Nature Search

Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Jiseung Kang
Hyeon Jin Kim
Dong Keon Yon
Research16 Jan 2026
Nature Medicine

P: 1-18
National Laboratories in India

A. RAHMAN
A. GHOSAL
A. K. ROY
Research08 Aug 1964
Nature

Volume: 203, P: 582-584
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Transforming jet flavour tagging at ATLAS

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

G. Aad
E. Aakvaag
L. Zwalinski
ResearchOpen Access14 Jan 2026
Nature Communications

Volume: 17, P: 1-22
Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina

This study detects Chlamydia pneumoniae in human retina and brain, increasing with AD severity. Retinal pathogen load with Aβ₄₂ may predict AD stage. In models, infection drives Aβ deposition and NLRP3 activation, worsening pathology and cognition.

Bhakta Prasad Gaire
Yosef Koronyo
Maya Koronyo-Hamaoui
ResearchOpen Access22 Jan 2026
Nature Communications

Volume: 17, P: 1-24
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

C. Ruwende
S. C. Khoo
A. V. S. Hill
Research20 Jul 1995
Nature

Volume: 376, P: 246-249
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Intersectional biases in narratives produced by open-ended prompting of generative language models

People use generative language models to inform all aspects of their lives. Here, the authors examine synthetic narratives produced by open-ended prompting of generative language models and identify patterns of omission, subordination, and stereotyping against minoritized intersectional subgroups.

Evan Shieh
Faye-Marie Vassel
Thema Monroe-White
ResearchOpen Access08 Jan 2026
Nature Communications

P: 1-20
cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Eric Van Buren
Yi Zhang
Xihong Lin
Research31 Dec 2025
Nature Methods

P: 1-12
Observation of deuteron and antideuteron formation from resonance-decay nucleons

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

S. Acharya
A. Agarwal
N. Zurlo
ResearchOpen Access10 Dec 2025
Nature

Volume: 648, P: 306-311
Author Correction: Elucidating lipid nanoparticle properties and structure through biophysical analyses

Marshall S. Padilla
Sarah J. Shepherd
Michael J. Mitchell
Amendments and Corrections22 Jan 2026
Nature Biotechnology

P: 1
PARP inhibition generates enhanced CD8⁺ central memory T cells by transcriptional and metabolic reprogramming

Here the authors show that PARP inhibition activates SIRT-1–FOXO1 signaling to drive transcriptional and metabolic reprogramming of CD8⁺ T cells into central memory T cells with superior recall capacity and efficacy in adoptive therapy.

Wael Traboulsi
Pankaj Gaur
Samir N. Khleif
Research12 Jan 2026
Nature Immunology

P: 1-11
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Host-derived interleukin-1α drives tumor immunosuppression by reprogramming tumor-associated myeloid cells

Manikanda Raja Keerthi Raja
Gourab Gupta
Hexin Chen
ResearchOpen Access17 Jan 2026
npj Breast Cancer

P: 1-9
Towards interpretable prediction of recurrence risk in breast cancer using pathology foundation models

Jakub R. Kaczmarzyk
Sarah C. Van Alsten
Joel H. Saltz
ResearchOpen Access16 Jan 2026
npj Digital Medicine

P: 1-12
Determination of the spin and parity of all-charm tetraquarks

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A. Hayrapetyan
V. Makarenko
A. Snigirev
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 58-63
Opiate tolerance and dependence induced in vitro in single myenteric neurones

R. ALAN NORTH
PETER J. KARRAS
Research02 Mar 1978
Nature

Volume: 272, P: 73-75
Microprobe measurement of Na, K and Cl concentration profiles in epithelial cells and intercellular spaces of rabbit ileum

BRIJ L. GUPTA
T. A. HALL
R. J. NAFTALIN
Research02 Mar 1978
Nature

Volume: 272, P: 70-73
Frictional moving load-induced dynamic response of a porous piezoelectric micro/nano plate with superficial parabolic discontinuity

A. R. Meghana
Soumik Das
Aymen Flah
ResearchOpen Access03 Jan 2026
Scientific Reports

P: 1-21
2–Aminofluorene modified DNA duplex exists in two interchangeable conformations

Linda M. Eckel
Thomas R. Krugh
Research01 Feb 1994
Nature Structural Biology

Volume: 1, P: 89-94
Human plasma proteomic profile of clonal hematopoiesis

Somatic mutations in blood cells (CHIP) are linked to diseases like heart disease, but the mechanisms are unclear. Here, the authors show that different CHIP driver genes alter unique sets of plasma proteins, some of which are validated in mouse models.

