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This study presents an electrolyte-free electrochemical system that leverages dual electrocatalytic zones to effectively remove a wide range of recalcitrant pollutants across various water matrices, including low-conductivity organic wastewater.

Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual colonization with probiotic E. coli.

Understanding how precise atomic structures govern catalytic activity remains a fundamental challenge. Now it has been shown that framework-encapsulated, molecularly defined polyoxometalate clusters enable clear structure–activity correlations and catalyse low-temperature CO₂ hydrogenation to methanol.

Interfacial water is of crucial importance in biology and engineering. Here, the authors identify structural transitions of interfacial water at graphite surfaces under varying electric fields and environmental conditions.

Researchers report real-time molecular detection of oxidized mercury species in the polar atmosphere, revealing discrepancies with current models and advancing understanding of neurotoxic mercury cycling in sensitive ecosystems.

Short-lived halogens have a substantial indirect cooling effect on climate and this cooling effect has increased since pre-industrial times owing to anthropogenic amplification of natural halogen emissions.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

In this study, the authors show that pulmonary fibroblasts act as dualfunction responders to the human-pathogenic fungus Aspergillus fumigatus, modulating immune responses while safeguarding tissue integrity.

The HIV-1 RNA-binding protein rev facilitates nuclear export of viral RNA. Here, the authors use native mass spectrometry to study the interactions between rev-derived peptides and rev response elements of HIV-1 RNA, providing mechanistic insights into rev recognition and recruitment.

Deletion of one allele of Rps19 or Rpl5 highlights how ribosomal proteins control fetal hematopoiesis. Imbalanced ribosomal protein stoichiometry disrupts developmental programs leading to pediatric disorders known as ribosomopathies.

The authors find that reconstructing the Moδ+ active site via multi-field coupling effectively boosts ammonia borane hydrolysis. They provide key insights into the plasmon polarization-induced carrier kinetics and hydrolysis mechanism.

A Hemostatic Tough Adhesive (HTA) is developed and evaluated, achieving hemostasis in both liver and spleen injuries within an in vivo preclinical porcine model.

This work effectively addresses the long-standing challenge of competitive kinetics in heterogeneous Fenton-like systems through the synergistic interaction between nitrogen vacancies (Nv) and Fe sites on carbon nitride.

Monoclonal antibodies (mAbs) represent a promising strategy as antiviral agents. Here, the authors selected four mAbs against Measles virus (MeV) and characterize their epitopes, specificities, and antiviral activities

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Response to vagus nerve stimulation cannot currently be predicted, leaving many children to undergo implantation without benefit. We present a deep representation learning model using preoperative T1-weighted MRI to predict treatment response.

Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.

The authors developed a microfluidic human stem cell model of the embryonic spinal cord. The model mimics complete dorsoventral patterning, reveals new retinoic acid-BMP signaling crosstalk, and enables direct tracking of neural crest cell migration.

Th17 cells play critical immunological roles and are exposed to oxidative stress but how the mechanisms behind how they deal with this are not well established. Here the authors suggest a role for Xeroderma Pigmentosum Complementation Group C in the protection of Th17 cells from oxidative stress in a murine model.

To determine causality between prenatal cannabis use and possible neurodevelopmental deficits, preclinical studies at relevant human fetal cannabinoid exposure must be conducted. Here the authors show these exposures which were successfully predicted by their maternal-fetal PBPK model.

Imaging strain in large catalytic particles with high precision remains a challenge. Here, the authors apply four-dimensional scanning transmission electron microscopy to map strain in perovskite-type hydroxides, revealing correlations that enable high-performance nitrate reduction to ammonia.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

The mycotoxin deoxynivalenol (DON) threatens global human and animal health. Here, the authors identify two key functional enzymes in a bacterium that initiate the complete degradation of DON to CO2, elucidating their core catalytic mechanisms and biotechnological application potential.

Terahertz emission spectroscopy on a ferromagnet–heavy metal heterostructure <3 nm thick reveals that orbital transport is confined to subnanometre scales.

Lactone monomers for recyclable polyesters are conventionally synthesized via endergonic, non-oxidative dehydrocyclization of fossil-derived diols in the vapor phase over precious-metal catalysts at elevated temperatures. Here, the authors demonstrate a low-temperature, solvent-free, oxidative route to lactones from bio-derivable liquid diols using earth-abundant calcium-copper mixed-metal oxide catalysts.

Combined Cdc42 loss and KRas activation trigger polarity-YAP-IL1/TNFα signaling to induce inflammation, stem cell loss, and necroptosis in mouse intestinal epithelia. Disrupting cell polarity in the context of an oncogenic insult causes a necrotizing enterocolitis-like disease.

The interplay between heavy fermion systems and geometric flat bands is often hindered by a scarcity of material realizations. Here, the authors report on the coexistence of geometrically frustrated flat bands and Kondo resonance states near the Fermi level in YbCr₆Ge₆.

Vaginal birth, exclusive breastfeeding and early contact with siblings promote colonization of the infant gut with bifidobacteria capable of producing aromatic lactates, a microbial and metabolite signal that is inversely related to the risk of allergen-specific sensitization and dermatitis later in life.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

DNA double-strand breaks are primarily repaired by non-homologous end joining, which requires synapsis of broken DNA ends. Here, the authors show that DNA end configurations, particularly short microhomologies, dictate synaptic complex formation and can bypass XLF to promote close end joining.

In healthy barrier tissues, type 3 lymphoid cells express IL-22 to maintain a protective immune balance, while IL-22 dysregulation contributes to disease. Here, the authors identify E22-1 and E22-2 as enhancers regulating IL-22 expression in health and disease; with E22-2 being restricted to IL-22 regulation in ILC3s.

An early event after lung injury is extracellular matrix remodelling. Here, the authors show that thrombospondin-1 (TSP1) from megakaryocytes/platelets protects the lung’s extracellular matrix, particularly basement protein COL6. Mice without TSP1 had greater lung damage and neutrophil activity, showing TSP1 reduces injury severity.

Cement production is one of the largest industrial sources of global CO2 emissions. This study presents an electrochemical process that recycles waste cement into hydrated lime for cement production, eliminating the need for limestone and reducing CO2 emissions by 99.8%

He et al. identified a cytosine hypermodification pathway in phage HY126. This pathway involves prereplicative deoxycytidine monophosphate hydroxylation and arabinofuranosylation, followed by postreplicative DNA arabinofuranosylation, and confers nuclease resistance.

A solar-powered strategy enables sustainable agriculture by integrating solar desalination, crop irrigation and food waste upcycling into an interconnected system, creating a circular economy for regions facing freshwater constraints.