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Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

The magnetospheric cusp is a key solar wind– magnetic field interface. Here, the authors show that Saturn’s cusp has a pronounced dawn–dusk asymmetry, with signatures reaching the postdusk region, unlike Earth’s near-noon cusp.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Identifying and classifying chiral phonons has been challenging, limiting their use in quantum and thermal technologies. Now, a symmetry-based framework and database describe phonon chirality across space groups and reveal promising material candidates.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Self-assembled hole-selective molecules can enable high performance in perovskite solar cells, but controlling the hole extraction efficiency is challenging. Tianyu Li et al. address this by designing molecules that adopt a quasi-random orientation on the substrate.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

Loss of mitochondrial integrity can promote T cell exhaustion through proteasome-mediated release of regulatory haem.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Intermolecular singlet fission (xSF) has typically been observed when the interchromophore separation is below ∼5.6 Å because the chromophore coupling is dominated by van der Waals forces. Now, using carbon nanohoop assemblies that allow the chromophore assembly and coupling to be modulated, efficient xSF has been observed at chromophore separations distances up to ∼16 Å.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Soil microbes recycle nutrients, but their global nutrient use efficiency is poorly understood. This study finds microbial nitrogen-use efficiency is nearly twice phosphorus-use efficiency, driven by soil carbon content, and is lowest in tundra and boreal forests.

Immune checkpoint inhibitors (ICIs) have shown limited efficacy in recurrent high-grade astrocytoma (rHGA). Here the authors report the results of a Phase 1/randomized Phase 2b trial of laser interstitial thermal therapy followed by anti-PD1 pembrolizumab in patients with rHGA.

Mixed trimers of pyrrole (Py) and benzene (Bz) provide an ideal benchmark to probe the interplay between strong directional forces and diffuse dispersion contacts that governs structural preferences in molecular assemblies. Here, the authors characterize Py-(Bz)₂ and (Py)₂-Bz trimers and the (Py)₂-(Bz)₂ tetramer using chirped-pulse Fourier transform microwave spectroscopy combined with dispersion-corrected DFT calculations and intensity-based cross-correlation analysis, showing that the overall geometries are dictated by space-filling principles that maximize dispersion contacts.

Urban-adapted mammals host a wide spectrum of zoonotic viruses, some posing high risks of human infection. These species may act as unmonitored reservoirs for viruses of public health concern.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Coupling two ionic thermoelectric effects in n-type materials is scarce, restricting the development of high-performance systems. Here, the authors present an ionic-thermoelectric material with interactive thermo-diffusion/galvanic coupling effect based on coordination chemistry.

Self-assembled monolayers are efficient hole-selective contacts but suffer from aggregation and adhesion issues. To address these, Wang et al. introduce a dimeric molecular design that forms a hydrogen-bond network, enabling 28.4% certified efficiency in all-perovskite tandem solar cells.

This study finds that native tree extinctions and alien naturalizations are pushing forests towards fast-growing, resource-demanding species. This global shift could affect carbon storage and ecosystem stability, highlighting the need to protect slow-growing trees.

A new platform making use of hexagonal boron nitride interfaced with the molecular superconductor κ-(BEDT-TTF)₂Cu[N(CN)₂]Br is demonstrated for realizing cavity-altered materials, confirmed by magnetic force microscopy and nano-optical measurements.

This study presents a clinical-grade autonomous pipeline combining high-resolution whole-slide tomography, edge computing and artificial intelligence, achieving high accuracy in cervical cytology and enabling scalable and objective diagnostics.

The early detection of degradation in lithium-ion batteries is crucial for effective predictive maintenance and recycling. Here, the authors propose a two-stage early-stage degradation prediction method based on GPT to predict the charging data of and state-of-health of batteries

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

In the phase 1/2 TRIDENT-1 trial, treatment of patients with NTRK fusion–positive advanced solid tumors with the tyrosine kinase inhibitor repotrectinib—selective for ROS1, TRKA−C and ALK—was safe and resulted in durable systemic and intracranial clinical response.

Li et al. report a spatially decoupled heavy atom antenna strategy by integrating alkyl bromides into a hybridized local and charge-transfer scaffold, originated from benzothiadiazole acceptors, to create an organic scintillator with a short radiative lifetime of 3.42 ns and spatial resolution around 50 lp mm^-1.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Chen et al. report a tailored self-assembled monolayer to create a localized 2D/3D perovskite heterojunction. This strategy reduces interfacial loss, achieving photovoltages >90% of thermodynamic limit for wide-bandgap cells, and enables perovskite-organic tandem solar cells with efficiency of 27.11%.

Isotope engineering can enhance spin coherence of solid-state defects, such as NV centers in diamond but progress for defects in hBN has been limited. Gong et al. report the optimization of isotopes in hBN and demonstrate improved coherence and relaxation times for the negatively charged boron vacancy centers.

Cosgun et al. show that, in B cell leukemia, β-catenin expression is maintained at low levels through glycogen synthase kinase 3B (GSK3β)-mediated phosphorylation. Inhibition of GSK3β results in β-catenin–Ikaros–NuRD complex formation, leading to B-ALL cell death through MYC repression.

The authors show that the cleavage region of B2 RNA acts as an architectural organizer, essential for maintaining the structural integrity required for ribozyme activity, protein interactions, and transcriptional regulation.

Nylon-11 is a common and durable polymer but possess low piezoelectric properties. Here, the authors use mechanical accelerations and strong electric fields to induce crystallization, hydrogen-bonding and dipole alignment in Nylon-11 films, achieving high piezoelectricity.

DBiTplus represents an integrated experimental and computational workflow that unifies sequencing-based and imaging-based spatial omics, demonstrated by combining transcriptomic profiling and multiplexed protein imaging on the same tissue section.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

The death of massive stars has traditionally been discovered by explosive events in the gamma-ray band. Liu et al. show that the sensitive wide-field monitor on board Einstein Probe can reveal a weak soft-X-ray signal much earlier than gamma rays.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

A skeleton of the alvarezsauroid Alnashetri cerropoliciensis—representing a highly complete alvarezsauroid skeleton from South America—provides evidence on the evolution of the peculiar anatomy and miniaturization within this unusual theropod dinosaur clade.

Iron pnictide compounds have recently been shown to have superconducting properties. Xuet al. show that the superconducting gap of underdoped pnictides scales linearly with the transition temperature, and that a pseudogap develops with underdoping.

Visual experience synchronizes V1–LM theta oscillations, strengthens V1 → LM connectivity, and drives dendritic spine remodeling in WT mice, the processes disrupted in Fmr1 KO mice, revealing impaired inter-areal binding in Fragile X syndrome.

Here, the authors show that multiplex autism spectrum disorder (ASD) families share more gut bacterial strains than healthy families, with distinct strain-sharing patterns highlighting how family environments shape microbial configurations in ASD.

Here the authors report NiGa₂O_4–x(OH)_y for light-driven CO₂ hydrogenation to methanol. The surface Lewis acid–base pairs and -OH groups act as conduits for H^- /H⁺ transport to active sites, enhancing photocatalytic methanol production.

The study of lattice vibrations coupled to electronic excitations may provide an avenue for exploring exotic physical phenomena. Here, Xuet al. observe a Fano resonance in the Weyl semimetal TaAs, revealing evidence for a strong coupling between phonons and Weyl fermions.

The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function.

Thermal lepton pairs are ideal probes for the temperature of quark-gluon plasma. Here, the STAR Collaboration uses thermal electron-positron pair production to measure quark-gluon plasma average temperature at different stages of the evolution.