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Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Analysing 30 cities worldwide, this study identifies bidirectional yet asymmetric causality between urban systems and traffic dynamics, revealing that urban systems more strongly shape mobility patterns than traffic feeds back into cities.

HELIX is a deep learning framework for modeling tissue- and context-specific RNA splicing and isoform usage, prioritizing splicing-altering genetic variants and their functional effects from bulk and single-cell RNA sequencing data.

Prime editing using non-canonical prime editing guide RNAs, where the reverse transcription template and primer binding site is integrated within the single guide RNA loops rather than attached to the 3′ ends of CRISPR–Cas guide RNAs, increases editing efficiency.

Du, Miao et al identify that the spatiotemporal recruitment and activation of Rab5 during early endosome formation are collectively determined by Rabex5/hRME6 recruitment and PI(4,5)P2 depletion during uncoated endocytic carrier formation.

A single-breath-hold 3D abdominal MRI technique (SSE-CEST) enables label-free mapping of glucose, glycogen and mobile protein in human liver, offering motion-robust, high-resolution imaging for cancer detection and metabolic monitoring.

Multidrug resistant tuberculosis (MDR-TB) is a major global health concern. This study uses novel phylogeographic approaches to determine the origin and global dispersion of a highly transmissible MDR-TB lineage first identified in Eastern Europe.

How site-specific tumor microenvironment (TME) drives the metastasis of high-grade serous ovarian cancer (HGSOC) remains unclear. Here, the authors employ an integrated single cell multi-omics approach to map the spatiotemporal heterogeneity of HGSOC metastasis TME and identify an interaction network within the TME driven by SELENOP⁺ macrophages and pre-exhausted CD8⁺ T cells.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

This study introduces a total atmospheric energy proxy into precipitation forecasts, improving extreme precipitation prediction at sub-seasonal and longer timescales. Moreover, it shows that the predictive value added by total energy has grown substantially in recent years.

Rice indica varieties have higher nitrogen use efficiency (NUE) than that of japonica varieties. Here, the authors show that natural variation of OsWRKY23 and its interaction with DULL NITROGEN RESPONSE1 (DNR1)-mediated auxin accumulation play a role in NUE divergence between the two rice subspecies.

Making phenols from lignocellulose without added hydrogen is attractive but typically requires high metal loadings and yields mostly saturated products. A single-atom Pt1Ni alloy converts birch sawdust to phenolic monomers with high yield and propenyl selectivity while leaving cellulose intact.

Human intracranial recordings reveal millisecond-scale visual flow from occipital cortex along parallel dorsal and ventral pathways to frontal and limbic regions, with category-specific dynamics for faces and places during novel visual processing.

Understanding the charge transfer at microbe–semiconductor interfaces in biohybrids is valuable for advancing solar-to-chemical conversion. Now, the reverse electron transfer in Shewanella–haematite hybrids is quantified using multimodal single-particle imaging, revealing facet-dependent efficiency.

Extensive measurements of the emissions of methane, nitrous oxide and ammonia from wastewater treatment facilities in the USA present higher values than are currently stated in national inventories. The results of this analysis show that greenhouse gas and nitrogenous emissions from the wastewater sector are often overlooked and that their impact on climate should be reassessed.

A potential premediator, 2-chloropyrimidine, could be a model material for molecular skeleton design enabling lithium–sulfur batteries to achieve a strong average capacity retention and help design functional molecules in broader organic chemical spaces.

Epitaxial CuO thin films exhibit crystal-symmetry-dependent orbital Rashba–Edelstein effects, enabling anisotropic orbital torque generation. The work reveals how crystal symmetry governs orbital angular momentum transport in oxide spintronic systems.

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

The genetic distance between parents influences hybrid performance in plants. Here Miller et al. show that Arabidopsishybrids produced from diverse parental ecotypes have reduced expression of stress responsive genes at certain times of the day and this correlates with greater biomass production.

