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Altermagnets combine spin-split electronic bands with zero net magnetization, making them ideal for integration into spin-based information processing devices. Here Guo, Chen, Zeng, and coauthors demonstrate a magnetic memory making use of the altermagnetic spin splitting torque in a three terminal MRAM device.

Kra-Dai language family exhibits great linguistic diversity and tremendous socio-cultural importance in East Asia. In this study, the authors found that Kra-Dai languages initially diverged ~4,000 years ago in Southern China coinciding with prehistoric demic and agricultural diffusions likely driven by climate change.

Liu et al. explore the impact of TPOAb levels on embryologic and pregnancy outcomes in euthyroid PCOS patients undergoing IVF/ICSI. They find no association between TPOAb positivity and adverse reproductive outcomes, suggesting that its clinical relevance may be limited.

Elevated intracellular Cu converts CTR1 trimers to monomers at Rab5⁺ sites prior to endocytosis, rapidly halting Cu uptake; an endocytosis-deficient mutant fails to mount this response.

The authors demonstrate a programmable topological photonic chip with large-scale integration of silicon photonic nanocircuits and microresonators that can be rapidly reprogrammed to implement diverse multifunctionalities.

Subsurface structure dictates the catalytic activity in heterogeneous catalysis. Here, the authors report an atomic diffusion pathway mediated subsurface engineering strategy, enabling precise control of subsurface atomic layers in Pt-based intermetallic compounds.

Limited improvement of systemic therapy has been achieved in first line treatment for advanced Biliary tract cancer (BTC). In this randomized phase 2 trial on BTC, the combination of sintilimab, anlotinib, and gemcitabine/cisplatin demonstrated an improvement in progression - free survival (PFS) and objective response rate (ORR) while reducing the risk of disease progression compared to chemotherapy monotherapy.

RABV upregulates FBXL18, which stabilizes BST2 via K11-linked ubiquitination at Lys109/110, thereby activating NF-κB. FBXL18 knockdown effectively suppresses inflammation and virulence, highlighting its potential as a therapeutic target for rabies.

Genome-wide data from 166 East Asian individuals dating to between 6000 bc and ad 1000 and from 46 present-day groups provide insights into the histories of mixture and migration of human populations in East Asia.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

In situ cryo-electron microscopy structures show the spatial arrangement of flagellin proteins and provide insight into mechanisms of assembly and rotation of the sheathed flagellum in Vibrio cholerae.

This study proposes a dual-modulation method for optical lattice clocks that synchronously modulates the lattice laser and probing laser to control atomic motion and light-atom interactions independently. The authors derive theoretically and verify experimentally the laws of micromotion shift, and achieving its effective suppression by optimizing modulation parameters.

Analysis of ancient DNA, stable isotope data and archaeological evidence from the Fujia archaeological site in eastern China suggests it was populated by a matrilineal Neolithic community between 2750 and 2500 bc.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Rab5 GTPases deliver RopGEF8 from endosomes to the pollen plasma membrane, establishing polarity for germination. This crosstalk between trafficking and signalling GTPases is crucial for the reproductive success of flowering plants.

We experimentally demonstrate the entanglement-controlled vectorial meta-holography for precise quantum state reconstruction and high SNR image remote control via idler photon polarization manipulation.

Intravesical bacillus Calmette–Guérin (BCG) is an established bacterial immunotherapy for bladder cancer. Here, the authors develop a personalized platform to identify microbial product cocktails that promote immune cell recruitment, infiltration, and activation for improving bladder cancer treatment.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

In this phase 3 trial, a two-dose Ebola vaccine regimen in healthy pregnant women in Rwanda was found to be safe and immunogenic in women and offspring through passive transfer.

Through a genome-wide CRISPR synthetic viability screen for PARP-inhibitor resistance, Chen and Ge et al. show that transmembrane nuclease NUMEN directs double-stranded DNA break repair pathway choice at the nuclear periphery.

Zheng et al. identify a role for CD160 in regulating CD8⁺ T cell exhaustion and cytotoxicity through the AKT–NF-κB pathway. The transfer of CD160⁺CD8⁺ T cells overcomes resistance to anti-PD-1 treatment in colorectal cancer models.

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

Thinopyrum intermedium and Roegneria kamoji are wheat relatives commonly used in distant hybridization breeding program. Here, the authors report the genome assemblies of the two species and reveal their phylogenetic relationship and genome compositions.

In the next generation of display technology for portable devices, lasers could replace LEDs to achieve more vibrant colours. Here, Zhao et al. demonstrate a dynamic full-color display in which each pixel is made up of three printed organic microlasers to cover the RGB space.

DART (drug acutely restricted by tethering) enables the manipulation of native receptors on genetically defined neurons. This work describes second-generation DART reagents for manipulating GABA_A and AMPA receptors with higher cellular specificity than previously achieved.

Merlini, Rafalski et al. show that dynamic microglial brain surveillance prevents hyperexcitability and seizures by G_i-dependent microglia–neuron interactions in response to evoked neuronal activity to maintain physiological network synchronization.

Analysis of high-quality genomes and transcriptomes of 13 closely related Oryza species coupled with proteomics finds about 50 de novo genes per million years.

The intrinsic robustness to perturbations makes antiferromagnets ideal building blocks for spintronic devices, however, it also manipulation and detection of antiferromagnetic ordering difficult. Here, Xu et al demonstrate an anisotropic tunnelling magnetoresistance in an all-antiferromagnetic tunnel junction.

Divergence estimates from phylogenetic analyses of 109 languages of the Sino-Tibetan family support a model in which this family originates in the Yellow River basin of northern China.

Poor stability of perovskite solar cells in humid conditions has hindered device fabrication and operation. Here, Tai et al. report the use of a lead thiocyanate precursor in preparing perovskite solar cells and without encapsulation showed better stability in air than typical perovskite solar cells.

Using two cohorts, Liu, Ge, Xiao, Lu and colleagues perform plasma metabolomics and lipidomics, linking reduced sarcosine to sarcopenia diagnosis. In mice, they demonstrate that sarcosine enhances muscle repair, boosts adipose thermogenesis and preserves muscle mass via macrophage modulation.

Long-term observations show that a rising fraction of ammonium nitrate in PM_2.5 reduces aerosol acidity, suppressing the heterogeneous conversion from NO₂ to HONO. This weakens its contribution to the HONO source and atmospheric oxidation capacity.

Ebola virus virion protein 35 (VP35) is a cofactor of the viral RNA-dependent RNA polymerase, required for viral assembly and IFN antagonist. Here, Zhu et al. provide evidence that EBOV VP35 induces an AKIP1-mediated (human A kinase interacting protein) activation of the PKA-CREB1 signaling pathway and contributes to viral replication and pathogenesis in vitro and in vivo.

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

A pangenome of oat, assembled from 33 wild and domesticated oat lines, sheds light on the evolution and genetic diversity of this cereal crop and will aid genomics-assisted breeding to improve productivity and sustainability.

Chromosome-level genome assemblies of 11 bamboo species comprising lineages from diploid (herbaceous) to tetraploid and hexaploid (woody) provide insights into dynamic subgenome dominance in bamboos.

By digitizing a large lexical dataset of Chinese dialects and comparing it to genetic profiles, Yang et al. reveal a hybrid model of language diffusion, consisting of both population migrations and social learning across different regions of China.

Methods of damaging cancer cells are of therapeutic interest. Here, the authors report on using gold nanoparticles as electron sinks with electroactive bacterial membranes to disrupt cancer cell redox balance, electron transfer induces oxidative stress and triggers cell death by apoptosis.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.