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A recent randomised controlled trial demonstrated effectiveness of a smart pillbox for oral HIV pre-exposure prophylaxis adherence in men who have sex with men in China. Here, the authors show that the intervention is cost effective, with greater benefits for more socially vulnerable groups.

This study demonstrates that the reduced serum serine in patients with chemotherapy or women with poor sleep, is linked to the decline of ovarian function. Serine supplementation prevented ovarian damage in mice by inhibiting ferroptosis in ovarian granulosa cells, without affecting chemotherapy efficacy.

Metal-cation-free CO₂ electroreduction in strong acid minimizes reactant loss and salt precipitation yet struggles with CO₂ activation and hydrogen evolution competition. Here, the authors report bioinspired sharp gold triangles with a proton-blocking layer that polarize CO₂ and suppress hydrogen evolution.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Floquet engineering is often limited by weak light–matter coupling and heating. Now it is shown that exciton-driven fields in monolayer semiconductors produce stronger, longer-lived Floquet effects and reveal hybridization linked to excitonic phases.

Therapeutic suppressor tRNAs are engineered to broaden their target range in vivo.

Chen et al. identify a brain-to-bone communication axis whereby extracellular vesicles from aged brain neurons transport WDFY1 protein to distal bone, driving bone-fat imbalance and promoting osteoporosis.

Using magnetic tweezers and atomistic simulations, the authors investigated RNA dynamics and uncovered how cations and, more surprisingly, anions, drastically distorts and softens RNA.

A peptide-based PD-L1-targeted nanorobot disrupts cancer cell membranes via pH-responsive fibril formation, and enhances T cell infiltration and immune activation, inducing a potent anticancer response in animal models of colorectal cancer.

Evidence for the presence of Homo during the Middle Pleistocene is limited in continental Southeast Asia. Here, the authors report a hominin molar from Tam Ngu Hao 2 (Cobra Cave), dated to 164–131 kyr. They use morphological and paleoproteomic analysis to show that it likely belonged to a female Denisovan.

The role of human glioma IDH1 mutations in regulation of antiviral response is unclear. Here, the authors show that D2HG produced by mutant IDH1 inhibits IFN antiviral responses in glioma cells, which confers sensitivity to oncolytic virotherapy.

Access to clean water is crucial, especially in underdeveloped areas. Here, authors develop electrically conductive membranes using carbon nanotubes and poly(vinylidene fluoride), achieving higher water permeance and improved antifouling, reducing costs and energy use

The study identifies PLUM, a uORF-encoded microprotein from Lin28b, as a key regulator that drives deterministic induction of naïve pluripotency through coordinated RNA regulation and metabolic remodeling.

The NSUN family, comprising seven members, is the primary RNA m5C methyltransferase in higher eukaryotes. Here, the authors demonstrate that NSUN7 is a catalytically inactive RNA m5C protein due to sequence variations in its motif IV. Instead, the authors reveal a noncatalytic, regulatory role of NSUN7 in sperm flagellum assembly.

Quantum light sources are promising for quantum circuits, yet facing an inherent trade-off between multifunction and brightness. By leveraging a strategy based on parity-time symmetry, we demonstrate an on-chip quantum light source with programmable lifetime, achieving a 20-fold tuning range of lifetime and balanced photon-pairs generation rate.

The mitochondrial membranes present a formidable barrier to the delivery of exogenous genes. Here, the authors report on the development of fluorinated lipid nanoparticles to efficiently introduce therapeutic genes into mitochondria, for the correction of mitochondrial genomic defects.

In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondria-enriched extracellular vesicles, which offer high-quality, abundant mitochondrial material for transplantation.

Magnetic fields in stellar upper atmospheres are key to understanding stellar activity and its planetary effects. Here, the authors study chromospheric magnetic fields in three M-dwarf stars using spectropolarimetric observations, finding fields reaching hundreds of Gauss with complex height-dependent structures.

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

Inspired by the regenerative capacity of deer antlers, Hao and colleagues report that antler blastema progenitor cell-derived extracellular vesicle treatment counteracts bone loss and epigenetic aging and is neuroprotective in mice and macaques.

CsPbI₃ nanolayers of two-octahedral layer thickness are required for full-color emission in mono-halide perovskites, but their synthesis is complicated by the high reactivity of I-containing crystallites. Here, the authors devise Pb deficiency to retard crystal growth and thus limit growth to two octahedral layers.

