Search

Kancharla, Kelly et al. identify an acridone antimalarial potent across all major parasite life stages. Lead candidate T111 shows oral efficacy, low toxicity, and synergy with tafenoquine, providing a unique mechanism to overcome resistance.

Direct regeneration of spent lithium-ion battery positive electrode materials is hindered by structural disorder and surface degradation. Here, authors use oxidation to reconstruct lithium transport pathways and regenerate dense single-crystal LiNi_0.5Co_0.2Mn_0.3O₂ with stable cycling performance.

Hua et al. report a rigid molecule to partially replace oleylamine ligands and vertically anchors on the CsPbI3 nanoplatelets, suppressing electron-phonon coupling. The rigid-ligand pinning strategy enables pure-red LEDs with a linewidth of 24 nm, efficiency of 29.8%, and operational lifetime of 128.2 h.

Difelikefalin is an FDA-approved KOR-targeted drug for chronic pruritus yet exhibits side effects. Here, researchers solve cryo-EM structure of difelikefalin KOR-Gi, identifying Y320^7.43 as a key bias residue. Substituting D-Phe1 with β-phenylalanine develops beta01 which retains analgesic/antipruritic efficacy via a unique receptor conformation that reduces adverse effects.

The community of microbes living in our gut plays a crucial role in our health. Here, authors develop a simple chemical sensor array that can rapidly identify different gut bacteria and distinguish between stages of colorectal cancer, offering a promising approach for disease diagnostics.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Many hospitalised children with acute illness in low- and middle-income countries experience incomplete recovery, readmission, and post-discharge mortality despite guideline-directed care. Here the authors report multiomic profiling to investigate biological drivers of hospital in-patient and post-discharge mortality in 3,101 acutely ill children across nine sites in sub-Saharan Africa and South Asia.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

Gene functional shifts can rewire molecular networks beyond expression changes. Here, authors present scDNS, which quantifies network divergence to infer gene perturbations and projects them to single cells, enabling sensitive detection of hidden regulation and heterogeneous responder states.

This study uses genome-wide screening and mouse genetics to uncover how cells control proinsulin, identifying the Golgi as a central hub and revealing PDIA6 as a key regulator of proinsulin production in pancreatic β-cells.

The enhancement of tribo-negative performance in traditional fluorinated polymers is important for the design of triboelectric devices. Here, the authors describe the enhancements of the tribo-negative properties of fluorinated copolymers via the synergistic effects of C-F and C-Cl bonds in the polymers.

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

The genomewide meta-analysis of lumbar spinal stenosis LSS identifies 73 previously unreported loci in addition to 15 known loci and highlights spinal degeneration as a key pathogenic mechanism. Overall, the findings expand knowledge of the genetic background of LSS.

Adult sex ratio is important in breeding systems and sexual selection. Here, the authors show that sex-biased demographic processes, including differences in mortality and maturation between males and females, shape adult sex ratio variation in 261 bird species.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

Flexible batteries often fail under harsh conditions. Here, authors developed a hydrogel electrolyte via synergism of nanophase separation, hydrated eutectic solvation, and hydrogen-bond networks, enabling flexible Zn||I₂ batteries with high specific energy and long lifespan across −40 to 80 °C.

The MoSi₂N₄ family is an emerging class of van der Waals materials with interesting properties. Here, the authors report a systematic characterization of point defects in monolayer WSi₂N₄ and MoSi₂N₄, showing their influence on the electronic properties of the materials.

Aqueous iron-ion batteries represent a compelling energy storage solution due to the cost-effectiveness, suitable redox potential, and high capacity of Fe negative electrodes. This study activates phosphorus redox activity in a carboxyl small molecule positive electrode for iron-ion batteries.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Electrochemical nitrate reduction rivals Haber-Bosch ammonia synthesis rates but suffers from poor energy efficiency. Here, the authors show that underpotential deposited hydrogen can be unlocked to accelerate nitrate conversion, offering an pathway to energy-efficient ammonia production.

Ischemic stroke involves complex peripheral and central pathologies. Here, authors develop a spatially tiered strategy using dual stiffness nanoparticles for compartment-specific drug delivery, offering a synergistic treatment paradigm.

Single-atom catalysts excel in selective hydrogenation but are limited by insufficient binding sites for larger multidentate substrates. Here, the authors report a heteronuclear Rh–Co dual-atom catalyst anchored on defective graphene, overcoming the activity–selectivity trade-off in nitrile hydrogenation.

