Nature Search

Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex

Cells rely on ER-associated degradation (ERAD) to eliminate misfolded proteins. Here, the authors report the cryo-EM structure of the mammalian SEL1L-HRD1 ERAD core complex, revealing a dimeric architecture and explaining how disease-linked mutations disrupt protein quality control.

Liangguang Leo Lin
Emir Maldosevic
Ling Qi
ResearchOpen Access27 Jan 2026
Nature Communications

P: 1-15
UV radiation from the young Sun and oxygen and ozone levels in the prebiological palaeoatmosphere

V. M. Canuto
J. S. Levine
C. L. Imhoff
Research01 Apr 1982
Nature

Volume: 296, P: 816-820
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Zhishan Chen
Wenqiang Song
Xingyi Guo
ResearchOpen Access15 Jan 2026
Nature Communications

P: 1-15
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
AKAP95 condensates regulate transcription and can be targeted in MLL-fusion driven oncogenesis

The role of RNA-binding protein (RBP) phase separation in transcriptional regulation and its contribution to tumorigenesis remains to be characterised. Here, the authors show that RBP AKAP95 physically co-condenses with the mixed lineage leukemia 1 (MLL1) translocated fragment commonly found in MLL rearranged (MLLr) leukemia to promote leukemogenesis.

Xiang Yan
Yongkun Luan
Wei Li
ResearchOpen Access07 Jan 2026
Nature Communications

P: 1-15
The young Sun and the atmosphere and photochemistry of the early Earth

V. M. Canuto
J. S. Levine
M. S. Giampapa
Research22 Sept 1983
Nature

Volume: 305, P: 281-286
Magnetic monopoles and the solar neutrino problem

J. S. Trefil
H. P. Kelly
R. T. Rood
Research10 Mar 1983
Nature

Volume: 302, P: 111-113
Chemical Constituents of Interstellar Clouds

DAVID BUHL
Research10 Dec 1971
Nature

Volume: 234, P: 332-334
Neutrinos from the primary proton–proton fusion process in the Sun

Spectral observations of the low-energy neutrinos produced by proton–proton fusion in the Sun demonstrate that about 99 per cent of the Sun’s power is generated by this process.

G. Bellini
J. Benziger
G. Zuzel
Research27 Aug 2014
Nature

Volume: 512, P: 383-386
Full-Sun observations for identifying the source of the slow solar wind

Both fast and slow solar winds emanate from our Sun, although the source of the slow component remains elusive. Towards identifying this, Brooks et al. present full-Sun spectral images from Hinode, combined with magnetic modelling, to produce a solar wind source map.

David H. Brooks
Ignacio Ugarte-Urra
Harry P. Warren
ResearchOpen Access06 Jan 2015
Nature Communications

Volume: 6, P: 1-9
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
Astrophysics: Neutrinos and the Sun

Virginia Trimble
News & Views18 Oct 1984
Nature

Volume: 311, P: 608-609
Experimental evidence of neutrinos produced in the CNO fusion cycle in the Sun

Direct experimental evidence of the carbon–nitrogen–oxygen fusion cycle in the Sun is provided by the detection of neutrinos emitted during this process.

M. Agostini
K. Altenmüller
G. Zuzel
Research25 Nov 2020
Nature

Volume: 587, P: 577-582
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID

Li and colleagues describe a monocyte-specific transcriptional state along with a persistent elevation of inflammatory markers specifically found in individuals with long COVID who had mild-to-moderate disease during acute SARS-CoV-2 infection.

Saumya Kumar
Chaofan Li
Yang Li
ResearchOpen Access14 Jan 2026
Nature Immunology

P: 1-13
Cross-ancestry comparison of aptamer and antibody protein measures

Affinity-proteomics platforms often yield poorly correlated measurements. Here, the authors show that protein-altering variants drive a portion of inter-platform inconsistency and that accounting for genetic variants can improve concordance of protein measures and phenotypic associations across ancestries.

Jayna C. Nicholas
Daniel H. Katz
Laura M. Raffield
ResearchOpen Access22 Jan 2026
Nature Communications

Volume: 17, P: 1-21
Prebiotic chemistry and atmospheric warming of early Earth by an active young Sun

An energetic process is needed to convert N₂ into compounds essential for life. Simulations show that interactions between powerful solar flares and Earth’s magnetic field could have facilitated nitrogen fixation in the early atmosphere.

