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When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Recovery of 48 bat and 9 horse HeV genomes from Australia (2016–2020) identified four Hendra virus clades, offering insights into evolutionary dynamics.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Previous studies have shown the importance of unidirectionally aligned domain nucleation for the growth of 2D semiconductor single crystals. Here, the authors report the observation of a self-alignment process of misoriented domains during the metal-organic chemical vapour deposition growth of 2D MoS₂ on sapphire, leading to single-crystalline films with improved carrier mobility.

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.

A widespread bacterial defence system called SNIPE is shown to localize to the cell membrane, where it identifies and cleaves the DNA of infecting phage as it is injected into the bacterial cell.

Dihydronicotinamide riboside, NRH, is a potent NAD precursor, yet its effects in vivo are poorly defined. Here the authors show that NRH prevents and treats diet-related metabolic damage, but these benefits can be halted by toxicity at high NRH doses

Confinement effects enable the design of intersubband polaritons (ISPs) in semiconductor quantum wells (QWs), but this type of light-matter excitations has been rarely explored in van der Waals materials. Here, the authors report the observation of hyperbolic ISPs in WO_x/WSe₂ QW heterostructures with electrically tunable dispersions.

Polyamides (PAs) or nylons are types of plastics with wide applications, but due to their accumulation in the environment, strategies for their deconstruction are of interest. Here, the authors screen 40 potential nylon-hydrolyzing enzymes (nylonases) using a mass spectrometry-based approach and identify a thermostabilized N-terminal nucleophile hydrolase as the most promising for further development, as well as crucial targets for progressing PA6 enzymatic depolymerization.

It remains unclear why some BRCA-deficient high-grade serous carcinomas (HGSC) do not respond to platinum-based therapy. Here, multi-omic analysis of BRCA1- and BRCA2-deficient HGSC attributes co-occurring mutations, DNA repair deficiency and tumor microenvironment features to short survival in these patients.

People often change their preferences to conform with others. Using a longitudinal design, the authors show that such conformity decreases over the course of adolescence and that this reduction in conformity is accompanied by a decreasing degree of uncertainty about what to like.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Analyses of snRNA genes in a French cohort of people with rare disorders, with validation through international collaboration, identify monoallelic and biallelic variants in RNU2-2 as frequent causes of neurodevelopmental disorders with epilepsy.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

B cell receptors (BCR) are the membrane-bound counterparts of antibodies, and the role of N-linked glycans in their functions are much less known than that of circulating immunoglobulins. Here authors study the site-specific glycosylation profiles of all 4 N-linked glycosylation sites of human Igµ BCRs expressed in naïve and memory B cells and conclude that these show high level of conservation across development and don’t contribute to differences in their expression and function.

Precision oncology requires access to high quality data, as well as the application of current technologies. Here, the authors use federated learning to predict clinical outcomes in anal cancer patients across 16 centres as part of the atomCAT consortium.

NV center-based quantum sensors integrated into diamond anvil cells have enabled magnetic imaging under high pressure but are less suited for studying magnetic van der Waals materials. Here, the authors demonstrate magnetic imaging of micrometer-sized flakes of 1T-CrTe2 under high pressure using spin-centers in a thin hBN layer.

Glasses characterized by solid-like dynamics yet liquid-like order are described as a phase out of equilibrium. Besseling et al. show a new equilibrium glass-forming rotator phase with glass-like positional coordinates and liquid-like rotations, reversibly switchable to a crystal under an electric field.

In most van der Waals ferromagnets, reducing the number of layers reduces the Curie temperature. Here, Chuang et al., find that Cr₂Se₃ has an increased Curie temperature for thinner samples, and through angle-resolved photoemission spectroscopy they attribute this to differences in the valley carrier density in different thickness samples.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Genetic analyses in more than 15,000 individuals from across the Americas, including individuals with autism and family members, define the genetic landscape of autism in Latin American populations and identify significant overlap with other ancestries.

Cooling efficiency in thermoelectric devices decreases considerably at lower temperatures. Now thermoelectric cooling at cryogenic temperatures is directly imaged in a van der Waals semimetal.

Genome-wide analysis coupled with long-read sequencing identifies a repeat expansion in GOLGA8A associated with high risk for atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions.

Drivers of fungal metabolic diversity are incompletely understood. Here, the authors conduct a global genomics study of over 1,000 pathogenic fungi to show that geography shapes the metabolic diversity in Aspergillus flavus revealing how climate drives fungal chemical adaptive evolution.

A tissue-engineered esophageal segment is functional in minipigs.

Previous work has shown the existence of spin-orbit-entangled excitons and their coupling to antiferromagnetism in the correlated insulator NiPS₃. Here the authors show that non-equilibrium driving of these excitons produces a transient metallic antiferromagnetic state that cannot be achieved by tuning the temperature in equilibrium.

