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The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

MAU2’s role in Cornelia de Lange syndrome was unclear. Here, the authors identify pathogenic MAU2 variants that disrupt NIPBL–MAU2 function, define MAU2‑specific episignatures, and show variable CdLS‑related phenotypes, supported by a Mau2 knockout mouse model.

SWI/SNF complexes are mutated in 20% of cancers, yet the underlying mechanisms are poorly understood. Here, the authors identify a compensatory mechanism of chromatin regulation that becomes essential in cancers carrying mutations that broadly inactivate SWI/SNF.

Hu et al. report a low-temperature polar-solvent strategy for high-yield (162 mg mL⁻¹) perovskite nanocrystal synthesis with suppressed self-absorption. The scintillator films achieve ~7 ns fast decay, 28,800 photons MeV⁻¹ light yield, and dynamic X-ray imaging at 7,680 frame per second.

During olfactory navigation, Caenorhabditis elegans can execute error-correcting turns. Whole-brain imaging and perturbation experiments identify an ensemble of neurons that control reorientation and turning behaviors.

Natural genetic variation of photosynthesis is an underexplored resource for plant genetic improvement. Here, the authors find allelic variations of YS1 affect Arabidopsis photosynthesis acclimation using genome-wide association study, reverse genetics, and quantitative complementation approaches.

Raam, Li, Gu and colleagues identify neural mechanisms underlying group huddling in mice during cold exposure. They find that the prefrontal cortex encodes decisions to huddle and that silencing neural activity in some animals causes partners to compensate in response.

Appel et al. found that deceptive networks reached over 37 million Facebook and 3 million Instagram users during the 2020 US elections, with the majority of this exposure driven by 3 networks and amplified by ordinary users resharing the content.

Emerging multidrug-resistant Neisseria gonorrhoeae is a global health threat in the treatment of gonorrhoea. This study reports the discovery and characterization of a promising antigonorrhoea agent that addresses antibiotic resistance.

The authors report an anti-β-tryptase antibody as a potential therapeutic for asthma with a superior mechanism of action that inhibits both tetrameric and monomeric β-tryptase activity. Structural analysis reveals that the molecular path of allosteric inhibition is due to a single antibody residue.

Natural scenes sparsely activate V1 neurons. Here, the authors show that a small number of active cells reliably represent visual contents of a natural image across trials regardless of response variability, due to the diverse and partially overlapping representations of individual cells.

Photoionization time delays provide insights on the interaction of photon with the electrons. Here the authors explore the role of the molecular potential to the attosecond time delays in the photoionization of CF4 molecule.

Exploiting the differences between quantum and classical physics typically requires nonlinear devices. Quantum nonlinear effects have now been demonstrated in a nanomechanical resonator due to strong coupling with an intrinsic two-level defect.

SeeDB-Live is a tissue-clearing approach for live samples such as tissue slices or the in vivo brain. It improves image quality while having minimal effects on electrophysiological properties of neurons.

Neurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations are of task-relevant locations.

This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preserving ST2⁺ regulatory T cells in white adipose tissues.

A high-resolution spectroscopic analysis reveals ultralow amounts of heavy elements in the star SDSS J0715−7334. The star originates from the Large Magellanic Cloud and probably formed directly after the first stars through dust cooling.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Homarine is a ubiquitous, phytoplankton-derived metabolite that is broken down by widely distributed and diverse marine bacteria containing a conserved homABCDER operon.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

High-harmonic spectroscopy provides attosecond-scale information about optical processes in molecules. Present techniques, however, cannot simultaneously measure the phase as a function of molecular angle and photon frequency. An approach that retrieves both the amplitude and the phase of high-harmonic emission is now demonstrated, and could enable a full reconstruction of the molecular wavefunction.

He et al. identify a central regulator of condensate size and dynamics in the Chlamydomonas CO₂-fixing condensate, the pyrenoid. KEY1 phosphorylates EPYC1, a linker protein for Rubisco, to maintain pyrenoid size and number through the cell cycle.

Chica et al. combined genetic network mapping, time-resolved imaging and deep learning to generate a dataset called AutoDRY that describes multilayered control of autophagy and uncovers new regulatory pathways.

Neural mechanisms underlying high visual acuity are not fully understood. Here the authors show that high resolution visual information is transmitted from the retina to the brain by neurons in the parvocellular geniculate pathway in macaques, where signals are now shown to most often originate from single cone photoreceptors, establishing the neural mechanism that limits resolution acuity prior to cortical processing.

