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Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual colonization with probiotic E. coli.

Here proteomic chromatome analysis shows metabolic enzymes widely localize to chromatin in cancer in a tissue-specific manner. Nuclear enzymes affect DNA damage/repair and transcription, revealing non-canonical nuclear metabolic roles in cancer.

‘Populations residing near nuclear power plants may experience low-level chronic exposure to ionizing radiation through environmental release pathways. In here the authors find higher cancer mortality rates in U.S. counties closer to operational nuclear power plants, with the strongest relative risks observed in older adults.’

FOXA1 is a master suppressor of prostate cancer tumorigenesis and lineage plasticity. Here, the authors discover that FOXA1 loss in mice drives basal-squamous de-differentiation and remodels the tumor microenvironment characterized by immunosuppressive myeloid cell accumulation and T-cell dysfunction.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The circuit that the suprachiasmatic nucleus uses to control the daily glucocorticoids surge remains unknown. Here, authors show two parallel neural pathways from the hypothalamus that control the daily surge of corticosteroid by mapping the circuits from the SPZ and DMH to the PVH.

Three-body low-energy s-wave states play an important role in few-body physics and associated universal phenomena, yet their experimental observation in nuclear system has been elusive. Here, the authors identify the three-body s-wave properties in neutron-rich ¹⁰He nuclei with improved statistics and sensitivities.

Monoclonal antibodies (mAbs) represent a promising strategy as antiviral agents. Here, the authors selected four mAbs against Measles virus (MeV) and characterize their epitopes, specificities, and antiviral activities

In NIID, toxic polyG from NOTCH2NLC GGC repeats disrupts nucleoli and chromatin, causing DNA damage and senescence. Here, the authors show that ASOs targeting the repeats reduce polyG buildup and reverse damage, suggesting a new treatment.

Response to vagus nerve stimulation cannot currently be predicted, leaving many children to undergo implantation without benefit. We present a deep representation learning model using preoperative T1-weighted MRI to predict treatment response.

Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.

Authors demonstrate layer-selective conductor–insulator transitions in twisted bilayer graphene driven by hydrogenation, realising an electrochemical interface with two decoupled 2D electron gases that enables configurable logic gates.

Antibody mediated prevention (AMP) trials with the broadly neutralizing antibody VRC01 showed protection against VRC01-sensitive viruses. Here, by deep sequencing plasma samples from 172 participants of the AMP trials, the authors show a high frequency of multilineage HIV infections (38%), including coinfection with both sensitive and resistant viruses, and demonstrate that VRC01 doesn’t alter the transmission bottleneck.

Using advanced MRI modeling, this study found distinct spatial and pathophysiological signatures in vascular- and neurodegeneration-related white matter hyperintensities, clarifying their interpretation using clinically translatable methods.

Ribosome production depends on precise processing of precursor RNAs. Here, the authors present NanoRibolyzer, a nanopore-based method that maps rRNA processing and modifications at single-nucleotide resolution, revealing new intermediates and spatial processing dynamics.

Authors present a framework that harmonizes electronic health record data across hospitals by integrating medical knowledge, large language models, and graph learning. It enables cross-institutional analysis without sharing patient-level data.

Placenta plays a central role in prenatal development, yet it has been notably underrepresented in large-scale tissue-specific genomic and transcriptomic initiatives. Here, the authors generate a comprehensive placental transcriptome reference using long-read sequencing, revealing unexpected transcriptional complexity. Applied to gestational diabetes data, the reference identified pregnancy hormone isoforms mediating effects on newborn birth weight.

Mucosal barriers play critical roles in the interaction with commensal and pathogenic microbes. Here the authors show non-canonical IL-22 signalling results in mucosal remodelling in a murine model during the immune response to Candida albicans.

Recent studies have shown that probing the heating and ionization dynamics of solid-density plasmas with x-ray free-electron laser (XFEL) beams is inherently challenging. Here, the authors demonstrate sub-picosecond time resolution of solid-density Cu plasmas driven by an optical laser pulse, by combining resonant x-ray emission spectroscopy and absorption imaging from an XFEL probe beam.

MAU2’s role in Cornelia de Lange syndrome was unclear. Here, the authors identify pathogenic MAU2 variants that disrupt NIPBL–MAU2 function, define MAU2‑specific episignatures, and show variable CdLS‑related phenotypes, supported by a Mau2 knockout mouse model.

Analyses of snRNA genes in a French cohort of people with rare disorders, with validation through international collaboration, identify monoallelic and biallelic variants in RNU2-2 as frequent causes of neurodevelopmental disorders with epilepsy.

A range of humoral related adverse events can occur after treatment of haematological malignancy with chimeric antigen receptor cell therapies. Here the authors characterise the persistence of humoral immunity and response to vaccination after patients receive B cell targeted chimeric antigen receptor T cell therapy.

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.

