Search

CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

The study reveals that GPX4 protects against myocardial ischemia/reperfusion injury by maintaining mitochondrial quality control. By stabilizing BNIP3 through USP20, GPX4 enhances mitophagy and reduces cardiac damage.

Pulmonary microbiotacomponents in bronchiectasis patients receive repeated antibiotic exposures, whereas previous studies on the effects ofantibiotic treatment focused on typical pathogens rather than commensals. By integrating experimental evolution withsingle-cell resolution, the authors reveal a multifaceted strategy by which Neisseria subflava, a common airwaycommensal associated with bronchiectasis, exploits antibiotic selection to transition towards pathogenicity.

Flexible displays face challenges in power use, resolution, and durability. This work presents a flexible micro-LED display driven by HZO-based FeMFETs, achieving low power, high resolution, and strong mechanical reliability.

Tyrosine kinase inhibitors (TKIs) combined with immunotherapy have improved outcomes in advanced renal cell carcinoma (aRCC), yet resistance persists. This group presents single-cell transcriptomic profiling of aRCC patients treated with TKIs and immune checkpoint inhibitors, uncovering an immunosuppressive microenvironment linked to therapeutic resistance.

Mutations in the follicle-stimulating hormone receptor (FSHR) cause spontaneous ovarian hyperstimulation syndrome (OHSS). Here, the authors report that estrildid finches naturally carry an analogous pathogenic mutation found in patients but avoid the syndrome by lowering a related receptor’s activity. Blocking this receptor successfully treats OHSS in mice.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Spatial principles of regulatory elements in primate cortex are poorly understood. Here, authors show a chromatin accessibility atlas identifying primate-specific cis-elements associated with psychiatric disease risks in specific cell types.

Using thermodynamically favourable organic oxidations instead of oxygen evolution enables energy-efficient cathodic reactions, but rates are limited by slow anodic kinetics. Here, the authors report decoupled charge‒discharge electrolysis using a solid redox reservoir to overcome this limitation.

Thrombolytic therapy with tPA risks hemorrhagic transformation (HT). Here, the authors show that tPA upregulates CD177⁺ neutrophils to promote HT, a fibrin-targeted, ROS-responsive polymersome is developed to deliver tPA and inhibit CD177⁺ neutrophils, enabling safe thrombolysis while preventing HT

SLCO4C1 is known for regulating kidney diseases. This study showed SLCO4C1 regulates hepatic cAMP uptake to suppress lipogenesis in MASLD. Targeting this pathway by FGF21 or forskolin suppressed lipogenesis.

Current single-cell models face data sparsity and interpretability limits. The authors introduce CellVQ to improve generalizability with a cell-state discretisation module, and CellVQ-Graph to integrate genes, interactions, and annotations into a knowledge graph for interpretability.

Narrowband deep-blue organic light-emitting diodes combining high colour purity, efficiency and stability are realized by using multiresonance thermally activated delayed fluorescence emitters with a highly twisted helical structure.

Global links between plant diversity and productivity via reduced herbivore and pathogen damage remain unclear. This meta-analysis shows that conserving diverse plant communities can potentially lower biotic losses and boost productivity.

A hallmark of the interaction between flat band and dispersive band states in quantum materials is the flat band resonance. Here, the authors report the observation of a flat band resonance in the kagome bilayer material CsCr₆Sb₆ originating from the doublet kagome bands of the bilayer unit.

Perovskite–organic-based solar cells typically show poor reverse-bias stability. By modulating the deep trap state in the bulk-heterojunction region, organic and perovskite–organic tandem solar cells show largely improved stability under reverse biases up to –40 V.

Converting light alkanes into useful olefins is hard because strong bonds and heat drive overoxidation. This study uses a copper-doped titanium dioxide photocatalyst to steer bond breaking, yielding ethylene and hydrogen.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Biomass-derived hard carbon negative electrodes can cut cost, but properties vary by feedstock. Here, authors use data-driven intelligent carbonization to unify performance across diverse biomass, yielding high-capacity, long-life negative electrodes with lower footprints.

Solid-state molecular motion is an important feature of a number of compounds, but visualization of these dynamics is challenging. Here, the authors report a molecular diffusion method for visualization and regulation of solid state molecular motion, and application in purity testing.

While previous studies of Kondo physics have largely focused on electronic properties, the authors here investigate magnon damping in the d-electron van der Waals magnet Fe₃GeTe₂. They observe logarithmic scaling of the damping at low temperatures and a minimum at an intermediate temperature, which they attribute to Kondo coupling between itinerant electrons and local moments.

The study introduces polyethyleneimine as an additive in a thermocell, enhancing thermopower from 1.4 to 7.76 mV/K. It achieves long-term stability and scalability by enabling thermosensitive adsorption-desorption, selective reactions, and Manning condensation, converting low-grade heat to electricity efficiently.

Frameworks of β-branched aromatic D-amino acids are crucial for the efficacy of pharmaceuticals, but the synthesis of such scaffolds remained undeveloped. Here, authors present the first asymmetric synthesis of β-branched aromatic D-amino acid analogues via the transaminase BsDAAT catalyzed dynamic kinetic resolution (DKR) process.

Axially chiral arylpyrroles hold significant promise in catalysis, medicinal chemistry and materials science. Here, the authors report a copper-catalyzed dynamic kinetic asymmetric (4 + 1) cyclization enabling atroposelective synthesis of arylpyrroles with single stereogenic axes or 1,2-diaxes from 1,3- enynes and amines.

Solid-state lithium-sulfur batteries face practical challenges such as low utilization and cycle life. Here, authors introduce design strategies that enable practical operation, leading to the demonstration of a high loading Li₂S-anode free pouch cell that operates under “low stack pressure” of 10 MPa.

You, Hu et al. discover a population of COTL1^high NK cells regulated by GITRL⁺ macrophages and demonstrate their functional importance in mediating anti-tumour immunity in cancer with impaired tumour-specific MHC-I expression.

The human LRP8 protein is a receptor for yellow fever viruses (YFVs). Knockdown of the mosquito orthologue reduces YFV infection in mosquitoes, whereas overexpression of human LRP8 aggravates YFV infection in mice. Purified LRP8 protein blocks YFV infection.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Researchers identify FOXJ3 variants in focal epilepsy and cortical dysplasia and show that FOXJ3 regulates neuronal migration and cortical layer formation by controlling the PTEN–mTOR pathway; disruption of this process leads to abnormal brain development.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Lithium dendrites are a major barrier to the use of high-energy lithium metal batteries. Now, a highly adhesive polymer electrolyte is designed to suppress lithium dendrites by confining lithium in a continuous nucleation state through strong interfacial binding interactions.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

The study identifies a single dominant, broad-spectrum powdery mildew resistance gene from cultivated emmer wheat, nominates a likely NLR candidate, and validates co-segregating markers to enable marker-assisted breeding in elite cultivars.

It was shown that early-day stem cell infusions reduced the severity of acute graft-versus-host disease (aGVHD). Our result suggested early morning cord blood transplantation reduces aGVHD severity and correlated with circadian sCD26 fluctuations.

In the presence of a sufficient magnetic field, magnetofluids can resist high-speed blood flow, offering a personalized and complete strategy for left atrial appendage occlusion.