Ultrafast electron imaging shows full phase-space dynamics of optical singularities, which can reach superluminal velocities before annihilation and break the particle-like analogy of topological defects.

Dissociative ionization of H₂ molecules by the combination of a phase-locked attosecond laser pair and a few-cycle NIR laser shows that ion–photoelectron entanglement influences electronic coherence in H₂⁺, allowing control over the degree of entanglement by varying the delay between the pulses.

Cardiac rhythm depends on tightly regulated sodium channel gating. Here, the authors determine the structure of human Na_v1.5 in an intermediate open state and show how specific N-terminal interactions and ion binding near the IFM motif together regulate fast inactivation.

LIGO–Virgo–KAGRA’s fourth Gravitational-Wave Transient Catalog shows evidence of a clear pair-instability gap in the distribution of binary black-hole secondary masses but is absent in the larger primary masses.

Chimeric Antigen Receptor (CAR)-T cells with high affinity for their targeted epitopes efficiently kill malignant cells at the expense of excessive and potentially harmful immune activation, while lower-affinity targeting shows a safer profile but compromises tumour cell killing. Here the authors show that the combination of high- and low-affinity CARs results in a T-cell product with maintained functionality while reducing cytokine release and CAR-T-cell exhaustion in mouse models.

Using cryo-EM, the authors identified 42 MIPs, including outer junction protein CFAP77 and outer dense fibers, in native doublet microtubules of Tetrahymena thermophila. Knockout of CFAP77 reduced ciliary beat frequency and led to outer junction damage.

Microbially derived 10-oxostearic acid (10-oxoSA) interacts with PPARα in the colon to alleviate gut inflammation in acute and chronic mice models.

Single-variant and ultrarare variant burden analyses leveraging exome sequencing data from 22 cohorts identify new risk genes for amyotrophic lateral sclerosis and show cumulative effects of several rare variants on disease risk.

ROCKET improves experimental structure elucidation by integrating implicit structural knowledge from OpenFold, a trainable reimplementation of AlphaFold2, with X-ray crystallographic and cryo-electron microscopy experiments.

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

Endosomal Toll-like receptors (TLRs) are central to the innate immune response but their overactivation can cause systemic inflammation and disease. Now, new small molecules targeting the interaction between Munc13-4 and syntaxin 7 essential for endosomal maturation impair overactivation of endosomal TLR-dependent pathways and inflammation.

Here, the authors develop mRNA-based therapeutics encoding single-chain variable fragment antibodies that target the T3SS of Pseudomonas aeruginosa, which shows therapeutic potential in an immunocompromised mouse infection model.

Here authors show in a human stem cell–derived model, neural cultures from children with MPSIIIA exhibit hyperactive excitatory synapses associated with excitation–inhibition imbalance, altered network dynamics, and broad dysregulation of genes involved in synaptic homeostasis.

Sugar porters are textbook examples of how transport activity is described by Michaelis–Menten kinetics. Here, using saturation transfer difference nuclear magnetic resonance spectroscopy, Ahn et al. conclude that the fully occluded state of a sugar transporter is analogous to the transition state in soluble enzymes.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

An analysis of satellite data follows ~1 km³ of flood water drain over only 3 weeks from a glacier-covered lake along a 50 km path beneath the ice to the glacier margin, providing important insight for predicting the future of glaciers and ice sheets.

An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing an experimental framework for the exploration of antigen diversification in Trypanosoma brucei and in other pathogenic microorganisms.

Femtosecond laser pulse-induced coherent helicity switching of magnetic vortices in permalloy disks on picosecond timescales is reported.

MsbA mediates the transport of lipopolysaccharide across the inner membrane. Here, the authors show specific MsbA-lipid interactions can tune the selectivity for binding ATP over ADP and present five structures of MsbA with one bound to lipid.

XRISM spectroscopy of the nucleus of the Circinus galaxy indicates elemental abundances suggestive of a dominant enrichment from core-collapse supernovae with progenitors below 20 solar masses; more massive stars may directly collapse into black holes.

Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in a specific manner via direct cell–cell contact.

Saccadic eye movements during free viewing exhibit patterns that reflect a strategy to increase neural responses by matching motor behavior with the statistics of the natural world and with the processing limitations of sensory systems.

N¹-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.

Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.