmopolitan Dengue Virus Serotype 2 in Yunnan, China, 2024 1.00
Influenza-associated excess mortality associated with influenza B in Hong Kong, 2014-2023 0.80
External validation of paediatric pneumonia and bronchiolitis risk scores to predict mortality in children hospitalised in Kenya: a retrospective cohort study 0.04
Impact and Cost-effectiveness of Regular Self-digital Anorectal Examination on Syphilis Among Gay, Bisexual, and Other Men Who Have Sex With Men: A Mathematical Modeling Study 0.18
Safety and Diagnostic Performance of Recombinant Fusion Protein ESAT6-CPF10 Skin Test in A Large Population: A Phase 4 Clinical Trial 1.00
Evaluating the Breadth and Reliability of Influenza Vaccine Protection Indicators: A Secondary Analysis of an Animal Challenge Trial 0.11
iStreptococcus pyogenes/i Surveillance Through Surface Swab Samples to Track the Emergence of Streptococcal Toxic Shock Syndrome in Rural Japan 0.01
12 8.77
Manifold Interactions between the Action-Mode Network and Sensorimotor Cortex during Human Motor Learning 0.11
GABA and Glx distinctively predict motor learning and retention in young and older adults 0.06
Edinger-Westphal neurons contribute to emergence from desflurane and sevoflurane anesthesia in mice 1.00
Amelioration of Symptomatic Alzheimer’s Disease after Selective Impairment of p75NTR Function in Adult Forebrain Excitatory Neurons 0.72
Specific Glutamatergic Projection to Claustrum for Regulating Methamphetamine Abstinence Anxiety-Like Behaviors 0.90
Medial Frontal Theta Reduction Impairs Rule Switching via Prediction Error 0.80
Altered regional brain activity underlying the higher postoperative analgesic requirements in abstinent smokers: A prospective cohort study 1.00
The Top-Down of Prefrontal Cortex to the Hippocampus Glutamatergic Pathway Regulates Reward Memory of Methamphetamine 0.93
Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles 1.00
Impaired Online and Enhanced Offline Motor Sequence Learning in Individuals with Parkinson's Disease 0.25
CaMKIIβ-mediated Phosphorylation Enhances Protein Stability of Spastin to Promote Neurite Outgrowth 1.00
Basal forebrain-ventral tegmental area glutamatergic pathway promotes emergence from isoflurane anesthesia in mice 1.00
1 0.57
Neurophysiological sensitivity to envelope and pulse timing interaural time differences in cochlear implanted rats with different hearing experiences 0.57
3 3.00
Transapical beating-heart approach is advantageous for surgical septal reduction therapy in pediatrics 1.00
The Safety and Efficiency of Overlapping Video-Assisted Thoracoscopic Lobectomies in a High-Volume Center: A Retrospective Cohort Study 1.00
Early outcomes and follow-up of robotic-assisted multivessel coronary artery bypass with in situ bilateral internal thoracic artery: report of 221 patients in a single center 1.00
1 0.02
Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis 0.02
13 12.89
Sequential small-molecule therapy for lymphocytic cicatricial alopecia: A multicenter prospective cohort pilot study 1.00
Early androgenetic alopecia as a possible indicator of diabetes mellitus and its link to cardiovascular risks: A cross-sectional study 1.00
Efficacy of oral JAK inhibitors combined with 308-nm excimer laser in pediatric progressive vitiligo: A multicenter study 1.00
KLRB1 and IL12RB1 are pretherapeutic predictors of time to relapse in patients of psoriasis treated with IL-17 blockade 1.00
Saturated saline immersion for the Treatment of Refractory Plantar Warts: An open-label, one-arm, single-center trial 1.00
Novel TYK2 inhibitor D-2570 in moderate to severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase 2 trial 1.00
Effectiveness of Biologics on synovitis and enthesitis using Musculoskeletal ultrasound assessment in subclinical psoriatic arthritis: A 12-week observational real-world study 1.00
Disparities in Survival and Tumor Characteristics in Patients With Single and Multiple Primary Merkel Cell Carcinomas 0.89
Caged-hypocrellin mediated antimicrobial photodynamic therapy as a dual-action strategy for fungal clearance and immune response regulation in drug-resistant Candida auris wound infections 1.00
Trametinib Treatment for Early-Stage Extracranial Arteriovenous Malformations: A Multicenter, Prospective, Single-Arm Pilot Study 1.00
The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies 1.00
Global, regional and national burdens of atopic dermatitis from 1990 to 2021: a trend analysis from the Global Burden of Disease Study 2021. 1.00
Safety and Efficacy of Topical Simvastatin Plus Cholesterol Cream vs Topical Simvastatin Cream Alone for Porokeratosis Ptychotropica: A randomized, single-blind, split-body, placebo-controlled investigator-initiated trial 1.00
16 14.87
Coupled Hydrogen-Bond–Electrostatic Recognition of Phosphatidylglycerol Drives the Design of Resistance-Suppressing Miniature Peptidomimetics 1.00
Photocatalytic Activation Strategy for Sequential Prodrug Release to Overcome Resistant Biofilms 1.00
A “Lung-Trap” Theranostic Strategy for Precision Management of Drug-Resistant Bacterial Pneumonia and Bacteremia 1.00
Chemical Evolution of Natural Product for Discovery and Mechanistic Exploration of Antibiotic against MRSA 1.00
Proteome-Mining and Chemical Activation of Hidden Bioactive Fragments as Antimicrobial Assemblies 1.00
PGLa and Magainin 2 Can Porate Membranes via Transient Hourglass-Shaped Toroidal Pores 0.24
A Fluorescence-Afterglow Reporter for In Vivo Differentiation of Three Tumor Immunophenotypes 1.00
Chirality-Driven Metal–Phenolic Artificial Enzymes Enable Renal Targeting and Antioxidative Therapy Enhancement for Acute Kidney Injury 1.00
Unanticipated Quinoline Modification on Vancomycin as an Effective Strategy to Alter the Antibacterial Profile and Combat Multidrug Resistance 1.00
Bacterial Phospholipid-Inducible Helix-Transformable Antimicrobial Polypeptides 1.00
A Bioinspired Lipopeptide Surmounts Therapeutic Dilemmas of Gram-Positive and Gram-Negative Polymicrobial Infection 1.00
Lanthanide Core–Satellite Nanoprobes with Dually Activatable Magnetic Resonance and Second Near-Infrared Fluorescence Signals for Perioperative Image-Guided Cancer Surgery 1.00
Flexible Double Bonds-Enhanced Photodynamic Therapy toward Antibacterial Resistance 0.64
Displaying In Vivo “Assembly–Disassembly” Cascade with “Off–On–Off” Magnetic Resonance Imaging Signals in Tumor 1.00
One-for-All Photoactivatable Manganese-Based Carbon Monoxide-Releasing Molecules (CORMs) for Synergistic Therapy of Mycobacterial Infection 1.00
Pyrazolone-Modified Photosensitizers for Precise Cell Membrane Rupture to Enhance Cancer Immunotherapy 1.00
2 1.48
Visual Acuity and Cardiovascular Mortality in 2.52 Million Older Adults in China 1.00
Long-Term Outcomes After Fractional Flow Reserve vs Intravascular Ultrasound to Guide PCI The FLAVOUR Trial Extended Follow-Up 0.48
3 1.33
Evaluating the Joint Effects of Dementia and Frailty on Burdensome Transitions Among Long‐Term Care Residents in Ontario, Canada 0.10
Physical Resilience After Hip Fracture: Unpacking the Roles of Resistance and Recovery 0.60
Mapping the Final Journey: End‐Of‐Life Frailty Trajectories and Cause of Death 0.63
14 8.93
Development and Validation of a Multivariable Prediction Model for Kidney Failure in Early Autosomal Dominant Polycystic Kidney Disease. 0.06
PACS-2 Alleviates Kidney Fibrosis by Inhibiting Tubular Epithelial Cell G2/M Arrest through CDKL1 Kinase 1.00
Ultrasound Localization Microscopy to Assess the Intrarenal Microvasculature in Autosomal Dominant Polycystic Kidney Disease 0.04
Mapping of PLA2R Epitopes in Idiopathic Membranous Nephropathy and Clinical Relevance of Epitope Profiles 1.00
A Five-Plasma Protein–Based Algorithm for Predicting Incident CKD in Type 2 Diabetes 1.00
Bmpr2 Drives Aberrant Activation and Injury of Glomerular Endothelial Cells in Lupus Nephritis. 1.00
Metabolic Dysregulation of 27-Hydroxycholesterol Sensitizes Proximal Tubular Epithelial Cells to Ferroptosis in Ischemic Acute Kidney Injury. 0.89
Mycophenolate Mofetil versus Cyclophosphamide for Initial Therapy in Childhood-Onset Proliferative Lupus Nephritis: A Prospective, Multicenter, Randomized Trial. 1.00
KRT20 Suppresses Exosomal Secretion of PRDX2 and Ferroptosis in Acute Kidney Injury. 0.92
Predictive Value of the Oxford Classification for the Effect of Glucocorticoid Therapy in IgA Nephropathy. 0.61
A Multiomics Study of Circulating Proteins and Kidney Stone Risk. 0.06
Discontinuation of Renin-Angiotensin System Inhibitors during Acute Kidney Injury Episode and All-cause Mortality: Target Trial Emulation Studies. 1.00
mTORc1 in Distal Convoluted Tubule (DCT) and Renal Potassium (K+) Handling. 0.33
Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci. 0.02
3 1.69
Menopausal hormone therapy and risk of liver cancer in a swedish population-based cohort study 0.17
Joint associations of accelerometer-measured physical activity and cardiovascular-kidney-metabolic syndrome stages with the risks of cancer and all-cause mortality 0.52
An immunosuppressive tertiary lymphoid structure is associated with adverse prognosis in gastric-type endocervical adenocarcinoma 1.00
12 8.57
Insights from the BLISS-LN Phase 3 study of biomarker associations with kidney response to belimumab in lupus nephritis 0.08
Evidence from multicenter clinical studies and humanized mouse models indicates that glomerular mesangial IgA2 deposition contributes to the pathogenesis of IgA nephropathy 0.92
Anti-PLA2R1 IgG-mediated podocyte PLA2R1 cleavage drives glomerular subepithelial immune complex deposition in membranous nephropathy 1.00
Increased Smoothened signaling promotes kidney fibrosis through inhibiting autophagy in fibroblasts 1.00
Klotho in the kidney distal convolution regulates urinary Klotho excretion and kidney calcium reabsorption, but not phosphate homeostasis 0.03
A secondary analysis of the TESTING trial predicted individual patient response to corticosteroid treatment in IgA nephropathy 0.13
