Nature Search

Obesity rise plateaus in developed nations and accelerates in developing nations

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Bin Zhou
Nowell H. Phelps
Majid Ezzati
ResearchOpen Access13 May 2026
Nature

Volume: 653, P: 510-518
Ubiquitination of glycogen and metabolites in cells and tissues

Marco Jochem
Simon A. Cobbold
David Komander
Research22 Apr 2026
Nature

P: 1-3
Safety and activity of RO7300490, a bispecific CD40 agonist targeted to fibroblast activation protein, in patients with advanced solid tumors: a single-arm, multicenter, first-in-human, phase 1 trial

Reis and colleagues demonstrated that targeting fibroblast activation protein by CD40 agonist was feasible and safe in patients with advanced solid tumors.

Ignacio Melero
Bernhard Reis
Stefan N. Symeonides
ResearchOpen Access01 May 2026
Nature Cancer

P: 1-17
Highly luminescent carbazole-functionalized tris(tribromophenyl)methyl radicals with stable circularly polarized photoluminescence

Brominated trityl radicals form stable enantiomers and present promising candidates for molecular qubits but their inherently weak photoluminescence limits optical spin readout. Here, the authors synthesize three carbazole-functionalized tris(2,4,6-tribromophenyl)methyl radicals with photoluminescence quantum yields of up to 72%.

Larissa Schöneburg
Markus Gross
Alexander J. C. Kuehne
ResearchOpen Access15 May 2026
Nature Communications

Volume: 17, P: 1-8
Native diversity buffers against severity of non-native tree invasions

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Camille S. Delavaux
Thomas W. Crowther
Daniel S. Maynard
ResearchOpen Access23 Aug 2023
Nature

Volume: 621, P: 773-781
Predicting temporal stability and resilience from resistance and recovery

New predictions for how temporal stability and resilience depend on their resistance and recovery components are explored.

Forest Isbell
Akira S. Mori
Chad R. Zirbel
ResearchOpen Access06 May 2026
Nature

P: 1-7
Predicting trajectories of illness using RNA velocity of whole blood

RNA velocity is a widely used method to predict the fate of single cells. Here the authors show that the concept can be adapted to predict the fate of individual human subjects, using RNA velocity of whole blood at a single point in time to predict future clinical outcomes and treatment responses.

Claire Dunican
Clare Wilson
Aubrey J. Cunnington
ResearchOpen Access06 May 2026
Nature Communications

Volume: 17, P: 1-20
CLUES A Comprehensive Workflow for Integrating Geospatial Data in Biomedical Research

The study presents CLUES, an open-source workflow that automates linking global environmental data with geolocated biomedical data, enabling scalable research while supporting FAIR data practices and privacy-aware integration.

Marcel Jentsch
Elli Polemiti
Zuo Zhang
ResearchOpen Access13 May 2026
Nature Communications

Volume: 17, P: 1-11
Investigating medicinal resource combinations in the Bornean orangutan diet

G. Allen
E. Freymann
H. C. Morrogh-Bernard
ResearchOpen Access13 May 2026
Scientific Reports

P: 1-12
Greater trophic diversity of soil animal communities under agricultural land use and tropical climate

Soil fauna is an important but often neglected component of terrestrial food webs. Here the authors use a large dataset of stable isotope observations to analyse how soil animal trophic diversity varies across climates and land-use types and identify potential biotic mechanisms.

Zheng Zhou
Nico Eisenhauer
Anton Potapov
ResearchOpen Access16 Mar 2026
Nature Ecology & Evolution

Volume: 10, P: 700-711
Free Nerve Endings as Transducers of Thermal Stimuli

H. J. V. TYRRELL
D. A. TAYLOR
C. M. WILLIAMS
Research13 Nov 1954
Nature

Volume: 174, P: 918-919
A Second Right-handed Helical Structure with the Parameters of the Pauling–Corey α-helix

GEORGE NÉMETHY
D. C. PHILLIPS
HAROLD A. SCHERAGA
Research22 Apr 1967
Nature

Volume: 214, P: 363-365
Prospective multicenter study of ctDNA versus tumor tissue guiding FGFR-targeted therapy in metastatic urothelial cancer

Plasma ctDNA testing for FGFR alterations in metastatic urothelial carcinoma shows high concordance with tissue testing and identifies additional patients with actionable alterations. Here, the authors show that clinical uptake of ctDNA FGFR testing can be combined with tissue-based approaches.

David C. Müller
Andrew J. Murtha
Bernhard J. Eigl
ResearchOpen Access27 Feb 2026
Nature Communications

Volume: 17, P: 1-10
Treatment strategies in giant cell arteritis and polymyalgia rheumatica: beyond glucocorticoids

In this Review, the authors provide an overview of current and emerging therapeutic strategies for giant cell arteritis and polymyalgia rheumatica, including glucocorticoids and glucocorticoid-sparing approaches, and also discuss challenges including monitoring disease activity, defining treatment targets and managing relapse.