V. S. Airapetian
A. Glocer
W. Danchi
Research23 May 2016
Nature Geoscience

Volume: 9, P: 452-455
Population ecology and biogeochemical implications of ssDNA and dsDNA viruses along a permafrost thaw gradient

The potential roles of viruses in microbial-induced permafrost thaw, which is accelerated by climate change, are unclear. Here, Trubl et al. sample a permafrost thaw gradient and identify thousands of new viruses carrying genes with metabolic-related functions, which might influence the fate of stored carbon.

Gareth Trubl
Simon Roux
Virginia I. Rich
ResearchOpen Access11 Dec 2025
Nature Communications

Volume: 17, P: 1-15
An aberrant immune–epithelial progenitor niche drives viral lung sequelae

CD8⁺ T cell–macrophage interactions have a central role in impairing alveolar regeneration and driving fibrotic sequelae after acute viral pneumonia in a mouse model of long COVID.

Harish Narasimhan
In Su Cheon
Jie Sun
Research04 Sept 2024
Nature

Volume: 634, P: 961-969
Why do Bedouins wear black robes in hot deserts?

Amiram Shkolnik
C. Richard Taylor
Arieh Borut
Research24 Jan 1980
Nature

Volume: 283, P: 373-375
Distinct type 1 immune networks underlie the severity of restrictive lung disease after COVID-19

This study presents a comprehensive immunological assessment of post-coronavirus disease (COVID) respiratory illness, finding signatures potentially associated with recovery and candidate biomarkers for more severe lung disease.

Glenda Canderan
Lyndsey M. Muehling
Judith A. Woodfolk
Research26 Mar 2025
Nature Immunology

Volume: 26, P: 595-606
Solar models with rotating cores

R. T. ROOD
R. K. ULRICH
Research29 Nov 1974
Nature

Volume: 252, P: 366-368
Electrified black holes

E. R. Harrison
Research01 Dec 1976
Nature

Volume: 264, P: 525-528
Detection of stratospheric HNO₃ and NO₂ response to short-term solar ultraviolet variability

G. M. Keating
J. Nicholson III
M. Pitts
Research03 Jul 1986
Nature

Volume: 322, P: 43-46
Non-biogenic fixed nitrogen in Antarctic surface waters (reply)

B. C. PARKER
L. E. HEISKILL
EDWARD J. ZELLER
Research02 Nov 1978
Nature

Volume: 276, P: 97
The Remarkable Sunsets

W. G. BROWN
Research31 Jan 1884
Nature

Volume: 29, P: 309
X- or γ rays from Supernovae in glacial ice

Robert T. Rood
Craig L. Sarazin
Bruce C. Parker
Research13 Dec 1979
Nature

Volume: 282, P: 701-703
Preliminary Results from a Meteorological Rocket Experiment

ROBERT M. HENRY
RODERICK S. QUIROZ
Research20 Jun 1970
Nature

Volume: 226, P: 1108-1110
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Mechanism of Turbulent Friction Reduction in Pipes by Dissolved Additives

WILLIAM SQUIRE
WALTER CASTRO
JAMES COSTRELL
Research11 Mar 1967
Nature

Volume: 213, P: 1008-1009
Immunological and Polyionic Interaction in Polyacrylamide Gel

H. F. MENGOLI
ALVIN L. WATNE
Research29 Oct 1966
Nature

Volume: 212, P: 481-483
Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells

Reduced fitness of the tumor microenvironment is mediated by a long non-coding RNA expressed in tumors.

Esha Madan
António M. Palma
Rajan Gogna
Research09 Dec 2024
Nature Biotechnology

Volume: 43, P: 1833-1847
10-cm Observations of Venus near Superior Conjunction

F. D. DRAKE
Research01 Sept 1962
Nature

Volume: 195, P: 894
Observations of the Crab Pulsar during an Occultation by the Solar Corona

SAMUEL J. GOLDSTEIN JUN.
DAVID D. MEISEL
Research25 Oct 1969
Nature

Volume: 224, P: 349-350
Ubiquitination by HRD1 is essential for TLR3 trafficking and its innate immune signaling

E3 ubiquitin ligase HRD1, a core component of the ER-associated degradation (ERAD) pathway, is essential for the TLR3-mediated innate immune response. HRD1 catalyzes polyubiquitination of TLR3 at lysine 813, which promotes its trafficking to endolysosomes and enables its proteolytic cleavage and functional activation.