Mitochondrial protein TOMM7 alleviates diabetic kidney disease by regulating mitophagy via intracellular redistribution of phospholipase PLA2G6 1.00
Protein UHRF1-mediated dual dysregulation of molecular chaperone GRP78 induces endoplasmic reticulum stress and aggravates diabetic nephropathy 1.00
Angiopoietin-like 4 exacerbates renal tubular epithelial cell pyroptosis in acute kidney injury via integrin β5/FAK signaling pathway 1.00
Kidney hepcidin protects the collecting duct against ferroptosis in ischemia/reperfusion-induced acute kidney injury 1.00
Protein kinase ROCK1 activates mitochondrial fission linking to oxidative stress and muscle atrophy 0.41
The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of TET2/NLRP3 inflammasome signaling pathway 1.00
4 2.45
Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks 0.15
Filament-mediated repurposing of toxic dITP for immunity in the Kongming system 0.31
The Ppl protein senses 3′-hydroxyl DNA overhangs and NTP depletion to halt phage infection 1.00
Molecular mechanism of Eco8-mediated anti-phage defense 1.00
72 60.19
Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study 0.03
Rapid rescue of despair behaviors by sonogenetic neuromodulation of the mPFC-DRN pathway 1.00
The Cognitive benefits of nitrate in patients with alcohol use disorder: unraveling the oral microbiome ectopic colonization pathway 0.94
Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis 0.04
A prefrontal cortex-nucleus accumbens circuit attenuates cocaine-conditioned place preference memories 0.36
Neural representations of dynamical state and trait impulsivity in individuals at risk for internet gaming disorder 1.00
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate microglial activation and alleviate depression-like behaviors in male mice 0.88
A longitudinal DNA methylation atlas and its link to brain structure and mental health 0.17
Brain structural abnormalities in treatment-resistant schizophrenia 0.08
A ventral striatal learning signal reflecting individual differences in the success of fear extinction 0.10
Cortical morphometry might predict currently prescribed vs. discontinued medications in bipolar disorder, even after controlling for the cumulative dose effects: An ENIGMA mega-analysis 0.01
Microbiota-Driven microglia reprogramming reverses depressive-like behaviors through Peripheral-to-Central immune crosstalk 0.86
Prediction of self-harm in people with newly-diagnosed depression: development and validation of risk prediction models 1.00
The dynamic impairment of synaptic transmission in the PCx-IL engram circuit contributes to early olfactory memory decline in Alzheimer’s disease 1.00
BDNF restores impaired long-term potentiation of GABAergic synapses induced by chronic ethanol exposure in the VTA and attenuates reward-seeking behavior 1.00
Large-scale proteomic analyses before depression diagnosis reveal novel pathophysiological insights 1.00
Peripheral immune–redox signatures associate with cortical network alterations in anhedonic depression 0.89
The global burden of mental and substance use disorders among adolescents and young adults 0.33
A nuclei-specific fronto-amygdala pathway and its neurotransmitter receptor distribution: Implications for Antidepressant Selection 1.00
Dual regulatory roles of CPT1C in chronic stress-induced depression-related outcomes 1.00
Methamphetamine induces long-lasting dysbiosis of the gut microbiota 1.00
Exploring the impact of cognitive profiles on the response to magnetic seizure therapy and electroconvulsive therapy 1.00
Dynamic interactions between gut microbiome and host lipidome in antenatal depression: a large longitudinal study 0.96
Cross-Platform and cross-species lipidomic profiling identifies promising biomarkers for adolescent major depressive disorder 0.83
Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression 0.98
Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors 0.97
Differential protein network and biological functions atlas from multi-tissue proteomics in patients with depression 1.00
Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders 1.00
Astroglial kappa opioid receptor-mediated reduction of glutamate exchanger xCT in the prelimbic cortex underlies chronic stress-induced depressive-like behaviors 1.00
Common alterations of whole and subregion-specific amygdala intrinsic functional connectivity across psychiatric disorders: a meta-analysis 0.77
Decoding depression: stress-derived formaldehyde initiates depressive symptoms in mouse and human 1.00
Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression 0.85
Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II 1.00
Gut microbiota modulates synaptic plasticity, connectivity, and dopamine transmission in the VTA-mPFC pathway in bipolar depression 1.00
Syn III participated in rTMS-modulated emotional rescue in the prefrontal cortex under simulated space composite environment 1.00
Unraveling sexually dimorphic offspring behaviors: maternal premating stress and the neuro-microbial-metabolic network 1.00
Cognitive trajectories of psychosis risk: temporal patterns and association with progression 1.00
Mapping the reciprocal interactions between antidepressants and the gut microbiome: novel targets for the personalisation and optimization of drug response 0.81
NLRP3-mediated trained immunity of microglia is involved in the recurrence-like episode of depressive disorders 1.00
Age-varying distinct neuroanatomy in young children with autism spectrum disorder and fragile X syndrome 0.88
Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by cocaine 1.00
Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex 1.00
Stress induces behavioral disorders by promoting microglial phagocytosis via decreasing neuronal Dkk3 1.00
Transcranial direct current stimulation restores addictive behavior via prefrontal-striatal circuit 0.89
Genome-wide association study provides insights into the genetic basis of Lewy body dementia 1.00
Regulation of stress susceptibility by chromatin-binding protein PHF6 in the pituitary intermediate lobe 1.00
Posttranslational regulation of CREB-binding protein expression by F-box leucine-rich repeat-containing protein 19 and ubiquitin-specific peptidase 14 in the paraventricular nucleus participates in chronic stress-induced symptomatology via the modulation of the hypothalamic‒pituitary‒adrenal axis 1.00
Accelerometer-measured physical activity, sedentary behavior, and incident neuropsychiatric diseases: a large prospective cohort study of 73411 participants 1.00
Mechanistic insights into taxane-induced psychiatric adverse events: a global pharmacovigilance and experimental investigation 1.00
Sustained antidepressant actions of ketamine involve TAMM41-mediated transfer of astrocytic sigma-1 receptor to neuron 1.00
Early-life inflammation increases aggressive behavior in adult male mice through an astrocyte-neuron signaling 1.00
Semaphorin 3A-mediated perineuronal nets formation incubates depressive-like behaviors in male mice via activating parvalbumin-expressing interneurons 1.00
Global burden of diseases attributed to mental and substance use disorders in reproductive-age women: an ecological analysis for the Global Burden of Disease Study 2021 1.00
Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth 0.01
Effects of esketamine on electrophysiology and metabolic reprogramming in brain organoids: insights into antidepressant mechanisms 0.95
Intermittent theta burst stimulation for non-suicidal self-injury in adolescents with major depressive disorder: a randomized, sham-controlled trial 1.00
Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations 0.67
Social hierarchy and resilience affect stress-induced PTSD via Uba7 gene expression and subsequent inflammation in microglia of the mPFC 1.00
Acute and chronic stress differentially regulate pain via distinct ensembles in the paraventricular nucleus of hypothalamus 1.00
Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents 0.53
Disease clusters and their genetic determinants following a diagnosis of depression: analyses based on a novel three-dimensional disease network approach 0.63
Adult hippocampal neurogenesis-mediated cognitive behavior participates in stress resilience to anxiety and depression-like behaviors in postpartum dams 1.00
Targeting complement C3/C3aR pathway restores rejuvenation factor PF4 and mitigates neurocognitive impairments in age-related perioperative neurocognitive disorders 0.86
A medial habenula neural circuit controlling anxiety-like behaviors in response to acute stress 1.00
Alterations in miR-151a-3p of plasma-derived exosomes and associated multimodal neuroimaging patterns in major depressive disorder 1.00
Characteristics of brain network connectome and connectome-based efficacy predictive model in bipolar depression 1.00
Stress-induced reduction of sodium leak currents causes social deficits by impairing dorsal dentate gyrus-medial septum glutamatergic projection 1.00
Single-cell transcriptomics reveals Sox6 positive interneurons enriched in the prefrontal cortex of female mice vulnerable to chronic social stress 0.88
Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions 0.04
Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer 1.00
Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder 1.00
A neural substrate of comorbid depressive symptoms in alcohol use 1.00
9 9.00
Injury-Retention Strategy for Discriminative Magnetic Resonance Imaging and Enhanced Antioxidant Therapy of Drug-Induced Liver Injury 1.00
Neutrophil-Mediated Drug Delivery Nanoplatform Constructed from Celastrol Loaded Liposome for Targeted Therapy of Rheumatoid Arthritis 1.00
Dual Chemical Regulations for Combined Anti-Resorption and Osteo-Anabolism to Reverse Osteoporosis 1.00
Sugar-Responsive Enzyme–Polyphenol ‘Tooth Nanoarmor’ for Long-Lasting Caries Prevention via Glucose Depletion and Biofilm Suppression 1.00
