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The yin–yang codec transcoding algorithm is proposed to improve the practicality and robustness of DNA data storage.

The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

The authors find that reconstructing the Moδ+ active site via multi-field coupling effectively boosts ammonia borane hydrolysis. They provide key insights into the plasmon polarization-induced carrier kinetics and hydrolysis mechanism.

A 2D nanochannel based on niobate perovskite enables alkali ion separation through a friction-differentiation strategy, offering a potential approach for lithium extraction relevant to renewable energy technologies.

Despite the global prevalence of SARS-CoV-2 infection, its maternal–fetal interface during the first trimester remains underexplored. Here, the authors combined a cohort of 700+ samples and determine that maternal SARS-CoV-2 infection in the first trimester rarely infects placental tissue but alters immune responses and cellular communication, which may influence pregnancy outcomes.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

In NIID, toxic polyG from NOTCH2NLC GGC repeats disrupts nucleoli and chromatin, causing DNA damage and senescence. Here, the authors show that ASOs targeting the repeats reduce polyG buildup and reverse damage, suggesting a new treatment.

Conversion-type batteries face performance decay under high loading due to shuttle effects and sluggish kinetics. Here, authors introduce an f-d orbital tag-team catalysis mechanism using cerium single-atom catalysts, achieving a competitive iodine loading of 44.7 mg cm⁻² and an areal capacity of 10.2 mAh cm⁻² in zinc–iodine batteries.

Authors created a new evaluation framework called GPBench that compares large language models (LLMs) against general practitioners. They found that current LLMs are not suitable for autonomous deployment and still require human oversight.

In maize, ZmDapF1 suppresses the activity of ZmMDH6 in chloroplasts, exacerbating oxidative damage under drought. Knocking out ZmDapF1 or using its favourable allele with lower gene expression enhances drought resilience without yield penalty.

During lytic regulated cell death, a transitional agonal stage exists between initiation and terminal death. Here, the authors found that agonal cells upregulated uptake and internalization of extracellular vesicles fused with the cell membrane via SNARE complexes to enhance membrane repair.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Early postoperative recurrence is a major cause of treatment failure in patients with locally advanced gastric cancer (LAGC). Here, the authors develop Recurrence Stratification and Assessment (RSA), a deep learning model that integrates histopathology with clinical variables to predict postoperative recurrence in LAGC; they also examine the influence of immunological activity in recurrence.

The core downstream mediator of the Norrin/β-catenin pathway remain elusive, hindering the treatment of familial exudative vitreoretinopathy. Here, the authors show that KIF11 acts as a key effector of this axis by preventing phosphorylation-driven PRDX1 phase separation and subsequent ferroptosis.

Phagocytic cells engulf bacteria as part of defence against infection, but intracellular bacteria could exploit these cells for transportation to new infection sites. Here the authors describe a neuroinvasion mechanism by which intracellular bacteria infect and metabolically transform a specific macrophage subtype, which then propagates and transports them through the blood-brain barrier without disrupting it.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

Prokaryotic Argonaute proteins are programmable nucleases. Here, the authors capturing structures of VbAgo at functional stages to show how its C terminus acts as a regulator and demonstrate its ability to cleave RNA in mammalian cells.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

Seawater electrolysis for green hydrogen is hindered by chloride-induced corrosion and local acidification of anodes. Here, the authors report an osmium-decorated cobalt phosphide anode that buffers protons and repels chloride, enabling stable ampere-level seawater electrolysis for 4500 h.

The role of long non-coding RNAs (lncRNAs) in regulating cancer progression remains to be explored. Here, the authors identify an antisense lncRNA in the IGF1R locus (IGF1RAS1) which strongly interacts with super enhancers and modulates MYC expression in metastatic prostate cancer.

Authors propose a triple-synergy strategy for dielectric ceramics that integrates medium-entropy superparaelectric design, local structural distortion and plate-like BiTO phase construction, thereby achieving remarkable energy storage performance.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Three-dimensional Raman modelling of multiphase inclusions in Sumdo eclogites reveals sulfur rich slab-derived fluids at sub-arc depths, providing direct constraints on deep sulfur cycling and copper mobilization in subduction zones.

Growth-coupled biosynthesis in microbes can stabilise production yields, yet their population-level effects are unclear. Here the authors use ScRNA-seq to reveal that an evolved glycyrrhetinic acid-producing growth-coupled yeast strain population achieves division of labour.

Electronic skins are capable to monitor stimuli such as temperature and pressure, though they are susceptible to crosstalk diminishing sensitivity. Here the authors report a mechanically and electronically hybrid network using vanadium oxide and liquid metal particles to optimize selectivity and sensitivity.

