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CRISPR-Cas12a diagnostics are limited by strict PAM requirements. Here, authors show that higher temperatures activate numerous noncanonical PAMs, enabling a versatile one-pot platform that improves sensitivity, specificity, and rapid on-site pathogen detection.

Phase transitions in Na layered transition metal oxide materials involving slab gliding and considerable lattice parameter changes limit the battery cycling life, especially at high voltages. Here, authors pre-engineer 15.8% O-type stacking faults to a P-type Na0.7Mn0.8Ni0.2O2, improving stability and enabling an electrode specific energy of 635 Wh kg-1 with 600-cycle life.

Defect formation and phase instability remain critical challenges for perovskite/organic tandem solar cells. Jiang et al. address this by designing an additive to modulate the crystallization thermodynamics of wide-bandgap perovskite, achieving a record efficiency of 22.1% in a flexible cell.

A body-induced electroluminescence device enables three-dimensional finger tracking, providing a versatile platform for human–machine interaction that senses motion both on and above the device surface.

Wastewater treatment plants harbour extensive but poorly characterized microbial genetic diversity. Using 828 metagenomes from wastewater treatement plants globally, this study reconstructs >24,000 metagenome-assembled genomes, including >12,000 new species, providing a genome-resolved framework for understanding and engineering activated sludge functions.

This study shows that pesticide pollution reduces the diversity and functions of plant-beneficial bacteria in soils worldwide, threatening soil health and crop yields. The authors find that nutrient supplementation could be a potential strategy for recovery.

Precisely constructing homochiral helical nanostructures from achiral molecules by non-covalent interactions is challenging due to the untraceable handedness control at different hierarchical levels. Here, the authors present an aurophilicity-assisted orthogonal assembly strategy for the homochiral assembly of an achiral carbene-anchored trinuclear gold cluster with chiral amines.

The underlying strategies to tackle A-site inhomogeneity of Rb-alloyed wide bandgap perovskites remain under investigation. Here, authors incorporate a melamine additive as a phase uniformity regulator, achieving stabilized efficiency of 33.5% for two-terminal perovskite/silicon tandem solar cells.

Achieving wide-gamut structural colours with brightness control is challenging. Here, the authors demonstrate colours beyond Rec.2020 and continuous, polarizer-free brightness tuning in dielectric metasurfaces via mode interference and diffraction control.

Soil viruses may impact soil carbon cycle. Here, the authors use metagenomic analysis of contaminated soil and 13 C labeled microcosm incubation to show that the DNA viral community enhances microbial carbon fixation capacity via auxiliary metabolic genes.

Thermal stability remains a key challenge for organic photovoltaics. Qin et al. now propose a strategy that stabilizes multiple components of the devices, enhancing their resilience under damp heat and thermal cycling conditions.

Using channel-level decoupling to design independent photovoltage channels for each Stokes parameter with minimal crosstalk, a metaphotonic photodetector can be created that provides direct Stokes quantification.

CytoTRACE 2 is an interpretable deep learning framework that leverages single-cell RNA sequencing data to predict absolute developmental potential across datasets.

PCBP2 is elevated in AD and forms condensates that sequester mitochondrial proteins and RBPs, disrupting mitochondrial function and the NMD of BACE1 mRNA, alongside amyloid deposition. The small molecule, CN-0928 mitigates AD pathology by inhibiting PCBP2 condensation.

The synthesis of ionic olefin linked threedimensional covalent organic frameworks (3D COFs) is challenging because of the difficulties in forming stable carbon-carbon double bonds. Here, the authors report a general synthesis of an ionic sp² carbon linked COFs and demonstrate selective capture of ReO₄⁻ ions.

Laser plasma instabilities are the main factors contributing to degradation of hohlraum performance in inertial confinement fusion experiments. Here, the authors show asymmetric backscattering within the same laser cone at the SG-100kJ laser facility, unveiling the role of crossed-beam energy transfer and laser polarization.

