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Pentatellurides exhibit magnetoresistance oscillations that deviate from conventional 1/B Landau-quantization. Here, the authors demonstrate robust non-1/B oscillations in ZrTe₅ and show that nonlinear Landau level backbending reconciles the diverse oscillatory regimes across the pentatellurides.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Coherent ferrons (or polarization waves) driven by an ultrafast laser source in ferroelectric van der Waals materials generate narrow-band terahertz radiation and propagate uniaxially with long coherence times.

Genome-wide analyses identify genetic loci and plasma proteins associated with polycystic ovary syndrome (PCOS). This study highlights the hormonal and metabolic foundations of the disease and explores the impact of polygenic risk for PCOS in both sexes.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Millisecond pulsar PSR J0435+3233, with a spin-down rate that is 100 times higher than those of other millisecond pulsars, occupies a unique position on the P–Ṗ diagram. This pulsar challenges classical recycling models and constrains spin-up theories.

Polymer thin films that emit and absorb circularly polarised light are promising in achieving important technological advances, but the origin of the large chiroptical effects in such films has remained elusive. Here the authors demonstrate that in non-aligned polymer thin films, large chiroptical effects are caused by magneto-electric coupling, not structural chirality as previously assumed.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Snyder et al. analyze two population-based birth cohorts to test associations of newborn metabolite concentrations and childhood respiratory outcomes. C4, C10:1, C18:2, and citrulline are associated with early-life wheezing and asthma, with C18:2 specifically associated with increased non-allergic asthma risk.

A chemical binding model that accounts for organic matter complexity resolves the interplay between the formation of iron minerals and iron organic matter phases that ultimately determines the ocean’s iron inventory.

This work establishes a unified framework where mantle plumelet dynamics, slab segmentation, and drip-like arc removal govern multi-scale deformation and seismicity in the Arabian-Eurasian post-subduction collision.

A wearable sensor fuses biopotential and biomechanical signals into a single cross-modal biosignal through in-sensor fusion, enabling accurate haemodynamic monitoring and improved gesture decoding.

Orbital hybridization and quantum confinement are used to realize Ising-like superconductivity in trilayers of gallium, which alone is probably not strongly enough spin–orbit coupled to host such superconductivity under high in-plane magnetic fields.

Two distinct types of atomic insulator can be distinguished by the distribution of charges within the unit cell. Now, real-space imaging of WSe₂ shows that it is a so-called obstructed insulator.

How the multiple manifestations of vascular aging cluster and predict overt cardiovascular disease (CVD) is unknown. Here, the authors identify three patterns of vascular aging, showing their independent association with incident CVD, and their added value for stroke risk stratification.

Efficient protocols for comparing quantum states generated on different quantum computing platforms are becoming increasingly important. Zhu et al. demonstrate cross-platform verification using randomized measurements that allow for scaling to larger systems as compared to full quantum state tomography.

Bimerons are magnetic solitons that are topologically equivalent to skyrmions in in-plane magnetized systems. This study demonstrates the room-temperature creation of bimerons in Co₈Zn₈Mn₄ via femtosecond laser pulse excitation, revealing dynamic topological control and morphological transitions of these solitons.

This study shows that the intestine uses a specific pathway to generate the energy (ATP) needed to move dietary fat out of intestinal cells. A protein called ANKRD9 helps regulate this energy supply; without it, fat builds up in the intestine, and the body remains lean.

Mutant isocitrate dehydrogenase 1/2-driven D-2-hydroxyglutarate (D2HG) and hypoxia-induced L-2-hydroxyglutarate (L2HG) are known to non-covalently inhibit α-ketoglutarate-dependent enzymes in several cancer types. Now, through use of chemical proteomics, stereoselective protein O-2-hydroxyglutarylation by D2HG or L2HG has been characterized as a distinct oncometabolite-induced post-translational modification with evidence for crosstalk with kinase activity.

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

This study utilized a longitudinal cohort of adolescents to identify distinct brain signatures linked to ADHD symptom trajectories, revealing that specific cortical and subcortical changes correlate with symptom persistence, remission and emergence, enhancing predictive capabilities for ADHD outcomes.

Germline and somatic interactions define actionable genomic patterns driving acquired therapy resistance in breast cancer.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

The ring opening of cyclopropenes provides a compelling platform for the rapid synthesis of various polysubstituted acyclic alkenes, but radical-mediated reactions of this type remain underexplored. Here, the authors report an aminative ring-opening of cyclopropenes with iron-aminyl radical to afford tetrasubstituted alkenyl nitriles.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Copper nanoclusters are promising photothermal heaters, but their conversion efficiency is limited efficiency. Here, the authors present a rotor-stator ligand architecture that enables enhanced photothermal conversion efficiency of copper nanoclusters.

Dark matter remains one of the greatest mysteries in physics, with the DAMA/LIBRA experiment uniquely claiming a direct detection signal. Here, the authors introduce COSINUS, combining scintillating sodium iodide crystals with dual phonon and scintillation light readout at cryogenic temperatures, enabling a direct and unambiguous assessment of DAMA/LIBRA’s claims while minimizing systematic uncertainties by using particle identification and the same target material.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Efficient low temperature oxygen activation is essential but hard to achieve with accessible metal sites. This work shows that zero-valent single Pt atoms on cobalt oxide donate electrons to oxygen, enabling low-temperature toluene oxidation.

Here, the authors introduce carbon-to-carbon metal migration as a platform for dynamic association and show how such migrations, in combination with the incorporation of a simple hydrocarbon, can be harnessed to achieve autonomous directional translational motion of a metal centre along the length of a polyaromatic thread.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Li, Cui, Yang, Lu, Jiang, Zhang and colleagues identify a lactate transport mechanism from tumour-associated macrophages that regulates DNA repair and immune cell infiltration, which could be targeted to enhance immunotherapy efficacy in glioblastoma models.

Ramaglia and colleagues show that aberrant formation of B cell-rich lymphoid structures in the brain meninges is associated with high CXCL13:BAFF ratios. Inhibiting the kinase BTK reduces the lymphotoxin signaling needed to sustain such structures, lowers CXCL13:BAFF ratios and reduces cortical tissue injury.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.