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The family of oxiranes encompasses a variety of compounds with extensive applications across different fields. Herein, the authors report the photochemical syntheses of a range of highly functionalized strained oxiranes.

DNA can store vast amounts of data, but current systems rely on many redundant copies and deep sequencing to correct synthetic, storage and readout errors. Here, authors present Gungnir, a DNA storage codec that recovers data from a single, highly error-prone sequence, reducing cost and improving reliability.

FLT3-ITD mutations drive relapse in acute myeloid leukemia (AML) despite targeted therapies. This group studies therapeutic potential and resistance mechanisms of FLT3-ITD inhibition with QUIZartinib and Omacetaxine Mepesuccinate (QUIZOM) in preclinical and clinical AML specimens.

Controlling the morphology of dendritic nanostructures is crucial for enhancing their functionality, but remains a challenge. Here, the authors demonstrate that the local electric field between gold nanoparticles and iron oxide branches promotes directional and accelerated growth.

Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

Hybrid perovskites show promise for spintronics but suffer from fast spin relaxation. The authors use isotope engineering, replacing hydrogen with deuterium, to suppress hyperfine interactions, boosting spin lifetime and enabling strong room-temperature spin transport and spin photovoltaic effects.

Chern ferromagnetism is established in twisted bilayer MoTe₂ devices at large twist angles. Here, the authors observe evidence of antiferromagnetic ground states with zero Hall resistance at an intermediate twist angle around three degrees, demonstrating the sensitivity of the magnetic ground state.

Precise transcriptional regulation is critical for cellular function and development. In this study, authors unravel a regulatory compensation mechanism that ensures stable and precise transcriptional output for SIN3A, and potentially other dosage-sensitive genes.

Lithium||sulfur batteries are limited by sluggish solid-state sulfur conversion. Here, authors investigate spin-state transitions as a key kinetic barrier and design a spin-regulated catalyst that accelerates sulfur conversion, suppresses polysulfide shuttling, and enables high-capacity pouch cells.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

Chen et al. report a crystal regulation strategy for 3D perovskites by using functional molecule to adsorb to specific perovskite facets and diminish random crystal facet-correlated defects, yielding pure-blue LEDs with emission peak at 473 nm, linewidth of only 14 nm, and efficiency of 14%.

Ischemic stroke involves complex peripheral and central pathologies. Here, authors develop a spatially tiered strategy using dual stiffness nanoparticles for compartment-specific drug delivery, offering a synergistic treatment paradigm.

Alport syndrome has diverse genetic causes that are often hard to detect. Here, the authors use a layered sequencing strategy in a large Chinese cohort to uncover coding and noncoding variants, including novel structural types, refining the genetic diagnosis of inherited kidney disease.

Tumors remain difficult to map. Here, the authors developed a 2.5 mm magnetic-driven multifunctional optoelectronic catheter that enables minimally invasive tumor mapping, targeted drug delivery, in situ sensing, and photodynamic therapy.

Copper nanoclusters are promising photothermal heaters, but their conversion efficiency is limited efficiency. Here, the authors present a rotor-stator ligand architecture that enables enhanced photothermal conversion efficiency of copper nanoclusters.

The hydrogen peroxide generation represents a promising avenue for sustainable chemical production. Here, the authors report a structure-adaptive electrocatalyst that stabilizes the valence state of single-atom Ni sites during the reaction, enabling the continuous output of hydrogen peroxide at 300 mA cm⁻².

Understanding the microscale interfacial properties in acid-catalyzed isobutane alkylation is challenging. Here the authors propose an interfacial mass transfer flux through coupling microscopic interfacial parameters and mesoscopic droplet mass transfer model of a liquid/liquid dispersion system.

In this work, authors develop and validate a plasma proteomics-based model for the prediction of secondary infections in hepatitis B virus-related liver failure.

Cancer cells could sense the availability of glucose to coordinate macromolecular synthetic processes. Here the authors find that glucose-activated adenylosuccinate lyase (ADSL) possesses a moonlighting function of promoting protein succination, thereby upregulating lipogenesis in hepatocellular carcinoma cells.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

SLCO4C1 is known for regulating kidney diseases. This study showed SLCO4C1 regulates hepatic cAMP uptake to suppress lipogenesis in MASLD. Targeting this pathway by FGF21 or forskolin suppressed lipogenesis.

