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Metal-cation-free CO₂ electroreduction in strong acid minimizes reactant loss and salt precipitation yet struggles with CO₂ activation and hydrogen evolution competition. Here, the authors report bioinspired sharp gold triangles with a proton-blocking layer that polarize CO₂ and suppress hydrogen evolution.

Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

Surgical tasks within tortuous and narrow lumens require interventional instruments with controllable mechanical adaptability. Here, the authors present the Helixoft microrobotic system, which enables continuous stiffness tuning and active steering of microcatheters with diameters down to 300 μm controlled by weak magnetic fields.

By integrating a ribo-seq dataset of 195 individuals with RNA-seq and proteomics data from the same cohort, researchers found prevalent post-transcriptional attenuation of eQTL effects and identified omic-specific QTLs associated with schizophrenia.

The authors develop tunable surface plasmon polariton (SPP) lattices using well-designed Kekulé metasurfaces, enabling precise control over intensity, spatial distribution, and orbital angular momentum, with applications in on-chip light emission and secure optical encryption

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Chondrule-like objects and CAIs in the Ryugu samples are early generations of chondrules and possibly oldest solids in the Solar System. They were transported from the inner solar nebula to the formation location of the Ryugu original parent body.

The authors demonstrate enhanced hydrovoltaic power generation using heat conduction effects to break through the slow heat replenishment limit common in evaporation-induced hydrovoltaic generators.

Adipose tissue inflammation contributes to the pathogenesis of obesity-related metabolic disorders. Here the authors report that adipocyte-specific genetic deficiency or pharmacological inhibition of TRPM7, a cation channel, attenuates adipose tissue inflammation, improves glucose homeostasis, and suppresses weight gain in obese male mice.

The development of polymer materials for water decontamination is important for environmental protection and public health. Herein, the authors report the preparation of metallacage-crosslinked free-standing supramolecular networks by photo-induced copolymerization of acrylate metallacages and butyl methacrylate for water decontamination.

This study identifies the TaDT1-A^hapI allele conferring drought resistance without yield penalty. Its 899-bp promoter deletion evades TaMYC2 repression and thereby enhances autophagy-mediated stomatal dynamics and water-use efficiency, providing a potential breeding target.

The paraventricular hypothalamus (PVH) exerts an indispensable role in body weight control. Here, authors demonstrate the role of PVH RUVBL2 in suppressing food intake and reveal two anorexigenic circuits of PVHRUVBL2 → ARCPOMC and PVHRUVBL2 → DMH.

An acid-free atmospheric leaching process extracts 97.4% Ni and 98.8% Co from critical minerals, limits iron dissolution (4.7%), and reduces CO₂ emissions by 59.5%, offering a sustainable alternative for battery-grade metal production.

This work focuses on the characterization of CLE peptide gene, revealing how the TaCLE24b-TaCLV1 signaling cascade together with TaSG-D1 modulate lateral root development and drought stress tolerance in wheat.

The feasibility and efficacy of neoadjuvant immunotherapy for resectable hepatocellular carcinoma (HCC) have been previously suggested. Here the authors report the results of a phase 1b trial of neoadjuvant tislelizumab plus stereotactic body radiotherapy and adjuvant tislelizumab in early-stage resectable HCC.

Splicing dysfunction has been observed in Alzheimer’s disease but it remains unclear whether splicing defects have a causal role. Here the authors generate a mouse model with perturbed U1 snRNP activity, recapitulating RNA splicing defects, neuron hyperexcitability, neurodegeneration and synergy with the amyloid cascade when crossed with 5xFAD mice.

CRISPR-Cas9 genome editing systems have great potential in cancer therapy. Here the authors report a gene-editing delivery system using functionalized nanovesicles derived from E. coli protoplasts to encapsulate Cas9-sgRNA ribonucleoprotein for the selective targeting of Pik3cg in tumor associated macrophages.

Intestinal microbiota alterations may affect heart function through the production of gut-derived metabolites. Here the authors found that gut microbiota-derived TMAVA is a key determinant for the development of cardiac hypertrophy through inhibition of carnitine synthesis and subsequent fatty acid oxidation.