Lianfeng Zhao
Zinan He
Tingbo Liang
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-19
Determination of the spin and parity of all-charm tetraquarks

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A. Hayrapetyan
V. Makarenko
A. Snigirev
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 58-63
Design behaviour for sustainability

An international expert panel probes how engineers, architects and behavioural scientists can work together to learn about design behaviour for sustainability — and what all interested scholars and practitioners might learn from it.

Leidy Klotz
John Pickering
Elke U. Weber
Comments & Opinion09 Dec 2019
Nature Sustainability

Volume: 2, P: 1067-1069
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Iridescent Clouds

W. G. BROWN
C. PIAZZI SMYTH
Research05 Feb 1885
Nature

Volume: 31, P: 315-316
Search for light sterile neutrinos with two neutrino beams at MicroBooNE

Data obtained from the MicroBooNE liquid-argon time projection chamber are used to exclude the single light sterile neutrino interpretation of the LSND and MiniBooNE anomalies at the 95% confidence level.

P. Abratenko
D. Andrade Aldana
C. Zhang
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 64-69
Chemistry of the solar neutrino problem

KENNETH C. JACOBS
Research14 Aug 1975
Nature

Volume: 256, P: 560-561
Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells

Travis Jerde
Zhong Wu
Wade Bushman
ResearchOpen Access01 Apr 2010
Nature Precedings

P: 1
Impact of common variants on brain gene expression from RNA to protein to schizophrenia risk

By integrating a ribo-seq dataset of 195 individuals with RNA-seq and proteomics data from the same cohort, researchers found prevalent post-transcriptional attenuation of eQTL effects and identified omic-specific QTLs associated with schizophrenia.

Qiuman Liang
Yi Jiang
Sidney H. Wang
ResearchOpen Access28 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Jupiter's rings

Tobias Owen
G. Edward Danielson
Thomas C. Duxbury
Research11 Oct 1979
Nature

Volume: 281, P: 442-446
Radio Observations of the Distribution of Chromospheric Brightness Temperature

M. SIMON
D. BUHL
C. ZAPATA
Research20 Jun 1970
Nature

Volume: 226, P: 1154-1155
Variations in the Flux Density of Some Quasi-stellar Sources

K. I. KELLERMANN
I. I. K. PAULINY-TOTH
Research11 Mar 1967
Nature

Volume: 213, P: 977-980
Ratiometric detection of perfluoroalkyl carboxylic acids using dual fluorescent nanoparticles and a miniaturised microfluidic platform

Legislative measures and an increased need for remediation of perfluoroalkyl substances (PFOA) require effective on-site analytical methods. Here the authors develop a green-fluorescent guanidine-BODIPY indicator monomer incorporated into a molecularly imprinted polymer for the selective detection of PFOA and related compounds.

Yijuan Sun
Víctor Pérez-Padilla
Knut Rurack
ResearchOpen Access02 Dec 2025
Nature Communications

Volume: 16, P: 1-16
Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39

Microglia and border-associated macrophages play a role in regulating cerebral blood flow (CBF), but the underlying mechanisms are unclear. Here, the authors show a role for microglial CD39 in the regulation of basal CBF and neurovascular coupling.

Zhongxiao Fu
Mallikarjunarao Ganesana
Chia-Yi Kuan
ResearchOpen Access22 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Genetic effects on gene expression across human tissues

Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

François Aguet
Andrew A. Brown
Jingchun Zhu
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 204-213
A High Rainbow

SIDNEY T. MORELAND
Research16 Jun 1898
Nature

Volume: 58, P: 151
Comprehensive measurement of pp-chain solar neutrinos

All components of the proton–proton nuclear fusion chain, in which hydrogen is converted into helium in the Sun, are described, with several implications for fundamental solar and particle physics.

M. Agostini
K. Altenmüller
G. Zuzel
Research24 Oct 2018
Nature

Volume: 562, P: 505-510

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