Search

Du, Miao et al identify that the spatiotemporal recruitment and activation of Rab5 during early endosome formation are collectively determined by Rabex5/hRME6 recruitment and PI(4,5)P2 depletion during uncoated endocytic carrier formation.

Metabolic reprogramming toward glycolysis is a hallmark of pathological cardiac hypertrophy, but the regulatory mechanisms remain unclear. Here the authors show that the adipokine, asprosin, drives hypertrophic metabolic remodeling by stabilizing PFKP and activating a YY1–asprosin–PFKP–PDK4–PDH axis.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Meiotic sex chromosome inactivation is essential for spermatogenesis, but how transcription is silenced after initiation remains unclear. Here, authors show that nucleolar components NPM1, SENP3 and rRNA form a phase-separated compartment that excludes RNA polymerase II to enforce XY chromosome silencing.

The rapid rise of artificial intelligence pushes the need for more efficient computing. Here, authors propose an electrically reconfigurable, all-optical logic processing unit based on the combination of Kerr nonlinearities and high-entropy MXene surface terminations. They achieve an accuracy of 97.7% for digit recognition on the MNIST dataset.

Low efficiency and immunotoxicity limit rAAVs clinical use. Here, the authors show that encapsulating rapamycin in PF127 micelles modulates cellular biomechanics, enhancing AAV-mediated gene transfer while reducing immunogenicity demonstrating application in osteoimmunological disorders.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Researchers develop a biomimetic covalent organic framework that uses multi-scale electric fields to direct charges to single-atom cobalt sites, achieving efficient solar hydrogen production without noble metals.

Microplastic-oil co-contaminants are environmentally concerning, though conventional membranes are typically designed for single pollutant removals. Here the authors design a membrane using a sodium periodate-assisted co-deposition of caffeic acid and ε-polylysine method for the removal of complex mixtures from water.

Magnetic tunnel junctions face challenges in emulating neuromorphic devices within a single film stack platform. Chen et al. fabricate spintronics-based artificial synapses and spiking neurons and implement a convolutional spiking neural network, showing 96% accuracy in a gesture recognition task.

The authors identify Npr1 as a nucleophagy receptor in fission yeast that acts redundantly with Epr1 to degrade nuclear components. Tethering chromatin to the inner nuclear membrane blocks nucleophagy, suggesting a genome protection mechanism.

Fe3GaTe2 is a room temperature van der Waals ferromagnet, which, despite having a centrosymmetric crystal structure, has both a large Dzyaloshinskii-Moriya interaction and hosts topological spin textures. Here, Xia, Luo, Malik and coauthors unravel this mystery, showing the critical role of field cooling in the breaking of inversion symmetry in Fe3GaTe2.

The PD-1/PD-L1 pathway is central to immunotherapy, but PD-L1 recycling limits durable responses. This study identifies TM9SF2 as a key regulator of PD-L1 trafficking and shows that disrupting its PGK1-dependent complex depletes PD-L1 and enhances antitumor immunity.

Hormone receptor-positive, HER2-negative advanced breast cancer lacks defined treatment options following CDK4/6 inhibitor (CDK4/6i) failure. Here, the authors present a phase Ib clinical trial where the CDK4/6i dalpiciclib is combined with the histone deacetylase inhibitor chidamide in this setting.

Conversion-type batteries face performance decay under high loading due to shuttle effects and sluggish kinetics. Here, authors introduce an f-d orbital tag-team catalysis mechanism using cerium single-atom catalysts, achieving a competitive iodine loading of 44.7 mg cm⁻² and an areal capacity of 10.2 mAh cm⁻² in zinc–iodine batteries.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

The design of metal-free carbon catalysts is limited by unclear active sites and defects. Here, the authors combine statistical analysis with theoretical calculations to identify effective sites, guiding the synthesis of nitrogen and fluorine co-doped carbons for efficient hydrogen peroxide production.

Phosphorus locked in carbonate rocks from seven global sites shows simultaneous marine phosphorus spikes during major mass extinctions. Modelling ties high marine phosphorus to eutrophication, CO2 drawdown, and global cooling.

Pyomelanin is resistant to UV light, and has antibacterial and anti-inflammatory effects, however, the yield of pyomelanin isolated from natural producers is low. Here the authors engineer Komagataella phaffii to produce 70.5 g/L and isolate the product.

