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Spin-crossover complexes are promising candidates for molecular bits owing to their magnetic bistability but engineering high-density bits is challenging due to cooperative switching dynamics. Here the authors modulate the cooperative dynamics of surface-confined spin-crossover complex chains.

Age-related inflammation is a key mediator of the pathogenesis of osteoarthritis (OA), but the mechanism is not fully understood. Here, the authors show that IL-36 agonists are systemic inflammatory factors released from aged skin to promote senescence in joint cells and aggravate OA progression.

How tree diversity effects on ecosystem functioning vary along climatic gradients is unclear. Here, analysing data from 15 experimental forest sites, the authors show that tree growth responses to neighbourhood species diversity are stronger in wetter climates but are unaffected by interannual climatic variation within sites.

Poly(vinylidene fluoride-co-trifluoroethylene)’s (PVDF-TrFE) piezoelectricity can be enhanced by annealing, however current annealing methods are slow. Here, the authors perform ultra-fast flash annealing of PVDF-TrFE to achieve a high piezoelectricity.

The rising incidence of young-onset sporadic colorectal cancer (yCRC) is global concern. Here, leveraging a substantial number of deep sequencing metagenomes, the authors show striking similarities in gut microbial patterns at both the taxonomic and selected gene marker levels between yCRC and old-onset CRC.

Characterizing the genetic architecture underlying egg production is important for chicken breeding. Here, the authors integrate RNA and whole-genome sequencing data to better understand the genetic regulation of egg production in chickens.

Drosophila has a single insulin/IGF receptor (dmIR) that responds to various s insulin-like peptides (DILP ligands). Here, authors determined the cryo-EM structures of dmIR bound with three different DILP ligands and revealed how distinct ligands fine-tune dmIR signaling.

A vapour post-treatment strategy enables fully printed carbon-electrode perovskite solar modules with an area of about 50 cm² and a certified power conversion efficiency of 19.26%. The modules show no performance decay after 1,000 h of continuous operation at 65 °C.

This study presents an analytic framework to link imaging-derived brain phenotypes to gene expression. In the future, this approach may facilitate in vivo pharmacotranscriptomics and the development of personalized (pharmacological) interventions.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Reversible structural surface relaxation under laser exposure is observed for monolayers of 2D metal halide perovskites. These structural changes also induce reversible shifts in the photoluminescence peaks of these materials.

This work demonstrates a monolithically integrated VCSEL with an embedded passive cavity, achieving an ultranarrow ~1 MHz linewidth and enabling high-stability chip-scale atomic clocks.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

The variability in clinical outcomes of SARS-CoV-2 infection is partly due to deficiencies in production or response to type I interferons (IFN). Here, the authors describe a FIP200-dependent lysosomal degradation pathway, independent of canonical autophagy and type I IFN, that restricts SARS-CoV-2 replication, offering insights into critical COVID-19 pneumonia mechanisms.

Nationwide implementation of a series of stringent multisectoral air pollution prevention and air-quality monitoring policies in China was associated with reduced hospital admissions for a wide range of cardiorespiratory, neuropsychiatric and kidney diseases due to substantial reductions in PM_2.5 and black carbon pollution over a period of 5 years.

For major events in China, such as the Olympic Games, air-pollution emission controls have been imposed in the host and neighboring cities to enhance the experience and reduce health risks. This study reveals the varying effectiveness of short-term emission controls between host and neighboring cities, showing weakening benefits over time as cities learned from past event-hosting experiences.

Ionizable lipids containing albumin-binding motifs are used in lipid-nanoparticle-based mRNA vaccines, facilitating lymph node enrichment and dendritic cell internalization to potentiate their efficacy and avoiding liver accumulation.

One of the major problems in Li–S batteries is the undesired shuttling of lithium polysulfides between electrodes. Here the authors present a metal–organic framework-based separator to mitigate the shuttle effect, leading to stable long cycles.

This study reports the horizontal gene transfer of CSP genes from bacteria to Triticeae, promoting the adaptation and spread of wheat through enhanced drought tolerance and photosynthetic efficiency.

The surface octahedral tilt in exfoliated 2D perovskites is directly visualized by STM and the degree of the tilt varies with the number of layers of inorganic slabs and result in different amounts of excitonic red shift in photoluminescence.

The authors find that highly ordered ferroelectric hybrid perovskite domains exhibit planar chirality that switches sign between adjacent domains, which manifest in a large dichroic ratio for circularly polarized second harmonic generation from the domain walls.

An appetite-regulating subnetwork in humans involving the lateral hypothalamus and the dorsolateral hippocampus is implicated in obesity and related eating disorders.

Extra-intestinal “creeping fat” is a hallmark of Crohn’s disease. Here, using single-cell transcriptomics and lipid metabolomics, the authors identify a subset of mesenchymal stem cells that promote adipogenesis in creeping fat formation.

At equilibrium, the ferroelectric polarization is proportional to the strain. At ultrafast timescales, an above-bandgap laser excitation decouples strain and polarization, which, out of equilibrium, is mainly determined by the photoexcited electrons.

Multilayers comprising alternating soft and hard layers offer enhanced toughness compared to all-hard structures. Here authors reveal how the hard and soft components in Ruddlesden–Popper perovskites work cooperatively to resist deformation under pressure, informing the design of alternating superlattices for engineering applications.

Treating osteoarthritis associated pain is challenging. Here, the authors on a hydrogel for extracellular RNA scavenging and releasing bevacizumab to block angiogenesis and neurogenesis at the osteochondral interface, mitigating pain and disease progression.

Cyclic dimeric adenosine monophosphate is found to be a second messenger in eukaryotic cells that is generated by adenylate cyclase 7 and connects Toll-like receptor 9 stimulation to nucleotide-binding domain, leucine-rich repeat protein 3 inflammasome activation.

Cyborg insects combine living insects with miniature electronic controllers, offering several advantages over conventional robots. Here, the authors propose an algorithm that can navigate a swarm of cyborgs from the start to a predetermined goal in an unknown sandy terrain in the presence of obstacles and hills.

Insulating molecular layers on the basal plane of 2D perovskite is a major bottleneck for charge injection that limiting device performance. Here, the authors show that plane-contacted graphene functions as a low barrier and gate-tunable contact to overcome this limitation.

The role of m⁶A in plants’ response to nutrient-deficiency stress remains unclear. Here, the authors report that Pi starvation-induced m⁶A modifications stabilize Pi starvation response (PSR)-related mRNAs, such as PHR1, to facilitate PSR signaling.

Here, the authors established and characterized the mouse gut microbial biobank (mGMB), which includes 244 strains and 126 species that enlarges previous mouse intestinal bacterial collections and represents a resource for studies using mouse models to investigate microbiome-associated health and disease.

Chiral state transfer typically requires nonadiabatic transitions and ultra-complex experimental control. Here, authors demonstrate a new mechanism arising from basins of attraction, enabling nonlinear chiral-like state transfer with a minimal set of parameters.

The mechanisms regulating Tat function for HIV-1 replication remain poorly understood. Here, the authors reveal that the transcriptional activity of Tat is modulated by a PRMT2-licensed switch between its nucleolar sequestration and phase separation into the nucleoplasmic Super Elongation Complex (SEC) droplets.

Confocal light-field microscopy allows volumetric voltage imaging in the mouse brain at speeds sufficiently high to extract the spiking activity of hundreds of neurons.

Fabricating high-performance cellulose fibres is desirable for the development of sustainable materials, but remains challenging. Here the authors report a draw spinning/de-acetylation method to fabricate cellulose fibres that exhibit mechanical strength exceeding that of existing fibre materials.