Boosting Cancer Chemotherapy through Targeted Akkermansia muciniphila Modulation by Tumor-Repopulating Cell-Derived Microparticles 1.00
A Metal–Phenolic Network-Coated Coacervate System Mediates Mitochondrial Modulation and Bone Homeostasis Restoration for Postmenopausal Osteoporosis Therapy 1.00
Enhancing 1O2 Production with Biomimetic Pt Catalysts through Electronic Structure Modification 1.00
Co-Assembled Cryptotanshinone Derivative and Glycyrrhizic Acid Carrier-Free Hydrogel: A Synergistic Approach to Acne Treatment 1.00
A Nanosystem Alleviates Severe Acute Pancreatitis via Reactive Oxygen Species Scavenging and Enhancing Mitochondrial Autophagy 1.00
12 8.36
Lipid metabolism drives dietary effects on T cell ferroptosis and immunity 0.41
A metabolic alarmin from keratinocytes potentiates systemic humoral immunity 1.00
Mosquito–capsid interactions contribute to flavivirus vector specificity 0.95
Psychedelics elicit their effects by 5-HT receptor-mediated G signalling 1.00
Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes 1.00
Prevalence of Alzheimer’s disease pathology in the community 0.02
Adenosine signalling drives antidepressant actions of ketamine and ECT 1.00
Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus 1.00
mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity 0.02
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution 0.97
Kupffer cell programming by maternal obesity triggers fatty liver disease 0.04
Targeting symbionts by apolipoprotein L proteins modulates gut immunity 0.94
1 1.00
Inducing bacterial calcification for systematic treatment and immunomodulation against methicillin-resistant Staphylococcus aureus 1.00
4 3.94
Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment 1.00
Dual cytosine modification through hydroxylation and arabinofuranosylation in phages 1.00
Structural insights into type-I and type-II Lamassu antiphage systems 1.00
Structure and mechanism of an actin-dependent bacterial phosphoryl AMPylase 0.94
305 249.89
Bifidobacterium bifidum-derived nanoparticles attenuate alcoholic liver disease via enhanced hepatic phagocytosis and gastrointestinal homeostasis 0.89
Escalating transmissibility of severe fever with thrombocytopenia syndrome in a high-endemic region of China 1.00
Clec3b⁺ fibroblasts are the primary effectors of portal fibrosis following activation via a KLF4/periostin axis 0.82
Uromodulin p.His36Tyr promotes macrophage pyroptosis via App-Cd74 signaling to drive renal inflammation in ADTKD 1.00
Generation of an autophagy-targeting influenza A virus as live attenuated vaccine 1.00
V- and VL-scores unveil viral signatures and origins of protein families 0.10
CFTR mediates Cl- transport in osteocytes to sustain cell viability and skeletal homeostasis 1.00
Acute sleep rebound following sleep restriction is associated with reduced mortality risk 0.50
RAISE: A computational tool for evaluating sarbecovirus spillover potential 1.00
Structures of dye-bound transthyretin amyloid fibrils from abdominal fat biopsies 1.00
Quinone-mediated, tissue-adaptive double-network hydrogel for instant hemostasis and wet-tissue adhesion 0.08
Low dose IL-2 therapy restores regulatory T cells in patients with systemic lupus erythematosus in a dose-dependent manner: a phase IIb trial 1.00
A pharmacokinetic and pharmacodynamic drug-drug interaction study of dorzagliatin and empagliflozin in patients with type 2 diabetes and obesity: an open-label phase I trial 0.91
Collagen hybridizing peptide imaging and delivery of therapeutic antibody in rheumatoid arthritis models 1.00
Hotspot pocket-based discovery of urea transporter selective inhibitors 1.00
Integrating optogenetic fMRI and spatial transcriptomics to reveal circuit-specific gene signatures in fronto- and hippo-thalamic networks 1.00
Multi-kingdom profiling reveals altered gut phage-bacteria-metabolite interactions in MASLD 0.87
A microbiome catalog of Chinese traditional artisanal cheeses provides insights into functional and microbial diversity 1.00
Wireless electrostimulation implants enable sphincter neuromuscular improvement toward mixed urinary incontinence 0.79
A deep learning–based digital biopsy for predicting early recurrence in gastric cancer 1.00
Hydroxylation of the HIV-1 antisense protein promotes immune evasion of HIV-1 via modulation of TBK1 1.00
Structural atlas of the intact jumbo phage phiKZ 1.00
JAK inhibitors alleviate EGFR-inhibitor-induced diarrhea by protecting intestinal stem cells from adaptive-immune-exacerbated injury 1.00
Multiomics characterization of acute child illness and mortality in Africa and South Asia 0.02
CBP/p300 is critical for the expansion and maintenance of functional pancreatic α cell mass 1.00
CD73high fibroblasts orchestrate keratinocyte inflammation in the psoriasis-associated epithelial immune microenvironment 0.93
Small nucleolar RNA drives self-renewal of intestinal stem cells via initiation of transcription 1.00
Lactate metabolism reprogramming through orthogonal tandem catalysis to reverse intervertebral disc degeneration 1.00
Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes 0.06
Social reward outcompetes drug seeking dopaminergic ensembles to prevent relapse 0.89
A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome 1.00
ZFP36L2 is an interferon β -induced inhibitor that restricts the nuclear export of HIV-1 transcripts 1.00
Sgk1 upregulation in hippocampus-projecting amygdala neurons underlies the delayed onset of PTSD-like avoidance behavior 1.00
A prospective multicenter trial of deep learning auto-segmentation for organs at risk in thoracic radiotherapy 1.00
Concurrent chemoradiotherapy plus nimotuzumab versus chemoradiotherapy alone for locoregionally advanced nasopharyngeal carcinoma with a suboptimal response to induction chemotherapy: a randomized phase 2 trial 1.00
Ultrasmall oral modulate gingival immunoactivation through type IV pili and TLR2-dependent endocytosis 0.04
Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthritis via Nav1.7 axis 0.97
Hemoadsorption combined with hemodialysis versus hemodialysis alone on mortality in end-stage kidney disease: a randomized, open-label, multicenter trial 1.00
SMART: spatial multi-omic aggregation using graph neural networks and metric learning 0.80
Single-bacterial cell insights into mechanisms of ceftriaxone resistance in Neisseria subflava 0.68
Valeric acid from oral microbiome suppresses esophageal cancer growth by disrupting eEF1A1 -mediated translational output 1.00
Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus 1.00
Unveiling the biodiversity of large DNA viruses in intertidal mudflats via metagenomics 1.00
Sequential sequencing reveals the architecture and complexity of genomic variants in patients with Alport syndrome 1.00
Prasugrel inhibits TLR7-driven autoimmunity in systemic lupus erythematosus by acetylating cGAS 1.00
Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model 1.00
Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum 1.00
Wireless, non-invasive, high-resolution thrill sensor for continuous vascular access monitoring of hemodialysis patients 1.00
Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation 1.00
A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice 1.00
Recycling senescent cell lipids for targeted senotherapy 1.00
Periplasmic gatekeeping of phage DNA entry by an rSAM enzyme matured effector with HxS repeats 0.93
Intrinsic capacity and stroke risk in a multiple cohort study 1.00
Biological valorization of methane and nitrogen gas-derived ammonia via methanotrophic bacteria for gut-beneficial nutrients 1.00
Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses 1.00
The role of amygdala GABA neurons in controlling stress and reproduction in female mice 0.04
Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate lung injury in preclinical models by promoting neutrophil cuproptosis 1.00
Proteomics-based machine learning model for predicting secondary infection in HBV-related liver failure 1.00
sRNA centered signaling activates nitrate respiration and enhances virulence in host environments 1.00
Contrast-free identification of glioma blood-brain barrier status via generative diffusion AI and non-contrast MRI 0.90
Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of 1.00
SOD1 lactylation impair its enzymatic activity by conformational change to aggravate intervertebral disc degeneration 1.00
TRIM13 in situ engineering boosts anti-inflammatory capacity of CAR-Ms for liver fibrosis therapy 1.00
Gut microbiome composition and strain-sharing in multiplex autism spectrum disorder families 1.00
DUSP26 protects against acute kidney injury by dephosphorylating p53 at serine 312 0.93
Chiral peptidoglycan mimics target bacterial wall biosynthesis for pathogen intervention 1.00
Photochemical nanomotors reverse anxiety- and depressive-related behaviors in rodents via spatiotemporal polarity dynamics tuning 0.91
Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in 1.00
A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a -associated program 1.00
Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices 0.50
Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms 1.00
In situ structures of the portal-neck-tail complex of bacteriophage T4 inform a viral genome positioning mechanism 0.23
A bacterial YopJ-family acetyltransferase suppresses host immune response by ε-acetylation of JAK1 0.92
Biomimetic metal-drug coordination nanoplatform to counteract drug resistance in via energy disruption 1.00
Brain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury 0.94
Sustained physical activity offers benefits beyond activity volume in chronic disease prevention 0.20
A missense variant in leads to lobodontia 0.03
Multi-modal AI for opportunistic screening, staging and progression risk stratification of steatotic liver disease 0.93
Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis 1.00
Granulomas microenvironment-guided sono-immunotherapy to treat and prevent recurrence of tuberculosis 1.00
