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Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

The design of metal-free carbon catalysts is limited by unclear active sites and defects. Here, the authors combine statistical analysis with theoretical calculations to identify effective sites, guiding the synthesis of nitrogen and fluorine co-doped carbons for efficient hydrogen peroxide production.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

This study reveals an sRNA-centered signaling pathway that activates nitrate respiration and enhances Cronobacter sakazakii virulence in oxygen-limited host environments, offering important insights into therapeutic strategies.

Ordered antihedgehog polar lattices are engineered in antiferroelectric PbZrO₃ thin films via interfacial dislocation networks. The authors reveal that these ordered topological structures originate from mismatch.

Single-atom catalysts promise efficient reactions, but readily aggregate at high temperatures, limiting durability. Confining single metal atoms in liquid metal stabilizes them, enabling long-lasting ethane dehydrogenation at high temperature.

Immune imprinting narrows the vaccine recall response towards dominant epitopes but protection against rapidly evolving viruses is enhanced if the breadth of responses is preserved. Here authors show in a ferret model that introducing optimized antigenic variation between prime and boost vaccines diversify the targeted epitopes and thus broadens immunity in a ferret model of influenza vaccination.

Elucidation of fundamental pancreatic-targeted mechanisms enables the development of lipid nanoparticles for the precise delivery of nucleic acid therapeutics to the pancreas, highlighting their promising potential in the treatment of pancreatic diseases.

Halide solid electrolytes typically require high lithium content, raising costs and exacerbating air sensitivity. Here, authors leverage anion clusters to synthesize an amorphous electrolyte with low lithium content of 2.4 wt%, high ionic conductivity of 1.5 mS cm^-1, and good air-stability.

Guo et al. report a surface-energy homogenization strategy to fabricate InP-based quantum dots with strong electron confinement, enabling green LEDs with efficiency of 23.50% and retaining a peak efficiency over 20% even at a resolution up to 8,460 PPI for active-matrix displays.

The flow of water between rivers and floodplains—surface water connectivity—showed a net global increase from 1984 to 2019 driven by climate and anthropogenic changes and shaping sediment transport, according to a study of satellite observations.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

An in situ computational spectrometer, implemented on a fully integrated 576-Kb memristor chip, can reconstruct a single spectrum in 125.0 ns and consumes only 6.7 nJ of energy, achieving software-equivalent accuracy.

The susceptibility of mouse and human T cells to ferroptosis is determined by the balance of systemic polyunsaturated and monounsaturated fatty acids, highlighting a key role for lipid metabolism and dietary composition in regulating T cell function.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Mechanical response of semiconducting polymers affects their electrical properties, yet the detail remains elusive. Zhong et al. examine the multiscale structural evolution of conjugated polymer thin films during uniaxial deformation and link it to mechanical resilience and solar cell performance.

Brain metastases are a common complication of advanced non-small cell lung cancer (NSCLC) and affect responses to immune checkpoint inhibitors (ICI). Here the authors perform single cell transcriptomics on samples from NSCLC and brain metastases and implicate transcriptomic signatures associated with responsiveness to ICI.

Droplet microlasers are emerging as powerful tools for label-free biosensing. Here, the authors demonstrate a new method for creating liquid photonic-molecule microlasers that combine low lasing threshold and enhanced sensitivity, achieving biomolecular detection limit down to attoMolar level.

Surface plasmon-mediated steady-state and on-demand electronic spin modulation effectively activates light-driven plasmonic catalysis, facilitating polarization reactant activation and preferential reaction pathway modulation.

The Efimov effect is a quantum phenomenon in which three particles form an infinite series of low-energy bound states at resonance, previously observed in three-dimensional systems. The authors extend this celebrated effect to long-range quantum spin systems, demonstrating long-range spin chains can also host Efimov states with widely tunable scaling ratios controlled by the interaction range.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

ASXL1 is often mutated in myeloid cancers. Here, the authors describe the molecular and structural mechanism by which ASXL1 associates with the transcriptional coactivator BRD4, helping to explain their high correlation in cancers.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Dang et al. integrate GWAS with functional genomics to analyze 15 common autoimmune diseases, mapping interconnections and differences in target genes, association signals, and the immune cell types in which signals act. They show cell-type-specific signals within loci, prioritize associated genes, and identify shared and distinct functional modules, clarifying regulatory mechanisms.

2D polymer materials are often limited in performance by insufficient in-plane conjugation and poor charge transport. Guided by theoretical calculations, the authors present diketopyrrolopyrrole-based crystalline 2D poly(arylene vinylene)s with narrow optical band gaps of 1 eV and high charge carrier mobility.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Cavity-adaptive crystals have useful phototunable properties, but can be challenging to prepare. Here, the authors report the development of such cocrystals by use of a non-macrocyclic host, with elasticity and lasing action.

Activating type I interferon (IFN-I) is beneficial for tumor therapy but how IFN-I is activated in nasopharyngeal carcinoma (NPC) remains unclear. The authors here show that targeting CD38 in NPC cells can inhibit MAVS degradation, promote IFN-I production and improve tumor prognosis via enhanced CD8 T cell response.

An integrated photonics scheme is presented for the manufacture of communication systems supporting the use of fibre and wireless infrastructures simultaneously, addressing the long-standing bandwidth mismatch between the two domains and demonstrating ultrahigh data rates.

To overcome the transverse wrinkles and voids between MXene nanosheets, the authors fabricated MXene fibers via a combination of static filling and dynamic thermal drawing, achieving optimized mechanical and electrical performance.