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The authors study a topological insulator (TI) sandwiched between two magnetic TIs. By keeping one of the magnetic TIs insulating, while tuning the other one into a metallic regime, they find half quantized anomalous Hall conductance, a boundary signature consistent with a quantized axion field.

Synthetic methylotrophic S. cerevisiae often faces energetic constrains during one-carbon assimilation. Here, the authors address this issue by engineering of heterologous methanol-formate-formaldehyde oxidation pathways to enable CO₂ assimilation via non-native Calvin cycle during methanol fermentation.

AI models consume growing amounts of energy. Here, the authors introduce a brain-inspired way to prune connections in randomly weighted resistive-memory chips, boosting accuracy while avoiding costly analog tuning to improve general efficiency and reduce power use.

Here the authors show how coronaviruses use host lipid metabolism and ER-associated degradation pathways to form double-membrane vesicles (DMVs) essential for RNA replication, demonstrating that the viral protein nsp6 tethers DMVs to lipid droplets and recruits ERAD-derived vesicles to enable membrane expansion and efficient replication.

Dysfunctional NK cells contribute to the immune-hostile tumour microenvironment of triple-negative breast cancers (TNBC). Here authors show that NKSM, a micropeptide encoded by the long non-coding RNA UGDH-AS1, is specifically expressed in the intra-tumoral NK cells in TNBC and interferes with their anti-tumour activity.

Electrochemical CO₂ reduction in acidic media offers a promising route for CO₂ valorization but faces challenges owing to competing hydrogen evolution and sluggish C–C coupling. Here the authors demonstrate that surface-adsorbed iodide ions enhance performance on Cu-based catalysts, doubling ethylene selectivity and reducing overpotentials.

Copper is a CO₂ electroreduction catalyst consisting of at least two distinct active sites. Here, the authors report that the activities toward multicarbon products at these two sites can be independently tuned by modifying polyvinylpyridine to form distinct microenvironments.

The response to immune checkpoint blockade in head and neck cancer has been heterogenous. Here, the authors utilise longitudinal sampling of a head and neck squamous cell carcinoma model to identify biomarkers of response.

Liu et al. experimentally demonstrate a terahertz chaos source based on a terahertz quantum cascade laser without any external perturbations. It is found that the chaos generation in the terahertz laser is ascribed to the defect-mediated turbulence.

Constructing C(sp³)–C(sp³) bonds using non-prefunctionalized substrates as radical precursors is challenging. Now an ene-reductase and an organophotoredox catalyst work together to enable the enantiodivergent hydroalkylation of electron-deficient C(sp³)–H bonds via radical intermediates generated from carbanions.

This study shows that keto-enol tautomerism in 2,4,6-trihydroxybenzaldehyde (Tp) imine COFs acts as variable electron/hole traps, boosting exciton dissociation and charge transfer. Tp COF (TpBpy) achieves an photocatalytic H₂O₂ generation rate of 8350 μmol h^-1 g^-1 under simulated light, and a solar-to-chemical conversion efficiency of 0.038% in a flow reactor under natural sunlight.

The mechanism of contact electrification remains a topic of debate. Here, the authors present a quantitative database of the triboelectric charge density and band structure of many inorganic materials, verifying that contact electrification between solids is an electron quantum transition effect.

Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.

Primary or acquired resistances to immune checkpoint inhibitors are often observed in patients with melanoma. Here the authors report the development of a method, immunotherapy resistance cell-cell interaction scanner (IRIS), for identifying cell-type-specific ligand-receptor interactions relevant to immunotherapy therapy response and resistance in melanoma.

Current treatments for fundus disorders face safety and efficacy challenges. Here, the authors developed a wearable electrodriven switch that enables macromolecule delivery to the fundus

The authors demonstrate a strategy for bacterial uptake of gold nanoparticles modified with glucose polymer. The particles aggregate in the bacterial cells upon laser irradiation, resulting in enhanced photoacoustic signal and antibacterial activity, enabling sensitive imaging of bacteria in vivo.

Researchers find that the shuffling of insulin’s disulfide bonds, while initially slowing protein aggregation, ultimately forms distinct and more toxic fibrils, providing key insights for therapeutic insulin safety and protein misfolding diseases.

Among 406,438 adults in the UK, Wang et al. find that people with SARS-CoV-2 infection were at increased risk (at 1 year) of incident and prevalent psychiatric disorders and psychotropic prescriptions, especially those hospitalized for COVID-19 or those not fully vaccinated.