This study shows that novelty exposure alleviates pain and anxiety in mice by activating a specific ensemble of neurons in the lateral hypothalamus, revealing distinct neural circuits that mediate the therapeutic benefits of attention distraction.

Palaeoproteomic analysis of ancient enamel proteins extracted from Middle Pleistocene Homo erectus specimens from the Zhoukoudian, Hexian and Sunjiadong sites in China suggests that they are a new genetic monogroup, and super-archaic introgression in Denisovans is likely to have originated from H. erectus.

Electric-field-controllable, stochastic alteration of multiple conductance states in a Sc₂C₂@C₈₈ cluster is observed. A matrix-chain multiplication of two 4 × 4 state-transition matrices is demonstrated using this cluster with maximum error of less than 0.05.

A cross-organ, multi-omics U-shaped relationship between sleep duration and biological ageing clocks highlights the potential of sleep optimization to promote healthy ageing, lower disease risk and extend longevity.

Widely used, effective methods to prevent adhesions after digit flexor tendon injury are lacking. Here, authors develop a bioresorbable, supramolecular hydrogel as a lubricating barrier to preserve tendon biomechanics and improve functional recovery.

Understanding dynamic heterogeneity in hydrogen evolution electrocatalysts is essential but difficult with limited spatio-temporal resolution. Here the authors use interferometric electro-optical microscopy to achieve nanometre–millisecond imaging of hydrogen evolution activity on MoS₂.

This study reveals that TOPOISOMERASE1 ALPHA inhibits lateral root primordium initiation in Arabidopsis by stabilizing a DNA G-quadruplex in CYP82C4, uncovering an epigenetic control over the reprogramming of pericycle cells into stem cells.

An integrated carbon nanotube sensor platform enables room-temperature gas detection with tunable selectivity and supports label-free classification of clinically relevant microorganisms for scalable, low-cost sensing applications.

Circadian redox oscillations in the rhizosphere are shown to generate methane in the presence of oxygen, revealing a chemical pathway contributing to paddy methane emissions, according to incubation experiments, geochemical analyses and machine-learning upscaling.

Hu et al. show that the transmembrane glycoprotein CD98hc in cerebral endothelial cells regulates the integrin–FAK signaling pathway, thereby promoting angiogenesis and maintaining blood–brain barrier integrity.

Zhu et al. have developed DeepFAN, a transformer-based deep learning model for diagnosis of incidental pulmonary nodules from computed tomography scans, and evaluated it for human–artificial intelligence collaboration in a multireader, multicase clinical trial.

The experimental observation of a fundamentally new type of anomalous Hall effect that couples both in-plane and out-of-plane orbital magnetizations in multilayer rhombohedral graphene is reported.

Parasitoid wasps are reared and released as biocontrol agents to manage aphids and protect crops. Here, the authors use genomes from 542 wasps to show that, in spite of wide scale release of low-diversity captive individuals, diversity in wild populations is maintained.

Reversible solid oxide cells can be limited by the kinetics of the reactions occurring at the oxygen electrode. Here the authors show that compositing a Gd_0.3Ca_2.7Co_3.82Cu_0.18O_9−δ catalyst with a balanced oxygen-ion- and hole-conducting BaCe_1−xZr_xO₃-based material leads to enhancements in performance.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Ma et al. report a laser polishing and surface reconstruction strategy to improve the surface quality of micron-thick Pb-Sn narrow-bandgap perovskites, enabling single-junction and all-perovskite tandem solar cells with efficiencies of 23.47% (certified) and 29.80%, respectively, by the antisolvent-free method.

Image-based drug discovery relies on uncovering how cells respond to treatments. Here, authors introduce PhenoProfiler, an end-to-end AI framework that converts high-content cellular images into quantitative phenotypic profiles, achieving superior accuracy, robustness, and generalisability.

Here the authors present a photoinduced Mn(II)-bipyridine catalyzed cross-coupling reaction between aryl halides, particularly less-reactive aryl chlorides, and nucleophiles containing nitrogen, oxygen, and sulfur.