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Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Chern ferromagnetism is established in twisted bilayer MoTe₂ devices at large twist angles. Here, the authors observe evidence of antiferromagnetic ground states with zero Hall resistance at an intermediate twist angle around three degrees, demonstrating the sensitivity of the magnetic ground state.

G-protein-coupled receptors (GPCRs) function as monomers and in multiple oligomeric forms. Here, authors present a set of 12 assemblies of the apelin receptor (APLNR), providing a detailed view of the monomer-dimer transition.

Skeletal muscle fiber type is key to metabolic health. Zhou et al. reveal that the protein BRD4 dictates muscle fiber identity, blocking it promotes energy-burning slow fibers and prevents obesity in mice, offering a new target for metabolic disease.

Accurately mapping diverse cell types in complex tissues remains a challenge for spatial transcriptomics. Here, the authors present UCASpatial, an entropy-weighted algorithm that enables ultra-precision deconvolution to resolve fine-grained immune landscapes and explore intercellular mechanisms.

Here, in a two-phase population trial, the authors show that composite polyphenols intervention could mitigate the increase in pro-inflammatory indicators associated with high microplastic exposure by modulating gut microbiota and up-regulating glycerophospholipid metabolism pathways.

The GABA_B receptor is a mandatory heterodimer. Here authors show the existence of GABA_B dimers of dimers in neurons, and their relevance in human health. By solving the structure of this tetramer, they show the structural basis for a negative cooperativity between the dimers within such a complex.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

This work develops DJX-A-KM, a small-molecule KRASG12C degrader that recruits E3 ligase FBXO28 via dual covalent binding, inducing potent degradation. This strategy can possibly be extended to pan-KRAS degraders against a broader spectrum of KRAS mutations.

How human mitochondrial ribosomes initiate translation remains elusive. Here, the authors combined biochemical reconstitution, single-molecule fluorescence spectroscopy, and cryo-EM approaches to define the heterogeneous pathways of human mitochondrial leaderless mRNA translation initiation.

Conventional neuromorphic vision systems based on pixels-to-one-memristor architecture face efficiency challenge. Here, Sun et al. report an architecture employing one-pixel-to-multiple-memristor structure, mapping weight updates to voltage vectors to enhance both processing speed and energy efficiency.

The study presents a fast model that predicts catalyst nanoparticle performance while accounting for surface crowding and diffusion between facets. It matches detailed simulations at far lower cost, enabling rapid catalyst screening

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

High-performance battery materials often degrade during standard cleaning processes. Here, the authors identify why water washing causes structural collapse in sodium-based oxides and demonstrate that ethylene glycol can safely remove impurities while maintaining the material’s integrity.

In vanadium flow batteries, crossovers are critical challenges for membrane design. Here, authors propose a balanced state electrolyte strategy that overcomes crossovers, thereby circumventing existing membrane-related constraints and establishing a new framework for advanced electrolyte design.

Cancer cells could sense the availability of glucose to coordinate macromolecular synthetic processes. Here the authors find that glucose-activated adenylosuccinate lyase (ADSL) possesses a moonlighting function of promoting protein succination, thereby upregulating lipogenesis in hepatocellular carcinoma cells.

Li et al. conduct a multi-omics analysis of nasopharyngeal carcinoma and identify three molecular subtypes with distinct immune profiles and responses to induction chemotherapy.

The impact of cooling through the Eocene-Oligocene transition on the marine biosphere is not well constrained. Here the authors construct a high-resolution record of foraminiferal species richness history spanning this transition that reveals differential diversity trends depending on foraminiferal habitat and life mode.

Nociceptive hypersensitivity and prolonged wound healing due to the interaction of peripheral neuropathy and local immune disorders hinder the regenerative repair of diabetic foot ulcer. Here, the authors report a low-intensity focused ultrasound-activated piezoelectric gel bandage with immune homeostasis modulation and neuropathic pain relief functions for comprehensive repair of diabetic wounds.

Leveraging multi-element symbiosis, protective interfacial nanolayers are engineered in an intermetallic alloy. This results in a high fatigue limit of ~1,100 MPa, far exceeding that of conventional intermetallic alloys.

Top-down trophic interactions are critical drivers of microbiome dynamics but are difficult to predict. Here, the authors demonstrate that nematode-driven shifts in microbiomes enhance pathogen suppression and promote plant health through a feedback loop involving nematodes and bacteria.

The genomewide meta-analysis of lumbar spinal stenosis LSS identifies 73 previously unreported loci in addition to 15 known loci and highlights spinal degeneration as a key pathogenic mechanism. Overall, the findings expand knowledge of the genetic background of LSS.

The weak contact between the oxide electrode and molecular layer in inverted perovskite solar cells is prone to deformation, limiting long-term device stability. A bulk nano-heterointerface is designed to strengthen the binding force between molecules and spherical silicon oxide nanoparticles, increasing the interfacial contact area and improving the operational stability of perovskite solar cells.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Nanopore peptide sensing faces throughput, library preparation and analysis challenges. Here, the authors develop a high-throughput platform that integrates library preparation with AI analysis to accurately identify peptides, enabling antibody validation and protein identification.

Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and superconducting behaviour. .

Florets of indica rice open earlier than japonica rice, hindering utilization of the cross subspecies heterosis. Here, the authors show that an OsMYB8-OsJAR1 module regulates diurnal floret opening time divergences between the two subspecies.

Upregulated HAS2 promotes pancreatic cancer immune evasion by stabilizing PD-L1 through AKT-dependent repression of the E3 ligase MARCH4. Targeting the HAS2–MARCH4–PD-L1 axis restores T-cell infiltration and slows disease.

Integrated photonic memory based on phase-change materials (PCM) offers a promising approach for neuromorphic computing. Here, we employ a multiscale simulation scheme, which combines density functional theory and finite-difference time-domain simulations, to investigate the low-loss origin of Sb₂Se₃, and design a programmable mode converter array with 5-bit precision and −0.65 dB insertion loss per node. This Sb₂Se₃-based photonic tensor core is predicted to be scalable to a large matrix size of 128 × 128, and simulated image recognition accuracy could be comparable to the pure software-based predictions. Our work is expected to stimulate the exploration of low-loss PCM for photonic computing.

The absence of odd Shapiro steps in microwave-irradiated Josephson junctions (JJs) is considered to be a possible indicator of 4π-periodic supercurrents that are induced by Majorana bound states. Here, by conducting measurements on Al/WTe₂ JJs, the authors suggest that the missing first Shapiro step can instead arise from the intrinsic non-linearity of the current–voltage characteristics in low-to-moderate transparency junctions.

Mechanistic modeling of scoliosis sheds light on the role of the exosome-mediated high cholesterol flow between spinal cartilage and bone tissue in the context of progression of scoliosis.

Copper nanoclusters are promising photothermal heaters, but their conversion efficiency is limited efficiency. Here, the authors present a rotor-stator ligand architecture that enables enhanced photothermal conversion efficiency of copper nanoclusters.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Effective therapies remain limited for patients with high-risk recurrence after hepatocellular carcinoma (HCC) resection. Here, the authors report a clinical trial investigating the adjuvant combination of the anti-PD-L1 antibody benmelstobart plus the multi-targeted tyrosine kinase inhibitor anlotinib, in patients with high-risk recurrence after resection of HCC.

A Dirac-vortex topological photonic crystal fiber is experimentally realized with broadband single polarization single-mode properties.