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Functional-group translocation allows modification of molecular architectures and functional group positions, but methodologies capable of achieving precise stereocontrol during such migrations are limited. Here, the authors present a photoenzymatic strategy for cyano translocation that achieves precise stereocontrol.

All-in-one computing, which merges sensing, linear computing, and nonlinear activation, is a critical goal for next-generation AI hardware. Here, Zhang et al. introduce a high-speed, reconfigurable split-floating-gate memory, enabling multi-function integration within a unified platform and hardware native neuromorphic processing.

Pancreatic ductal adenocarcinoma (PDAC) shows immunotherapy resistance and has limited treatment options. Here the authors show that arachidonic acid, a ω-6 polyunsaturated fatty acid, can induce pyroptosis and enhace anti-PD-1 therapy in an immunocompetent PDAC model.

Elite and viremic controllers of HIV can spontaneously regulate viral replication, but some lose this ability over time. In this longitudinal cohort study, 31% of viremic and 3% of elite HIV controllers lost viral control over 17 years. Specific T-cell– related proteins distinguish controller types and predict loss years in advance.

Spin transport properties of magnetically ordered materials have been well studied. Here, the authors report an anomalous spin signal exhibiting spin transport over 480 microns in the frustrated hyperkagome magnetic insulator Gd₃Ga₅O₁₂.

Achieving efficient violet, yellow, and red emission in a single robust, scalable host is challenging. The authors achieve this by constructing Gd³⁺-mediated cluster traps in alkaline-earth fluorochlorides to reduce energy loss during electron migration.

In this work, Wu et al. develop and present PolyCLOVER, a framework that integrates multi-stage learning, active learning, and high-throughput experimentation to iteratively discover potent, low-toxicity polymeric antibiotics without relying on external labelled data.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

Indoles are privileged structural motifs in N-heterocyclic chemistry, while developing a general and facile platform capable of directly transforming commodity chemicals into multi-functionalized indoles persists as a challenge. Herein, the authors present a photo-driven bifunctional iron-catalyzed strategy integrating photocatalysis and Lewis acid catalysis for one-pot synthesis of indoles from readily available arylamines and alkanes/carboxylic acids.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

van der Waals (vdW) dielectric materials with a wide bandgap and high dielectric constant are necessary for the development of 2D electronics. Here, the authors report the synthesis of quasi-vdW layered Sm₂O₂SO₄ thin crystals, showing a bandgap of ~5.54 eV and a dielectric constant ~18, leading to high performance 2D MoS₂ transistors.

Paclitaxel is a prominent cancer therapy drug with poor synthetic efficiency due to the low activity and selectivity of the hydrolases involved. Here the authors develop a TteUPO oxidase toolbox for taxane oxidation, offering an unconventional route towards paclitaxel and paclitaxel analogues.

Negative regulator of thermotolerance 1 (NAT1) is identified as a negative regulator of thermotolerance in rice through the NAT1–bHLH110–CER1/CER1L module. Modifying NAT1 by targeted gene editing increases wax deposition and enhances thermotolerance in rice.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

A Dirac-vortex topological photonic crystal fiber is experimentally realized with broadband single polarization single-mode properties.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

Effective therapies remain limited for patients with high-risk recurrence after hepatocellular carcinoma (HCC) resection. Here, the authors report a clinical trial investigating the adjuvant combination of the anti-PD-L1 antibody benmelstobart plus the multi-targeted tyrosine kinase inhibitor anlotinib, in patients with high-risk recurrence after resection of HCC.

The authors develop textile electronic substrates with tailored stiffness and interfacial affinities by selective and controllable laser-matter interaction, addressing the mechanical mismatch between hybrid electronics and elastic textiles.

Direct enantioselective α-C(sp³)–H functionalization of Lewis-basic N-alkyl anilines has remained a significant challenge in synthetic chemistry. Now it has been shown that a metallaphotoredox-catalysed radical approach, with a sterically hindered aryl ketone photocatalyst, enables site-selective, enantioselective (hetero)arylation with exceptional functional group tolerance.

Circadian rhythms shape epidermal stem cell fate by regulating rhythmic gene expression in human EPSCs. ZFP42 maintains stemness by sustaining CRY1 expression, promoting proliferation and restraining differentiation to preserve epidermal homeostasis.

A virus-mimicking micelle selectively delivers drugs to diseased chondrocytes in osteoarthritis, significantly alleviating disease progression in mouse and sheep models.

Here, in a large-scale clinical trial, the authors associate gut microbiota composition and metabolic status with effectiveness of dietary fiber intervention in prediabetes, and provide a clinically applicable model to guide microbiome-targeted personalized medicine.

The authors found esterified pectin localized at the stiff poles of maize stomata, modulating stomatal opening. These results reveal novel targets for stomatal engineering and breeding crops with higher water use efficiency.

Li and colleagues describe a monocyte-specific transcriptional state along with a persistent elevation of inflammatory markers specifically found in individuals with long COVID who had mild-to-moderate disease during acute SARS-CoV-2 infection.

Here they show that gasdermin-E (GSDME) acts as a key driver of abdominal aortic aneurysm (AAA) by triggering senescence in vascular smooth muscle cells, a process reversible with senolytic drugs, highlighting a promising therapeutic target of AAA.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Follow-up telephone interviews are crucial but labour intensive in large-scale clinical trials. Here, the authors show that a specialized large language model automates this process, outperforming both existing AI systems and human experts in accuracy and efficiency.

Synovitis is a key early driver of osteoarthritis (OA), and RANKL contributes to cartilage degradation in OA. Here the authors show that denosumab, an anti-RNKL antibody, reduces synovitis and delays OA progression in animal models and patients.

A new AM titanium alloy design tailors the metastability-strengthening synergy and achieves high yield strength with enhanced work hardening and ductility by leveraging a complete, sequential martensitic transformation pathway.

Pla2g7 is a secreted enzyme mainly produced by myeloid cells and exerts a significant role in a spectrum of metabolic and inflammatory disorders. Here they show that Pla2g7 expression is enriched in osteoclasts and is associated with bone resorption, revealing an important role in bone homeostasis.

Semi-metallic single crystals of antimony can be deposited using molecular beam epitaxy on molybdenum disulfide to create ohmic contacts with resistance of under 100 Ω µm at a contact length of 18 nm.

Electrocatalytic CO₂-to-acetate remains challenging for metal catalysts due to the linear scaling relationship. Here, the authors report a deposition-etching strategy to modulate sp²/sp³ carbon hybridization in diamond, regulating adsorption equilibrium of key intermediates for acetate formation.

Earlier thawing of permafrost in northern high latitudes is reshaping the timing of spring growth and energy balance of Arctic ecosystems. This study suggests that advancing thaw increasingly stimulates land surface greening through enhanced water availability, earlier vegetation activity, and reduced albedo.

Noise-induced hearing loss is commonly attributed to direct damage to sensory hair cells. Here, the authors reveal that non-sensory supporting cells play a critical role in the damage through Gasdermin D-mediated exacerbation of hair cell oxidative stress.

Thermomechanical pressing and immediate quenching of electro spun nanofibers produces transparent, poling-free piezoelectric films with nearly doubled piezoelectric output and significantly improved mechanical strength.

This work presents EqGPT, a knowledge-guided generative framework that leverages documented PDE structures to autonomously generate, evaluate, and optimize candidate equations for recovering and uncovering complex PDEs.