Zhi Yu
Amélie Vromman
Pradeep Natarajan
ResearchOpen Access27 Nov 2025
Nature Communications

Volume: 16, P: 1-17
Mechanobiologically-optimized non-resorbable artificial bone for patient-matched scaffold-guided bone regeneration

Scaffold-guided bone regeneration is a promising treatment strategy for segmental defects, but clinical translation has been hindered, partially by mechanical function limitations. Here, Clark et al. describes a permanent printed polymer with a resorbable stem cell laden ceramic core for reconstructing segmental mandibular defects, which is tested in an ovine model.

Jonathan R. Clark
D. S. Abdullah Al Maruf
Jeremy M. Crook
ResearchOpen Access24 Oct 2025
Nature Communications

Volume: 16, P: 1-20
A Test of a New Type of Stellar Interferometer on Sirius

R. HANBURY BROWN
R. Q. TWISS
Research10 Nov 1956
Nature

Volume: 178, P: 1046-1048
Seawater-immersed glass-polyester composites with optimized mechanical properties

Issam Touil
Rania Saadeh
Mohamed Kezzar
ResearchOpen Access13 Jan 2026
Scientific Reports

Volume: 16, P: 1-18
Microbial signals in primary and metastatic brain tumors

A combination of high-resolution spatial imaging, spatial proteomics and transcriptional data reveals sparse and heterogeneous bacterial signals in gliomas and brain metastases.

Golnaz Morad
Ashish V. Damania
Jennifer A. Wargo
ResearchOpen Access14 Nov 2025
Nature Medicine

Volume: 31, P: 3675-3688
Over 0.1 W root-mean-square output achieved in magneto-mechano-electric generators using Mn-doped PIN-PMN-PT single crystals

Here, the authors report magneto-mechano-electric energy generation based on Mn-doped PIN–PMN–PT single crystals. Their device provides sufficiently high and stable output power density for efficient self-powered operation of wireless IoT systems and other large-scale energy harvesting applications.

Srinivas Pattipaka
Sung-Dae Kim
Geon-Tae Hwang
ResearchOpen Access11 Dec 2025
Nature Communications

Volume: 16, P: 1-13
Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer

An analysis of 18 metagenomic datasets of individuals with colorectal cancer, adenomas and healthy controls yields improved cancer prediction accuracy based solely on gut metagenomics, as well as the identification of new species associated with the development of cancer.

Gianmarco Piccinno
Kelsey N. Thompson
Nicola Segata
ResearchOpen Access03 Jun 2025
Nature Medicine

Volume: 31, P: 2416-2429
Discovery of a small molecule TLR3 agonist adjuvant

Adjuvants are an important component of modern vaccines. Here, the authors employ a phenotypic screen of ~200k compounds and identify PVP-057, a TLR3 agonist with a simple scalable 3-step synthesis, as an adjuvant that induces durable humoral and cellular immunity to varicella-zoster virus (VZV) gE in mice.

Branden Lee
Danica Dong
David J. Dowling
ResearchOpen Access04 Dec 2025
Nature Communications

Volume: 17, P: 1-17
Apparent Angular Sizes of Discrete Radio Sources: Observations at Jodrell Bank, Manchester

R. HANBURY BROWN
R. C. JENNISON
M. K. DAS GUPTA
Research20 Dec 1952
Nature

Volume: 170, P: 1061-1063
Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829
Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling

PD-L2 can bind the immune checkpoint PD-1. However, its potential as a therapeutic target for immune checkpoint blockade in cancer has not been extensively explored. Here, the authors demonstrate that αPD-L2 is effective in aged, but not young, melanoma murine models.

Carlos O. Ontiveros
Myrna G. Garcia
Tyler J. Curiel
ResearchOpen Access19 Nov 2025
Nature Communications

Volume: 16, P: 1-18
Rheological and mechanical performance of sustainable LC3 concrete modified with nano-silica and rubber latex

Badrinarayan Rath
T. R. Praveenkumar
Mitiku Adare Tufa
ResearchOpen Access28 Jan 2026
Scientific Reports

Volume: 16, P: 1-20
Distinguishing pairwise and higher-order interactions in coupled oscillators from time series

Rhythmic phenomena, ubiquitous in biological systems, are often modeled as networks of coupled limit-cycle oscillators. This study introduces an adaptive LASSO based approach to infer the interaction type-"including pairwise and higher-order interactions-" from time-series data, demonstrating its effectiveness on synthetic datasets and human brain network data.

