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This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Abdominal aortic aneurysm (AAA) is a life-threatening condition, but its underlying mechanisms are unclear. Here, the authors show that PDK4 contributes to abdominal aortic aneurysm by promoting metabolic reprogramming in vascular smooth muscle cells, leading to activation of NLRP3.

Oocyte-specific isoforms play crucial roles in oocyte maturation. This study utilizes single-cell full-length isoform sequencing to unveil the diversity of RNA isoforms, as well as TE co-option for novel isoform generation and isoform stability during human and mouse oocyte maturation.

Organic solar cells need acceptor molecules with long exciton diffusion lengths, but most available materials fail in thick films. The authors design new fluorinated quinoxaline acceptors that significantly improve carrier mobilities resulting in superior efficiency in both binary and ternary devices.

Hua et al. report a rigid molecule to partially replace oleylamine ligands and vertically anchors on the CsPbI3 nanoplatelets, suppressing electron-phonon coupling. The rigid-ligand pinning strategy enables pure-red LEDs with a linewidth of 24 nm, efficiency of 29.8%, and operational lifetime of 128.2 h.

CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

The work presents a method for injection molding that uses controlled shrinkage to create customizable shapes. By manipulating temperature and pressure, it enables the production of complex geometries from a single mold, potentially offering scalable and cost-efficient mass customization.

Chern ferromagnetism is established in twisted bilayer MoTe₂ devices at large twist angles. Here, the authors observe evidence of antiferromagnetic ground states with zero Hall resistance at an intermediate twist angle around three degrees, demonstrating the sensitivity of the magnetic ground state.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

A single-breath-hold 3D abdominal MRI technique (SSE-CEST) enables label-free mapping of glucose, glycogen and mobile protein in human liver, offering motion-robust, high-resolution imaging for cancer detection and metabolic monitoring.

Using artificial intelligence, authors model how air pollution may increase susceptibility to SARS-CoV-2. NPC1 is identified via genetic and laboratory analyses as a key pathway that enhances viral entry after exposure to fine particulate matter.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

The GABA_B receptor is a mandatory heterodimer. Here authors show the existence of GABA_B dimers of dimers in neurons, and their relevance in human health. By solving the structure of this tetramer, they show the structural basis for a negative cooperativity between the dimers within such a complex.

He et al. report that the host-derived macrophages/monocytes enhanced malaria transmission by reducing the abundance of transmission-blocking microbiota in mosquito midgut via SRA-mediated phagocytosis. In addition, the depletion of macrophages/monocytes or the use anti-SR-A neutralizing antibodies significantly enhances the transmission-blocking efficacy of anti-Pfs25 monoclonal antibodies.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

Sunlight triggers ammonium chloride in aerosols to produce Cl₂ gas, explaining 12-55% of daytime levels. This chlorine source, boosted by black carbon, impacts atmospheric oxidation.

The genomewide meta-analysis of lumbar spinal stenosis LSS identifies 73 previously unreported loci in addition to 15 known loci and highlights spinal degeneration as a key pathogenic mechanism. Overall, the findings expand knowledge of the genetic background of LSS.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

The MoSi₂N₄ family is an emerging class of van der Waals materials with interesting properties. Here, the authors report a systematic characterization of point defects in monolayer WSi₂N₄ and MoSi₂N₄, showing their influence on the electronic properties of the materials.

Electrochemical nitrate reduction rivals Haber-Bosch ammonia synthesis rates but suffers from poor energy efficiency. Here, the authors show that underpotential deposited hydrogen can be unlocked to accelerate nitrate conversion, offering an pathway to energy-efficient ammonia production.

A MoSe₂ piezocatalyst with lattice strain upcycles wastewater pollutants into value-added chemicals, offering an environmental and energy solution by accelerating carbon reduction and lowering reaction energy barriers.

Neural mechanisms underlying energy metabolism are not fully understood. Here authors show that Phf6-expressing neurons in the medial preoptic area as key regulators of physical activity and energy expenditure, revealing a neural mechanism underlying obesity in Börjeson-Forssman-Lehmann syndrome.

Piezotronics are promising for mechano-sensation but limited in direct-current electronics. The authors propose the capacitive piezotronics, giving a new approach for mechanically controlled devices in high-frequency alternating-current systems.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of premature infants with unclear mechanisms. Here, the authors show that CD177⁺ neutrophil–platelet aggregates promote neutrophil extracellular trap (NET)-linked thromboinflammation in NEC and that blocking CD177/NET formation or low-molecular-weight heparin alleviates disease in mouse models.

