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Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

A ZnO/CuO catalyst featuring dual-site cooperative framework for polymerization-based wastewater treatment. Zn sites preferentially adsorb/activate organics, whereas Cu sites predominantly activate the oxidant, showcasing atomic-scale design to reactor-scale implementation.

The bacterial type-IV Thoeris system produces, in response to phage infection, a signal molecule that triggers protein degradation and stops viral replication. Here, the authors identify a phage protein that sequesters the signal, thus blocking the antiviral response.

The study reports on a peritectic engineering strategy to achieve enhanced electrical performance in InSb thermoelectrics. This material platform enables smart prosthetics with machine learning-assisted tactile sensing and messaging capabilities.

Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

Wang et al. report dual cationic imidazole ligands to control perovskite dimensionality, from 0D to parallel 1D, and bridged 1D structures. Bridged 1D/3D perovskite heterostructure enables solar cells with certified efficiency of 27.02% and 30×30 cm² solar modules with efficiency of 21.41%.

Twisted 2D transition metal dichalcogenides (TMDs) have attracted significant attention due to their emerging physical properties, but their bottom-up synthesis remains challenging. Here, the authors report a heating rate-controlled chemical vapour deposition method to grow various TMD heterostructures with improved control over the twist angle.

G-protein-coupled receptors (GPCRs) function as monomers and in multiple oligomeric forms. Here, authors present a set of 12 assemblies of the apelin receptor (APLNR), providing a detailed view of the monomer-dimer transition.

Researchers developed scDiffusion-X, a multimodal generative diffusion model that generates realistic single-cell multi-omics data, enables cross-modality prediction, and reveals gene regulatory relationships, providing a scalable and interpretable tool for studying cellular biology.

The ferromagnetic cobalt-based catalyst with fully exposed strained Co(111) lattice plane boosts peracetic acid utilization under a mild magnetic field, producing plenty of reactive species for pollutant abatement and greener water remediations.

Despite the success of CAR T cell-based immunotherapies, patients with non-Hodgkin lymphoma (NHL) face a high risk of recurrence. Here, the authors report clinical outcomes of a phaseI/II study on refractory NHL patients treated with anti-CD19-anti-CD20 CAR T cell product epigenetically reprogrammed with decitabine and CAR T cel properties. In addition, they investigate the persistence and fate of the CAR T cell product, indicating the acquisition of memory-like features, maintained cytotoxicity and reduced exhaustion signature.

Authors propose a triple-synergy strategy for dielectric ceramics that integrates medium-entropy superparaelectric design, local structural distortion and plate-like BiTO phase construction, thereby achieving remarkable energy storage performance.

By introducing local ferroelectric regions into a high-entropy superparaelectric, researchers develop a design strategy for high-performance energy storage ceramics. They incorporate ferroelectric PbTiO₃ into a high-entropy matrix, achieving a high recoverable energy density.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

This study uncovers how amyloid-β boosts astrocyte calcium activity, increasing cholesterol and disrupting brain waste clearance in an Alzheimer’s disease mouse model. Targeting astrocyte calcium or cholesterol restores clearance and improves cognition.

Lymph node metastasis is critical in cancer staging and prognosis. Here, the authors use multimodal omics to explore the tumor microenvironment in non-small cell lung cancer (NSCLC) and identify FTH1-relevant cancer stemness, CXCL13+ T cell exhaustion and immune evasion contribute to lymph node metastasis of NSCLC.

Site-selective valence isomerism in a Ni–carboxylate metal–organic framework simultaneously modulates magnetic properties, chiroptical response, and oxygen evolution catalysis, demonstrating that controlled metal-node valence states enable multifunctionality in reticular materials.

Forestation creates a climate trade-off between carbon uptake and wind energy. This study reveals forestation has high carbon sequestration potential with lower wind energy loss in tropical regions but has high wind energy loss in Europe and the US.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

Bacterial therapies for cancer face safety and complexity challenges. Here, the authors develop an engineered Serratia marcescens platform that leverages natural pigment biosynthesis to trigger antitumor immunity and enable rapid bacterial clearance, controlled by near-infrared light.

Developing high-performance organic ferromagnetic semiconductors is hindered by the coupling between radical generation and molecular assembly during synthesis. Here, the authors use topochemical reduction to enable radical generation in pre-ordered perylene diimide films, maintaining their long-range order and achieving room temperature ferromagnetism and semiconducting behaviour

Zinc isotopes in basalts along a 1,100-km transect of the Gakkel Ridge record widespread mantle recycling of surface carbonates via ancient oceanic subduction, explaining the unusually carbon-rich nature of the Arctic asthenosphere.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

Organic electrode materials are attractive for sustainable batteries but are often limited by poor charge transport. Here, authors demonstrate that a universal thiourea coupling strategy enhances both electron and proton transport in quinone electrodes, enabling stable operation of aqueous zinc batteries under practical conditions.

