Search

Gene functional shifts can rewire molecular networks beyond expression changes. Here, authors present scDNS, which quantifies network divergence to infer gene perturbations and projects them to single cells, enabling sensitive detection of hidden regulation and heterogeneous responder states.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Rare cells in single-cell and spatial omics are often hidden within dominant populations. Here, the authors introduce RareQ, a small-world-inspired graph method that uses neighborhood cliquishness (Q) to detect rare cell types and reveal fine-grained spatial structures.

The family of oxiranes encompasses a variety of compounds with extensive applications across different fields. Herein, the authors report the photochemical syntheses of a range of highly functionalized strained oxiranes.

Neural mechanisms underlying social behavior are not fully understood. Here authors show two lateral septum neuron types in male mice that bidirectionally regulate social memory via distinct hippocampal-hypothalamic circuits.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

Han et al. report a highly conductive composite electrode with low equivalent sheet resistance of 1.5 Ω sq-1. A self-masking method is developed to prevent shunting caused by uneven grid surfaces, enabling flexible organic solar cells with efficiencies of 15.20% (4 cm² devices) and 14.24% (16 cm² devices).

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Spatial principles of regulatory elements in primate cortex are poorly understood. Here, authors show a chromatin accessibility atlas identifying primate-specific cis-elements associated with psychiatric disease risks in specific cell types.

Elevated exposure to 4-hydroxyphenanthrene (4-OHPhe) is positively associated with obesity risk. Here, the authors show that exposure to 4-OHPhe downregulates expression of hydroxylamine reductase genes in Bacteroides uniformis, leading to altered gut microbiota-bile acid-FXR axis and suppression of adipose thermogenesis.

This study reveals that coagulation pretreatment can unexpectedly worsen reverse osmosis membrane fouling by altering solution chemistry and microbial behaviour, challenging its role in long-term membrane performance in zero-liquid discharge systems.

High-performance battery materials often degrade during standard cleaning processes. Here, the authors identify why water washing causes structural collapse in sodium-based oxides and demonstrate that ethylene glycol can safely remove impurities while maintaining the material’s integrity.

Conventional rechargeable zinc-air batteries face slow kinetics and thermodynamic incompatibility. Here, the authors propose a dual-cathode zinc-ethylene glycol/air battery, enabling concurrent efficient electricity generation and electro-reforming of plastic wastes into high-value C2 chemicals.

Excessive inflammation contributes to mortality in sepsis. Here, the authors propose a protective function for DPEP2 in monocytes, with sepsis-induced repression of DPEP2 causing a metabolic shift toward inflammatory cytokine production, while LNP-mediated Dpep2 expression restoration shows therapeutic potential.

Mechanistic investigation of zearalenone-induced reproductive lipotoxicity identifies the ERα-CD36/TLR4 axis as a key mediator and therapeutic target.

Targeted sequencing of neurodegenerative disease genes and transcriptome-wide sequencing in postmortem brain and spinal cord samples from individuals with amyotrophic lateral sclerosis or frontotemporal dementia identify somatic mutations as likely drivers of disease pathology.

Standard of care CD19-targeting CAR-T therapy for Relapsed-Refractory Diffuse Large B Cell Lymphoma (r/r DLBCL) faces frequent resistance often driven by regulatory T cell (Treg) activation. This study identifies Timosaponin AIII (TAIII) as A2AR inhibitor for enhanced CAR-T activity while depleting CAR-Treg formation.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Adsorption of trace transition-metal cations endows common Ca/Mg-carbonates and phyllosilicates with catalytic activity for electrochemical CO2 reduction under planetary conditions, potentially promoting prebiotic chemistry and the origin of life.

Wu et al. identify circulating proteins associated with cardiovascular and neurological imaging traits and diseases, and validate GDF15 as a shared determinant of heart and brain pathologies in mice.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.

Qi Wu and colleagues report a field trial integrating fixed and mobile networks over a single optical carrier using amplitude phase layered modulation. Their approach simultaneously delivers 128 Gb/s digital data and high fidelity analog wireless signals up to 16384-QAM over 109 km, supporting advanced modulation formats and achieving record performance, highlighting a scalable path toward converged 6G ready fiber infrastructures.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

SDM based on multi-core fiber is a promising approach for capacity scaling in submarine cables. Yingyu Chen, Jinkai Zhou, and colleagues report the field validation of a deployed 7-core fiber submarine link, achieving 410.5 Tbit/s over 140 km with C + L band cladding-pumped MC-EDFAs.

Pulmonary fibrosis involves chronic inflammation and extracellular matrix remodeling but the contribution of neutrophils is unclear. Here the authors show that reverse-migrating neutrophils anchored in the lung extracellular matrix exacerbate fibrosis via ICAM1 and macrophage derived cathepsin C.

A pragmatic, cluster randomized trial in rural Guangdong, China, showed that 12-month implementation of a comprehensive antibiotic stewardship program involving physician training, point-of-care prompts, monthly peer review feedback and smartphone-based patient education substantially reduced antibiotic prescriptions for acute respiratory infections compared to control consultations.

NCR1 (nitrate concentration regulator 1) promotes root-to-shoot nitrate transport by regulating the transcription of nitrate transporter NRT2.3, thereby contributing to grain yield in maize.

The growth of the smallest aerosol particles is critical to their impacts on climate and air quality. Here, the concentration gradient of nanoparticles is shown to be an important microphysical mechanism for their rapid initial growth.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

Vitamin B2 metabolism is important for essential biological processes, such as protection against oxidative damage and facilitating the immune response. Here authors show that contrary to its protective role in other contexts, upregulated Vitamin B2 metabolism via flavin adenine dinucleotide synthase propels the growth of tumour cells in hepatocellular cancer, while suppressing the anti-tumour CD8⁺ T cell response.

The study develops a global, long-term rice dataset (GlobalRice500) and reveals that paddy rice widely cools the land surface, reducing global mean daytime land surface temperature by up to 0.27 °C. The findings highlight the biophysical role of rice in climate regulation.

The development of novel two-dimensional antiferromagnets is crucial for enhancing the performance of spintronic devices. Here, authors realize the synthesis of CrOCl monolayer films and nanosheets that exhibit excellent performance.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.