Search

Diverse AI models empower pathology, but varying downstream performance complicates selection and data barriers prevent joint pretraining. Here, authors propose Meta-Encoder, unifying multiple foundation models to achieve superior cancer detection and molecular predictions.

Pathological mechanisms underlying the onset and progression of PTSD (post-traumatic stress disorder) are not fully understood. Here authors show that stress-induced Sgk1 upregulation in basolateral amygdala neurons projecting to the hippocampus as a key mechanism underlying the delayed PTSD-like avoidance behavior in mice.

Twisted 2D transition metal dichalcogenides (TMDs) have attracted significant attention due to their emerging physical properties, but their bottom-up synthesis remains challenging. Here, the authors report a heating rate-controlled chemical vapour deposition method to grow various TMD heterostructures with improved control over the twist angle.

Lipoatrophy is a feature of premature aging, including in a rare genetic form of premature aging caused by a mutation in A-type lamin gene (Lmna). Here the authors report that adipocyte-specific expression of the LmnaG609G mutation leads to progressive white adipose tissue atrophy, accelerated aging and shortens lifespan mediated by cyclooxygenase-2 in male mice, whereas female mice remain unaffected.

The study reports on a peritectic engineering strategy to achieve enhanced electrical performance in InSb thermoelectrics. This material platform enables smart prosthetics with machine learning-assisted tactile sensing and messaging capabilities.

Electronic skins are capable to monitor stimuli such as temperature and pressure, though they are susceptible to crosstalk diminishing sensitivity. Here the authors report a mechanically and electronically hybrid network using vanadium oxide and liquid metal particles to optimize selectivity and sensitivity.

Rare cancers can be challenging to diagnose from imaging due to limited data and previous expert experience. Here, the authors develop the PathPT framework to improve subtyping and tumour localisation.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

Achieving high power scaling in ultrawide bandgap electronics remains challenging. Here, the authors present a Ga₂O₃ module using a high permittivity interface that enables fast megawatt pulsed switching with improved thermal performance.

Efficient cryogenic electronics are essential for quantum computing at millikelvin temperatures. Yang et al. report a SiC-based negative differential resistance device with high on/off ratio at millikelvin and demonstrate programmable cryogenic neuromorphic circuits including sensory, logic and spiking neurons.

High-performance battery materials often degrade during standard cleaning processes. Here, the authors identify why water washing causes structural collapse in sodium-based oxides and demonstrate that ethylene glycol can safely remove impurities while maintaining the material’s integrity.

HorusEye is a foundation model for universal X-ray tomography restoration that learns realistic degradation directly from data. It supports imaging at substantially lower doses and reduces hardware requirements while improving expert analysis and downstream AI performance.

Grand anti-desertification schemes often fail when trees die and funding dries up — yet one project has broken the mould.

Both endogenous and exogenous signaling pathways are involved in the maintenance of self-renewal and pluripotency of human embryonic stem cells (hESCs). Here, the authors uncover that endogenous VEGF signaling safeguards pluripotency and prevents extra-embryonic differentiation in primed hESCs via activation of transcription factor NANOG and suppression of BMP signaling activity.

This study reveals that Amphotericin B activates glucocerebrosidase to remodel late endosomal lipid and protein composition, promoting respiratory viral entry. This highlights a risk of secondary viral infections during antifungal therapy.

By assembling into ‘virion vesicles’, the H129 strain of herpes simplex virus-1 hijacks synaptic machinery for its anterograde spread, co-opting voltage-gated Ca²⁺ channels, Syt7 and SNAREs for presynaptic exit, then nectin-1/CME for postsynaptic entry.

Prime editing using non-canonical prime editing guide RNAs, where the reverse transcription template and primer binding site is integrated within the single guide RNA loops rather than attached to the 3′ ends of CRISPR–Cas guide RNAs, increases editing efficiency.

This study reveals that tissue redox rhythms are altered in ageing mice but can be restored through time-restricted application of antioxidants or pro-oxidants, leading to improved physiological functions and ameliorated ageing-related impairments.

The vinylcyclopropane–cyclopentene (VCP–CPent) rearrangement is a fundamental method for constructing five-membered carbocycles from vinylcyclopropanes. Now an enantioconvergent VCP–CPent rearrangement has been developed, enabling the conversion of racemic VCP into chiral cyclopentene products. Vessel-controlled chemodivergence selectively delivers either gem-difluorocyclopentenes or cyclopentenones from identical substrates.

Chen, Cai et al., present a rigorous human-in-the-loop framework for evaluating the medical performance of AI-generated responses to real clinical questions, using a scale aligned with physician career stages. Although some models perform at levels comparable to early-career physicians, substantial rates of incompetent answers and hallucinations demonstrate that unmonitored clinical deployment remains risky, underscoring the continuing need for expert oversight.

A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.

Administrative-driven hierarchical management (ADHM) encourages general practitioners to act as voluntary gatekeepers in China’s non-mandatory medical system. Here the authors show that ADHM lowers cardiovascular events, mortality, and healthcare costs in atrial fibrillation patients compared with usual care.

In a prospective multi-centre cohort in China, people living in areas of high soil selenium had a 35% increased risk of incident diabetes over a 3-year study period, with a stronger effect seen for men.

The weak contact between the oxide electrode and molecular layer in inverted perovskite solar cells is prone to deformation, limiting long-term device stability. A bulk nano-heterointerface is designed to strengthen the binding force between molecules and spherical silicon oxide nanoparticles, increasing the interfacial contact area and improving the operational stability of perovskite solar cells.

SnRK1β1A in rice promotes susceptibility to multiple fungal diseases, and disrupting this infection-inducible gene confers broad-spectrum resistance without compromising growth or yield under normal field conditions.

Bone marrow ssDNA, specifically EHBP1-ssDNA, drives prostate cancer bone metastasis via integrin α6-FAK signaling, and Defactinib blocks this pathway.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

In vivo base editing of a causative mutation that leads to the neurodevelopmental disorder Snijders Blok–Campeau syndrome restores protein dosage and ameliorates molecular and behavioural deficits in a humanized mouse model of the condition.

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N⁶-methyladenosine (m⁶A) sites that are important for prostate cancer cells and validate the role of a top m⁶A target, CHD9, in this context.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.