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A wearable capacitive temperature sensor that is based on exceptional-point-enhanced phase sensing can measure temperatures from 36 °C to 55.5 °C—a perturbation from 0% to 3.95%—with a maximum normalized sensitivity of 400, an estimated dynamic range of 53.52 dB and an estimated signal-to-noise ratio of 63.8 dB.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

CrPS₄, a 2D van der Waals A-type antiferromagnet, is shown to exhibit ideal characteristics of Stoner–Wohlfarth antiferromagnets, such as ferromagnet-like binary switching rather than layer-by-layer flipping as in other 2D A-type antiferromagnets.

A strategy compatible with a broad range of materials by precisely manipulating optofluidic interactions within a confined 3D space to control the assembly of colloidal microparticles/nanoparticles is demonstrated, enabling the precise manufacture of complex microstructures/nanostructures.

Badkul et al. develop eMOSAIC, a method that improves drug discovery by accurately predicting the interaction mechanics of various compounds with multiple proteins.

Direct observation of the Migdal effect in neutron–nucleus collisions is reported, which resolves a long-standing gap in experimental validation.

Interactions between dark matter and neutrinos would leave observable imprints on cosmic structures. Combining cosmic microwave background and weak lensing data shows a nearly three-sigma preference for such interactions.

Tropical cyclones cool the ocean surface less than previously thought, indicating that current projections may underestimate their future intensity and frequency, according to an analysis of global sea surface drifters data over 1992–2021.

Efferocytosis inhibition leads to the release of immunogenic contents into the tumor microenvironment. Here the authors developed a nanosystem that inhibits MerTK-mediated efferocytosis and captures tumor-associated agents to enhance antitumour immunity.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Metasurface design driven by AI faces challenges, such as extrapolation to unexplored performance regimes. MetaAI, a physics-aware current-diffusion framework, is introduced to advance metamaterial discovery from interpolation to extrapolation.

Pyoverdine is secreted by the opportunistic pathogen Pseudomonas aeruginosa to scavenge iron from its hosts. Here, the authors show that under stress conditions P. aeruginosa uses a ‘conditional privatization’ strategy, reserving pyoverdine intracellularly to protect against oxidative damage.

This study identifies a primary oseltamivir-resistance mutation in influenza hemagglutinin, which arises independently and enhances resistance when combined with a known neuraminidase mutation, underscoring the need for broader antiviral surveillance beyond neuraminidase.

Deep learning (DL)-based automated treatment planning has the potential to improve radiotherapy planning for patients in cancer but how best to implement them in the clinic is less clear. Here, the authors propose a hybrid strategy to develop a DL-based automated radiotherapy planning solution and demonstrate its real-world effectiveness in producing clinically deliverable plans.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Deep learning generative models hold significant promise for exploring the configuration space of crystalline materials. Here, the authors present CrystalFlow, a flow-based generative model for crystal structure prediction and materials discovery.

Environmental Li pollution and health problems have been becoming an important concern worldwide. Here, the authors show that Li exposure causes trophoblast cell ferroptosis and thus induces unexplained miscarriage through a non-canonical MBOAT1 pathway.

Single-atom catalysts represent a promising materials class for efficient catalytic transformations. Here, authors prepare a high surface distribution density of iridium atoms on nickel-iron sulfide nanosheet arrays to deliver high water oxidation activity and stability.

The Nernst effect of transverse thermoelectric flow is usually small in less ordered systems with low charge mobility. Here, the authors show that conjugated polymers defy this expectation with Nernst effects orders of magnitude larger than predicted.

China’s crowded coasts must balance seafood demand with conserving migratory shorebirds that rely on tidal flats along the East Asian–Australasian Flyway. This study suggests that well-managed mariculture feeds shorebirds and limits overharvest, benefiting seafood production and biodiversity.

Using Floquet engineering, an ensemble of ytterbium-171 ions in an yttrium orthovanadate host crystal provides a platform for studying the dynamics of different quantum many-body models, including the realization of a time-crystalline phase.

Wafer-scale 3R-MoS₂ with high phase purity is achieved through a homoepitaxy strategy, which demonstrates ferroelectricity and holds promise for multifunctional integration.

Existing cell type deconvolution methods, crucial for studying tumour environments, overlook some critical issues. Here, authors analyse how these issues impact on deconvolution and develop methods to counter them, significantly enhancing cell type percentage prediction accuracy of mixtures.

This study elucidates nanoscopic strain evolution in single-crystal Ni-rich positive electrodes, demonstrating that mechanical failure results from lattice distortions, and redefines the roles of cobalt and manganese in battery cycling stability.

