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The St Elias orogen in Alaska is one of the world’s highest coastal mountain ranges. An age analysis of detrital material in active sediment systems in the inaccessible ice-covered valley bottoms reveals localized exhumation that is driven by coupling between erosion and active tectonic rock uplift.

Intense glaciation during the middle Pleistocene epoch led to focused denudation and mass redistribution within the St Elias orogen in southern Alaska, and resulted in structural reorganization of the orogen. The tectonic response of this orogen to climate change is consistent with predictions of numerical models.

African ancestry is a known risk factor for prostate cancer development, but the genetic determinants of this are incompletely understood. Here, the authors identify 172 potentially pathogenic variants which are enriched in an African population.

This study found higher RSV antibody levels were associated with lower RSV risk in children outside the hospital. An earlier rise in incidence and higher incidence rates were observed among children <5 years compared to older children and adults.

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

Lipid particles loaded with RNA coding for tumour-unspecific antigens can enhance early responses of type-I interferons, mediating the success of immune checkpoint inhibitors as well as epitope spreading.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

This analysis of whole-genome sequencing data from 421 multiple myeloma samples elucidates the timing of key genomic events and shows associations between the timing of 1q gain and clinical outcome.

The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.

Pulmonary large cell neuroendocrine carcinoma is an aggressive subtype of lung cancer. Here, the authors identify distinct subtypes based on genomic alterations and transcriptomic alterations.

EchoNext, a deep learning model for electrocardiograms trained and validated in diverse health systems, successfully detects many forms of structural heart disease, supporting the potential of artificial intelligence to expand access to heart disease screening at scale.

A survey across 90 societies reveals that variation and change in everyday norms are explained by a single value dimension: the priority societies place on individualizing versus binding moral concerns.

Bifunctional methyltransferase–cyclases both transfer a methyl group to alkenes and induce cyclization—a process called methylcyclization. Now a non-enzymatic silver(I)-mediated electrophilic methylcyclization has been reported. The reaction uses commercial reagents, is applicable to a wide range of substrates and affords structures that are difficult to access by conventional synthetic methods.

Borcoman and colleagues present the efficacy and safety results of the phase 2 PEVOsq basket trial investigating the combination of pembrolizumab with the epidrug vorinostat in patients with recurrent and/or metastatic squamous cell carcinoma.

Together with a companion paper, the generation of a transcriptomic atlas for the mouse lemur and analyses of example cell types establish this animal as a molecularly tractable primate model organism.

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

This study establishes how aperiodic activity, a ubiquitous signal linked to neural noise, develops in localized brain regions and illuminates the development of prefrontal control during adolescence in the development of attention and memory.

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

Membrane lipid packing, influenced by cholesterol, lipid chain length, and saturation, regulates the affinity of biomolecular condensates, enhancing their interactions with less ordered membranes and driving membrane remodeling, including nanotube and double-membrane sheet formation.

Small intestinal neuroendocrine tumours (siNETs) are rare bowel tumors generally considered to be a single entity. Here, the authors perform a multiomics analysis of siNETs and reveal four distinct molecular groups with clinical relevance, including groups linked to differentiation patterns, immunity, and mesenchymal properties.

Using JWST, the molecules seen in planetary atmospheres can be traced back to their cold origins in ices formed in dense interstellar clouds, before the onset of star formation, revealing that chemical diversity and complexity is achieved early.

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

Using slitless spectroscopy, JWST/NIRCam has simultaneously mapped three ice species across a dense cloud along 44 lines of sight. This cospatial mapping enables the local cloud chemistry to be probed with a spatial resolution of hundreds of astronomical units, representing a step change in ice mapping.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Existing DNA stains for live cell microscopy are either toxic, require illumination with blue light, or are not compatible with super-resolution microscopy. Here the authors develop SiRHoechst, a non-toxic far-red DNA stain that is compatible with super-resolution microscopy.

The magnetocaloric effect is well understood in spin-frustrated low-dimensional systems, and should be observable in certain high-symmetry molecular structures. Here, the authors report the experimental observation of sub-Kelvin cooling with a molecular magnet, and probe the low-temperature spin behaviour.

Graphene on boron nitride gives rise to a moiré superlattice displaying the Hofstadter butterfly: a fractal dependence of energy bands on external magnetic fields. Now, by means of capacitance spectroscopy, further aspects of this system are revealed—most notably, suppression of quantum Hall antiferromagnetism at particular commensurate magnetic fluxes.

Growth rate dynamics after temperature shifts can be explained by metabolic rearrangement due to temperature-sensitive enzyme activities in bacteria and yeast.

This paper describes the first evidence of a role for gap junctions in neuronal migration, and also shows that the adhesive properties of the gap junctions, not the conductivity of their channels, are important for the migration.

DiNardo et al. perform a phase 1b/2 clinical trial of telaglenastat (CB-839) in combination with azacytidine in persons with advanced myelodysplastic syndromes and report on the treatment safety and efficacy, including a definition of clinical responders.

The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

Eukaryotic Arf family proteins involved in endomembrane organelle dynamics arose from the Asgard archaeal ArfR GTPases, indicating this capability likely originated in the archaeal ancestor of eukaryotes.

Here authors investigate the effects of different metals incorporated in the structures and possible additional phases have on the CO₂ uptake of pyrene-based MOFs. Results show that when additional phases are present, the pore volume is reduced and CO₂ binding sites in the structure are different, leading to different adsorption properties.