Direct regeneration of spent lithium-ion battery positive electrode materials is hindered by structural disorder and surface degradation. Here, authors use oxidation to reconstruct lithium transport pathways and regenerate dense single-crystal LiNi_0.5Co_0.2Mn_0.3O₂ with stable cycling performance.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

The ability to diagnosing and differentiating intracerebral hemorrhage from ischemic stroke is clinically needed. Here, the authors report on a rapid blood test which analyses protein signatures from 90-180 nm extracellular vesicles for prehospital diagnosis.

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

Bile acids, including glycocholic acid (GCA), have been associated to poor prognosis and cancer progression. Here, the authors discover that GCA inactivation of FXR reduces CD8 + T cell-mediated antitumor response in colorectal cancer.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Despite being a wonder drug for COVID-19, Paxlovid suffers deficiencies pertinent to ritonavir associated toxicity and rising resistance to nirmatrelvir, which authors in this work show can be overcome by redesigned viral main protease inhibitors as a mono-therapeutic agent.

Turning lignin into clean fuels is hard because catalysts struggle to balance hydrogenation and oxygen removal. This study builds Ru/RuO_x sites on carbon nanofibers that work together to boost hydrodeoxygenation and favor cycloalkanes.

Metabolic profiling of extracellular vesicles for diagnostic applications remains challenging. Here authors develop ACTIVITY, a cascade-catalysis strategy to detect metabolically active extracellular vesicles, enabling macrophage phenotyping and differentiation of pneumonia patients from healthy controls.

Current artificial vision systems suffer from high energy consumption and latency due to the von Neumann bottleneck and separated spatiotemporal processing. Wu et al. propose a vision system achieving native spatiotemporal co-processing with millisecond latency and 95% action recognition accuracy at low computational cost.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

The authors show that the leucine metabolic enzyme AUH promotes fat burn and protects against obesity. AUH drives thermogenesis via Ucp1 mRNA stabilization and PPARγ modification via metabolite HMG-CoA, linking amino acid metabolism to weight regulation.

Molecular ferroelectrics are promising for human interfaced high frequency acoustic sensing, though existing ferroelectric materials are often brittle making them impractical for sensors. Here the authors describe a stretchable ferroelectric material, using trimethylchloromethyl ammonium cadmium chloride and polyurethane electrospun for high-accuracy speech recognition under stretching.

Organic solar cells need acceptor molecules with long exciton diffusion lengths, but most available materials fail in thick films. The authors design new fluorinated quinoxaline acceptors that significantly improve carrier mobilities resulting in superior efficiency in both binary and ternary devices.

The authors demonstrate a non-contact approach for detecting nanoscale hot electrons by sensing thermal Casimir forces, enabling direct operando mapping of nonequilibrium hot-electron distributions in semiconductor nanodevices.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

Current artificial intelligence lacks the ability to perceive the emotions conveyed through human touch. Here, the study develops a bio-inspired hairy electronic skin that can recognize emotions from touch, facilitating natural affective communication for robots.

Meiotic sex chromosome inactivation is essential for spermatogenesis, but how transcription is silenced after initiation remains unclear. Here, authors show that nucleolar components NPM1, SENP3 and rRNA form a phase-separated compartment that excludes RNA polymerase II to enforce XY chromosome silencing.

The rapid rise of artificial intelligence pushes the need for more efficient computing. Here, authors propose an electrically reconfigurable, all-optical logic processing unit based on the combination of Kerr nonlinearities and high-entropy MXene surface terminations. They achieve an accuracy of 97.7% for digit recognition on the MNIST dataset.

Direct observation of second sound in graphite at ambient conditions reveals phonon-hydrodynamic transport. By controlling isotope scattering, this work demonstrates wave-like heat propagation, exceeding conventional diffusive thermal limits.

A “confined molecular encapsulation” strategy enables one-step fabrication of biomimetic ion-selective membranes. The in-situ formed MOFs with tunable sizes facilitate highly precise ion differentiation.

This work presents a quantum-cutting heterostructure that emits tunable near-infrared light (900-2200 nm) under ultralow-power excitation. It enables AI-assisted multiplexed gas detection, offering a scalable strategy for broadband NIR light sources

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Water and oxygen jointly influence the oxidation of copper, but their respective roles are difficult to disentangle. Here, the authors show that hydroxyl species adsorb at the Cu/CuO_x interface, roughen the surface, and enable deeper oxygen penetration and higher Cu mobility.

Pathological mechanisms underlying the onset and progression of PTSD (post-traumatic stress disorder) are not fully understood. Here authors show that stress-induced Sgk1 upregulation in basolateral amygdala neurons projecting to the hippocampus as a key mechanism underlying the delayed PTSD-like avoidance behavior in mice.

LHAASO has detected γ-ray emission with a spectrum extending to 2 PeV from the pulsar wind nebula (PWN) powered by PSR J1849-0001, indicating an extreme particle acceleration efficiency and challenging the current particle acceleration theories.