Search

Biocompatible macroporous hydrogen-bonded organic frameworks (HOFs) of high crystallinity are promising for biomedical applications, but their fabrication is difficult. Here, the authors synthesize highly ordered macroporous HOFs in single-crystal form via a template method, using small biocompatible molecular building blocks with multiple hydrogen donor/acceptor sites and extensive π-conjugation.

This study finds HFD downregulates RKIP expression via inhibiting its Spalmitoylation. This impairs translation of PEMT, an essential enzyme for ER lipid homeostasis, exacerbating PC/PE imbalance and ER stress, thereby driving MAFLD progression.

The authors develop textile electronic substrates with tailored stiffness and interfacial affinities by selective and controllable laser-matter interaction, addressing the mechanical mismatch between hybrid electronics and elastic textiles.

This study reports that genomic signatures composed of the loss of pluripotency inhibitors, expansion of pluripotency activators and maintenance of an epigenetically permissive state contribute to the plantlet formation in Kalanchoe.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.

Efforts to develop P2X7 drugs are hampered by species differences. Here, authors reveal the structural basis for these disparities and show that transgenic mice provide a powerful model for testing selective inhibitors with greater clinical relevance.

This study reports a metastable dual-vacancy catalytic design that enhances proton-coupled electron transfer by balancing proton supply and charge separation. The system achieves nearly 100% CO₂-to-CH₄ selectivity with a 75-fold higher rate than pristine TiO₂, offering a new pathway for designing selective catalytic systems.

DNA G-quadruplexes help regulate genes, but their strand-specific roles are unclear. Here, the authors develop ssG4-seq to map G4s genome-wide, showing abundant enhancer- and promoter-localised structures that activate transcription via SP1 and are disrupted by cancer-linked mutations.

Most bio-derived polymers deteriorate during environmental exposure. Here, the authors report a bio-derived polyester containing aromatic p-conjugated vinylidene units, these provided self-reinforcement through [2 + 2] cycloadditions, leading to mechanical enhancements during ageing.

The authors reveal that interfacial dead layers in ferroelectric ScAlN originate from nitrogen vacancies and strain, highlighting their critical role in unlocking the full potential of nitride ferroelectrics for advanced device architectures.

The authors develop a molecular dopant to avoid the dimerization of the electron-selective material phenyl-C₆₁-butyric acid methyl ester, resulting in enhanced stability and efficiency in inverted perovskite solar cells.

Pt/CeO₂ ensemble catalysts show great potential for hydrocarbon oxidation, but the nature of active sites and interfacial evolution during reaction has been debated. Here, the authors demonstrate metallic Pt ensembles serve as the true active sites for C₃H₆ oxidation, and confirm dynamic nature of oxygen activation with the threshold temperature around 170 °C.

An entanglement filter based on Rydberg atoms is demonstrated. It transmits a desired photonic entangled state and blocks unwanted ones. Near-perfect photonic entanglement can be extracted from a noisy input with arbitrarily low initial fidelity.

Tumor pericytes are located surrounding blood vessels, and can regulate tumor vascular structure. Here, the authors discover that a subpopulation of NKX2-3 high tumor pericytes modulates vasodilation and hemodynamics to promote metastasis.

Dihydrouridine (D) is an abundant RNA modification but its functions are currently unclear. Here, authors develop CRACI, a sensitive method for transcriptome-wide, single-base D mapping, identifying sites across mammalian and plant transcriptomes and identifying DUS2L as a mitochondrial D writer.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

Here a Cu(I)/Cu(III)/Cu(II)/Cu(III)/Cu(I) redox sequence is revealed in copper-catalysed aryl iodide coupling, capturing intermediate species and redefining the mechanistic understanding of the reaction.

The molecular mechanisms determining the response to radiotherapy remain incompletely understood. Here, the authors demonstrate that the E3 ubiquitin ligase and intracellular Fc receptor, TRIM21, impairs CD8⁺ T cell responses in nasopharyngeal carcinoma tumour models following ionizing radiation.

An avian influenza H7N9 virus causes severe human disease, including acute and often lethal respiratory failure. Here, the authors report that plasma levels of angiotensin II, a regulatory peptide of the renin–angiotensin system, are associated with disease severity and fatal outcome in infected patients.

Many methods exist for the atroposelective synthesis of axially chiral biaryls, but axially chiral styrenes are much less explored. Here the authors report an organocatalytic procedure for the synthesis of configurationally stable, axially chiral styrenes with high enantio- and diastereoselectivities.

The conversion of carbon dioxide to higher-value chemicals is an industrially important reaction. Here, the authors report a hybrid catalyst manganese oxide nanoparticle supported on mesoporous cobalt oxide, which catalyses the conversion of carbon dioxide to methanol at high yields.

