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Tan and colleagues develop DNA nanodevices to detect the pH of the lysosomal outer surface, observing an acidic layer generated by TMEM175 that regulates lysosome positioning in response to changes in juxta-lysosomal pH.

Using a molecular engineering approach, wafer-scale uniaxially oriented Te nanowire thin films are synthesized with excellent controllability and uniformity. The anchor-rope structural molecules form a periodic self-assembled supramolecular membrane, which facilitates the adsorption and well-arranged growth of Te nanowires on grooved sapphire.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Myocardial infarction triggers inflammation driven by immune cell reprogramming, but the epigenetic regulators involved remain unclear. Here, the authors show that histone acetyltransferase 1 enhances postinfarction inflammation by promoting histone succinylation in monocytes.

Gold-based layered hybrid superlattices with tunable interlayer spacing are synthesized as an efficient strategy to modulate intersystem crossing (ISC). Reduced interlayer spacing enhances Au–π conjugation, accelerating the ISC to 0.26 ps and enabling tailored spin–orbit interactions for advanced optoelectronic applications.

Central thalamic patterns index recovery in patients with disorders of consciousness (DoC) across different severities, etiologies and ages, revealing a shared mechanism underlying consciousness recovery in DoC and informing treatment strategies.

Epitaxial BaTiO₃ on LSAT shows large Pockels coefficients via polymorphic phase boundaries, enabling low-voltage, high-speed electro-optic modulators.

A bonding and debonding strategy is used to stack epitaxially grown semiconductor monolayers into various structures with precise control of the layer number and interlayer twist angle.

Fungal infections can be debilitating and life-threatening. Here, the authors report a fungicidal strategy by the combination of cell wall digestion and cuproptosis using lywallzyme-assembled copper-phenolic nanoflowers demonstrating synergistic effects in fungal infection and fungal keratitis models.

Here the authors show that PCIF1 can regulate CD8⁺ T cell antitumor responses in mice and use this information to enhance chimeric antigen receptor T cell design.

Aberrant coagulation and thrombosis are associated with severe SARS-CoV-2 infection. Here, the authors show that the E protein are associated with coagulation disorders in COVID-19 patients and could directly enhance platelet activation and thrombosis through a CD36/p38 MAPK/NF-kB signaling axis.

The direct conversion of low alkane-like ethane into high-value chemicals has posed a significant challenge. Herein, the authors successfully accomplish a one-step conversion of ethane to C2 oxygenates using a Rh single-atom catalyst under mild conditions.

A detailed understanding of particle stopping in matter is essential for nuclear fusion and high energy density science. Here, the authors report one order of magnitude enhancement of intense laser-accelerated proton beam stopping in dense ionized matter in comparison with currently used models describing ion stopping in matter.

Wang and colleagues generate two protein-level mutant p53 reporters and use them to identify precancerous clones in normal tissues in vivo, characterized by increased amino acid metabolism and a transcriptomic signature that includes Ybx3.

Here, the authors identify key DNA methylation sites associated with incident acute coronary syndrome (ACS), improving ACS prediction and highlighting potential biomarkers and therapeutic targets for ACS.

The transmembrane P-glycoprotein (P-gp) pumps are known to promote drug resistance by enhancing drug efflux. Here, the authors deliver P-gp inhibitor and a chemotherapeutic agent using tumor blood vessel-targeting nanoparticle, to overcome drug resistance.

Chemically modified nucleobases and oligonucleotides are essential in several fields but introducing functional groups into nucleobases requires laborious chemical synthesis. Here, the authors report site-selective alkylation at the C8-position of guanines in guanosine, GMP, GDP, and GTP, as well as late-stage alkylation of RNA/DNA oligonucleotides through photomediated Minisci reaction.

Reversible and asymmetric adhesion is needed in removable post-operative patches to reduce trauma and prevent tissue adhesions. Here, the authors report on a conductive musselinspired adhesive Janus hydrogel with an anti-adhesive top for cardiac repair which can be removed using glutathione solutions.

The authors report a stretchable tactile array with strain insensitivity, and a visual-tactile joint learning framework, achieving high-accuracy force measurement and replicating full states of hand and manipulated objects with fine-grained geometry.

Ammonia synthesis is an energy-intensive process due to the high activation barrier for N₂ dissociation. Here, Hosono and co-workers show that the intermetallic compound LaCoSi can lower the energy requirement for N₂ activation and shift the rate-determining step of the process to NH _x formation under mild conditions.

Long-term treatment of myocardial infarction remains challenging despite advances in medical technology. Here, the authors show that P-MSN/miR199a-5p nanoparticles can effectively repair myocardial infarction by enhancing contractility and limiting apoptosis, highlighting the therapeutic potential of miR199a-5p for long-term management of myocardial infarction.

Stabilize the active metal single atoms under harsh conditions is critical for the development of single atom catalysts. Here the authors report a nanoporous crystal, 12CaO·7Al₂O₃, that can firmly stabilize Pt single atoms in its surface cavities for efficient catalytic hydrogenation of nitroarenes.

The authors employ Micro-C-XL to investigate chromatin structures in plants, specifically focusing on nucleosome-resolution chromatin organizations and enhancer-promoter chromatin loops in Arabidopsis, rice, and soybean.

Magnetic reconnection governs many astrophysical phenomena, but its details are poorly understood. The extreme magnetic fields generated by the interaction of a high-intensity laser with a plasma enables the study of magnetic reconnection processes similar to those that occur in solar flares.

Injectable and electrically conductive scaffolds displaying shape-memory behaviour and a hierarchical porous structure enhance the functional repair of infarcted heart muscle in rats and minipigs.

This study shows repulsion between virus and host codon usage bias when they are too similar, due to increased viral expression leading to levels of tRNA consumption that impede host translation.

A study on human and mice using 16SrRNA gene sequencing and targeted metabolomic analysis suggests that iodine intake alters intestinal microbiota composition and metabolic changes influencing the microbiota-gut-thyroid axis.