Research articles

Cryo-EM structures of ZYG11B-EloB-EloC-substrate complex reveal architecture of CRL2^ZYG11B E3 ligase. ZYG11B forms both monomeric and dimeric assemblies, and functional assays show that dimerization enhances substrate ubiquitination and degradation.

Marine heatwaves (MHWs) systematically alter ocean net primary production (NPP) patterns meridionally, reflecting regional differences in baseline nutrient availability and pointing to an emerging poleward redistribution of ocean productivity.

Multidrug resistant tuberculosis (MDR-TB) is a major global health concern. This study uses novel phylogeographic approaches to determine the origin and global dispersion of a highly transmissible MDR-TB lineage first identified in Eastern Europe.

Acute rheumatic fever (ARF) is a serious sequela of Strep A infection, for which a diagnostic biomarker is still lacking. Here, the authors demonstrate that CXCR3 directs T cells to heart valves in patients with ARF, linking inflammation to tissue damage.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Superionic conductors are typically engineered from static crystal structures. Here, authors present how flexible polyanion rotations induce dynamic disorder in lithium sublattice, enabling liquid-like ion diffusion and enhanced ionic conductivity.

Distinct KIF1A mutations cause neurological disease, but the mechanism for many variants remains unclear. Here, the authors use cryo-EM and motility assays to show that R350 mutations disrupt a conserved, conformation-dependent kinesin–tubulin salt bridge, altering motor function.

Stress increases the intake of high-fat food, contributing to obesity and eating disorders. Here authors show, in mice, that stress impairs the control of the prefrontal cortex over feeding centers in the hypothalamus, driving excess fat intake.

The authors propose a local structure design to overcome the restrictive relationship between polarization behavior and electric field durability, yielding an ultrahigh Wrec of 14.5 J cm^-3, which offers a feasible route for the cutting-edge energy-storage applications.

Reduced expression of STING in cancer cells due to ER and Golgi dysfunction enables tumor immune escape and limits STING targeted therapies. The authors here develop a cell membrane derived nanodisc system ND-cGAMP-HP that delivers activated STING directly to tumor cells bypassing ER Golgi translocation which activates the IFN-I signaling pathway and induces potent cellular immune responses.

Here, the authors use single-cell transcriptomics and imaging to profile the Quorum-sensing (QS) response of Pseudomonas aeruginosa. Their findings show that heterogeneity differs at each QS stage and that individuality guides cooperation in bacterial populations.

Whether habits emerge gradually or suddenly remains an open question. Here the authors show that mice abruptly switch from goal-directed to habitual control, marked by a rapid dorsal striatal shift from outcome- to stimulus-driven processing.

Efficient electrical control of domain walls underpins fast, low-energy magnetic memories. Wu et al report field-free domain wall velocities of 1 km s⁻¹ at 20 MA cm⁻² in ferrimagnetic NiCo₂O₄, arising from giant nonadiabatic spin-transfer torque.

Neural population activity evolves on low-dimensional manifolds. Here, the authors identify shared and exclusive neural spaces in ECoG signals for motor execution and imagery, and show how these latent structures enable partial demixing of concurrently executed and imagined movements.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

Oxygen vacancy defects, crucial to properties such as conductivity and thermal expansion, exhibited unique temperature dependence when cation mixing distorts the lattice, creating an energetic distribution of vacancy sites.

The transcriptome and proteome provide complementary information about the cellular phenotype, state and function. Here, the authors introduce SPARO, a method that enables simultaneous profiling of cell type-specific transcriptomes and proteomes in vitro and in vivo by leveraging TurboID-based biotinylation of RNA-interacting cytosolic proteins to enrich both proteins and associated RNAs.

Using an evolutionary optimization approach, the authors report a culture medium that matures stem cell-derived heart cells, improving their structure, metabolism and electrical activity to advance highly functional models for in vitro testing.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

Widely used, effective methods to prevent adhesions after digit flexor tendon injury are lacking. Here, authors develop a bioresorbable, supramolecular hydrogel as a lubricating barrier to preserve tendon biomechanics and improve functional recovery.