De-domestication is the process by which cultivated plants adopt characteristics similar to that of their wild predecessors. Here Qiuet al. re-sequence de-domesticated weedy rice and matched cultivated varieties and identify genetic variants indicative of convergent evolution across multiple de-domestication events.

Partial pressure of oxygen adjusted indirect Fick method incorporates the effect of dissolved oxygen in vasoreactivity testing by inhaling oxygen in simple congenital heart diseases.

The quantum fusion of two independent 10-user networks is demonstrated based on multi-user entanglement swapping. Active temporal and wavelength multiplexing schemes are developed to merge the two networks into a larger network with 18 users in the quantum correlation layer.

Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending healthspan.

The development of robust catalysts that could work under industrial-scale current densities bring promise but also a challenge for hydrogen production. Here, the authors report an in situ activation method to produce ferromagnetic ruthenium clusters that can catalyze the hydrogen evolution reaction at high current densities.

Monocytes derived from bone marrow leucocytes are chemically conjugated with a Tau-specific aptamer via bioorthogonal chemistry, enabling systemic delivery across the blood–brain barrier and targeted clearance of extracellular Tau in Alzheimer’s disease mouse models.

Block copolymer self-assembly enables complex nanostructures including spherical micelles, continuous cubic gyroids and Frank-Kasper phases. Here, the authors show how film surface self-assemblies of binary and ternary block copolymer micelle alloys pave a path to controlled multicomponent assemblies.

The strange metal state, characterized by a linear-in-temperature resistivity, is often seen in the normal state of high-temperature superconductors. Here, the authors report the breakdown of both the strange metal and superconducting states at a pressure-induced quantum critical point in an iron-pnictide superconductor.

Diverse plant species synthesize salicylic acid from phenylalanine through a pathway that includes a conserved triple-enzyme module that converts benzoyl-CoA to salicylic acid.

Prime editing with CRISPR-Cas12a broadens targeting scope and enables multiplexing.

In this large-scale study, the authors used multimodal neuroimaging and cognitive data from UK Biobank participants to examine the relationship between regional adiposity and brain health.

Lead leakage from damaged perovskite solar cells poses a challenge to the deployment of such technology. Here, Jiang, Qiu and co-workers quantify lead leakage caused by a simulated hail impact under a number of weather conditions and show that self-healing encapsulations can effectively reduce it.

REF6 is a H3K27me3 histone demethylase that targets regions of active chromatin in the Arabidopsis genome. Here Qiu et al. show that REF6 preferentially binds unmethylated DNA via its zinc-finger domains suggesting that DNA methylation might deter REF6 binding in heterochromatin.

Incorporating carbon-carbon triple bonds into conjugated chains typically requires acetylenic precursors. Here, the authors synthesize poly(p-phenylene ethynylene) molecular wires on Cu(111) by directly coupling trichloromethyl-containing precursors, forming C-C triple bonds in situ

Significant progress has been made in the field of CRISPR diagnostics, but it is still challenging to achieve multiplexed detection. Here authors exploit CRISPR-Cas12a cis-cleavage to develop a multiplexed assay which includes a portable device incorporating multiplexed PCR, Cas12a cis-cleavage, and lateral flow detection.

Endovascular thrombectomy (EVT) achieves high recanalization rates in acute stroke, but many patients still experience poor outcomes. Here, the authors show that intravenous edaravone dexborneol (ED) is safe and reduces early hemorrhage but does not significantly improve 90-day functional outcomes in stroke patients after EVT.

Covalent polymers with helical conformations offer an adaptive scaffold for smart materials, but polymer-to-monomer deconstruction is inhibited by the covalent backbone. Now it has been shown that poly(disulfide)s can be folded into helices driven by side-chain hydrogen-bonding self-assembly, resulting in a synthetic helical polymer that can be fully recycled.

Iron and phosphorus exist at low concentrations in surface waters and may be co-limiting resources for phytoplankton growth. Here, the authors show that phosphorus deficiency increases the growth of iron-limited cyanobacteria through a PhoB-mediated regulatory network.