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Recovery of 48 bat and 9 horse HeV genomes from Australia (2016–2020) identified four Hendra virus clades, offering insights into evolutionary dynamics.

JWST phase-curve observations reveal that the two innermost TRAPPIST-1 planets emit thermal radiation consistent with bare rocky surfaces, indicating that both lack thick atmospheres.

The Akt-mTOR axis influences cell activation, differentiation and metabolism. Jordan and colleagues show that thymic and inducible T_H17 cells exhibit different requirements for mTORC1 and mTORC2 as well as Akt isoforms.

A new calculation for the anomalous magnetic moment of the muon using a hybrid approach combining experimental and lattice data in different energy ranges represents a validation of the standard model to 11 digits.

The authors resolve 63 structurally diverse haplotype structures for the 22q11.2 deletion syndrome region. Deletion risk differs depending on structure; individuals of African ancestry are enriched for inverted repeats that predispose to inversion.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

Reducing dissipation when generating spin currents remains a central challenge in spintronics. Now, an artificial ferrimagnet is shown to produce spin current output and simultaneously lower magnetic damping.

The long-term natural history of long-COVID is not well understood. In this population-based cohort study from Scotland, the authors describe symptom prevalence and health-related quality of life up to 18 months after a positive SARS-CoV-2 test and compare with matched test-negative controls.

Intensified and prolonged flash droughts reduce summer crop yields in the United States, mainly via soil moisture stress, according to a study that integrates multiple data sources and structural equation modeling.

This study identifies extensive lateral interdigitations in the kidney’s ascending thin limb and demonstrates that Claudin-10b regulates both epithelial architecture and urine-concentrating function in this distinct nephron segment.

Fatigue is a common side effect of treatment in prostate cancer. Here, the authors carried out a genome wide association study to find correlations between genetic loci and risk of fatigue.

ThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.

Global observations show that ecosystems sustain transpiration at temperatures above those that maximize photosynthesis. This thermal gap reveals that carbon uptake declines before water loss under climate warming.

This study shows that atmospheric desert dust keeps about twice as much infrared heat from escaping to space as climate models predict, highlighting that improving dust in models could sharpen weather forecasts and climate projections.

Th17 cells play critical immunological roles and are exposed to oxidative stress but how the mechanisms behind how they deal with this are not well established. Here the authors suggest a role for Xeroderma Pigmentosum Complementation Group C in the protection of Th17 cells from oxidative stress in a murine model.

This case study reports human immunodeficiency virus remission without antiretroviral treatment in an individual who received an allogeneic haematopoietic stem cell transplantation from a sibling donor with a homozygous CCR5Δ32 mutation.

Argon-42 is a background in experiments that search for dark matter or neutrinoless double-beta decay. Now, the isotope’s abundance is measured by combining a laser-based atom trapping technique with isotope pre-enrichment.

Mitoxantrone is an FDA-approved anticancer drug that also acts as a general inhibitor of group I intron self-splicing. Here the authors show that Mitoxantrone repartitions RNA conformational ensembles rather than simply binding RNA, stabilizing specific GC-rich structures. This reduces 5′ UTR heterogeneity and increases translation efficiency.

Cooperation is primarily associated with tolerant societies. By studying six macaque species, this study demonstrates how despotic societies can have higher, yet more partner-specific, cooperation driven by strong interdependencies between pairs of individuals.

Here, using data from the COPSAC2010 birth cohort, the authors show that early gut bacteria and having older siblings predict restoration of C-section-perturbed microbiome by age 1, linked to lower asthma risk, with findings replicated in an independent Canadian birth cohort (CHILD).

mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8⁺ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.

The study identifies novel genetic variants linked to core cerebrospinal fluid Alzheimer’s Disease biomarkers using a genome-wide analysis, showing how endophenotypes can identify genes and disease mechanisms not captured by case-control studies.

A sample of X-ray-weak active galactic nuclei at high redshift may be accreting above the Eddington limit. This could explain their large masses without the need for heavy supermassive black hole seeds at cosmic dawn.

Analyses of epidemiological, clinical and molecular data from a prospective cohort of 3,100 patients with esophageal carcinoma suggest intestinal metaplasia as a single precancer pathway preceding the disease.

Kim et al. revealed how taste receptor type 2 member 43, a bitter taste receptor that detects coffee-derived compounds, recognizes bitter tastants through cryo-electron microscopy structures of ligand-bound complexes, supported by biochemical and computational analyses, providing a structural framework for coffee bitter taste signaling.

Curiosity detected over 20 organic molecules in 3.5-billion-year-old Martian rocks using a wet chemistry experiment, showing complex carbon compounds can survive for billions of years and may preserve clues about Mars’ past habitability

The two species of African elephants are facing severe declines. Here, authors assess their continent-wide genomic diversity, identifying differences in their evolutionary histories and highlighting the formative role of gene flow.

Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

Preclinical studies have evaluated murine double minue 2 (MDM2) inhibitors as a treatment for adenoid cystic carcinoma (ACC). Here the authors present a phase I clinical trial reporting tolerability and efficacy preliminary data for the MDM2 inhibitor alrizomadlin (APG-115) in patients with TP53 wild type salivary gland cancers, especially adenoid cystic carcinoma.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Microbially derived 10-oxostearic acid (10-oxoSA) interacts with PPARα in the colon to alleviate gut inflammation in acute and chronic mice models.

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.

Repurposing existing drugs for vascular dementia (VaD) could have clinical impact. Here, using Mendelian randomization, researchers tested whether cholesterol, anti-inflammatory or blood pressure drug targets affect risk of VaD, finding little evidence to support repurposing opportunities. A potential benefit was seen for beta-blocker target ADRB1 while ACE inhibition was observed to potentially increase risk of VaD.

Multi-ancestry and ancestry-stratified genome-wide analyses identify genetic variants associated with refractive error and enable construction of an enhanced polygenic predictor incorporating functional annotations.

Long-term effects of in utero Chikungunya exposure are not well characterized, although intrapartum exposure is known to be associated with neonatal mortality. Here, the authors assess risk of all-cause hospitalization and mortality up to three years following in-utero exposure in a cohort from Brazil.

Huot et al. investigate the differences in natural killer (NK) cells in lymph nodes during pathogenic and nonpathogenic simian immunodeficiency virus (SIV) infection of cynomolgus macaques and African green monkeys (AGMs), respectively. Their findings suggest that NK cells are specifically recruited to follicles in AGMs and regulate SIV replication in the lymph node.

By projecting the multimoded, spatiotemporally structured signal photon onto a single spatial mode to herald the arrival of the idler photon, a diffraction-free single-photon space-time wave packet in the idler that did not traverse the spectral modulator is remotely prepared.

Escherichia coli is widespread in healthy breastfed infants, yet its ecological role is unclear. Here, the authors provide insights into the mechanisms supporting its persistence and co-existence with dominant Bifidobacterium, including potential cross-feeding of human milk oligosaccharides.

Here, the authors leverage stable isotope and peptide analyses to show that some 18th century Māori individuals ate largely plant-based diets. This work aligns with Māori oral history and archaeological evidence, which points to sweet potato and taro cultivation as important for population growth and cultural change at the time.