The role of interspecific interactions in biodiversity–ecosystem stability relationships is unclear. Here the authors develop a theoretical approach and show that empirical diversity–stability relationships in grasslands are best explained by species-specific dynamics rather than by interspecific interactions.

Rare-earth elements find a broad range of applications due to their unique magnetic, catalytic, and phosphorescent properties, but their efficient extraction poses challenges. Using Dysprosium as a representative example, this study introduces a framework incorporating tailored magnetic separation, revealing enhanced extraction kinetics through solutomagnetic convection with potential environmental implications.

The limit of X-ray detection is an important figure of merit for X-ray detectors, yet the suitability of method adopted from Currie’s 1968 paper and the following international standard is in doubt. Here, the authors propose a statistical model that correlates dark current and photo-current, show how it can be used to determine detection limit.

Parity-time (PT) symmetric systems with balanced gain and loss can exhibit nonreciprocal transmission, but its high insertion loss in the broken phase poses a challenge. This work demonstrates electrically tunable nonreciprocal transmission in PT-symmetric silicon micromechanical resonators operating in the exact phase, achieving non-reciprocity with low insertion loss.

SCUBA-D is a denoising diffusion probabilistic model that can perform a variety of protein backbone design tasks, including generation of backbones from random noise, from user-sketched designs, and backbones to scaffold predefined motifs that can bind small molecules or other proteins.

While photoelectrochemical water splitting produces fuel from solar energy, a large fraction of photoanode photoexcited charge carriers cannot be extracted efficiently at low bias voltages. Here, authors improve the charge transport in P-doped BiVO₄ by mediating polaron hopping and trap states.

Frequent recalibration poses a challenge to the reliability of cuffless blood pressure monitoring devices. Here, the authors introduce a conformal and stretchable piezoelectric microsystem combined with a demographic-adaptive model, enabling calibration-free, continuous BP tracking.

Surface/interface engineering promotes the development of electromagnetic wave absorbers. Here, the authors present a unique three-dimensional multilayered gradient core-shell structured MAX phase ceramic and report its absorption mechanism.

The authors propose a targeted doping strategy that enables copper atoms to occupy specific positions within the material’s crystal structure, avoiding the unwanted defects typically introduced by conventional methods.

The association between metabolism rewiring and the tumour microenvironment has been shown to be relevant for cancer progression. Here, the authors show that the lipid metabolism-related enzyme ECI2 reduces ether-lipid generation leading to decreased neutrophil recruitment and neutrophil extracellular traps formation for colorectal cancer suppression.

Positive relationships between biodiversity and temporal stability through species asynchrony are well-documented, but the underlying mechanisms remain debated. Here, the authors show that statistical averaging is the main mechanism of plant diversity effects on community stability.

Dynamic topological phenomena remain challenging to be probed experimentally. Here, Wang et al. theoretically characterize and experimentally detect dynamical skyrmions in parity‐time‐symmetric non‐unitary quench dynamics in single‐photon discrete‐time quantum walks.

470-fold super compression of atmospheric data has been achieved through Aeolus, a two-stage deep-learning-based variational autoencoder framework.

Observing the photonic analogue of an unpaired Dirac point is hard, as it requires breaking the time-reversal symmetry. Here, the authors use gyromagnetic materials to do that, and thus succeed in observing an unpaired Dirac point in a planar photonic crystal operating at microwave frequencies.

A recurrent ECSIT mutation in individuals with extranodal natural killer/T cell lymphoma induces NFκB in cancer cells, leading to macrophage activation, and associates with progression to fatal hemophagocytic syndrome. NFκB-targeting therapy produced stable remission in two patients.

This paper analyzes global trends in “socioeconomic farm size.” It shows that the average size rose 14% (2000-2020) and may triple by 2100, underscoring the urgent need for tailored policies to balance sustainability, equity, and food security.

High-throughput computational screening of multicomponent molecular photocatalytic systems offers a strategy to minimize the screening of large numbers of photosensitizer–catalyst combinations. Here a machine learning-accelerated approach using multiple descriptors shows strong predictive power in experimentally validated systems for CO₂ reduction.

Existing 3D Spatial Transcriptomics reconstruction approaches often overlook spatial information or experiment-induced distortions. Here, authors propose ST-GEARS to bridge the gap between in vivo cell locations and in vitro analysis, accurately recovering spatial profiles.

GNSS data and AI were used to track slow slip events (SSEs) evolution in Cascadia subduction zone. A 2021 event occurred during a “braking” phase of declining moment rates, triggering secondary slip accelerations and rupture expansions.

Wu et al. report the sequential crystallization in quasi-2D tin-based perovskites, achieved by preferential formation of low-dimensional templates and delayed 3D growth, yielding vertically oriented and low-defect films for field-effect transistors with high mobility, negligible hysteresis, and improved stability.