Weiwei Su
Shigefumi Hata
Ryota Kobayashi
ResearchOpen Access31 Dec 2025
Communications Physics

P: 1-12
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database

Here the authors provide an explanation for 95% of examined predicted loss of function variants found in disease-associated haploinsufficient genes in the Genome Aggregation Database (gnomAD), underscoring the power of the presented analysis to minimize false assignments of disease risk.

Sanna Gudmundsson
Moriel Singer-Berk
Anne O’Donnell-Luria
ResearchOpen Access31 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

Tracy M. Bryan
Anna Englezou
Roger R. Reddel
Research01 Nov 1997
Nature Medicine

Volume: 3, P: 1271-1274
Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure

Pressure overload in the heart, such as from aortic stenosis, triggers early molecular changes before visible damage occurs. Here, the authors show that combining proteomics, transcriptomics, and genetic data reveals key drivers of heart failure, highlighting potential targets for treatment.

Brian R. Lindman
Andrew S. Perry
Sammy Elmariah
ResearchOpen Access26 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects

Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse populations.

Konrad J. Karczewski
Rahul Gupta
Alicia R. Martin
Research18 Sept 2025
Nature Genetics

Volume: 57, P: 2408-2417
Elucidating lipid nanoparticle properties and structure through biophysical analyses

Guidance for optimizing lipid nanoparticle formulations is derived using sophisticated biophysical techniques.

Marshall S. Padilla
Sarah J. Shepherd
Michael J. Mitchell
Research23 Oct 2025
Nature Biotechnology

P: 1-14
Local avalanche photodetectors driven by lightning-rod effect and surface plasmon excitations

This study presents an approach to enhancing the local field of avalanche photodetectors by integrating the lightning-rod effect with localized surface plasmon excitations.

Zhao Fu
Jia Liu
Rong Zhang
ResearchOpen Access03 Dec 2025
Nature Communications

Volume: 17, P: 1-9
Nucleo-Cytoplasmic Interactions in the Rat Liver Cell

E. R. GODWIN
K. R. REES
J. S. VARCOE
Research16 Oct 1965
Nature

Volume: 208, P: 246-247
Infra-Slow Rhythmic Oscillations of The Steady Potential of the Cerebral Cortex

N. A. ALADJALOVA
Research11 May 1957
Nature

Volume: 179, P: 957-959
Devonian Conodonts from Kashmir

V. J. GUPTA
F. H. T. RHODES
R. L. AUSTIN
Research01 Nov 1967
Nature

Volume: 216, P: 468-469
A pangenome and pantranscriptome of hexaploid oat

A pangenome of oat, assembled from 33 wild and domesticated oat lines, sheds light on the evolution and genetic diversity of this cereal crop and will aid genomics-assisted breeding to improve productivity and sustainability.

Raz Avni
Nadia Kamal
Martin Mascher
ResearchOpen Access29 Oct 2025
Nature

Volume: 649, P: 131-139
Monitoring biological effects of somatic cell genome editing

CRISPR-based genome editing therapeutics are entering the clinic, but in vitro and in vivo tools are needed to assess their safety and efficacy. The authors review complementary technologies to monitor the biological effects of genome editing across scales, including the direct measurement of editing outcomes in DNA, human microphysiological systems and non-invasive in vivo imaging.

Benjamin S. Freedman
Jeff W. M. Bulte
Shengdar Q. Tsai
Reviews13 Jan 2026
Nature Reviews Genetics

P: 1-20
Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

K. Bhatia
K. Huppi
I. Magrath
Research01 Sept 1993
Nature Genetics

Volume: 5, P: 56-61
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782
Global genomic population structure of wild and cultivated oat reveals signatures of chromosome rearrangements

Oat is an important food crop, but the genetic diversity within the gene pool remains unclear. Here, the authors report the analyses of worldwide diversity and population structure of hexaploid oat, and identify signatures of structural rearrangements within the germplasm collection.

Wubishet A. Bekele
Raz Avni
Nicholas A. Tinker
ResearchOpen Access29 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Use of Small-Size Plots in Sample Surveys for Crop Yields

P. C. MAHALANOBIS
Research30 Nov 1946
Nature

Volume: 158, P: 798-799
Radiative Thermal Conductivity in Planetary Interiors

J. R. ARONSON
S. W. ECKROAD
P. C. VON THÜNA
Research01 Dec 1967
Nature

Volume: 216, P: 1096-1097
Electrospun Ni-doped ZnO nanofiber coatings on carbon fabric for enhanced electromagnetic interference shielding

R. Suresha
Jagadeesh R. B. Chandra
B. Shivamurthy
ResearchOpen Access29 Dec 2025
Scientific Reports

Volume: 15, P: 1-13

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