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The GABA_B receptor is a mandatory heterodimer. Here authors show the existence of GABA_B dimers of dimers in neurons, and their relevance in human health. By solving the structure of this tetramer, they show the structural basis for a negative cooperativity between the dimers within such a complex.

Water-floating nanotransfer printing (WF-nTP) is proposed for transferring nanostructures onto three-dimensional substrates. Using WFnTP, an Au SERS nanomesh for pesticide detection on plants and a Pd-based hydrogen gas sensor are demonstrated.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

Mechanical computing is promising for environment-adaptive information processing, however existing methods have limited scalability. Here the authors report a polyaniline composite film enabling scalable logical operations.

Here, the authors show that the PLA2G6 protein is a component of the IP3R1–GRP75–VDAC1 complex at the mitochondria-associated endoplasmic reticulum (ER) membrane, maintaining the integrity and function of ER–mitochondria contacts.

Developing robust anode catalysts that can operate at industrial-level current densities is essential for efficient hydrogen production. Here, the authors report a mesoporous ruthenium–titanium oxide solid solution with an engineered three-phase reaction interface for stable water electrolysis.

Alternative splicing may help explain genetic risk for joint diseases. Here, the authors generate cartilage and synovium sQTL maps, revealing tissue‑specific splicing variants and pinpointing effector genes for osteoarthritis, rheumatoid arthritis, and height

Breaking down durable polyolefins into reusable building blocks remains difficult. A tailored liquid alloy catalyst converts real waste into light olefins with high yield and stability, even under solar-powered operation.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

Electrocatalytic oxidation of fatty alcohols in aqueous media is limited by mass transport due to their low solubility. Here, the authors propose ligand engineering to create hydrophobic microenvironments in Nickel MOFs, enabling efficient oxidation to fatty acids by enriching reactants.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

The authors reveal how two insect-selective animal peptide toxins engage distinct sites on an insect sodium channel to disrupt fast inactivation and leverage these structural insights to AI-design a more potent toxin for biopesticide development.

Pangenome analyses of 28 representative Gossypium hirsutum accessions, including a telomere-to-telomere genome for NDM13, and transcriptomic profiling across 15 tissues highlight structural variations associated with breeding traits.

Standard of care CD19-targeting CAR-T therapy for Relapsed-Refractory Diffuse Large B Cell Lymphoma (r/r DLBCL) faces frequent resistance often driven by regulatory T cell (Treg) activation. This study identifies Timosaponin AIII (TAIII) as A2AR inhibitor for enhanced CAR-T activity while depleting CAR-Treg formation.

The superconducting diode effect describes non-reciprocal transport of the superconducting current and there is focus on how to engineer and apply this property practically. Here, the authors utilise a heterostructure to implement a dual-mode superconducting diode effect, where dissipationless current flows along a single direction, that can be activated by both out-of-plane and in-plane magnetic field. The dual modes share similar diode efficiency but requires different magnitude of magnetic field to be operated.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Solution processing of 2D/3D perovskite structures for solar cells offers limited control over layer formation. Lee et al. propose a dry approach, bringing the 2D and 3D perovskite layers into physical contact, to enhance the quality of the perovskite film.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

The lack of effective reinforcement has hindered the widespread use of 3D-printed concrete. The authors developed an in-process embedding technology for simultaneously printing concrete and flexible fiber-reinforced polymer (FRP) grids.

Protein homeostasis is essential for cell health and function, with the proteostasis network safeguarding protein production, folding and degradation. Disruption of any of the multiple pathways involved is a hallmark of aging and many pathologies. We asked experts studying proteostasis to share with us which unresolved questions they are most interested in addressing and how they envision the field in the future.

Efficiency loss in thick film organic solar cells is a bottleneck for scalable manufacturing. Here, the authors present an exciton spin-manipulation strategy to extend exciton diffusion length and reduce non-radiative recombination losses.

In vivo base editing of a causative mutation that leads to the neurodevelopmental disorder Snijders Blok–Campeau syndrome restores protein dosage and ameliorates molecular and behavioural deficits in a humanized mouse model of the condition.

Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoural visceral adipose tissue and colorectal tumour microenvironment and report an immune escape mechanism, which may be potentially targeted for improved immunotherapy.

The molecular mechanisms of lipid regulation of membrane proteins remain unclear. Here, authors combine solid-state NMR, biochemistry experiments, and molecular dynamics simulations to elucidate how lipids distinctly regulate membrane protein structure and function in lipid bilayers.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

A mechanism is uncovered that results in fetal hepatocytes having a paracrine role in providing genome protection to haematopoietic stem and progenitor cells.

The performance of 2D photodetectors in the near-infrared range is usually constrained by fundamental limits. Here, the authors report hybrid photodetectors based on 2D MoS₂/WSe₂ heterostructures integrated with plasmonic metasurfaces, exploiting anapole states to enhance the responsivity and improve their chiral discrimination ratio in the telecommunication range.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

The role of protein UFMylation in cancer remains to be understood. Here, the authors show that UFM1-specific ligase 1 and AKT positively regulate each other through UFMylation and phosphorylation, facilitating lipid synthesis and breast tumor growth.

Altermagnets are characterized by fully compensated magnetic moments yet break time-reversal symmetry, leading to symmetry-enforced momentum dependent spin splitting. While demonstrations of almagnetism have typically proceeded via spectroscopic probes like ARPES, here Mali, Zhao and coauthors show that nonlinear transport can serve as a sensitive probe to screen for altermagnetic candidates, using Ca₃Ru₂O₇ as a case study.

Urbanization often leaves cities with fewer iconic species, and not just of animals. This study focusing on urban trees finds that urban trees have homogenized over large geographic differences but diversified over short ones.

This study presents MAOSS, a multimodal AI model that repurposes non-contrast CT scans and leverages clinical features to detect and stage liver steatosis and fibrosis. Here the authors show MAOSS accurately stratifies cirrhosis progression risk when embedded into the standard clinical workflow, enabling scalable, opportunistic screening for early intervention of steatotic liver disease.