The cellular origin and developmental trajectory of DICER1 syndrome-associated tumors are currently unknown. Here, the authors employ a lineage-traceable genetically modified mouse model for DICER1 syndrome to identify universal fibroblasts as the likely cellular origin of mouse Dicer1 sarcoma and map their developmental trajectory, findings that are validated in human DICER1 mesenchymal tumors.

Coronary artery disease has several genetic risk factors. Here, the authors develop a model that combines germline and somatic genetic drivers to predict coronary artery disease risk, identifying high-risk individuals not detected by polygenic risk scores alone.

Here the authors report real-world evidence through a retrospective analysis of a multinational cohort of 1.8 M older adults showing that GLP1RAs and SGLT2 inhibitors carry lower risk for hyperkalemia than sulfonylureas. However, SGLT2 inhibitors increased risk of ketoacidosis. Findings support safety-conscious prescribing for older adults, who are often underrepresented in clinical trials.

Ribosomal Protein S15 (RPS15) is recurrently mutated in B-cell leukemia but its leukemogenic role remains unclear. Here, the authors establish mutant RPS15 as a cancer driver and reveal mechanisms by which these mutations induce translational defects, DNA damage and genomic instability that together promote leukemogenesis.

This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

IMiD-based PROTACs may degrade IKZF1/3 with hematologic effects. This study profiles these liabilities using hematopoietic assays showing stem cell rewiring and interferon activation and introduces a CRBN ligand that reduces them.

This article presents a method capable of imaging the 3D orientation and lateral positions of fluorescent single-molecule labels in cells. It is applied to the 3D organization of actin filaments within complex, densely packed cellular networks.

Mirvetuximab soravtansine (MIRV) is an antibody drug conjugate comprised of a folate receptor alpha-targeted monoclonal antibody and the anti-tubulin maytansinoid payload, DM4. Here the authors report the results of a phase II trial of MIRV in combination with anti-PD1 pembrolizumab in patients with recurrent folate receptor alpha-positive uterine serous carcinoma.

Time crystals, which break time translation symmetry, have garnered significant interest in both quantum and classical systems due to their potential applications and fundamental implications. This study demonstrates the emergence of classical discrete space-time crystals in chiral liquid crystals, revealing the behavior of Majorana-like quasiparticles within facilitating period-doubling phenomena across various conditions.

Enhanced quasi-biennial variability of East Asian Summer Monsoon rainfall over the Yangtze River Basin, along with more frequent floods in recent decades, is linked to intensified and faster baroclinic wave activity in the tropical Indian Ocean.

Here, the authors show that strategies to restore host–microbiota symbiosis by preserving butyrate levels delay multimorbidity and extend lifespan in mice with mitochondrial dysfunction, in association with epigenetic remodeling in the intestine

Mitoxantrone is an FDA-approved anticancer drug that also acts as a general inhibitor of group I intron self-splicing. Here the authors show that Mitoxantrone repartitions RNA conformational ensembles rather than simply binding RNA, stabilizing specific GC-rich structures. This reduces 5′ UTR heterogeneity and increases translation efficiency.

Drug development is slowed down by manual formulation and testing. Here, the authors present an integrated digital formulator and self-driving tableting system that rapidly designs and manufactures tablets, thereby reducing material consumption and development time.

The mode of action of eukaryotic initiation factor 5A (eIF5A), a translation factor activated by hypusination, remains to be characterized. Here, the authors suggest that hypusinated eIF5A is involved in mitochondrial metabolism and translation promoting prostate cancer progression.

An early event after lung injury is extracellular matrix remodelling. Here, the authors show that thrombospondin-1 (TSP1) from megakaryocytes/platelets protects the lung’s extracellular matrix, particularly basement protein COL6. Mice without TSP1 had greater lung damage and neutrophil activity, showing TSP1 reduces injury severity.

Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

BUSGen is a foundation generative model designed for analysing breast ultrasound images that supports diverse tasks and improves breast cancer screening, diagnosis and prognosis.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

The impact of cooling through the Eocene-Oligocene transition on the marine biosphere is not well constrained. Here the authors construct a high-resolution record of foraminiferal species richness history spanning this transition that reveals differential diversity trends depending on foraminiferal habitat and life mode.

Solid-state synthesis of single-crystalline battery cathodes is widely used but remains poorly understood. Here, authors reveal competing multiscale chemical and structural processes during sintering that are crucial for understanding structure–property relationships and guiding materials optimization.

Marine photosynthetic organisms sense light underwater, yet the role of phytochromes has remained poorly understood. This study shows that phytochromes in a Phaeodactylum diatom drive a coordinated, light-dependent collective motion under blue or far-red light, suggesting a new mode of microbial communication.

In this work the authors employed deep learning-based methods to design mini-protein that block membrane insertion of complement C9. These well performed inhibitors provide an alternative approach for preventing diseases associated with abnormal complement activation.