Search

The design of metal-free carbon catalysts is limited by unclear active sites and defects. Here, the authors combine statistical analysis with theoretical calculations to identify effective sites, guiding the synthesis of nitrogen and fluorine co-doped carbons for efficient hydrogen peroxide production.

High entropy spinel oxides host multiple metals in one crystal structure with tunable catalytic properties, but controlling coordination site occupancy of metal cations is difficult. Here, the authors exploit site preference energy differences to direct metal occupancy, boosting conductivity and oxygen evolution activity.

Understanding interfaces at sub-nanometer scales is vital for complex chemical reactions. Here, the authors advance Pattern-enhanced Resonant Soft X-ray Scattering, enabling efficient operando probing of chemical and structural dynamics at solid-liquid interfaces.

Hydrogen fuel cell electric vehicles are poised to transform the automotive industry, but the lack of safe, high density solid state hydrogen storage solutions is stifling progress. Here, the authors develop a graphene oxide/magnesium nanocomposite which appears to overcome many of the existing challenges.

Water splitting using earth-abundant materials promises a low cost solution to the problem of large scale energy storage. Here, the authors fabricate a haematite and silicon-based high-efficiency water splitting device, which operates without the need for an externally applied bias.

The conversion of carbon dioxide to higher-value chemicals is an industrially important reaction. Here, the authors report a hybrid catalyst manganese oxide nanoparticle supported on mesoporous cobalt oxide, which catalyses the conversion of carbon dioxide to methanol at high yields.

Non-obstructive azoospermia (NOA) is a major cause of male infertility. Here, the authors provide insight into the genetic basis of NOA by identifying three new genetic risk loci in a genome-wide association study and reporting a fourth potential NOA susceptibility locus based on a Drosophilaknockdown experiment.

This paper proposes a knowledge-guided self-learning mixed platoon control strategy for the coexistence of autonomous and traditional vehicles. The framework provides a generalizable and scalable solution for the development and adoption of connected autonomous vehicle systems.

Current lithium-ion batteries still rely heavily on nickel (Ni), whose growing demand raises serious economic and environmental concerns. This work now presents a cathode that delivers longer cycle life than high-Ni chemistry while substantially reducing Ni use.

Han et.al. report the isolation and characterization of two neutralizing antibodies, C34 and C37, from a convalescent CHIKV patient. These antibodies demonstrate in vitro and in vivo efficacy against Chikungunya virus by targeting an epitope on the E2 protein and blocking the Mxra8 receptor.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Modulation of random heteropolymers results in globular polymer clusters with catalytic activity mimicking proteins.

The mechanisms underlying the invasiveness and aggressiveness of pituitary neuroendocrine tumours (PitNETs) remain poorly understood. Here, the authors perform single-cell RNA sequencing and spatial transcriptomics to characterise the tumour microenvironment of PitNETs and identify potential therapeutic targets.

Here the authors report the synthesis of defect-rich boron nitride by flux reconstruction method, which exhibited good reactivity for semihydrogenation of low concentration acetylene in ethylene-abundant gas stream.

Understanding the intricate relationship between alloying elements and oxidation processes is essential for the integrity and performance of materials. Here, the authors study the effects of atomic size and redox potential to understand the oxidation process and structural changes in surface oxides.

The gut symbiont Bacteroides fragilis secretes an antimicrobial ubiquitin homologue (BfUbb) that drives intraspecies bacterial competition. Here, the authors identify a highly conserved TonB-dependent transporter SusCD in B. fragilis as the BfUbb transporter and show species-specific antagonism of BfUbb and the BfUbb bound SusCD complex structure, revealing potential therapeutic applications of BfUbb against enterotoxigenic B. fragilis-related diseases.

Here, the authors examine the human anterior cruciate femoral and tibial entheses and identify two thin-graduated mineralization regions with distinct biomolecular compositions and mineral assembly patterns to adapt to their respective mechanical functions.

Proteome profiling of plasma samples in human pan-cancer cohorts reveals patterns of biomarkers for diagnosis.