Copolymerization of methacrylates and vinyl esters is extremely challenging because of their large difference in reactivity ratio. Here, the authors design a side-armed bisoxazoline catalyst which achieves strong binding ability to propagating radicals in photoinduced cobalt-mediated radical polymerization, enabling the facile synthesis of methacrylate-vinyl ester copolymers.

While chemotherapy may initially be effective in patient with nasopharyngeal carcinoma (NPC), resistance often develops. Here, the authors identify PJA1 as a driver of resistance to docetaxel via inhibition of GSDME-mediated proptosis and target this using a PJA1 inhibitor to restore sensitivity in preclinical models of NPC.

Basalt clasts returned by Chang’e-6 suggest a lunar farside mantle potential temperature that is approximately 100 °C cooler than the nearside mantle, according to a petrologic study combined with thermobarometric modelling and remote sensing data.

Exotic chiral fermions beyond Weyl fermions have recently been discovered in a series of chiral crystals such as CoSi. Here, the authors report the evidences of chiral fermions in RhSn with opposite handedness compared to those observed in CoSi, where the structural chirality is also opposite.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Multi-ion pores produce a lower conduction rate when faced with a mixture of two conducting ions than with either single one, in what is called the anomalous mole fraction effect. Now high-resolution structures of the bacterial K⁺ channel MthK pore, together with functional studies, reveal that K⁺ occupancy of specific sites in the selectivity filter can block the passage of Na⁺ ions.

Ye et al. characterize the cardioprotective effect of SIRT2 in primates and reveal an important role for the SIRT2–STAT3–CDKN2B regulatory axis in primate cardiac aging, improving understanding of the epigenetic mechanism governing cardiac aging.

In the multicenter phase 2 OptiTROP-Lung01 trial in patients with treatment-naive advanced non-small-cell lung cancers, the antibody–drug conjugate sacituzumab tirumotecan with anti-PD-L1 tagitanlimab was safe and showed encouraging clinical efficacy.

This study leverages the empirical datasets and microbial-explicit SOC model to show a thermal threshold of microbial CUE and heterotrophic respiration at 15 °C, implying a potential abrupt transition to more vulnerable SOC under climate warming.

Yao et al. observe and characterize genomic redistribution of the PBAF complexes upon PBRM1 loss, leading to sustained RELA occupancy by SMARCA4, activation of the NF-kB pathway and enhanced kidney tumourigenesis.

Multiple pathogenic viruses are identified in a large set of pangolins, which shows that trading pangolins for scales or flesh may increase the risk of emergence of viral infections.

The molecular mechanism underlying how lithocholic acid recapitulates the lifespan and healthspan benefits of calorie restriction is revealed to involve TULP3, sirtuins, v-ATPase and AMPK.

Analysis of whole-genome sequencing data from 3,023 human genomes from mainland Southeast Asia identifies high genetic heterogeneity among populations in the region and many unique small and structural variants.

Nylon-12 monomers are traditionally produced through chemical synthesis and more recently by bioconversion of plant-derived lauric acid. Here, the authors report the construction of E. coli cell factory to enable de novo biosynthesis of the nylon 12 monomer ω-aminolauric acid from glucose.

Spin defects in 2D materials offer practical advantages for quantum sensing over their 3D counterparts. Here, the authors demonstrate quantum sensing under high pressure using boron vacancy centers in hBN placed inside a diamond anvil cell and use it to detect both stress gradient inside the pressure chamber and pressure-induced magnetic phase transitions.

Diarrhoea is a major cause of morbidity and mortality in China. Here, the authors present results from a large sentinel surveillance scheme from 217 hospitals in all 31 provinces in mainland China, including ~150,000 patients with acute diarrhoea and covering years 2009-2018.

China operates a national surveillance program for acute respiratory infections and sampled over 200,000 patients between 2009–2019. Here, the authors present results from this program and describe patterns by age, pathogen type, presence of pneumonia, and season.

Precipitation is a key driver of plant growth. Here the authors integrate ground-based observations, remote sensing and process-based models to disentangle the relative contribution of preceding-year and current-year precipitation on plant productivity and identify its predictors across biomes.

Dual-scale chemical ordering in CoNiV-based alloys improves the synergy of strength and ductility at cryogenic temperatures, providing an approach for obtaining high-performance metallic materials for cryogenic applications.

Logical operations can be performed fault-tolerantly with only a constant number of syndrome extraction rounds for a broad class of quantum error correction codes, including the surface code with magic state inputs and feedforward, to achieve ‘transversal algorithmic fault tolerance’.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The authors develop a miniaturized Mg3Bi2-based thermoelectric cooler, achieving a high cooling power density of 5.7 W cm-2 and a cooling speed of 65 K s-1, demonstrating great promise for localized thermal management in electronics.

Developing Ru-intermetallic catalysts for mild ammonia synthesis faces structural complexity. Here, machine learning identified Sc_1/8Nd_7/8Ru₂, optimizing Ru–N bonding and orbital hybridization, enhancing catalytic activity under mild conditions.