Francesco Muratore
Kenneth J. Warrington
Carlo Salvarani
Reviews20 May 2026
Nature Reviews Rheumatology

P: 1-18
RanBP2-dependent annulate lamellae drive nuclear pore assembly and nuclear expansion

Whether annulate lamellae (AL) occur in normal somatic cells was an open question. Here, the authors demonstrate that AL drive nuclear pore complex assembly and nuclear expansion during G1, defining a RanBP2-dependent assembly route.

Junyan Lin
Arantxa Agote-Aran
Izabela Sumara
ResearchOpen Access25 Mar 2026
Nature Communications

Volume: 17, P: 1-25
Morphological Transformation of Mouse Embryo Cells in vitro by Murine Sarcoma Virus (Harvey)

P. J. SIMONS
R. R. DOURMASHKIN
F. C. CHESTERMAN
Research27 May 1967
Nature

Volume: 214, P: 897-898
Loss-of-function variants in the CAPN1 activator CD99L2 cause X-linked spastic ataxia

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

Benita Menden
Rana D. Incebacak Eltemur
Tobias B. Haack
ResearchOpen Access14 Feb 2026
Nature Communications

Volume: 17, P: 1-21
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Mechanism of Intestinal Absorption of Fat

A. C. FRAZER
Research19 Mar 1955
Nature

Volume: 175, P: 491-493
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Ter, a Function which generates the Ends of the Mature λ Chromosome

S. MOUSSET
R. THOMAS
Research18 Jan 1969
Nature

Volume: 221, P: 242-244
Heliotherapy and Phototherapy

W. CRAMER
Research19 Jan 1924
Nature

Volume: 113, P: 80
Secondary Clumping Effect in Human Citrated Platelet-Rich Plasma Produced by Adenosine Diphosphate and Adrenaline

D. C. MACMILLAN
Research09 Jul 1966
Nature

Volume: 211, P: 140-144
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry

Annunziato, Quan and Donckele et al. identify G3BP2 (Ras–GAP SH3 domain-binding protein 2) as a molecular glue-induced neosubstrate of the CRL4^CRBN E3 ubiquitin ligase. The CRBN–glue neosurface uses a molecular surface mimicry mechanism to recruit and degrade G3BP2 in a compound-dependent manner.

Stefano Annunziato
Chao Quan
Georg Petzold
ResearchOpen Access20 Jan 2026
Nature Structural & Molecular Biology

Volume: 33, P: 479-487
Oral immunization with filovirus-like particles partially protects IFNAR⁻/⁻ mice against lethal ebola virus challenge

Beatriz Escudero-Pérez
Fátima Lasala
Rafael Delgado
ResearchOpen Access26 Mar 2026
Scientific Reports

Volume: 16, P: 1-14
Femtosecond concerted rotation of molecules on a 2D material interface

Molecular motion at interfaces to 2D materials is governed by interfacial interactions. Here, the authors use a multimodal time-resolved photoemission approach to reveal collective molecular rotation on a 2D material following photoexcitation.

Kiana Baumgärtner
Misa Nozaki
Markus Scholz
ResearchOpen Access27 Feb 2026
Nature Communications

Volume: 17, P: 1-8
Strychnine as a Depressant of Primary Inhibition

K. BRADLEY
J. C. ECCLES
Research13 Jun 1953
Nature

Volume: 171, P: 1061-1062
Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus

G. Biesecker
J. Ieuan Harris
A. J. Wonacott
Research24 Mar 1977
Nature

Volume: 266, P: 328-333
Bispecific T cell engagers for treatment-refractory autoimmune connective tissue diseases

In a case series of five patients with treatment-refractory antisynthetase syndrome and five patients with treatment-refractory systemic sclerosis, bispecific T cell engagers blinatumomab and teclistamab improved disease activity and were well tolerated.

Christina Düsing
Andrea-Hermina Györfi
Jörg H. W. Distler
ResearchOpen Access19 Feb 2026
Nature Medicine

Volume: 32, P: 1530-1542
Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy

Bernhard H. F. Weber
Gudrun Vogt
Ute Felbor
Research01 Dec 1994
Nature Genetics

Volume: 8, P: 352-356
Using the linear references from the pangenome to discover missing autism variants

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Yang Sui
Jiadong Lin
Evan E. Eichler
ResearchOpen Access23 Jan 2026
Nature Communications

Volume: 17, P: 1-16
Search for a Human Breast Cancer Virus

DAN H. MOORE
JESSE CHARNEY
A. B. VAIDYA
Research26 Feb 1971
Nature

Volume: 229, P: 611-615
Surprisingly rapid spreading of newly formed intermediate waters across the North Atlantic Ocean

Alexander Sy
Monika Rhein
Manfred Bersch
Research17 Apr 1997
Nature

Volume: 386, P: 675-679
Gut microbial ethanol metabolism contributes to auto-brewery syndrome in an observational cohort

Gut microorganisms capable of producing ethanol cause alcohol intoxication, which can be corrected via faecal microbiota transplantation.