Layered double hydroxides (LDH) are ideal for charge storage, however, the sluggish reaction dynamics are obstacle to their development. Here, triggered by mismatching integration of Mn sites, the authors configure wrinkled Mn/NiCo-LDH with strains and defects, where promoted mass & charge transport behaviors are realized.

The Bacteroides fragilis ubiquitin homologue, BfUbb, mediates intraspecies competition and provides a competitive advantage for encoding strains in the gut.

Here the authors show that the growth plate (GP)-epiphysis interface possesses a strong modulus transition and acts as a mineralization inhibition zone, while the GP-metaphysis interface has a gradual transition and stimulates bone formation. They also identify proteins at these boundaries which inhibit or promote bone mineralization.

This study shows that global warming has led to both earlier and later snowmelt floods in different regions over the past 70 years, challenging the prevailing idea that warming always advances floods and highlighting the complex nature of snowmelt flood timing shifts.

New influenza neuramidase inhibitors may increase preparedness against influenza outbreaks. Vavricka et al.confirm the catalytic mechanism of neuramidase and show that it can be inhibited irreversibly with covalent inhibitors.

New study shows forests with ectomycorrhizal strategies accumulate more carbon stocks than forests dominated by arbuscular mycorrhizal or mixed mycorrhizal strategies in high-latitude.

Macrophage inflammation promotes insulin resistance during diet-induced obesity. Here the authors show that macrophage NOC4L is decreased in humans and mice with obesity, that macrophage NOC4L deficiency aggravated high-fat diet induced inflammation and insulin resistance, and that NOC4L interacts with toll-like receptor 4, to inhibit endocytosis, and thus blocks TLF4/TRIF inflammatory signaling.

Hepatic insulin resistance plays a central role in metabolic syndrome. Here, the authors show that transcription factor BACH1 acts as a negative regulator of insulin signaling and that hepatic BACH1 deficiency ameliorates hyperglycemia and insulin resistance in high-fat diet-fed or diabetic mice

Herpesvirus glycoprotein D binds to nectin 1 and the herpes virus entry mediator protein on the surface of host cells. In this study, Zhanget al. report the crystal structure of glycoprotein D in complex with the immunoglobulin-like domains of nectin 1, which suggests that binding of glycoprotein D to nectin 1 prevents nectin 1 dimerization.

The molecular-level mechanism by which manganese enhances cobalt catalysts for Fischer−Tropsch synthesis (FTS) of long-chain hydrocarbons from syngas is not well understood. Here, the authors demonstrate that manganese promotes long-chain hydrocarbon production in Co-based FTS catalysts by binding H at basic O sites on MnO, reducing chain termination on Co and thus promoting C₅₊ products.

All-solid-state sodium-ion batteries are promising candidates for grid-scale energy storage, but they require superior solid-state electrolytes (SSEs). Here sodium-ion SSEs based on dual-anion frameworks of oxychloride are studied and found to show high ionic conductivity and electrochemical oxidative stability with mechanical softness.

The intact structure of mammalian multi-enzymatic pyruvate dehydrogenase complex (PDHc) remains poorly understood. Through in-situ structural analysis, the authors unveil its intrinsic dynamics and propose a distinctive regulatory mechanism for PDHc.

Elemental immiscibility limits the development of solid solution materials. Here, authors create a nonequilibrium flame aerosol method to mix nearly any pair of metal elements in a single-phase nano-ceramic. Also, an exsolution behavior is presented to produce active and stable nanoparticles.

Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The consequent impairment of insulin signaling can be rescued by pharmacological inhibition of P300.

Lithium-rich nickel manganese cobalt oxide cathodes are widely explored due to their high capacities related to their anionic redox chemistry. A compositional optimization pathway for these materials investigating the variation of using cobalt and nickel now provides valuable guidelines for future high-capacity cathode design.

H7N9 influenza A viruses capable of infecting humans have recently emerged in China. Here, the authors show that these viruses remain genetically diverse, suggesting that they are still in the process of adapting to human hosts.

This meta-analysis of genome-wide association studies identifies four genetic loci associated with circulating leptin levels independent of adiposity. Examination in mouse adipose tissue explants provides functional support for the leptin-associated loci.