A study finds that RUVBL2 is a conserved component of eukaryotic circadian clocks and suggests that slow ATPase activity, which was initially discovered in cyanobacteria, is a shared feature of eukaryotic clocks.

Fluoride-treated CsPbBr₃ nanocrystals emit light with near unity efficiency at temperatures of up to 373 K.

Mechanism of high altitude adaptation of wheat remains unknown. Here, the authors assemble the draft genome of a Tibetan semi-wild wheat accession and resequence 245 wheat accessions to reveal that Tibetan semi-wild wheat has been de-domesticated from local landraces to adapt to high altitude.

The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective.

A nitrate-induced transcription factor TaTCP6 is identified as a central regulator for the efficient and balanced utilization of nitrate and phosphorus, and a moderate increase in its expression promotes wheat yield.

This study maps proteomic changes in Alzheimer’s mouse models, identifying shared pathways with humans, amyloid-driven protein turnover, and proteome-transcriptome differences, offering insights into disease mechanisms and potential targets.

Global detections of ultralow velocity zones in high-velocity lowermost mantle regions are associated with thermochemical anomalies linked to subducted slabs, according to analysis of SKKKP B-caustic diffractions with anomalous seismic structures in the mantle and outer core.

Sample mix-up is a potential problem in large-scale omic studies due to the complexity of sample processing. Here, the authors present a pipeline for sample matching in proteogenomics to verify sample identity and ensure data integrity.

CIGS is a high-resolution dataset comprising chemical perturbation-induced 319,045,108 gene expression events.

Post hoc analysis of the DAPA-HF and DELIVER trials reports on the approach of win statistics to evaluate the effect of dapagliflozin on a hierarchical composite kidney outcome in patients with heart failure.

Adenocarcinoma at the gastroesophageal junction has a dismal prognosis and few drug options. Here, the authors present genomic and transcriptomic features and potential therapeutic targets and prognostic biomarkers of Chinese and Caucasian tumours, and reveal the molecular similarities.

The assembly of oligopeptide and polypeptide molecules can reconstruct various ordered advanced structures. Here the authors develop a “molecular velcro”-inspired amphiphilic supramolecular co-assembly strategy, which improves the mechanical strength and cartilaginous regeneration efficiency through conformation transition.

T cells play a critical role in intestinal homeostasis, with increasing evidence suggesting a role for the microbiome metabolome in modulating this response. Here the authors show short-chain fatty acids promote IL-10 production in Th1 cells.

The mechanisms underlying bacterial persisters formation remain poorly understood. Here, Chen et al. identify a complex formed by extracellular poly(dC) and the binding protein RmlB that controls Pseudomonas aeruginosa persister formation in response to environmental stimuli.

Dysregulation of ribonucleoprotein complex granules, previously implicated in neuromuscular disease, can drive pathogenesis in a genetic form of dilated cardiomyopathy, as shown in gene-edited pigs and patient-derived cardiomyocytes.

There is a continuous arms race between pathogens and their host plants. Li et al. reveal that PR1 prevents entry of a fungal effector into plant cells from the apoplast that otherwise would quench host defence oxidizing agents via phase separation.

Yang, Zhang et al. identify a non-canonical form of necroptosis driven by nuclear RIPK1-mediated nuclear membrane rupture as a result of ZMPSTE24 deficiency and defective prelamin A processing commonly observed in progeroid disorders.

Esophageal squamous-cell carcinomas (ESCC) have poor prognosis, and detailed molecular profiles are necessary to identify prognostic markers. Here the authors analyse 60 ESCC patient samples using scRNA-seq, TCR-seq and genomics; they find mucosal immunity markers associated with survival and immunosuppressive microenvironments.

Biomaterials that can be non-invasively activated to promote bone growth would be useful tools to repair bone defects in patients with comorbidities like inflammation or impaired osteogenesis. Here, the authors develop a composite membrane that can be stimulated by an external magnetic field and use it to correct skull defects in rats treated to reflect such comorbidities.

A strategy that depends on attenuated brassinosteroid signalling is described for the design of semi-dwarf wheat varieties with improved grain yield compared with that of green revolution varieties.