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Tools to identify who will develop Crohn’s disease in the future are limited. Here, the authors develop and validate a proteomics-based model that predicts disease onset up to 16 years before clinical diagnosis.

Antimicrobial resistance poses a significant global health threat, necessitating swift and precise diagnostic solutions. Here, the authors introduce a culture-free diagnostic platform integrating microfluidic cell enrichment, single-cell Raman spectroscopy, and deep learning, that identifies bacterial and fungal infections directly from clinical samples within 20 minutes.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

In West Junggar, China, the unique genesis of oceanic slab-derived adakites explains their distinct platinum-group element and copper patterns relative to typical arc magmas, according to isotopic and trace elemental analyses.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Z-DNA forms at highly active genes, but its function is unclear. Here, the authors show that MYC recruits FACT to promote Z-DNA formation within nucleosomes, enabling RNA Polymerase II loading and enhancing transcription, revealing a mechanistic role for Z-DNA in MYC-driven regulation.

A newly identified coronavirus isolated from farmed minks can use the receptor ACE2 to infect cells of different mammalian species, including human cells, which has implications for potential zoonotic spillover events.

Copper-based asymmetric photocatalysis has great synthetic potential, however it has been rarely exploited due to challenges inherent to such systems. Here, a chiral bisoxazoline copper catalyst is involved in a SET process, photoredox catalysis, Lewis acid activation and asymmetric induction to construct chiral vicinal diamines.

Orbital-angular-momentum (OAM) beams have great potential for multiplexing signals in optical communication, but creating a compact source is challenging. The authors integrate a chip-scale optical vortex emitter and DFB laser into a single monolithic device for direct electrically pumped production of OAM beams.

This study reports age-dependent negative correlations between temporal changes in maximal leaf area index and growing season length, indicating contrasting leaf acclimation strategies driving vegetation greening in young versus old deciduous broadleaf forests.

Chromosome-level genome assemblies of allotetraploid Nicotiana tabacum and its ancestors, along with their transcriptomes, epigenomes and genotype and phenotype data for 5,196 N. tabacum germplasms, provide insights into genome evolution and complex trait regulation.

Single reference genomes and short-read sequencing data are not enough to harness the full genetic variation of a species. Here, the authors report pan-genome of Arabidopsis thaliana based on chromosomal-level genomes of 32 accessions and identify variations associated with local adaptation.

The efficiency of a quantum computer depends on which basic operations it can implement. Now a scheme that can implement any two-qubit logic gate has been demonstrated on a superconducting architecture.

Platelet-activating factor (PAF) and PAF-like phospholipids were identified as propagators of ferroptosis, whereas PAFAH2 suppressed synchronized ferroptosis and, thus, prevented tubular cell death in acute kidney injury.

In a phase 1/2 trial in patients with advanced non-small-cell lung cancer (NSCLC), followed by a phase 2 trial in an EGFR-mutant selected population, treatment with the TROP2-targeting antibody–drug conjugate sacituzumab tirumotecan led to encouraging clinical response rates, especially in patients with EGFR-mutant NSCLC, which was supported by mechanistic data.

Defect engineering plays a pivotal role in materials science but achieving precise control over defects in pure organic systems remains a challenge. Here, the authors demonstrate the creation of controllable defects in molecular crystals through the supersaturated solution-fed seeded self-assembly of two strategically designed molecules.

The Ca²⁺ modulated pulsatile glucagon and insulin secretions by pancreatic α and β cells are critical in glucose homeostasis. Here the authors show that the Ca²⁺ oscillations of α and β cells are phase-locked, and that the oscillation pattern is tuned by paracrine interactions between α and β cells.

Monitoring the early-stage healing of severe traumatic nerve injuries is essential to gather pathological information for timely interventions. Here, the authors introduce a biodegradable and restorative neural interface for wireless real-time tracking.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Middle-aged individuals are more susceptible to obesity, but the mechanisms are unclear. Here, the authors show that extracellular vesicles from adipose progenitor cells in middle-aged individuals lack miR-145-5p, driving inflammation, and that restoring miR-145-5p could prevent midlife obesity.

The authors show that SARS-CoV-2-specific T cells in the lung are key to fighting infection and persist after viral clearance, contributing to long-term immunity and protection.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

The existing recycling methods for spent lithium-ion batteries face high entropy-increasing problems. Here, authors propose a galvanic leaching strategy that can recover battery metals without crushing mixing or additional reductants, and achieve a 30-fold increase in leaching kinetics.

Nitrate electroreduction to ammonia can decrease pollutants and produce high-value ammonia. Here, the authors design a Fe/Cu diatomic catalyst on nitrogen-doped graphene, which exhibits high catalytic activities of and selectivity for ammonia.

The chromatin remodelling protein CHR2 interacts with Serrate in Arabidopsis to regulate microRNA biogenesis.

Optoelectronic neural interfaces allow for non-genetic and remote modulation of neural activity. Here, the authors propose a biodegradable, flexible and miniaturized neural interface based on molybdenum-modified silicon diodes that allows transdermal neuromodulation and promotes nerve regeneration.

Photocatalytic oxidative coupling of methane is a promising approach to create muti-carbon products. Here, the authors use Ce dopants to construct electronically asymmetric lattice oxygen sites in ZnO to enhance methyl migration and promote C-C coupling.

Convergence of heavy or light chains in antibodies recognising pathogens could drive mutations in these pathogens. Here the authors examine antibodies against SARS-CoV-2 and find that a conserved VL6-57 light chain recognising a conserved motif in the spike protein is associated with virus mutations and could drive changes in SARS-CoV-2 omicron variants.

Wood is one of the most renewable materials with applications in construction and other industries. The authors show a process that gives low-value wood and biomass residuals a new life by transforming them into materials with mechanical properties comparable to metals and other structural elements.

Influenza surveillance over 15 cities across 5 provinces in China from October 2013 to July 2014 shows that the virus has diverged into distinct clades, becoming established in chickens and also disseminating to wider geographic regions.

Hypothalamic melanocortin neurons control energy homoeostasis by modulating appetite. Here, the authors reveal a role for the transcription factor Tbx3 as a regulator of the peptidergic identity and function of immature and mature mouse melanocortin neurons.

The current use of elastography ultrasound faces challenges, including vulnerability to subjective manipulation, echo signal attenuation, unknown risks of elastic pressure and high imaging hardware cost. Here, the author shows a virtual elastography to empower low-end ultrasound devices with state-of-art elastography function.

A localized Wnt3a signal has been shown to induce asymmetric division of mouse embryonic stem cells. Here the authors develop SET-seq, an approach to jointly profile epigenome and transcriptome in the same single cell and use it to provide mechanistic insights into the gene regulatory programs for maintaining and resetting stem cell fate during differentiation.

The dynamics of planted forests in China over the past three decades have contributed ~1198tg of above-ground carbon storage.

This study uncovered a gene duplication in legumes that produces a nodule-enriched nKCBP protein, a plant-specific kinesin motor, and found that rhizobia co-opts nKCBP to control vacuole morphogenesis in symbiotic cells, thus achieving successful endosymbiosis.

Zheng et al. generate and utilize a biobank of colorectal cancer PDOs to find that high LGR4 is linked to chemoresistance. They develop a monoclonal antibody against LGR4 that activates ferroptosis and is therapeutically beneficial.

The formation of secondary organic aerosol in Chinese megacities is dominated by the condensation of anthropogenic organic vapours, according to measurements across three urbanized regions.