The authors introduce a structural design with a well-ordered local structure for barium titanate-based ceramics, which decreases Curie temperature while preserves a sharp phase transition, enabling tunable polarization, large dielectric constant and intrinsic electrocaloric effect near room temperature.

A thin-film engineering method is employed to preserve high pressure solids in diamond capsules at ambient conditions, enabling tunable preserved pressures, controllable particle size, atomic-scale characterization, and potential large-scale uses.

Leaf rust threatens wheat production worldwide. Here, the authors report a high-quality genome assembly of the leaf rust resistant durum wheat landrace PI 192051 and the cloning of the leaf rust resistance gene Lr.ace-4A/Lr30.

The pathological effects of Zika virus (ZIKV) infection on placental trophoblast progenitor cells in early human embryos are not well understood. In this study, using human trophoblast stem cells (hTSCs), Wu et al. show that hTSCs are readily infected by ZIKV, but that there is increasing resistance to the virus as differentiation towards mature lineages proceeds.

Binding of particles to molecular or macroscopic objects generates a universal entropic pulling force. Simulations and experiments on vibrating bead-chains and DNA with multivalent ions confirm this entropic pulling effect, with implications for cellular disassembly processes and molecular machine design.

Crosstalk between the brain and CLNs is critical in brain pathologies. Here, the authors show in a mouse model that extravasated erythrocytes following SAH are degraded by cathepsin S of medullary LECs in CLNs, which plays an important role in SAH pathology.

Here the authors report that hepatic loss of GTPase-activating protein-binding protein1 (G3BP1) exacerbates MASLD and MASH pathogenesis in a study with male mice. Mechanistically, G3BP1 interacts with SNARE proteins and promotes autophagosome-lysosome fusion, and facilitates nuclear translocation of the transcription factor TFE3.

Fabricating semiconductor devices with dimensions below 10 nm presents significant challenges. Here, Liu et al. use controlled electron irradiation to remove atoms in an MoS₂ sheet, creating Mo₅S₄nanoribbons with a uniform width of 0.35 nm and a theoretical band gap of 0.77 eV.

P2X3 activation requires tightening the inner pocket of the head domain (IP-HD) following ATP binding. Here the authors demonstrate that targeting the IP-HD with allosteric small molecules presents a potential strategy for the development of therapeutics for refractory chronic cough without taste abnormalities.

This study reports age-dependent negative correlations between temporal changes in maximal leaf area index and growing season length, indicating contrasting leaf acclimation strategies driving vegetation greening in young versus old deciduous broadleaf forests.

This work introduces roll-to-roll fluidics, a method that enhances reagent efficiency and reduces turnaround time, enabling rapid and economical next-generation sequencing.

Superionic states of matter simultaneously exhibit some of the properties of a liquid and of a solid. Detailed numerical simulations predict two superionic phases in mixtures of helium and water.

Fault-tolerant manipulation of quantum bits is demonstrated experimentally on an eight-photon cluster state using topological error correction.

Liquid crystal elastomers are used in actuators, though methods to pre-program actuation limits the geometric design. Here the authors show a method of treating the elastomers in free-radical initiator to program actuation.

Abiotic methylation triggered by plastic debris can occur independently of light conditions and therefore drive methylmercury formation in dark waters, according to an experimental study combined with density functional theory calculations.

Lancelot, a compute-efficient federated learning framework using homomorphic encryption to prevent information leakage, is presented, achieving 20 times faster processing speeds through advanced cryptographic and encrypted sorting techniques.

The authors design a flexible Ag₂Se-based thermoelectric device with optimized electrode materials, structure, and selenization time, capable of various applications including rapid response to human motion signals as electronic skin.

MSI2 regulates steroid synthesis and gonadotropin secretion via the dentate gyrus-ovary axis. Msi2 knock-out drives reproductive aging in a pattern of early reproductive enhancement followed by accelerated depletion.

The strong scattering of biological tissue causes challenges when monitoring temperature changes at the microscale. Here, the authors propose a nanothermometer based on lanthanide luminescence, enabling minimally invasive imaging of the cerebrovascular system of mice at nearly 200 μm resolution.

In osteoporosis, bone marrow adipocytes (BMAds) accumulate, but their functions are not well understood. Here, Lin et al. show that BMAds promote senescence in neighbouring cells by releasing excess fatty acids, then develop a BMAd targeting nanoparticle to interfere with BMAd lipid metabolism as a strategy to treat osteoporosis.