Magnetic tunnel junctions face challenges in emulating neuromorphic devices within a single film stack platform. Chen et al. fabricate spintronics-based artificial synapses and spiking neurons and implement a convolutional spiking neural network, showing 96% accuracy in a gesture recognition task.

The biological basis of afternoon nap remains unclear. Here, authors show that NPAS2 in mPFC TH-positive neurons activates POU2F2 to suppress TH level and dopamine production, thereby reducing wake-promoting neural activity and driving nap behavior.

Maintaining nanocatalysts under extreme heat is a major challenge due to structural disintegration. Pre-filling support vacancies creates a confinement field that anchors rhodium nanoparticles, preserving their integrity and activity during methane oxidation.

The weak contact between the oxide electrode and molecular layer in inverted perovskite solar cells is prone to deformation, limiting long-term device stability. A bulk nano-heterointerface is designed to strengthen the binding force between molecules and spherical silicon oxide nanoparticles, increasing the interfacial contact area and improving the operational stability of perovskite solar cells.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

This study identifies an autocrine role for hepatic FGF1, wherein its circadian rhythmicity synchronizes triglyceride secretion with activity. Disruption of this clock-regulated pathway impairs lipid homeostasis.

By engineering single residue of protein with a light-switchable molecule, this study reveals that local hydrophobicity propagates through hydrogen bond network to reshape protein structure and function, shifting the paradigm to structure–hydration– function.

Mixed-matrix membranes incorporating soluble macrocycle compounds represent a promising class of materials for gas separation but achieving high selectivity for helium extraction from natural gas remains challenging. Here the authors incorporate a cyclic Cyclen with specific intra-ring dimensions as a pore-structure modifier to enhance He/CH₄ selectivity.

Ji, He, Cai, and colleagues report an engineered senescence therapy that exploits lipid metabolic features of senescent cells, repurposing excess lipids as functional resources to improve joint function, and thus alleviating osteoarthritis without eliminating the cells.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

The function of metal-organic frameworks is governed by their synthesis precision. Here, the authors report a light-driven strategy enabling ambient-temperature synthesis for cobalt-porphyrin frameworks, overcoming traditional thermal constraints.

In this study, the authors identify a microcircuit containing three subgroups of neurons associated with sensory-induced escape in the mouse temporal association cortex (TeA): sensory, sensory-motor decision and motor command neurons.

In this study, the authors present two distinct neuronal subpopulations, sharing a speed encoding model, in the mouse dorsal periaqueductal grey, controlling running and backing away behaviors, respectively.

Traditional recycling of polyoxymethylene plastic often leads to significant material loss and toxic emissions. Here, the authors introduce an acidic electrochemical process that efficiently converts plastic waste into valuable chemicals with conversion efficiency approaching 90%.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Neutrophils are known to be important in COPD pathogenesis and calcium signaling is involved in this process. Here the authors examine the function of Na⁺Ca²⁺ exchanger 1 (NCX1) in neutrophil function in mouse models of chronic cigarette smoke exposure and show that inhibition of NCX1 reduces neutrophil accumulation in the lungs and formation of neutrophil extracellular traps (NETs).

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal cancer with poor prognosis and limited treatment options. This study identifies Prolyl 3- hydroxylase 1 (P3H1) as a critical regulator of PDAC progression through PLK1-β-catenin signaling, driving tumor-associated macrophage recruitment and tumor growth.

Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the equator and declined towards higher latitudes, partly linked to temperature, legumes, mycorrhizal associations and canopy nursing effect.

Determining the optimal start of the growing season presents a fundamental dilemma for plants. This meta-analysis suggests that plants exhibit high freezing resistance (to -12 °C) and low lethal frost risk (safety margin of 17 °C) during spring emergence, indicating strong long-term evolutionary pressure.

A retrospective analysis of a publicly funded NIPT programme in Hebei province, China, covering more than 1.18 million pregnancies, shows that first-tier NIPT achieved high coverage, reduced invasive testing by 97% and was more cost-effective than maternal serum screening, and the NIPT positive results were linked to higher risks of adverse pregnancy outcomes, suggesting potential early warning value.