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The properties of electronic transport through edge states of three-dimensional quantum Hall-like states are not yet resolved. Now, increasing the surface area of the edges is shown to produce increased conductance, suggesting that chiral surface states are present.

Here the authors present NCATS-SM0225, a small molecule that inhibits ERAD and selectively kills cancer cells by binding VDACs, disrupting calcium homeostasis, and triggering the PERK-STIM1 pathway to degrade ERAD regulators.

Calcium imaging of mouse hippocampal neurons while mice learn a reward-based task over several weeks provides insight into the evolution of the hippocampal reward representation during extended periods of experience.

It remains unknown why only some sickle cell disease (SCD) patients develop lung thrombosis. Here, the authors show that an extracellular vesicle-dependent mechanism prevents lung thrombosis in SCD and how a CD39 polymorphism impairs this protection to promote lung thrombosis in subset of patients.

How the brain supports speaking and listening during conversation of its natural form remains poorly understood. Here, by combining intracranial EEG recordings with Natural Language Processing, the authors show broadly distributed frontotemporal neural signals that encode context-dependent linguistic information during both speaking and listening..

NiPS₃ is a van der Waals antiferromagnetic semiconductor where the exciton formation is strongly influenced by the magnetic ordering. Previous studies have been limited to magneto-optical approaches, but here, Lebedev, Gish and coauthors succeed in making field effect transistors that operate below the Néel temperature and observe an ultranarrow electroluminescence with a high degree of linear polarization.

Climate change can alter when and how animals grow, breed, and migrate, but it is unclear whether this allows populations to persist. This global study shows that shifts in seasonal timing are key to helping vertebrate species maintain population growth under global warming.

High-resolution satellite data enables a unique verification of national methane emissions worldwide. Global estimates are 63 Tg a⁻¹ for oil-gas, 30% higher than the UNFCCC reports due to under-reporting by four largest emitters, and 33 Tg a⁻¹ for coal, consistent with previous estimates.

The Ocean Equity Index provides a systematic, twelve-criteria framework to assess and improve equity in ocean initiatives, projects and policies, producing structured data that guide evidence-based decisions and support more equitable outcomes for coastal communities and ecosystems.

The authors use data on the entire Finnish population to develop a machine learning model for predicting COVID-19 vaccination uptake. Important predictors are proxies of socio-economic status, and those at high risk for COVID-19 consequences are less likely to get vaccinated.

A national classification system of wetland hydrologic connectivity to streams, which could be applied globally, demonstrates and advances current understanding of how wetland connectivity affects surface water quality.

Climate limits where insects can live and which species can coexist. Using thermal tolerances of 653 moths on Asian mountains, this study shows warmer temperatures broaden thermal tolerance traits diversity; daily variation has little influence, and strong seasonality mildly weakens this pattern.

This study advances methods for benchmarking macromolecular complex predictions by introducing a scalable open-source framework used in recent community assessments to compare structures, interfaces and ligand interactions against experimental data.

Wildfire observations reveal that 21% of black carbon aerosols contain multiple cores, and accounting for this morphology increases global absorption by 19%, highlighting a missing source of radiative forcing in current models.

Here, the authors introduce a cryogenic scanning probe photoelectrical sensing technique, termed exciton-resonant microwave impedance microscopy, to measure the excitonic responses in monolayer MoSe2 and identify exciton polarons and their Rydberg states.

Motivated by the need for a non-living and versatile multiblock semi-crystalline polyolefin synthetic method, the authors report a method for producing previously inaccessible iPP-b-LLDPE linear multiblocks wherein the overall molecular weights, individual block lengths, and crystallinity can be controlled.

The West Antarctic Ice Sheet responded to different natural forcing mechanisms than the East Antarctic Ice Sheet through the mid-Pliocene due to a greater sensitivity to oceanic feedbacks, according to iceberg-rafted debris records and ice-sheet modelling experiments.

The authors synthesize bee assemblage data from 681 crop fields across three continents, finding that local pesticide hazards and decreasing adjacent semi-natural habitats both negatively affected wild bee abundance and species richness in crop fields, while pesticides also reduced functional diversity.

ABC toxins are bacterial insecticides with biotechnological potential. Here, Low et al. have deciphered soluble and membrane-inserted structures of YenTc that highlight structural and mechanistic diversity in the ABC toxin family and provide insights into their evolution.

Here, the authors present archaeology of the Namorotukunan site in Kenya’s Turkana Basin that demonstrates adaptive shifts in hominin tool-making behaviour spanning 300,000 years and increasing environmental variability. They contextualize these findings with paleoenvironmental proxies, dating, and geological descriptions.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

Supersolids combine superfluid and crystal order and their response to external driving remains unclear. Now it is shown that, in a dipolar supersolid, rotation induces synchronization of the crystal motion via vortex nucleation.