Final survival analysis of induction chemotherapy with lobaplatin and fluorouracil versus cisplatin and fluorouracil followed by concurrent chemoradiotherapy in nasopharyngeal carcinoma: a multicenter, randomized, phase 3 trial 1.00
A synthetic system for RNA-responsive pyroptosis based on type III-E CRISPR nuclease-protease 1.00
Molecular mechanism of action of small molecule SMT-738 on bacterial lipoprotein transporter LolCDE 1.00
Cryo-EM structures of bacteriophage T4 portal-neck assembly intermediates reveal a viral genome retention mechanism 0.62
Discovery of antimicrobial peptides targeting via a pre-trained and fine-tuned few-shot learning-based pipeline 1.00
Combined bacteriophage and antibiotic therapy for refractory peritoneal dialysis-related peritonitis caused by Klebsiella pneumoniae 1.00
Identification of protein precursor for thyroid hormone synthesis in basal chordate ascidian 0.75
A montmorillonite-based oral fermentation system enables long-lasting in-situ biosynthesis to restore intestinal homeostasis 1.00
Hierarchical picot-fiber hydrogel coating with ultralow friction and high wear resistance 1.00
Mycobacterium tuberculosis modulates phosphorylation of host ATP6V1E1 to promote intracellular survival 1.00
Automated diagnostic of cervical spondylosis on multimodal medical images with a multi-task deep learning model 1.00
Prefrontal chandelier cells encode stimulus salience to influence learning in male mice 0.92
HCMV infection disrupts barrier functions and promotes epithelial–mesenchymal transition in a cholangiocyte organoid model 1.00
promotes colorectal cancer metastasis by maintaining enhancer-promoter loops through releasing neutrophil extracellular traps 1.00
Biomarker-integrated prognostic stagings for Alzheimer’s Disease 0.02
Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation 1.00
Ultra-fast self-gelling self-expanding self-propelling high-adhesion procoagulant hemostatic powder for non-compressible hemorrhage hemostasis in pigs 1.00
Domain-specific schema reuse supports flexible learning to learn in the primate brain 1.00
Using the linear references from the pangenome to discover missing autism variants 0.01
A bacterial defense system targeting modified cytosine of phage genomic DNA 1.00
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice 0.96
A comprehensive catalogue of receptor-binding domains in extracellular contractile injection systems 0.60
Impact and cost-effectiveness of doxycycline post-exposure prophylaxis in Australian men who have sex with men 0.31
Unbiased clustering of acute-on-chronic liver failure patients using machine learning in a real-world ICU cohort 0.60
High-entropy alloy Janus artificial enzymes for pH-gated sequential redox therapy of drug-resistant bacterial infection 0.92
Near-infrared light-driven nanomotors-based microneedles for the active therapy of bacterial infected acne 1.00
Structure of a bacteriophage reveals cell wall adsorption mechanism in Gram-positive infecting siphophages 1.00
Identification of antimicrobial peptides from ancient gut microbiomes 0.69
Aged skin exacerbates experimental osteoarthritis via enhanced IL-36R signaling 1.00
Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis 0.02
The interconnected wirings between medial prefrontal cortex and claustrum and their governing roles in the methamphetamine reward memory in male mice 0.89
Dual-action bisphosphonate hydrogel preserves cortical bone integrity and restores healing cascade in osteoporotic fracture-related infection 1.00
Once and thrice weekly interval training in adults with central obesity: a randomized controlled trial 0.88
Arachidonic acid induces pyroptosis via a non-autophagic function of mitophagy and enhances immunotherapy in a PDAC model 1.00
Endothelial IRE1α promotes thrombospondin-1 mRNA decay and supports metabolic stress adaptation of pancreatic islets 0.96
Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis 1.00
Co-occurrence of diverse defense systems shapes complex microbe-virus relationships in deep-sea cold seeps 1.00
Efficacy and safety of low-dose interleukin 2 for Behçet’s syndrome: a randomized, placebo-controlled, double-blind, phase 2 clinical trial 1.00
Efficacy and safety of cAMP signalling-biased GLP-1 analogue ecnoglutide monotherapy versus placebo in patients with type 2 diabetes (EECOH-1): a multi-centre, randomised, double-blind, placebo-controlled, phase 3 trial 0.97
A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice 1.00
Distinct antidepressant therapies act on a common brain network 1.00
Methionine restriction alleviates kidney fibrosis through epigenetic repression of the TGF-β-Smad3-Hoxc8/P-TEFb axis 1.00
Distinct diet-microbiome associations in autism spectrum disorder 1.00
IL-17a induces age-related olfactory dysfunction by impairing regeneration and promoting respiratory metaplasia in mice 1.00
Multi-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis 1.00
Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis 0.16
In vivo electrochemical reduction-induced reconfiguration of Prussian blue for metal counterion-free potassium removal in hyperkalemia 1.00
Risk of major adverse cardiovascular events with aripiprazole versus olanzapine, quetiapine, and risperidone in severe mental illness: a target trial emulation 0.06
Tracing the origin of myofibroblasts in kidney fibrosis 1.00
Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism 1.00
Staphylococcus aureus fatty acid metabolism governs saeRS-mediated aggregation in joint infections 1.00
Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial 1.00
Utilizing nanoinducers for precision degradation of bacterial protein to mitigate antibiotic resistance 1.00
Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera) 0.90
Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling 1.00
Cryo-EM structure of renal AL amyloid fibrils from a patient with λ1 light chain amyloidosis 1.00
Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells 0.96
Development of a replication-defective mpox virus platform for fundamental and therapeutic research 0.71
Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy 1.00
Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial 0.98
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations 0.03
Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset 0.95
Infectome analysis of small mammals in Southern China reveals pathogen ecology and emerging risks 0.98
Mid-gestational cell-type-specific transcriptomic signatures in the prefrontal and superior temporal cortex in Down syndrome 1.00
Gut Phage Biobank: a collection of bacteriophages targeting human commensal bacteria 0.88
Pathogenicity, virological features, and immune evasion of SARS-CoV-2 JN.1-derived variants including JN.1.7, KP.2, KP.3, and KP.3.1.1 1.00
A B cell-IgA-epithelial axis enhances antitumor immunity and improves outcome in HPV-associated penile squamous cell carcinoma 1.00
Lactate bridges mesangial cells to the differentiation of follicular helper T cells in lupus nephritis 0.91
Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway 1.00
A corticospinal signature for interindividual pain sensitivity 0.81
Structures of human glucose-6-phosphate transporter reveal reciprocal antiport mechanism driving glucose-6-phosphate and inorganic phosphate exchange 1.00
PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis 0.02
Photo-reversible amyloid nanoNETs for regenerative antimicrobial therapies 0.48
Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis 1.00
Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation 1.00
Carboxymethylcytosine is a natural base modification and a handle for bacteriophage DNA hypermodification 0.88
Influenza vaccines promote humoral and cellular immune responses: a randomized, double-blind, phase 3 trial 0.05
Lack of intestinal Mucin-1 impairs intestinal epithelial barrier and promotes metabolic dysfunction-associated steatotic liver disease in male mice 0.92
Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function 1.00
Anti-phage defense mechanism involving phage-encoded DNA binding protein and bacterial reverse transcriptase DRT4 1.00
A niche-dependent redox rheostat regulates epithelial stem cell fate 0.05
Neural correlates of trial outcome monitoring during long-term learning in primate posterior parietal cortex 1.00
Stage-dependent patterns of cognitive network connectivity in early psychosis 1.00
Estimation of the epidemiological characteristics of scabies 0.17
Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation 0.04
Disrupted theta synchronization and synaptic connectivity in the visual cortex of Fmr1 KO mice 0.07
An antimicrobial peptide as a potential therapy for bacterial pneumonia that alleviates antimicrobial resistance 1.00
Tetrazine-enhanced donor-acceptor-donor metal-organic frameworks for photodynamic antibacterial therapy and wound healing 1.00
Unraveling the mechanism behind the probable extinction of the B/Yamagata lineage of influenza B viruses 1.00
Flexible Use of Limited Resources for Sequence Working Memory in Macaque Prefrontal Cortex 1.00
High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures 0.04
Human gut prophage landscape identifies a prophage-mediated fucosylation mechanism alleviating colitis 0.93
Adaptive stretching of representations across brain regions and deep learning model layers 0.13
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair 1.00
Clinical and genomic features of Lynch syndrome differ by tumor site and disease spectrum 0.94
Mitochondria relay cholesterol signal exacerbates osteoarthritis in mice 0.95
Polygenic risk score and cluster-based analysis suggests links between type 2 diabetes and vascular dementia in the KARE study 1.00
Stable intracranial imaging of dura mater-engrafted pancreatic islet cells in awake mice 0.05
Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity 0.65
Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health 1.00
A Pseudomonas aeruginosa quorum-sensing metabolite manipulates macrophage ferroptosis through a methylation pathway 1.00
Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosis 0.80
Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome 0.02
Physical activity levels may impact on the risk of premature mortality in people with epilepsy 0.78
In situ gut microbiota editing: enhancing therapeutic efficacy for bacterial colitis by compatible oral hydrogel microspheres with phages 0.79
transmission in China during the COVID-19 pandemic period (2020–2021) compared with the pre-pandemic period (2017–2019) 0.54
Toxoplasma gondii chromatin remodeler SWI/SNF controls parasite division and gene expression 1.00
Systematic evidence grading evaluates multisystemic associations and risks of vitiligo 1.00
Proteome atlas for mechanistic discovery and risk prediction of diabetic retinopathy 0.70
Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability 1.00
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database 0.01
DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms 0.05
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice 1.00
Modality-projection universal model for comprehensive full-body medical imaging segmentation 1.00
Ambient biothermal stress, preconceptional thyrotropin abnormalities, and the risk of preterm birth: a nationwide Chinese cohort study 1.00
Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model 1.00
Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia 0.75
Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice 1.00
Virus-inspired lipopeptide-derived nucleic acid delivery to cartilage for osteoarthritis therapy 0.93
Thalamic regulation of reinforcement learning strategies across prefrontal-striatal networks 0.22
DLFea4AMPGen de novo design of antimicrobial peptides by integrating features learned from deep learning models 1.00
Single cell transcriptomics of human psoriasis and epidermal specific Ube2l3 deficient mice highlight CXCL16/CXCR6 involvement in psoriasis development 1.00
Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder 0.05
Amplified copper ion interference and immunomodulation using self-thermophoretic nanomotors to treat refractory implant-associated biofilm infections 1.00
Crotonate enhances intestinal regeneration after injury via HBO1-mediated H3K14 crotonylation 1.00
Keratinocyte-specific H4K12 lactylation drives a non-canonical IL-17-dependent signaling in psoriasis progression in mice 1.00
Rising dengue risk with increasing El Niño–Southern Oscillation amplitude and teleconnections 0.59
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow 1.00
Injectable therapeutic system incorporating neurogenesis-programmed stem cells concomitantly promoting muscle regeneration treats stress urinary incontinence 1.00
Optimized in vivo base editing restores auditory function in a DFNA15 mouse model 1.00
Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’s disease 1.00
Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging 0.04
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice 1.00
NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization 0.93
Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening 1.00
Granzyme B activated near-infrared-II ratiometric fluorescent nanoprobe for early detection of tumor response to immunotherapy 1.00
Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions 1.00
Trait anxiety is associated with reduced reward-related replay at rest 0.81
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration 1.00
Biodegradable ultrasound contrast tape for tracing intestinal motility 1.00
Neural correlates of human fear conditioning and sources of variability in 2199 individuals 0.01
Designed optogenetic tool for bridging single-neuronal multimodal information in intact animals 1.00
Deep learning approach for screening neonatal cerebral lesions on ultrasound in China 1.00
Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy 0.25
Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating 1.00
Biosilica nanoparticulate scavengers for the therapy of hepatic ischemia–reperfusion injury in preclinical models 1.00
Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis 1.00
Microalgae-based Intestinal villi-targeting multistage biosystem for irritable bowel syndrome treatment 1.00
Immunogenicity and safety of a recombinant gE-Fc fusion protein subunit vaccine for herpes zoster in adults ≥50 years of age: a randomised, active-controlled, non-inferiority trial 1.00
CCR7+ dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse 0.97
Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial 1.00
Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation 0.95
Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization 0.96
The long non-coding RNA RSDR protects against acute kidney injury in mice by interacting with hnRNPK to regulate DHODH-mediated ferroptosis 1.00
DeepISLES: a clinically validated ischemic stroke segmentation model from the ISLES'22 challenge 0.05
Physical and chemical niche of human growth plate for polarized bone development 1.00
Crosstalk between inovirus core gene and accessory toxin-antitoxin system mediates polylysogeny 1.00
The HM-TARGET personalised real-time haemodynamic targets in critical care 0.14
Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial 1.00
PAM-flexible adenine base editing rescues hearing loss in a humanized mouse model harboring an East Asian founder mutation 0.53
Mechanism of substrate recognition and release of human SGLT2 1.00
A multicellular self-organized probiotic platform for oral delivery enhances intestinal colonization 1.00
March5-mediated Trim28 degradation preserves islet β-cell function in mice 1.00
Health risks and genetic architecture of objectively measured multidimensional sleep health 0.83
A broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance 1.00
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice 0.94
A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron 0.75
A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images 0.85
Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury 1.00
CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis 1.00
Distinct role of claustrum and anterior cingulate cortex bidirectional circuits in methamphetamine taking and seeking 1.00
UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines 1.00
PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation 0.85
Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities 0.83
Zika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA 1.00
A longitudinal cohort study uncovers plasma protein biomarkers predating clinical onset and treatment response of rheumatoid arthritis 0.73
Near-infrared light-driven metabolic reprogramming of synoviocytes for the treatment of rheumatoid arthritis 1.00
Mycobacterium bovis frd operon phase variation hijacks succinate signaling to drive immunometabolic rewiring and pathogenicity 1.00
Molecular mechanism of drug inhibition of URAT1 1.00
Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study 0.21
Eradicating fungal biofilm-based infections by ultrasound-assisted semiconductor sensitized upconversion photodynamic therapy 1.00
The defensome of prokaryotes in aquifers 1.00
Carbene formation as a mechanism for efficient intracellular uptake of cationic antimicrobial carbon acid polymers 0.04
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge 0.06
Genetic risk-dependent brain markers of resilience to childhood Trauma 0.23
Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment 1.00
A molecularly defined brain circuit module for regulating panic-like defensive state 1.00
An intracranial dissection of human escape circuits 0.78
Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice 1.00
Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease 0.01
Positional BMP signaling orchestrates villus length in the small intestine 1.00
Increase in H5N1 vaccine antibodies confers cross-neutralization of highly pathogenic avian influenza H5N1 1.00
Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy 1.00
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression 0.83
Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote biofilm formation 1.00
Targeting lipid raft-related stomatin to ameliorate osteoporosis in preclinical models 1.00
Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults 1.00
Protein kinase A is a dependent factor and therapeutic target in mouse models of fibrous dysplasia 1.00
Prion-induced ferroptosis is facilitated by RAC3 0.05
Distinct neural population code and causal roles of primate caudate nucleus in multimodal decision-making 1.00
Molecular basis of the urate transporter URAT1 inhibition by gout drugs 0.18
Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians 0.81
Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment 1.00
Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience 1.00
Blood-triggered self-sealing and tissue adhesive hemostatic nanofabric 1.00
HSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials 1.00
Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity 0.03
Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference 1.00
ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice 1.00
Modulation of host ATP levels by secreted bacterial effectors 0.77
A midbrain circuit mechanism for noise-induced negative valence coding 0.93
Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis 0.02
PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub 1.00
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis 0.94
Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis 1.00
Regulating obesity-induced osteoarthritis by targeting p53-FOXO3, osteoclast ferroptosis, and mesenchymal stem cell adipogenesis 1.00
A clinically applicable AI system for detection and diagnosis of bone metastases using CT scans 1.00
Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis 1.00
Estimating transmissibility of Zika virus in Colombia in the presence of surveillance bias 0.44
BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription 0.20
Dysregulated mast cell activation induced by diabetic milieu exacerbates the progression of diabetic peripheral neuropathy in mice 1.00
snCED-seq: high-fidelity cryogenic enzymatic dissociation of nuclei for single-nucleus RNA-seq of FFPE tissues 1.00
Artificial intelligence driven 3D reconstruction for enhanced lung surgery planning 1.00
T cell toxicity induced by tigecycline binding to the mitochondrial ribosome 0.05
Vision transformer-based model can optimize curative-intent treatment for patients with recurrent hepatocellular carcinoma 1.00
1 0.25
Mosaic integration of spatial multi-omics with SpaMosaic 0.25
2 1.25
Representational dynamics during extinction of fear memories in the human brain 0.29
Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9 0.97
1 0.03
Enteric nervous system-derived VIP restrains differentiation of LGR5 stem cells toward the secretory lineage impeding type 2 immune programs 0.03
8 4.31
Deleterious coding variation associated with autism is shared across ancestries 0.03
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial 0.33
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study 0.03
A meta-analysis of albuminuria as a surrogate endpoint for kidney failure 0.04
A full life cycle biological clock based on routine clinical data and its impact in health and diseases 0.88
Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial 1.00
Large language model-based biological age prediction in large-scale populations 1.00
Recombinant monoclonal antibody siltartoxatug versus plasma-derived human tetanus immunoglobulin for tetanus: a randomized, double-blind, active-controlled, phase 3 trial 1.00
3 2.85
3d-OT: a deep geometry-aware framework for heterogeneous slices alignment of spatial multi-omics 1.00
Bridging the dimensional gap from planar spatial transcriptomics to 3D cell atlases 0.85
TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice 1.00
3 2.60
Viral glycoprotein-mimicking peptide-functionalized micelles promote drug delivery to diseased chondrocytes for osteoarthritis alleviation 0.95
Bioengineered photosynthetic nanothylakoids reshape the inflammatory microenvironment for rheumatoid arthritis therapy 0.75
Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages 0.90
6 5.71
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability 0.91
Charting brain morphology in international healthy and neurological populations 0.98
A mouse brain atlas based on dendritic microenvironments 1.00
Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons 0.88
A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors 0.95
Social rank modulates methamphetamine-seeking in dominant and subordinate male rodents via distinct dopaminergic pathways 1.00
2 1.12
Structural basis of glucose-6-phosphate transport by human SLC37A2 1.00
A nanobody-based therapeutic targeting Nipah virus limits viral escape 0.12
13 11.83
Human hippocampal ripples prioritize model-based learning 1.00
Noninvasive tactile stimulation engaging a thalamic-amygdala circuit ameliorates mood dysfunction in mouse models of depression-like behavior 0.93
A septal inhibitory circuit constrains alcohol reward and mediates liraglutide’s suppressive effects on alcohol intake in mice 1.00
Alteration of cellular representation in the central amygdala mediates stress-induced analgesia in mice 1.00
Circuit and molecular mechanisms underlying incubation of methamphetamine craving in the prelimbic cortex 0.96
Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits 1.00
Sympathetic functional units encoded by genetically defined postganglionic neurons 1.00
Multisensory integration in the mouse ventral visual thalamus mediates stress coping via locus coeruleus-related circuits 1.00
An enteric-DRG pathway for interoception and visceral pain in mice 1.00
Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health 0.03
Ultrabright chemical labeling enables rapid neural connectivity profiling in large tissue samples 0.90
Corticotropin-releasing hormone signaling from piriform cortex to amygdala mediates social homophily in opioid addiction 1.00
The paraventricular thalamus mediates visceral pain and anxiety-like behaviors via two distinct pathways 1.00
1 1.00
Total Synthesis of the Conjugation-Ready Tetrasaccharide Repeating Unit of iAcinetobacter baumannii/i MAR13-1452 (K125) Capsular Polysaccharide for Vaccine Development 1.00
8 6.73
Structures of the human glucose-6-phosphate transporter provide insights into its transport cycle and substrate recognition 1.00
Dynamic expectation strength and precision shape human pain perception through shared and dissociable α-oscillatory mechanisms 0.86
Augmentation of frontoparietal gamma-band phase coupling enhances human altruistic behavior 0.17
Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation 0.90
The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation 1.00
Neural variability reliably encodes interindividual differences in the perception of pain intensity 0.89
The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input 0.92
Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load. 1.00
6 5.01
COG5 deficiency disrupts cellular copper homeostasis and underlies the impaired mitochondrial OXPHOS function 1.00
Transcription factor ZEB2 is essential for ureteral smooth muscle cell differentiation 0.08
Shared latent genetic liability across fibromyalgia and psychiatric traits: Novel insights from genomic structural equation modeling 1.00
20-hydroxyecdysone promotes brain development via upregulating MMP2 expression during metamorphosis in Helicoverpa armigera 1.00
Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis 0.93
The role of hypothyroidism in cirrhosis pathogenesis: A retrospective cohort study and multi-omics integration analysis 1.00
4 3.64
Cost-effectiveness of esketamine versus alternative treatment strategies for treatment-resistant depression in Hong Kong: A multi-armed modeling study 0.83
Physical frailty, genetic risk, mediating biomarkers, and risk of suicide attempt: A prospective cohort study 1.00
Medication adherence and its associated factors among oral pre-exposure prophylaxis (PrEP) users in China: The Real-world E-consumer Cohort of PrEP study. 0.94
Predicting knee osteoarthritis progression using neural network with longitudinal MRI radiomics, and biochemical biomarkers: A modeling study 0.87
1 1.00
Composite Orbital Angular Momentum for Super-resolution Ultrasound Imaging 1.00
1 0.07
Phage Display Derived Antibodies Against Antimicrobial Peptide FsPDF2 Reveal Stress Response in European Beech 0.07
44 37.43
Perception of a bacterial quorum sensing signal activates a tripartite plant immune strategy 0.90
Pseudorabies virus triggers ferritinophagy-mediated ferroptosis and neuroinflammation in viral encephalitis 1.00
Cell-type-resolved transcriptomic landscape of human focal cortical dysplasia 0.96
A discrete serotonergic circuit involved in the generation of tinnitus behavior 0.93
A farnesol-sensing triad in Pseudomonas aeruginosa drives interkingdom predation on Candida albicans via signal transduction 1.00
Identification of somatostatin+ inhibitory engrams for extinction in the basolateral amygdala 0.76
Reprogrammed SimCells for antimicrobial therapy 0.43
Structural insight into the CUB2 domain’s role in enteropeptidase-mediated trypsinogen activation 0.92
Reducing PTSD symptoms through unconscious intervention 0.88
Conserved use of tetraspanin CD9 as an entry receptor by rhabdoviruses spanning multiple genera 0.94
Personalized functional topography–based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression 0.98
Divergent BLA engram circuits orchestrate social preference dynamics in bystander male mice with self-experienced stress 1.00
Fear extinction induces maladaptive generalization via noradrenergic and GABAergic systems 0.96
NMI promotes the secretion of IL-17 and exacerbates psoriasis 1.00
Microbial metabolite oxindole curbs acute lung injury by suppressing CXCL13 1.00
Genetic recording of pancreatic beta cell proliferation 1.00
Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system 0.15
Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis 1.00
Legionella effector Ceg10 acetylates RPS20 to inhibit host translation and induce cell cycle arrest 1.00
Enhanced insulin signaling via circulating ATG7: A potential therapeutic strategy for diabetes 0.86
SPNS1 is an essential cellular factor for EV-A71 by acting as a transporter of viral pocket factor 1.00
Glomerular endothelial cells eliminate nicotinamide adenine dinucleotide to instruct CD103+ T cells in human lupus nephritis 0.83
Asparagine endopeptidase prompts breast cancer–related pericardial calcification by regulating IGF2 and integrin αvβ5 1.00
The SWI/SNF chromatin-remodeling subunit DPF2 regulates macrophage inflammation in intestinal injury via the CACNA1D-mediated MAPK pathway 1.00
Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning 1.00
Habenula–ventral tegmental area functional coupling and risk aversion in humans 0.56
Modulating the microbiome as an approach to anticancer drug development 0.55
Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation 0.05
Goblet cells dictate viral tropism and pathogenesis in nasal and intestinal mucosae 1.00
Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition 0.88
Tubular ACSM3 deficiency impairs medium-chain fatty acid metabolism and aggravates kidney fibrosis 1.00
Therapeutic restoration of mitochondria–endoplasmic reticulum cross talk for osteoarthritis 0.77
Broad neutralizing antibody response of a monomeric spike–based SARS-CoV-2 bivalent vaccine against diverse variants 1.00
Blood–labyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus 0.93
Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission 0.93