Achieving simultaneous flexibility, thermal stability and strong absorption in conventional X-ray sensors is challenging. Here, the authors develop an all-inorganic fabric X-ray sensor working from 80 K to 1373 K, enabling real-time imaging of molten metals and superconducting magnets.

Organic electrode materials are attractive for sustainable batteries but are often limited by poor charge transport. Here, authors demonstrate that a universal thiourea coupling strategy enhances both electron and proton transport in quinone electrodes, enabling stable operation of aqueous zinc batteries under practical conditions.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.

Hypoxia triggers distinct epidermal and dermal metabolic responses, driving skin organoids from spherical aggregates to planar embryonic-like structures. This reveals how cells use low oxygen to construct functional tissue.

Aging boosts diabetic kidney disease risk via shared renal pathology. Renal RORγ is downregulated in diabetes/aging; its tubule-specific loss worsens injury, and overexpression protects. RORγ stabilizes INSIG1 via YOD1/CAB39, blocking SREBP2/STING.

The authors develop a polyvinylidene fluoride and mica bimorph to enhance pyroelectric response. The secondary pyroelectric contribution employs interfacial thermal stress to improve the pyroelectric performance for flexible electronics.

High-nickel layered positive electrodes suffer from lattice oxygen loss and inherent lattice strain. Here, authors report a self-derived subtractive strategy to form a coherent spinel-phase shell with tunable thickness to confine active oxygen intermediates and suppresses interfacial side reactions.

Hypothalamic POMC neurons are critical for energy balance. Here, authors show that TOX3 in these neurons regulates metabolism by promoting PTEN degradation and AKT activation, enhancing thermogenesis to protect against obesity.

Developing noble-metal-free electrocatalysts for acidic water electrolysis is vital for hydrogen production. The authors design a Cr and Nd co-doped Co3O4 anode catalyst with enhanced activity and durability and introduce an in-situ acid circulation strategy to mitigate membrane poisoning.

High yield and wide adaptation rice are crucial for grain supply and food security. Here the authors report OsPI4Kγ7 which contributes to different “adaptability-yield” trade-offs in japonica and indica, and provides an alternative breeding strategy for raising grain yield in different latitudes.

The authors engineer an octahedrally rigid perovskite dielectric with a dual-cubic framework and cold-sintering-enabled microstructure, enabling stable capacitive energy storage up to 270 °C.

The study reports on a peritectic engineering strategy to achieve enhanced electrical performance in InSb thermoelectrics. This material platform enables smart prosthetics with machine learning-assisted tactile sensing and messaging capabilities.

Aortic aneurysm and dissection are life-threatening vascular conditions with limited treatment options. Here, the authors identify the glutamine transporter SLC1A5 as a protective factor, demonstrating its role in maintaining vascular smooth muscle cell homeostasis by coupling glutamine metabolism to epigenetic regulation of contractile genes and STAT3-mediated inflammation. SLC1A5 overexpression attenuates disease progression in preclinical models.

Electrosynthesis of H₂O₂ in acidic conditions offers a sustainable alternative to traditional methods but is hindered by low selectivity. Here, the authors report that adding alkali metal cations restructures interfacial water networks to suppress proton transport, boosting H₂O₂ production.

Fe-based metallic glasses are reported as efficient oxygen scavengers, achieving removal rates 1–4 orders of magnitude higher than conventional systems through rapid adsorption and autocatalytic effect, while approaching theoretical capacity limits.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Gel-based soft materials are attractive for flexible electronics, though are constrained by unfavorable mechanical properties. Here the authors design a geometry programmed self-wrinkling strategy for organo-hydrogels, enhancing mechanical and electronic properties.

Current artificial vision systems suffer from high energy consumption and latency due to the von Neumann bottleneck and separated spatiotemporal processing. Wu et al. propose a vision system achieving native spatiotemporal co-processing with millisecond latency and 95% action recognition accuracy at low computational cost.

Microbial biosynthesis of monoterpene esters remains a major challenge due to the limited repertoire of highly selective alcohol acyltransferases (AATs). Here the authors discovered and engineered AATs for various monoterpene esters using a dual-substrate microbial platform.

Flexible batteries often fail under harsh conditions. Here, authors developed a hydrogel electrolyte via synergism of nanophase separation, hydrated eutectic solvation, and hydrogen-bond networks, enabling flexible Zn||I₂ batteries with high specific energy and long lifespan across −40 to 80 °C.