Ultrafast electron imaging shows full phase-space dynamics of optical singularities, which can reach superluminal velocities before annihilation and break the particle-like analogy of topological defects.

How the multiple manifestations of vascular aging cluster and predict overt cardiovascular disease (CVD) is unknown. Here, the authors identify three patterns of vascular aging, showing their independent association with incident CVD, and their added value for stroke risk stratification.

After performing a focused CRISPR–Cas9 screen, Skafar et al. identify riboflavin (vitamin B₂) as a regulator of FSP1 stability that modulates phospholipid peroxidation and ferroptosis sensitivity in cancer cells.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Hodgson, Huang, Lang et al. show that TDP-43 limits ribonucleoprotein particle condensation into paraspeckles in a concentration- and polymerization-dependent manner. They also link paraspeckle condensation to stress response and neuroprotection.

A nano-optical probe of the Purcell effect in a van der Waals waveguide is demonstrated, exploiting its highly confined infrared waveguide modes and the capacity for infrared emission in the monolayer limit of atomically layered van der Waals materials.

Van der Waals materials can exhibit strong coupling between the lattice and other degrees of freedom. Here, Ergeçen et al reveal the presence of bound states emerging from the strong interaction between the lattice vibrations and d-orbitals in the van der Waals antiferromagnet NiPS₃.

Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.

Frank et al. introduce Euclidean fast attention, a linear-scaling framework for 3D data. By leveraging Euclidean rotary encodings, the method overcomes the quadratic cost of standard attention to accurately capture long-range effects in physical systems.

The authors observe strong coupling between valley excitons in a monolayer WS2 and intrinsically chiral photons shaped by a metasurface. The polaritons display enhanced chiral emission with their spin configuration controlled by the light source.

Electric field gradients (EFGs) have the potential to significantly influence fluid behavior in various natural and technological contexts, yet their effects on polar fluids at the microscopic level have been largely unexplored. This study introduces the concept of “dielectrocapillarity,” demonstrating that EFGs can be harnessed to finely control fluid structure, phase transitions, and capillary effects, thereby enhancing fluid uptake in nanoporous materials.

Longitudinal metatranscriptomics in a prospective cohort of 1,164 adults hospitalized for COVID-19 reveals that azithromycin offered no apparent anti-inflammatory benefit but enriched the respiratory microbiome with potential pathogens and antimicrobial resistance genes.

Superconductivity has been discovered in atomically thin two-dimensional van der Waals materials by resistance measurements, but magnetic measurements are lacking. Here, the authors use a micron-scale SQUID magnetometer to measure the superfluid response of exfoliated MoS₂.

Artificial intelligence (AI) could help improve risk predictions in acute leukaemia and reduce systemic health disparities in the diagnostic process. Here, the authors assemble a diverse, international cohort of 6,206 patients with acute leukaemias and deploy an AI tool to support diagnosis based on standard laboratory results, with refinements for both adult and peadiatric leukaemias.

Element-element bonded multiply charged cationic species are well known as dimers or small cyclic oligomers in the condensed phase but the smallest acyclic version, a trinuclear unit possessing greater than a monocationic charge, has remained elusive. Here the authors report a bis(phosphine) supported low valent triantimony-based tricationic compound.

Helimagnetic materials host a twisted magnetic texture, realizing screws, cycloids, and cones. While helimagnets are common in three dimensional materials, layered van der Waals helimagnets are exceedingly rare. Here, Akatsuka et al. demonstrate conical ordering in the easily cleavable magnet DyTe3.

Optical spin orientation of itinerant ferromagnets in twisted MoTe₂ homobilayers is demonstrated, enabling control of topological Chern numbers with circularly polarized light.

The spontaneous topological Hall effect, combining non-coplanar antiferromagnetic order with finite scalar spin chirality in the absence of a magnetic field, is now experimentally demonstrated for the triangular lattice compounds CoTa₃S₆ and CoNb₃S₆.

Each valley of the mini-Brillouin zone ("mini valley") of twisted bilayer graphene (TBG) contains two Dirac cones that hybridize to form flat bands. Theory predicts that these two Dirac cones have the same chirality, leading to topological obstruction. Here, the authors confirm this prediction experimentally.

Ideal tunnel junctions require high-quality, defect-free insulating barriers. Here, the authors demonstrate that van der Waals tunnel barriers atop bulk and ultrathin superconducting NbSe₂ sustain a stable tunneling current and allow mapping of the spectral evolution of layered superconductors.

Recent studies have reported the exceptional plasticity of InSe van der Waals crystals, but their deformation-correlated lattice dynamics remains unexplored. Here, the authors investigate the correlations of plastic interlayer slip, lattice anharmonicity and thermal transport in β-InSe crystals via neutron scattering techniques.

Boron-dipyrromethenes (BODIPYs) are fluorophores applicable for imaging and sensing, though are sensitive to acidic deboronation. Here the authors design macrocyclic BODIPYs resistant to acid, and have stable photophysical properties.