OMT and tensor SVD–based deep learning model for segmentation and predicting genetic markers of glioma: A multicenter study 0.96
EIAV encodes an accessory protein that antagonizes the host restriction factor equine tetherin 1.00
Genetic contributions to brain criticality and its relationship with human cognitive functions 1.00
Targeting of hyperlipid-producing senescent synovial fibroblasts to ameliorate cartilage degeneration 1.00
Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue–regulated energy metabolism 1.00
Autophagy-mediated downregulation of AXL and TIM-1 promotes sustained Zika virus infection 0.07
BRD9 functions as an HIV-1 latency regulatory factor 1.00
Physical exercise activates a PVN–NAc oxytocin circuit to relieve stress-induced depressive-like behaviors 1.00
Population imaging of enterochromaffin cell activity reveals regulation by somatostatin 0.22
1 0.03
Integrating microclimate to understand vector development and disease patterns: challenges and lessons from plague in Madagascar’s Central Highlands 0.03
17 14.29
Midbrain Energy Homeostasis Biomarker for Differential Diagnosis of Early-Stage Parkinson Disease: A 1H and 31P MRI Study. 0.79
Decoupling Alzheimer Disease Pathologic Abnormalities at PET with Improved Clinical Relevance by Interpretable Adversarial Decomposition Learning. 1.00
Contrast-Enhanced US Using Perfluorobutane for Diagnosing Small HCC in High-Risk Patients: Comparison with MRI LI-RADS Version 2018. 0.93
Nodular Transformation-driven Circulatory Remodeling in Biliary Atresia-induced Pediatric Biliary Cirrhosis: A Three-dimensional Phase-Contrast CT Rendering. 1.00
Prospective Multicenter Evaluation of Hepatocellular Carcinoma Surveillance under American Association for the Study of Liver Diseases Version 2023 Guidance. 1.00
Ultra-Low-Dose Photon-counting Detector CT for Emphysema Assessment: A Head-to-Head Comparative Study with Low-Dose CT. 1.00
Integrating Contrast-Enhanced Dark-Light-Dark Sign and MRI Features for Rectal Cancer Lymph Node Diagnosis. 1.00
Contrast-enhanced US Evaluation of Residual Hepatocellular Carcinoma Following Lenvatinib Combined with Anti-PD-1 Antibody Downstaging Therapy. 1.00
Spatiotemporal Development and Clinical Correlates of MRI-based Brain Myelination in Term- and Preterm-born Children. 0.97
Liver MRI-derived Proton Density Fat Fraction Predicts Diabetes Risk in Patients with Obesity: A Dose-Response Study. 1.00
Identifying Distinct Spatiotemporal Patterns of Juxtacortical Microstructure in Alzheimer Disease Using Diffusion MRI-derived Free Water Fraction. 1.00
Risk Stratification of Sudden Cardiac Death in Nonischemic Dilated Cardiomyopathy: Arrhythmogenic Substrate Assessment in Cardiac MRI. 0.81
Comparison of a Specialized Large Language Model with GPT-4o for CT and MRI Radiology Report Summarization. 0.80
Intratumoral Microbiome-related MRI Model for Predicting Breast Cancer Shrinkage Pattern Following Neoadjuvant Therapy. 0.85
Metabolic Dysfunction-Associated Steatotic Liver Disease at Quantitative US: International Prospective Study. 0.86
Impact of LI-RADS CT and MRI Ancillary Features on Diagnostic Performance: An Individual Participant Data Meta-Analysis. 0.16
Diagnostic Performance of CT/MRI LI-RADS Version 2018 Major Feature Combinations: Individual Participant Data Meta-Analysis. 0.11
6 4.01
From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus 0.96
A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation 1.00
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis 1.00
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation 0.04
Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex 0.01
Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense 1.00
47 43.42
Transcobalamin 1 is a keratinocyte-derived autoantigen driving psoriasis through T helper 17 cell activation 1.00
Enhancing biomedical optical volumetric imaging via self-supervised orthogonal learning 1.00
High-gradient magnetic separation chip–based small extracellular vesicle isolation for noninvasive subtyping of primary aldosteronism 1.00
Phosphorylation of PfiA modulates Pf4 phage production through PfiA/PfiT stoichiometric reconfiguration in Pseudomonas aeruginosa 1.00
Reduced MGE burden, virulence optimization, and acid stress tolerance shape the clonal succession of MRSA ST59 1.00
Sympathetic nerve aggravates autoimmune skin disease via NE–adrenergic receptor axis: Neuroimmune cross-talk insights from vitiligo 1.00
Stress ensemble in the BNST mediates comorbid anxiety and sleep disruption 1.00
Animal-associated jumbo phages as widespread and active modulators of gut microbiome ecology and metabolism 0.75
Bacteriocin-transport–inspired oral peptide-probiotic delivery ameliorates IBD complications via autophagy and gut homeostasis 1.00
Dynamic adaptive coassembled sericin protein orchestrating stem cell development for nucleus pulposus regeneration 0.80
Integrin inhibition facilitates fibrocartilaginous transformation in connective tissue in osteoarthritis 0.95
SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes 0.87
Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation 1.00
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase 1.00
A central CeA-LC-PVH circuit mediates stress-induced osteopenia via skeletal sympathetic nerves in male mice 1.00
A self-assembled nano micelle-exosome with high selectivity and penetrability achieves precise intracartilage lipid delivery 1.00
Single coadministration of erythrocyte-uricase conjugate and immunosuppressant induces durable immune tolerance for gout therapy 1.00
Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation 1.00
Thiol-polarity dual cascade–triggered two-photon imaging of protein unfolding for early atherosclerosis diagnosis 1.00
Mapping neurophysiological and molecular profiles of heterogeneity and homogeneity in schizophrenia-bipolar disorder 0.77
The two-component nuclease-active KELShedu system confers broad antiphage activity via abortive infection 1.00
Activatable fluorescent ratiometric probes for early diagnosis and prognostic assessment of acute kidney injury 1.00
Loss-of-function variants in ciliary genes confer high risk for tetralogy of Fallot 1.00
Evolutionary selection of trimethoprim-resistant dfrA genes in lytic phages affects phage and host fitness during infection 0.87
Microenvironment-driven transformable self-assembly nanoplatform enables spatiotemporal remodeling for rheumatoid arthritis therapy 1.00
Bacteriophage immunotherapy with artificial antigen-directed immune labeling against bacterial infection 1.00
Microbiota metabolite taurodeoxycholic acid maintains intestinal tissue residency of innate lymphoid cells via engagement with P2Y10 receptor 1.00
A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation 1.00
Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease 1.00
Elucidating the characteristics and clonal evolutionary trajectory of influenza neuraminidase broadly reactive B cell 1.00
TH17 cells regulate chemokine expression in epithelial cells through C/EBPβ and dictate host sensitivity to colitis and cancer immunity 0.08
Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones 1.00
Insights into the spool-like architecture and infection strategy of an enveloped archaeal virus 1.00
Nicotinamide boosts oocyte quantity and quality by promoting N4-acetylation modification in lupus mice 1.00
Proteolytic-resistant self-assembling peptide nanofibers combat specific bacterial infections via trap and kill 1.00
Adaptive reward representations integrate expected uncertainty signals in orbitofrontal cortex 1.00
Microglial BDNF modulates arketamine’s antidepressant-like effects through cortico-accumbal pathways 0.91
Wearing bacteriophages individually with an adhesive drug-loadable nanohelmet for treating ocular infections 1.00
Autoinducing peptides regulate antibiotic production to potentially shape root microbiome 1.00
Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis 0.92
Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety 1.00
Complementary corticostriatal circuits orchestrate action repetition and switching 0.50
Snora54 negatively regulates self-renewal of intestinal stem cells and gut regeneration via suppression of Notch2 signaling 1.00
Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection 1.00
Structural maturation of the matrix lattice is not required for HIV-1 particle infectivity 0.05
Noninvasive prognostic classification of ITH in HCC with multi-omics insights and therapeutic implications 1.00
A rationally designed injury kidney targeting peptide library and its application in rescuing acute kidney injury 0.95
17 12.38
Quantifying myocardial oxygen consumption and efficiency with motion-resolved cardiac MRI 0.14
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational diabetes–induced glucose intolerance in offspring 0.96
Parenteral vaccination with an adjuvanted mRNA vaccine induces protective mucosal immunity against rotavirus in neonatal mice 0.98
The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity 1.00
Meteorin-like is associated with poor outcome in invasive candidiasis in mouse models and in humans 0.92
A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models 1.00
snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice 0.93
Depletion of plasmacytoid dendritic cells rescues HIV-reactive stem-like CD8+ T cells during chronic HIV-1 infection 0.03
A randomized, double-blind, placebo-controlled phase 1 trial of the topical pan–lysyl oxidase inhibitor PXS-6302 in mature scars 0.03
Inhibiting SLC38A2 lowers blood pressure in rodent models of hypertension 1.00
An epitope vaccine derived by analyzing clinical trial samples safeguards hosts with prior exposure to S. aureus against reinfection 1.00
Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis 0.38
NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis 0.10
A cationic polymer drives glycosaminoglycan assembly and secretion for preclinical osteoarthritis therapy 0.93
