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Zhendan Lu et al present a novel framework for degradation modelling of chaotic systems through random walks in phase space. This approach effectively overcomes the computational inefficiency of time-domain iterative methods while maintaining high predictive accuracy.

Nkx2.5+ progenitor cells within the anterior lateral plate mesoderm, defined as the heart field, give rise to distinct cardiopharyngeal lineages and structures. Here, the authors show that the nkx2.5+ progenitor cells are heterogenous in the classic heart field and are spatially patterned based on their future migratory paths.

“Methanol is an ideal feedstock for sustainable biomanufacturing. Here, the authors metabolically engineered a methylotrophic yeast for efficient production of the biodegradable plastic monomer L-lactate, which might support a circular economy.”

p97-UFD1L-NPLOC4 unfolds proteins for proteasomal degradation, but whether it suffices to extract proteins from lipid bilayers is unclear. We show that the UBH-UBX module in FAF2 and its homologs double p97’s ATPase and unfolding activity, and drives membrane protein extraction.

Developing an energy-efficient method to transform the chemically inert CO₂ into methanol is a key goal in sustainable chemistry. Here, the authors introduce an indirect route for methanol production at temperatures below 100 °C, using CO₂-derived dimethyl carbonate as an intermediate molecule.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Artatrovirenols A and B are two natural sesquiterpenoids with a complex tetracyclic backbone, and their chemical total synthesis is challenging. Here, the authors report a concise synthesis of artatrovirenols A and B in 9 and 8 steps, respectively, featuring a bioinspired [4 + 2] cycloaddition reaction to construct the tetracyclic core.

Aging is the risk factor for chronic pancreatitis and its acute attack. Here, the authors show that exocrine acinar cells received endocrine β-cell-derived miR-503-322 and caused pancreas autodigestion and anti-proliferation by repressing MKNK1 thereby promoting pancreatitis in the elderly

Single-nucleus RNA sequencing can be applied to FFPE tissues, but isolating intact nuclei remains challenging. Here the authors develop a low-temperature enzymatic dissociation strategy for rapid, high-yield and high-fidelity nuclei extraction, and demonstrate its applicability to single-nucleus sequencing of various sample types.

In situ methods for water quality monitoring is crucial for global water use and management, though many conventional sensors have slow response time and are non-recyclable. Here, the authors report a recyclable amphiphobic dielectric material for fast monitoring of water pollutants.

High-resolution sensitivity experiments show that tropical cyclones can induce long-term oceanic temperature perturbations, which affect the mean state and variability of the Kuroshio Current through geostrophic processes.

Tuberculosis is a major global health issue. Here the authors report Mycobacterium-pre-activated macrophage membrane-coated photothermal nanoparticles for targeted tuberculous granuloma and pathogen dual imaging and antibacterial photothermal therapy.

Iron dysregulation is a hallmark of many human diseases and cancers. In this study, the authors show that iron depletion, overload, or improper storage drive templated insertions at chromosome breaks, a class of events that are common yet poorly understood in cancer.

Simultaneous transfer of chirality and energy is desirable, but challenging to achieve in synthetic systems. Here, the authors report a system inspired by chlorosomes in which donor-acceptor chromophores form helical stacks, shielding them from water and allowing chirality and energy transfer.

The para rubber tree is the world’s sole commercial source of natural rubber. Here, the authors assemble the pangenome based on five genomes of H. brasiliensis and three genomes of other Hevea species, and reveal species delineation and rubber trait evolution through phylogenomic analyses.

Solid-state pressure sensors have performance limitations in liquid environments. Here, the authors design a pressure sensor using solid–liquid–liquid–gas multiphasic interfaces where a trapped air layer modulates capacitance changes with pressure to achieve near-friction-free contact line motions for near-ideal pressure sensing.

This randomized trial assessed the effectiveness and safety of single blastocyst transfer vs single cleavage-stage embryo transfer among women with good prognosis. Here, the authors show improved cumulative live birth rates and relatively unfavorable perinatal outcomes after blastocyst transfer.