Inspired by dynamic textural modulation in cephalopod skin, polymer films whose colour and surface texture can be dynamically and independently controlled are developed and demonstrated using standard electron-beam patterning tools.

This study addresses opioid misuse prediction by integrating physiological data and electronic health records. Utilizing personalized deep-learning models, it achieves a high accuracy in risk assessment through entropy feature extraction and relevance-based temporal fusion, demonstrating effective intervention potential.

The evolution of insecticide resistance in the major malaria vector, Anopheles gambiae, remains an important issue in sustainable malaria control in Africa. Here, the authors present a framework for identifying resistance mechanisms before they arise in field mosquito populations. The findings have implications for public health surveillance and vector control.

PropMolFlow is a flow-matching method for property-guided molecule generation that matches diffusion model performance while generating stable, valid structures more quickly and enabling the discovery of molecules with under-represented property values.

Man-made ammonia emissions have harmful effects on human health and ecosystems, yet global mitigation strategies remain underexploited. A study now finds that emissions could be halved cost-effectively by 2050 through targeted and prioritized measures, with benefits far outweighing costs.

Reanalysis of radiometric data from Cassini indicates that Titan does not contain a subsurface ocean, as strong tidal dissipation observed in its gravity field is not consistent with the presence of a liquid layer.

Wearable devices generate vast streams of health data, but making sense of these measurements requires complex numerical reasoning beyond the reach of conventional language models. This study introduces a large language model agent that interprets wearable data to deliver accurate, personalized health insights.

Experimental evidence demonstrates long-distance remote epitaxial interactions of thin films even through thick amorphous carbon buffer layers and shows that these can be induced through dislocations in the substrate.

In terahertz sideband generation, an electron–hole pair is accelerated in a semiconductor by a terahertz field to then recombines forming a frequency comb, but so far experimental realizations have relied on the large fields of free electron lasers. Here, Crosse et al.propose bi-layer graphene for sideband generation at lower fields.

Fire hydrants can create stagnant zones in drinking water systems that degrade water quality. This study shows that stagnant water has much higher metal and microbial levels than flowing water, revealing distinct chemical and microbial shifts that may pose health risks.

The authors report the synthesis of (La_0.9Y_0.1)H₁₀ superhydrides and their characterization using synchrotron-based, spatially resolved x-ray diffraction and electrical transport imaging. They reveal μm-scale structural inhomogeneity with coexisting cubic and hexagonal clathrate phases exhibiting distinct superconducting transition temperatures.

Ultrathin alumina encapsulation protects the magnetic, magnonic, and optical properties of air-sensitive V[TCNE]ₓ, enabling characterization of intrinsic material properties and integration of this organic-based magnet into cryogenic quantum devices.

Experimental evidence of coherent charge transport in the normal state of the kagome metal CsV₃Sb₅ is presented, revealing the nature of correlated order in kagome metals and new directions for exploring quantum coherence in correlated electron systems.

Baked sediment, heat-shattered artefacts and introduced pyrite in a 400,000-year-old Palaeolithic occupation site in Suffolk, UK provide evidence of intentional fire-making, marking a pivotal moment in human development.

Termites, the largest lineage of non-hymenopteran social insects, are important decomposers of plant organic matter in the tropics. Here, the authors sequence the genomes of 45 termites and two cockroach outgroups and investigate the influence of diet on the evolution of termite genomes.

Differentiating DCs express ALDH1A2, which produces retinoic acid and suppresses DC activity. Blocking this pathway with a new inhibitor, KyA33, enhances immune responses and boosts the effectiveness of DC cancer vaccines in mouse models.

This study introduces P3T-Net, a pseudo-3D deep learning model that enables accurate and efficient cross-domain transfer of large 3D material images, improving image quality and ensuring image consistency across diverse imaging conditions.

The reconstructed Holocene Australian summer monsoon in this study, together with the Asian monsoon records, show that the coupling evolution of Holocene Asian-Australian monsoon was dominated by the thermal imbalance between two hemispheres.

Tellurium thin films thermally evaporated at cryogenic temperatures enable the fabrication of high-performance wafer-scale p-type field-effect transistors and three-dimensional circuits.

The SuperCam microphone aboard the Perseverance rover captured 55 triboelectric discharges during dust events on Mars over two Martian years, providing implications for examining the planet’s surface chemistry, habitability and human exploration.

How landscapes are arranged affects soil pathogenic fungi worldwide. The authors reveal the global pattern and pronounced scale-dependency of landscape complexity and land-cover quantity on soil pathogenic fungal diversity.

Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible population-level codes.

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

Birth season has been associated with differences in epigenetic, developmental and health outcomes, but associations to developing metabolome are unclear. Here the authors report a secondary exploratory analysis of The Early Life Interventions for Childhood growth and development in Tanzania (ELICIT) trial showing that in rural Tanzania, an infant’s birth season shapes their metabolism up to 18 months of life, linked to rainfall, food insecurity and breastmilk composition.