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors 1.00
A host defense peptide–mimicking prodrug activated by drug-resistant Gram-negative bacterial infections 1.00
Islet transplantation in immunomodulatory nanoparticle–remodeled spleens 1.00
4 4.00
Thermal adaptation, perception and regulation for the elderly under intense urban heat: A cross-activity study 1.00
Enhancing urban biosecurity and sustainability through a microclimatic bioaerosol risk management framework 1.00
Pedestrians thermal responses under variable exposure conditions during heatwaves 1.00
Estimating the real-life infection risk of the SARS-CoV-2 virus in a typical metro compartment 1.00
12 8.97
Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis 0.74
Standard chemoradiotherapy with concurrent and adjuvant camrelizumab in patients with high risk nasopharyngeal carcinoma: multicentre, randomised, open label, phase 3 trial 1.00
Reliability of urological telesurgery compared with local surgery: multicentre randomised controlled trial 1.00
Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis 0.02
Preimplantation genetic testing for aneuploidy versus no genetic testing in couples undergoing intracytoplasmic sperm injection for severe male infertility: multicentre, open label, randomised controlled trial 0.95
Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial 0.81
Comparative efficacy and safety of exercise modalities in knee osteoarthritis: systematic review and network meta-analysis 0.79
Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial 0.96
Efficacy and safety of anrikefon in patients with pruritus undergoing haemodialysis: multicentre, double blind, randomised placebo controlled phase 3 trial 1.00
Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis 0.49
Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study 0.22
No-touch versus conventional vein in coronary artery bypass grafting: three year follow-up of multicentre randomised PATENCY trial 1.00
9 8.03
The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling 1.00
Simultaneous inhibition of bacterial virulence and anti-phage defense systems by synergistic bacteriophage counter-defense proteins 1.00
A gut-brain-gut axis orchestrates host responses counteracting microbiome-induced iron insufficiency 1.00
Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition. 1.00
Macrophages form dendrite-like pseudopods to enhance bacterial ingestion 1.00
Deletion of EP3 prostaglandin receptor in murine macrophages aggravates diet-induced obesity by suppressing SPARC. 1.00
Structural basis of Fanconi anemia pathway activation by FANCM. 0.11
The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder. 1.00
Ductal or Ngn3+ cells do not contribute to adult pancreatic islet beta-cell neogenesis in homeostasis 0.92
8 7.04
Phage receptor specificity drives cross-resistance patterns and governs fitness trade-offs during sequential resistance acquisition in Salmonella 1.00
Microoxic conditions promote Escherichia-associated cellulase expression in the giant panda gut 1.00
Fecal microbiota transplantation and Akkermansia muciniphila restore neurodevelopment and behavior via the gut-brain axis in autism-like zebrafish 1.00
Sulfoquinovose degradation by cow rumen microbiota 0.04
Gut microbial production of lithocholic acid reprograms pro-resolutive macrophages to enhance vedolizumab responsiveness via the TGR5/FXR-NF-κB axis 1.00
Global distribution of α/β hydrolase family macrolide esterases in Gram-positive bacteria 1.00
Diversity and Evolution of Prokaryotic Viral Lytic Proteins 1.00
Decoding the SCFA-CpxAR-OMP Axis as a Dietary Checkpoint against Antimicrobial Resistance Transmission across Gut-Environment Interfaces 1.00
15 12.15
ADAM8 mediates eosinophil and neutrophil infiltration and tissue remodeling in chronic rhinosinusitis with nasal polyps 0.91
Deep learning and statistical methods identify novel asthma risk variants in Europeans 0.83
IL-2 synergizes with proinflammatory type 3 inducers to amplify mixed type 2–type 3 inflammation in nasal polyps 0.91
Staphylococcal superantigen–specific IgE reveals functional superantigen production beyond Staphylococcus aureus in CRSwNP 0.88
Efferocytosis Deficiency Exacerbates Local Inflammation and Predicts Recurrence in Chronic Rhinosinusitis with Nasal Polyps 1.00
Aberrant ceramide accumulation fuels eosinophilic inflammation by promoting EET formation and release in CRSwNP 1.00
Remibrutinib in chronic spontaneous urticaria: 52-Week results from two phase 3 studies 0.09
CB2R-cAMP-Epac1 Pathway Orchestrates Epithelial-Neural-Immune Interactions in Atopic Dermatitis 1.00
Explainable artificial intelligence for predicting inflammatory signatures and spatial molecular heterogeneity from nasal polyp histology 1.00
S-Ruxolitinib: a novel JAK/STAT-targeted therapy through restoring mucosal homeostasis for chronic rhinosinusitis with nasal polyps 0.91
Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: Systematic review and network meta-analysis 0.01
S. aureus upregulation of MUC13 modulates mucosal remodeling in chronic rhinosinusitis via MEK1/2 and WNT2B 1.00
Opsin 3 in keratinocytes mediates the light-induced exaggeration of atopic dermatitis 1.00
Small Proline-Rich Protein 2A Drives Epithelial Remodeling in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps via SAA2 Upregulation 0.60
Dupilumab-induced inhibition of myeloid dendritic cells function via TIM-3-TGF-β1 feedback loop in treatment of atopic dermatitis 1.00
1 0.92
Nanoclay-Interface-Mediating Charge Redistribution for Effective Wound Healing 0.92
3 0.87
Survival outcome of VATS compared with open lobectomy for lung cancer: an individual patient data meta-analysis of randomised trials 0.22
TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198 0.12
Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II): a multiregional, seasonal, hospital-based, cluster-randomised, controlled trial in China 0.53
6 1.44
11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050 0.11
Efficacy and safety of tirzepatide added to basal insulin in patients with type 2 diabetes in China (SURPASS-CN-INS): a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial 1.00
Cycle characterisation and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study 0.07
Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis 0.06
Once‑weekly IcoSema versus once‑weekly insulin icodec in type 2 diabetes management (COMBINE 1): an open‑label, multicentre, treat‑to‑target, randomised, phase 3a trial 0.10
Once-weekly IcoSema versus multiple daily insulin injections in type 2 diabetes management (COMBINE 3): an open-label, multicentre, treat-to-target, non-inferiority, randomised, phase 3a trial 0.10
2 0.98
Global antibiotic consumption and regional antimicrobial resistance, 2010–21: an analysis of pharmaceutical sales and antimicrobial resistance surveillance data 0.92
Global variation in patient factors, interventions, and postoperative outcomes for those undergoing trauma laparotomy: an international, prospective, observational cohort study 0.05
3 1.95
Efficacy and safety of iclepertin for cognitive impairment associated with schizophrenia (CONNEX programme): results from three phase 3 randomised controlled trials 0.09
Disease relapse, all-cause mortality, and adverse events associated with long-acting injectable antipsychotics versus oral antipsychotics in older people with schizophrenia in Hong Kong: a population-based within-subject analysis 0.87
Clozapine use and risk of infections in patients with schizophrenia in Hong Kong: a population-based cohort study 0.99
10 2.35
Finerenone in Type 1 Diabetes and Chronic Kidney Disease 0.05
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes 0.04
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial 0.04
A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy 0.05
Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents 0.13
A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus 0.86
Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer 1.00
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension 0.08
A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery 0.04
Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes 0.07
3 2.61
Generalisability of ARDS biological subphenotype models in Asians: an international, multicentre, prospective biomarker study 0.61
Combining tuberculin skin test with follow-on interferon gamma release assay markedly improves screening of household contacts 1.00
Dynamic oxygenation subgroup bringing new insights in ARDS: more predictive of outcomes and response to PEEP than static PaO2/FiO2 1.00
10 9.29
Worker exposure to bioaerosols from sludge dewatering facilities: risks and mitigations 0.85
Metatranscriptomics Reveals System-Specific Viral Adaptive Strategies and Prokaryotic Defense Trade-offs Across Anaerobic Digestion Systems 0.89
Rapid Elimination of Harmful Cyanobacteria via Synergistic Effects of Photo-oxidation and Flocculation 1.00
Carbon composites with photo-allosteric switch for waterborne virus removal 0.64
Inactivation mechanisms of intracellular coliphages in host bacteria by chemical disinfection with ozone, chlorine oxide, chlorine and chloramine 1.00
Simultaneously disinfection of amoebae, endosymbiotic bacteria, and resistance genes using a novel two-electron water oxidation strategy 1.00
Prevalence and functional impact of the interactions between lysogenic phages and hosts in activated sludge systems: insights from large-scale metagenomics and experimental evidence 1.00
Bioluminescent-reporter phagosensor for quantitative detection of viable Escherichia coli in water 0.92
Engineering intermolecular C-F…C=O interactions in covalent organic framework promotes dual-path H2O2 photosynthesis for sustainable disinfection 1.00
Responses of Viral Communities in Aerobic Biofilms under Antibiotic Stress 1.00

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