A reverse osmosis membrane synthesized via a vapour–solid interfacial reaction demonstrates high permselectivity and exhibits good anti-fouling performance, providing a simple and effective methylation approach to enhancing membrane-fouling resistance.

To date, little is known about the regulatory landscape of the pig genome. Here, the authors characterize cis-regulatory elements in the pig genome using RNA-seq, ChIP-Seq and ATAC-seq, finding a higher degree of usage conservation between pig and human than mouse and human.

Organic-inorganic hybrid halide perovskites have been emerged as promising candidates for X-ray detectors while toxicity and instability are known issues. Here, Zhang et al. grow large size lead-free single crystals for high performance X-ray detection and imaging devices that can operate at 100 °C.

Biorefinery of waste biomass provides a sustainable route to produce chemicals and feedstocks. Now, the efficient production of free fatty acids and 3-hydroxypropionic acid from lignocellulose has been achieved via the co-utilization of xylose and glucose from lignocellulose using an engineered yeast.

Satellite data used to generate high-resolution maps across Southeast Asia show that rubber-related deforestation is at least twofold to threefold higher than suggested by estimates used for setting policy.

Liang, Yan, Long, Ji et al. find that the origin and dynamics of 5-hydroxymethylcytosine (5hmC) during early development are not conserved between humans and mice and that 5hmC contributes to the activation of human embryonic genes.

The current use of elastography ultrasound faces challenges, including vulnerability to subjective manipulation, echo signal attenuation, unknown risks of elastic pressure and high imaging hardware cost. Here, the author shows a virtual elastography to empower low-end ultrasound devices with state-of-art elastography function.

Jiayang Li, Xudong Zhu, Qian Qian and colleagues report cloning of the Grain Length on Chromosome 7 (GL7) locus in rice and identify a copy number variant that increases grain length and improves grain quality. They demonstrate how interactions with other grain length–related genes may be used to improve breeding.

Vitrification of preantral follicles is a promising strategy for female fertility preservation, but requires high concentrations of toxic cryoprotectants. Here, the authors accomplish follicle vitrification with low cryoprotectants by taking advantage of microencapsulation and nanowarming.

Gao et al. devise a global metabolic rewiring approach to overcome methanol toxicity and use it as sole substrate for enhanced free fatty acid production in yeast, which may then be beneficial for global carbon neutrality.

Current mesenchymal stem cell (MSC) transplantation practices are limited by the loss or reduced performance of MSCs. Here the authors develop a bead-jet printer for intraoperative formulation and printing of MSCs-laden Matrigel beads to improve skeletal muscle and hair follicle regeneration.

Hybrid halide perovskite single crystals show excellent optoelectronic properties but their small size and large thickness limit their application. Herein Liu et al. grow large area ultrathin flexible crystalline membrane of layered perovskite and demonstrate high detectivity in the flexible photosensors.

Adipose beiging is a positive biological change, which is often thought to be primarily sympathetically induced. Here, the authors show that M2 macrophages can independently promote beige adipogenesis, further revealing the adipocyte transcription factor Ets1 as a negative regulator of this process.

Xiaowu Wang, Jian Wu, Guusje Bonnema and colleagues report resequencing and subgenome selection analysis of 199 Brassica rapa and 119 Brassica oleracea accessions representing diverse morphotypes. They identify 4 subgenome loci with evidence of parallel selection among subgenomes and 15 subgenome loci with evidence of parallel selection between species.

Gratings are used for pulse compression and stretching in chirped pulse amplification (CPA) or optical parametric CPA methods. Here the authors demonstrate ultra-broadband gold gratings that can compress single-cycle pulses with powers around 100 petawatts.

Many software suites and spectral libraries have been developed for DIA proteomics data analysis. Here, the authors create benchmark data sets to evaluate four commonly used software tools combined with seven spectral libraries in both global proteomics and phosphoproteomics analysis.

Electrocatalytic reduction of nitrogen has emerged as a sustainable means for the production of ammonia. Here the authors design bimetallic Fe–Co single-atom catalysts dispersed on carbon that enable unprecedented ammonia yield rates.