Using pear as a study system, the biosynthetic pathway of acetophenones has been elucidated: naturally impaired side-chain shortening of aromatic 3-ketoacyl-CoAs leads them to undergo hydrolysis, followed by decarboxylation, to yield acetophenones.

The MFS-type tripartite efflux pump EmrAB-TolC mediates resistance to multiple antimicrobial drugs. Here the authors report the high-resolution structure of the EmrAB TolC pump, along with functional data that support a model for one-step drug transport across the entire envelope of Gram-negative bacteria.

Genome evolutionary history of wild Arachis species remains unclear. Here, the authors report the origin of small chromosome A08 and genome evolution of Arachis species via comparative oligopainting and genomic analysis of A. hoehnei.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Electrocatalytic oxidation of fatty alcohols in aqueous media is limited by mass transport due to their low solubility. Here, the authors propose ligand engineering to create hydrophobic microenvironments in Nickel MOFs, enabling efficient oxidation to fatty acids by enriching reactants.

Atomic radius differences between the constituent elements of nano-alloys can lead to excessive lattice distortions or even phase separation. This work reports a plasma-assisted carbothermal flash sintering strategy for the synthesis of sub-5 nm high-entropy alloy nanoparticles accommodating large- and small-size atoms.

Ischemic stroke involves complex peripheral and central pathologies. Here, authors develop a spatially tiered strategy using dual stiffness nanoparticles for compartment-specific drug delivery, offering a synergistic treatment paradigm.

Du and colleagues present SMART, a scalable and computationally efficient framework for integrating spatial multi-omics data to identify tissue domains. The approach shows applicability to large and multi-section spatial profiling datasets.

Authors show that mapping waterbird activity entropy has the potential for identifying hotspots of avian influenza risk. The framework reveals substantial surveillance gaps, particularly across sub-Saharan Africa.

Zheng et al. show that extending the guide RNA restores the reduced activity of a high-fidelity CRISPR–Cas9 enzyme while preserving accuracy, revealing how strengthened PAM-distal interactions can improve genome-editing performance.

This study shows that ROS1 mediates DNA demethylation mainly via an occupancy-based passive mechanism, challenging the traditional active model, and reveals that ROS1 occupancy marks and regulates accessible chromatin, highlighting its diverse roles.

Xiang, Wang, Tian et al. report that during nutrient insufficiency, inflammatory cytokines promote a ZBTB5-mediated mechanism to activate mTORC1 signalling, thereby enhancing amino acid uptake in tumour cells and restricting antitumour immune response.

Xie et al. identify a distinct subset of CD4⁺ helper T cells expressing EOMES and granzyme K in both mice and human models of colitis.

Two-dimensional (2D) metal halide perovskites exhibit efficient photoinduced emission at room temperature, but control over charge carrier transport remains limited. Here formamidinium-based layered 2D perovskites are developed with high predicted symmetry. The absence of octahedral distortion results in an exciton diffusion length of 2.5 µm.

Bilayer CrTe₂ films grown via molecular beam epitaxy are found to host room-temperature multiferroicity and strong magnetoelectric coupling.

Tunnel oxide passivating contact silicon solar cells are a promising next-generation photovoltaic technology. Yang et al. engineer the front and back contact, further increasing the power conversion efficiency to 26.66%.

Antarctic sea ice declined sharply between 2015 and 2017, and this study uses ocean observations and atmospheric data to determine contributing factors. The authors show that thinning of Winter Water in the previous decade, followed by strong winds, brought warm deep water into contact with sea ice.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Machine learning upscaling analyses of global FLUXNET carbon and water flux measurements indicate that dryland vegetation productivity showed a negligible increase between 1982–2000 and 2001–2022, whereas humid-region vegetation productivity exhibited a nearly constant increase.

Supplementation with BSH-enriched Lactobacillus paragasseri LPG-9 remodels the bile acid profile in intrahepatic cholestasis of pregnancy, activating placental TGR5 to inhibit TLR4-NF-κB signaling and promoting hepatic bile acid excretion via BSEP.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Post-translational redox modification of protein cysteine residues has emerged as a mode of immune cell regulation. Now, a deep redox proteomics study identifies redox-regulated and druggable cysteines in immunological proteins.

cf-EpiTracing enables automated profiling of histone modifications in cell-free DNA from human plasma, allowing identification of the cells of origin and disease diagnosis.