Gut microbiota-derived succinate promotes CitC succinyltransferase-dependent succinylation of PurR to alleviate T3SS repression and promote virulence in enterohaemorrhagic Escherichia coli and Citrobacter rodentium.

The authors present multifunctional nanoagents that can be used for imaging and treatment of bacterial infections. The nanoagents are made of fluorescent silicon nanoparticles functionalized with a glucose polymer and loaded with chlorin e6, and are taken up by bacteria via ABC transporters.

De novo genome assembly and analyses of 12 maize FILs provide insights into genomic and phenotypic differentiation of various heterotic groups and the molecular basis of heterosis in maize.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

A lipid-nanoparticle-based formulation incorporating engineered lipids containing a blood–brain-barrier-crossing moiety effectively delivers mRNA to neurons and astrocytes following systemic administration in mice.

The impact of modifiable lifestyle factors on the risk of post-COVID-19 sequelae is not well understood. Here, the authors perform a prospective cohort study amongst UK Biobank participants and show that a healthy lifestyle is associated with lower risk of post-COVID-19 sequelae across multiple organ systems.

IL-6 and RasGRP1 have been shown to have important functions during inflammation and cancer. Here the authors propose the protein and mRNA of RasGRP1 have opposing functions by promoting IL-6 mediated acute inflammation and inhibiting inflammation-associated cancer through mRNA and protein mechanisms respectively.

Immunoengineering-based cancer therapies have huge potential. Here the authors report on the lipid nanoparticle delivery, to cancer cells, of self-amplifying RNA encoding SARS-CoV-2 spike epitope-loaded MHC I molecules to take advantage of anti-SARS-CoV-2 immunity from a vaccinated population to treat cancer.

Jupiter’s radiation belt exhibits complex electron distributions shaped by wave–particle interactions and moon absorption. Here, the authors identify an electron slot region and quantify its formation driven by whistler waves via Juno mission data and simulations.

Adrenergic and muscarinic receptors are key GPCRs involved in vital functions. Here, the authors engineer toxin variants that selectively target α2A and M4AChR, offering new tools and therapeutic leads through a structure-guided design strategy.

Incorporation of a ‘liquid diode’ into a wearable electronic platform enhances comfort and stability by shunting away sweat as it accumulates.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

Dark pulse microcombs have been realized in dissipation-engineered lithium niobate microresonators, unlocking broadband, high-power coherent light sources for communication and microwave applications in integrated lithium niobate photonic.

Cepharanthine is a secondary metabolite isolated from Stephania with a variety of medicinal properties. Here, the authors assembled three Stephania genomes, propose cepharanthine biosynthetic pathway, and assess the antiviral potential of cepharanthine-related metabolites.

Human leucocyte antigens are important in the adaptive immune response. Here, the authors use data from the UK Biobank linked to electronic health records to investigate the association between genetic variation in HLA alleles and antibody responses to SARS-CoV-2 vaccination and breakthrough COVID-19 outcomes.

A selective shielding strategy achieves the differentiation and quantification of distinct plasmonic photocatalytic mechanisms including hot carrier-driven photochemistry, resonant field-mediated energy transfers, and thermal contributions.

The anomalous Hall angle parameter tanθ^A can be formulated as a function of the product of electrical resistivity and anomalous Hall conductivity, a scheme that allows the anomalous Hall angle in the magnetic Weyl semimetal Co₃Sn₂S₂ to be increased to 25°.

A well-designed national coal phase-out pathway in China that considers diverse technology portfolios and plant-level sequential decision-making processes can save over 700 billion dollars and elevate mitigation potential.

The low activity of PylRS hinders the efficient production of ncAA containing proteins. Here, authors apply machine learning to engineer the tRNA-binding domain of PylRS, obtaining variants with improved stop codon suppression efficiency and achieving higher yields of proteins containing various ncAAs.

Existing ingestible electronics suffer from poor tissue contact, short dwell time, and limited battery life. Here, the authors report an ingestible, battery- free, and tissue-adhering robotic interface for non-invasive and chronic electrostimulation of the gut.

The mechanisms involved in the formation of the premetastatic niche in hepatocellular carcinoma (HCC) are not completely elucidated. Here, the authors show that matrix stiffness in HCC induces cancer-exosome release which increases glucose availability in the lung premetastatic niche favouring metastasis formation and growing.