Cynthia L. Hsu
Shikha Shukla
Bernd Schnabl
Research08 Jan 2026
Nature Microbiology

Volume: 11, P: 415-428
Generalist foundation models from a multimodal dataset for 3D computed tomography

The CT-RATE dataset pairs 3D chest computed tomography volumes with radiology reports to train a foundation model for medical imaging.

Ibrahim Ethem Hamamci
Sezgin Er
Bjoern Menze
Research12 Feb 2026
Nature Biomedical Engineering

P: 1-19
Sorsby's fundus dystrophy is genetically linked to chromosome 22q13–qter

Bernhard H.F. Weber
Gudrun Vogt
Cecil C. Ewing
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 158-161
Highly efficient exciton-exciton annihilation in single conjugated polymer chains

This work finds that chromophores on conjugated polymer chains are very efficiently electronically coupled together. Fast exciton-exciton annihilation ensures that a single chain can only support one or two excitons after 100 ps.

Nicola J. Fairbairn
Olga Vodianova
Gordon J. Hedley
ResearchOpen Access06 Jan 2026
Nature Communications

Volume: 17, P: 1-7
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Formation of stable crystalline enzyme–substrate intermediates at sub-zero temperatures

Anthony L. Fink
Ahmed I. Ahmed
Research23 Sept 1976
Nature

Volume: 263, P: 294-297
AN ELECTRICAL HYPOTHESIS OF CENTRAL INHIBITION

C. McC. BROOKS
J. C. ECCLES
Research07 Jun 1947
Nature

Volume: 159, P: 760-764
Isoprene chemistry under upper-tropospheric conditions

Experiments under upper-tropospheric conditions map the chemical formation of isoprene oxygenated organic molecules (important molecules for new particle formation) and reveal that relative radical ratios control their composition

Douglas M. Russell
Felix Kunkler
Joachim Curtius
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-14
A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation

A molecular glue induces CRBN homodimerization and degradation through degron mimicry, revealing a distinct glue mechanism and offering a tool to study CRBN biology.

Gerasimos Langousis
Pablo Gainza
Débora Bonenfant
ResearchOpen Access19 Nov 2025
Nature Communications

Volume: 16, P: 1-12
CNDP1 (CTG)₅ allele and cardiovascular events in high-risk patients: LURIC study results

Steffen A. Hettler
Angela Moissl
Marcus E. Kleber
ResearchOpen Access21 Apr 2026
Scientific Reports

Volume: 16, P: 1-8
Chamber-specific chromatin architecture guides functional interpretation of disease-associated Cis-regulatory elements in human cardiomyocytes

Here the authors functionally test and resolve the spatial genome organization of cis-regulatory elements and genetic variants in atrial, ventricular, and failing human cardiomyocytes and linked them to heart disease traits, including QT syndrome.

S. Haydar
R. Bednarz
R. Gilsbach
ResearchOpen Access12 Jan 2026
Nature Communications

Volume: 17, P: 1-21
Evaluation of CD4+ T Cells in HIV Patients Presenting with Malaria at the University of Ilorin Teaching Hospital Nigeria

Olajide Agbede
Temitope Ajiboye
Louis Odeigha
ResearchOpen Access13 Nov 2009
Nature Precedings

P: 1
Publisher Correction: Greater trophic diversity of soil animal communities under agricultural land use and tropical climate

Zheng Zhou
Nico Eisenhauer
Anton Potapov
Amendments and CorrectionsOpen Access01 Apr 2026
Nature Ecology & Evolution

Volume: 10, P: 823
Climatic changes, Norsemen and modern man

W. Dansgaard
S. J. Johnsen
C. U. Hammer
Research01 May 1975
Nature

Volume: 255, P: 24-28
Factors controlling the Interconversion of Enzyme–Substrate Compounds of Pig Heart Lactate Dehydrogenase

R. S. CRIDDLE
C. H. McMURRAY
H. GUTFREUND
Research14 Dec 1968
Nature

Volume: 220, P: 1091-1095
Reduction of Nitrate, Nitrite and Hydroxylamine to Ammonia by Enzymes Extracted from Higher Plants

R. H. HAGEMAN
C. F. CRESSWELL
E. J. HEWITT
Research20 Jan 1962
Nature

Volume: 193, P: 247-250
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

Reza Asadollahi
Aisha Ahmad
Noa Lipstein
ResearchOpen Access22 Oct 2025
Nature Genetics

Volume: 57, P: 2691-2704

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