Search

Replicating the human brain’s imaginative ability has long been a core AI goal, yet current systems remain limited in speed and efficiency. Yang et al. present a hardware platform based on resistive memory, enabling high-speed, low-power AI content generation while fully preserving output quality.

Lithium||sulfur batteries face slow lithium polysulfide (LiPS) conversion under lean electrolyte condition. Here, authors identify chiral LiPS-LiTFSI dimers and design biomimetic MOF catalysts with L-histidine-Cu for selective recognition and enzyme-like kinetics. The catalyst enables pouch cells with 408 Wh kg⁻¹ (without packaging), underscoring chiral coordination in Li||S chemistry.

Oxidative stress and dsRNA are key drivers of skin inflammation, while therapies targeting oxidative stress are common, dsRNA targeting is not. Here, the authors report on a cerium-doped polyoxometalate with anti-oxidative and dsRNA binding properties showing potential for a transdermal strategy to reduce skin inflammation.

Disordered orientations of the 1D component limit carrier transport in 1D/3D heterostructures. Chen et al. report bilayer interface engineering to induce vertically ordered 1D capping layers, enhancing charge transport, and achieving a certified efficiency of 26.0% with strong thermal and light stability.

Immunosuppressive tumor-associated macrophages (TAM) contribute to resistance to immune checkpoint blockade. Here, the authors propose BCAT1 to inhibit crotonate-mediated epigenetic reprogramming of tumor-associated macrophages, with BCAT1 loss promoting immune escape in hepatocellular carcinoma mouse models.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Meng et al. reveal that CCDC120 forms dynamic droplets with PKP2 through liquid-liquid phase separation to maintain desmosome integrity. Disrupting this process weakens cellular junctions and leads to cardiac dysfunction in mice.

Liquid crystal elastomers (LCEs) are promising materials for soft robotics due to their ability to undergo significant shape changes in response to thermal stimuli, but traditional methods of synthesizing LCEs often require high energy inputs and result in limited actuation performance. This study introduces a non-mesogenic approach to synthesize LCEs that enables high actuation strains at low temperatures, allowing for the development of autonomous soft robots that can operate using ambient thermal energy.

Excess free fatty acids are toxic to cells. Here, the authors identify TMEM120A as a GPAT4 activator that promotes the incorporation of medium- and long-chain fatty acids into glycerolipids to prevent lipotoxicity.

This work establishes a relationship between the cavity radius of hydrated electrons and PFAS degradation, which shifts focus from PFAS structure to reactive species structures, thus opening an overlooked way to tune advanced reduction processes.

Researchers develop a light-switchable CRISPR platform using upconversion nanoparticles to enable RNA manipulation in deep tissues. Near-infrared activation triggers precise, localised RNA knockdown or editing, offering a versatile approach for diseases requiring targeted RNA modulation.

Early postoperative recurrence is a major cause of treatment failure in patients with locally advanced gastric cancer (LAGC). Here, the authors develop Recurrence Stratification and Assessment (RSA), a deep learning model that integrates histopathology with clinical variables to predict postoperative recurrence in LAGC; they also examine the influence of immunological activity in recurrence.

The authors develop a polyvinylidene fluoride and mica bimorph to enhance pyroelectric response. The secondary pyroelectric contribution employs interfacial thermal stress to improve the pyroelectric performance for flexible electronics.

Phagocytic cells engulf bacteria as part of defence against infection, but intracellular bacteria could exploit these cells for transportation to new infection sites. Here the authors describe a neuroinvasion mechanism by which intracellular bacteria infect and metabolically transform a specific macrophage subtype, which then propagates and transports them through the blood-brain barrier without disrupting it.

A Walden inversion-like transformation and multiple Feshbach resonances are observed in the Cl + NH₃ reaction, providing a complete mapping of the transition-state region for a chlorine-involved polyatomic reaction.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Organic solar cells need acceptor molecules with long exciton diffusion lengths, but most available materials fail in thick films. The authors design new fluorinated quinoxaline acceptors that significantly improve carrier mobilities resulting in superior efficiency in both binary and ternary devices.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Direct non-oxidative conversion of methane into valuable hydrocarbons is a highly promising low-carbon pathway. This study presents a filament-catalyst reactor that spatially separates high-temperature methane activation from low-temperature product formation for better efficiency and selectivity.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

Natural variation of the F-box protein ZmFBL41 in maize confers resistance to Rhizoctonia solani, the causal fungus for banded leaf and sheath blight in maize, through decreased interaction of ZmFBL41 with the cinnamyl alcohol dehydrogenase ZmCAD.

Tuning symmetry breaking in magnetic transitions via twist-angle engineering is challenging, as twisted two-dimensional magnets often inherit the magnetic ground states of their constituent parts. Now this tunability is achieved in a double-bilayer moiré magnet.

Decade-long warming increased soil antibiotic-resistance genes by about 24%, enriching resistant microbes and gene transfer, driven by selection for thermal tolerance and linked traits, with implications for public health.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Global travel hubs could be key in future pandemic surveillance efforts. Here, using a global metapopulation model calibrated to epidemiology, phylogeography and air travel, the authors show that traveler-focused genomic surveillance at key hubs can speed up detection of SARS-CoV-2 variants under resource constraints.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

The response of soil carbon to warming is critical feedback that has been difficult to constrain. This study uses a long-term experiment to show that precipitation modulates microbial and therefore carbon dynamics; drought leads to carbon loss with warming, but wet conditions increase soil carbon.

The reprocessability of covalent adaptable networks often comes at the expense of mechanical performance and thermomechanical stability. Herein, the authors introduce a dynamic N-hydroxyphthalimide-urethane bond to achieve thermomechanical stability and reprocessability in covalent adaptable networks.

Intrauterine adhesions (IUA) are a leading cause of female infertility. Here, authors engineer a Tβ4-releasing ECM hydrogel that mimics decidualization to promote endometrial regeneration as a therapeutic strategy for treatment of IUA.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

Soil viruses influence carbon cycling across pH gradients, with acidic soils showing greater lysogeny and carbon related genes, as revealed by viral communities recovered through size fractionation and tangential flow filtration from twelve paddy fields.

The authors demonstrate that targeted protein degradation of the dengue virus capsid suppresses infection through capsid-dependent pathways rather than classical inhibition, revealing a new antiviral strategy effective against resistant viral variants.

ANNEVO advances accurate and scalable ab initio gene annotation of evolutionarily diverse genomes using deep learning approach modeling sequence evolution and long-range dependencies and mixture of experts (MoE) architecture.

Here, the authors show that residues N490 and M492 of Hepatitis E Virus capsid protein are pivotal, albeit not exclusive, host tropism determinants of hepatitis E virus (HEV) for swine infection, which enhance the understanding of HEV’s zoonotic transmission and host specificity.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Thermochromic materials are promising for optical switching devices, though many examples are sensitive to environmental conditions. Here the authors report a phase-separating thermochromic ionogel with a wide temperature stability and enhanced mechanical properties.