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Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

The scaffold protein AXIN can promote the formation of two opposing complexes: the Wnt signalosome and a degradation complex that inhibits Wnt. Here, the authors show that mechanical compression and the presence/absence of Wnt ligand are inputs in a circuit that acts as a logic gate to control which complex is formed.

Researchers report a spontaneous method that produces chlorine directly from chloride-containing brines by harnessing their inherent osmotic energy and chloride ions, without any external energy input.

Spin transport properties of magnetically ordered materials have been well studied. Here, the authors report an anomalous spin signal exhibiting spin transport over 480 microns in the frustrated hyperkagome magnetic insulator Gd₃Ga₅O₁₂.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

The inter-system crossing induced by selenium may undesirably enhance formation of triplet excitons in non-fullerene acceptors, leading to increased non-radiative losses. Here, the authors introduce achiral N-alkyl substituents, achieving maximum efficiency of 20.4% for ternary organic solar cells.

This work demonstrates superadiabatic topological pumping on photonic chips, achieving a 20-fold device miniaturization and high-efficiency operation across a 650–920 nm bandwidth, paving the way for ultracompact integrated photonic transports.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

Light-dependent phosphorylation can modulate rice blast immunity. Here the authors show that the receptor-like kinase OsLIKE1 phosphorylates LHCB5 to confer blast resistance and identify SNPs that could potentially be used to breed resistant cultivars.

Distributed quantum sensing typically requires shared reference frames to coordinate measurements. Here, authors develop a reversed-encoding protocol that circumvents this requirement, enabling Heisenberg-limited precision in quantum networks without frame alignment.

Cryosection pathology is essential for intraoperative diagnosis of diffuse midline gliomas (DMGs), but often requires re-sampling for an accurate assessment. Here, the authors develop CryoAID, an AI-augmented framework for rapid and accurate molecular outcome prediction during surgery for DMG, reducing re-biopsy rates in clinical cohorts.

Here, with multi-omics analyses of human cohorts and murine models, the authors identify Odoribacter splanchnicus depletion to impair intestinal P-glycoprotein function via loss of microbial, GDP-L-fucose, which in turn promotes eIF4E phosphorylation and c-Jun–driven ABCB1 expression, maintaining xenobiotic efflux.

Arctic sea ice loss is reshaping the ocean’s carbon pump. Satellite data show an early boost, then stagnation, while models warn of future weakening under ice-free conditions, threatening carbon storage and ecosystems.

Iron‒sulfur nanozymes catalyse the production of an indole derivative, 2-indolecarboxylic acid, in Lactobacillus vaginalis, leading to a synergistic antibacterial activity that protects mice and weaned pigs against Salmonella Typhimurium infection.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondria-enriched extracellular vesicles, which offer high-quality, abundant mitochondrial material for transplantation.

Increasing evidence suggests that activation of oncogenic pathways contributes to an unfavorable tumor microenvironment. Here, the authors show that wild-type KRAS plays a key role in immune evasion in hepatocellular carcinoma by impairing interferon-mediated immunity and promoting resistance to immunotherapy via the EGFR/MEK/ERK pathway.

Transition metal dichalcogenide nanotubes possess symmetry-breaking properties promising for fundamental physics research. Here, the authors report a direct synthesis of crystalline MoS₂ nanotubes exhibiting strong polarization and bulk photovoltaic effects.

Confocal Airy beam integrated with single-photon oblique light-sheet tomography (CAB-OLST) is a high-throughput imaging approach for brain-wide mapping of neurons, as demonstrated in cleared mouse brains.

Ovarian endometriomas, with distinct microenvironment and heightened hormonal sensitivity, are recognized as precursors of ovarian carcinomas. This study decodes ovarian endometriomas by integrating single-cell and spatial transcriptomics with spatial metabolomics to reveal key markers and altered pathways, offering new avenues for diagnosis and therapy.

The mitochondrial membranes present a formidable barrier to the delivery of exogenous genes. Here, the authors report on the development of fluorinated lipid nanoparticles to efficiently introduce therapeutic genes into mitochondria, for the correction of mitochondrial genomic defects.

PCBP2 is elevated in AD and forms condensates that sequester mitochondrial proteins and RBPs, disrupting mitochondrial function and the NMD of BACE1 mRNA, alongside amyloid deposition. The small molecule, CN-0928 mitigates AD pathology by inhibiting PCBP2 condensation.

To overcome the transverse wrinkles and voids between MXene nanosheets, the authors fabricated MXene fibers via a combination of static filling and dynamic thermal drawing, achieving optimized mechanical and electrical performance.

The authors realize a two-dimensional hybrid perovskite with robust multiaxial ferroelectricity and nonlinear optical response via molecular fluorination and lone pair expression of Ge²⁺, enabling prominent piezoelectric sensing in composite device

Most optical tools for cortex-wide imaging are focused on either neuronal physiology or hemodynamics. Here, the authors present a cortex-wide multimodal imaging approach that facilitates simultaneous observation of neural activity and hemodynamics in awake mice.

Whether and how gamma entrainment using sensory stimuli (GENUS) has a role in antiepileptogenesis is not fully understood. Here authors show that GENUS reduces seizure susceptibility in male mice. These effects are mediated via specific visual neural pathway.

Phenotypic screening of an endophyte-derived compound library led to identification of a potent anti-non-small cell lung cancer (NSCLC) lead compound, the 3,4-diisobutyryl derivative of auxarthrol A, uncovering dynein light intermediate chain 1 as a druggable vulnerability and a key regulator of autophagy in NSCLC.

Uncontrolled crystallization of perovskite limits the performance of solar cells. Zhou et al. address this through aromatic interactions between naphthalene ammonium salts and naphthalenesulfonates, achieving improved efficiency in cells and modules.

Significant efforts are needed to leap from the identification of trait-associated genetic variants to the revealing of the causal gene. Here, the authors translate genomic variants into gene-level functional haplotypes for GWAS and identify a gene encoding ferulic acid 5-hydroxylase 1 is responsible for superior cotton fiber quality.

The role of TGFβ in cancer is paradoxical and context-dependent. Here, the authors discover that a preserved, DLD-mediated metabolic suppression by TGFβ undermines anti-TGFβ therapy, promoting gastric cancer growth.

CRISPR-Cas9-based screens have allowed the study of gene-drug interactions. Here, the authors develop CRISPR-Cas9 knock-out, activation and repression screens in human gastric 3D organoids, also integrating single-cell CRISPR screens, to identify genes involved in the response to cisplatin in gastric cancer.

Visualizing mechanical stress distribution in soft and live biomaterials is key to understand biological processes and improve material design. Here, the authors design a biosensor to visualize the stress distribution in soft biomaterials and living tissues.

Constructing two-dimensional (2D) polymers with complex tessellation patterns is important for the fabrication of advanced materials but achieving such complexity is a great challenge. Here the authors report a tessellated 2D covalent organic framework with increased structural complexity as well as different pore structures.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Mechanical force is critical for the development and remodeling of bones. Here the authors report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine via regulating the expression of the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 in osteoblasts.