Removing trace acetylene from ethylene is vital for plastic production, yet catalysts often overreact and waste the product. This work reveals that palladium dual-atom catalyst on carbon greatly speeds the reaction while keeping ethylene intact.

A deep learning framework integrates protein language models, protein interactions and domains, medical knowledge graphs and electronic health records to map variants to phenotypes.

Whether annulate lamellae (AL) occur in normal somatic cells was an open question. Here, the authors demonstrate that AL drive nuclear pore complex assembly and nuclear expansion during G1, defining a RanBP2-dependent assembly route.

Plasma phosphorylated tau 217 levels predict future accumulation of Alzheimer’s disease pathology in cognitively unimpaired older adults without elevated brain amyloid-β (“A-”) on positron emission tomography.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

The paper presents a piezoelectric resonator-based DC-DC converter with an embedded flying capacitor and multipath operation. Implemented with an integrated circuit, the design achieves 96.2% efficiency at greater than the optimal 9:1 voltage conversion ratio with enhanced current handling for data center applications.

This study identifies extensive lateral interdigitations in the kidney’s ascending thin limb and demonstrates that Claudin-10b regulates both epithelial architecture and urine-concentrating function in this distinct nephron segment.

Liquid metals can create flexible, conductive composites, but often show a trade-off between these properties. Here, the authors optimise the interactions between liquid-metal and polyurethane to obtain a composite with high thermal conductivity and stretchability at low liquid metal loading.

Here, the authors reveal that the mitotic motor KIF11 functions in postmitotic neurons as a microtubule-dynamics rheostat to regulate dendritic arborization. Additionally, they show how MCLID mutations impair KIF11 oligomerization, ATP hydrolysis, neuronal structure, and communication.

Atomic radius differences between the constituent elements of nano-alloys can lead to excessive lattice distortions or even phase separation. This work reports a plasma-assisted carbothermal flash sintering strategy for the synthesis of sub-5 nm high-entropy alloy nanoparticles accommodating large- and small-size atoms.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

The authors have applied an eight-tissue rat multi-omic dataset to analyze the gene regulatory landscape of endurance exercise training, identifying tissue-specific regulatory patterns involved in muscle function, metabolism and immune response.

Electrochemical conversion of propylene to propylene oxide using seawater is attractive but limited by inefficient use of reactive chlorine species. Here, the authors incorporate lithium into a cobalt catalyst to enhance radical generation, achieving industrial-level yields and high efficiency

TDP-43 pathology is a key event in ALS/FTD and selectively affects specific neurons in the motor cortex. Here, the authors report which neuron types are affected and demonstrate that transcriptomic changes are cell-type specific.

As Nature Climate Change celebrates its 15 year anniversary, we look back at some of the journal’s published works. In this Viewpoint, seven early-career researchers discuss how these papers influenced their research and careers.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Photoredox catalysis promises transformative advances in proximity labeling and noninvasive therapy, yet photocatalysts rarely combine low-energy light absorption with high excited-state potentials. Here, the authors report Ru-based bio-photocatalysts that integrate greenlight absorption with strong redox power, enabling selective protein and phenol coupling.

NPM3 promotes histone lactylation (H3K18la/K27la) and drives FASN transcription and cardiomyocyte necroptosis in diabetic cardiomyopathy. Targeting this pathway with dihydroartemisinin alleviates cardiac dysfunction.

Native top-down proteomics reveals epidermal growth factor receptor–estrogen receptor-alpha (EGFR–ER) signaling crosstalk in breast cancer cells and dissociation of nuclear transport factor 2 (NUTF2) dimers to modulate ER signaling and cell growth.

Achieving lateral doping gradients in organic semiconductors (OSCs) via solution processing is crucial but remains a challenge. A gold-activated persulfate doping strategy can locally oxidize OSCs and create a lateral doping gradient, enabling low contact resistance and high carrier mobility in solution-processed organic field-effect transistors.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Emulating biological vision with dual functions of photoreceptors and photosynapses through light-modulated ion transport presents a significant challenge. Here, the authors present a light-regulated nanofluidic iontronic device that can mimic the dual visual functionalities with adjustable polarity-switching behaviour.

Vascular smooth muscle cells undergo complex transitions to multiple disease-related phenotypes in coronary artery disease. Using vascular smooth muscle lineage-traced single-cell RNA and ATAC sequencing, the authors map molecular spatiotemporal patterns of murine atherosclerosis and discover molecular mechanisms of TCF21-mediated coronary artery disease risk.