Here, a pulsed Joule heating strategy for the synthesis of high-quality graphite is developed achieving a growth rate of up to 730 nm min^-1, an order of magnitude faster than conventional approaches, and producing large-area films with excellent thermal conductivity.

Polybrominated diphenyl ethers (PBDEs) are linked to dyslipidemia, but why individuals respond differently is unclear. Here, the authors use a national biomonitoring cohort to reveal how specific genetic variants interact with PBDE exposure to increase risk, identifying a key mechanism that disrupts cholesterol metabolism.

Inborn errors of cell death (IECD) with autoinflammatory manifestations could be induced by excessive T cell death. Here the authors characterize IECD patients with autoinflammatory manifestations who possess overactive RIPK1 variants which promote T cell death, secretion of TNF and IFN-γ along with activation of monocytes and macrophages which promotes further autoinflammation.

Wan, Li, Cao and colleagues report a feedback crosstalk between THY1⁺ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes metastasis.

Hybrid sites of single atoms and clusters promise to overcome scaling relations but are limited by spatial decoupling. Here, the authors report an electrocatalyst (Zn₁Fe_1+x/f-NC) with Fe_x clusters and Fe/Zn-N₄ sites within nano-fingerprint carbon layers, enhancing ORR and Zn-air battery performance.

Dietary capsaicin alleviates Alzheimer’s disease-like pathologies in 5xFAD mice via reshaping gut bacteria and elevating the production of lipid metabolites 24-hydroxycholesterol.

Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoural visceral adipose tissue and colorectal tumour microenvironment and report an immune escape mechanism, which may be potentially targeted for improved immunotherapy.

Voltage losses at the perovskite/C₆₀ interface limit the efficiency of perovskite solar cells. Mubai Li et al. design an electron-selective charge-transport self-assembled monolayer that balances electron extraction and the interfacial charge-carrier density.

Wafer-scale lithium tantalate-on-silicon nitride modulators achieve 100 GHz bandwidth and 581 Gbit/s data rates. With low loss and high stability, this hybrid platform offers a robust solution for next-generation optical communications.

The practical application of photocatalytic uranium removal is hampered by the inefficient charge separation of electron-hole pairs in photocatalytic systems, which limits the generation of reactive oxygen species needed for uranium precipitation. Here, the authors show that weakly localized electrons enhance the electronic coherence in fluorine-functionalized covalent organic frameworks strengthening charge separation and promoting directional electron transport to boost the photocatalytic uranium removal from nuclear wastewater.

Turning methane into methanol with H₂O₂ is hard because reactive oxygen is difficult to control. Here, Fe and Cu atoms placed in different regions of a zeolite guide oxygen chemistry, boosting methanol yield and selectivity while limiting overoxidation.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Cargo transport from the ER to the Golgi is highly selective. Here the authors identify three secretory pathway localized proteins that regulate ER sorting of receptor kinases in Arabidopsis and are required to support pollen tube growth.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.

The susceptibility of mouse and human T cells to ferroptosis is determined by the balance of systemic polyunsaturated and monounsaturated fatty acids, highlighting a key role for lipid metabolism and dietary composition in regulating T cell function.

Although lithium–sulfur batteries are prized for their sustainability, practical energy densities are often limited by heavy host materials. The authors report a graphdiyne architecture that integrates anchoring and catalytic functions, enabling ultrahigh sulfur loading and exceptional energy densities, even in pouch-cell configuration.

Hydrogels can be integrated into skin bioelectronics, though balancing stability, mechanical properties, and breathability remains challenging. Here the authors design a crosslinked organohydrogel using a solvent replacement strategy integrated into on-skin sensors.

The antibody Fab5 cross-neutralizes gammaherpesviruses by binding to a conserved region in the membrane fusion protein gB on the virus; this region could form the basis for a herpesvirus vaccine.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.