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Long-term observations show that a rising fraction of ammonium nitrate in PM_2.5 reduces aerosol acidity, suppressing the heterogeneous conversion from NO₂ to HONO. This weakens its contribution to the HONO source and atmospheric oxidation capacity.

Uterine fluid supports early embryo development. This study reveals maternal high-fat diet alters tsRNA/rsRNA profiles in uterine fluid, leading to abnormal embryonic metabolism and offspring disorders, demonstrating a novel mode of RNA-mediated communication.

The realization of high-performance flexible perovskite/crystalline-silicon tandem solar cells requires efficient photocarrier transport and mitigation of residual stress. Here, authors reveal the critical role of perovskite phase homogeneity, achieving flexible devices with efficiency of 29.88%.

The authors demonstrate enhanced energy storage performance and thermal stability in lead-free Bi_0.5Na_0.5TiO₃-based multilayer capacitors by employing a hierarchical design strategy across composition, microstructure, and device architecture.

The apelin receptor regulates heart and metabolic health via G-protein and β-arrestin signaling pathways. Here, authors present receptor-β-arrestin complex structures with distinct stoichiometries that provide insight into biased signaling, guiding targeted drug design.

A quantum microsatellite, with a payload weighing only 23 kilograms, in combination with portable ground stations that weigh merely 100 kilograms, is capable of performing space-to-ground real-time quantum key distribution.

A new p-type small molecule enhances defect passivation and improves interfacial charge transport in perovskite solar cells, enabling devices with a certified power conversion efficiency of 26.72%, 97% of which is maintained after 2,500 h of continuous operation.

Exercise exerts health benefits, yet the long-term effects of early-life regular exercise on later-life health and lifespan remain poorly understood. Here, the authors show early-life exercise in mice extends healthspan, though it does not affect lifespan.

The authors reveal nearly two-order magnitude of decoupling of the mean free path of the dominant electrons to that of phonons in Bi-Sb alloy, achieving an atomically homogeneous, coarse-grained sample through ultrafast quenching, enabling thermoelectric cooling down to the liquid nitrogen regime.

Partial differential equation modelling of mitochondrial spatiotemporal dynamics provides mechanistic and quantitative insights into transport disruptions of neuronal axons deficient for Dystonin and Neurofilament light polypeptide.

Linear scaling relationships often hinder the optimization of heterogeneous catalysts. Now, an intermediate spillover strategy is put forward by designing bi-component catalysts, thereby decoupling elementary electron-transfer steps and circumventing linear scaling relationships.

Nationwide implementation of a series of stringent multisectoral air pollution prevention and air-quality monitoring policies in China was associated with reduced hospital admissions for a wide range of cardiorespiratory, neuropsychiatric and kidney diseases due to substantial reductions in PM_2.5 and black carbon pollution over a period of 5 years.

Sequencing the genome and microbiome of about 1,500 tick samples from regions across China revealed host–microbe associations in ticks that could have implications for controlling ticks and tick-borne diseases.

The poor interpretation of glycopeptide spectra limits the site-specific glycan quantification at the proteomics scale. Here, the authors develop GlyPep-Quant, a glycopeptide quantification tool using library-based match-between-runs strategy, to enhance coverage of site-specific glycan analysis.

Fabricating wide-bandgap perovskite films with a thickness of 1 μm on nano-textured silicon substrates remains a formidable challenge. Here, authors design an amphoteric coplanar conjugated molecule for improve bulk and interfacial properties of perovskites for high-efficiency tandem solar cells.

Fluid shear stress plays a role in medulloblastoma metastasis through a PIEZO2-actomyosin-GLUT1 signalling cascade.

Spin defects in 2D materials offer practical advantages for quantum sensing over their 3D counterparts. Here, the authors demonstrate quantum sensing under high pressure using boron vacancy centers in hBN placed inside a diamond anvil cell and use it to detect both stress gradient inside the pressure chamber and pressure-induced magnetic phase transitions.

Single-cell omics data contain complex, entangled biological signals that challenge interpretation. Here, authors present CausCell, a causal disentanglement framework that outperforms current methods in generating explainable, generalisable, and controllable representations.

HD5 induces filopodial extensions in epithelial cells that the pathogen Shigella exploits to facilitate invasion and infection.

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Several molecular mechanisms, including TIRR-53BP1 repair axis, regulate DNA repair pathway choice and PARP inhibitor sensitivity. Here, the authors show that ubiquitination of TIRR by DTX3L is a critical process that regulates NHEJ pathway activity and PARP inhibitor sensitivity by facilitating XPO1-mediated TIRR nuclear export and degradation upon DNA damage.

This paper reports engineering of metal vacancy to activate lattice oxygen in NiO, enabling photocatalytic ethane dehydrogenation to ethylene at 604.5 μmol g⁻¹ h⁻¹ with 100% selectivity and stable 200-cycle recyclability via a light-enhanced Mars-van Krevelen mechanism.

The efficiency of a quantum computer depends on which basic operations it can implement. Now a scheme that can implement any two-qubit logic gate has been demonstrated on a superconducting architecture.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Dopaminergic dysfunction is a key of Alzheimer’s disease pathogenesis. Here, the authors developed a multifunctional neural interface that simultaneously monitors dopamine dynamics and neural activity while delivering 40 Hz stimulation to rescue cognitive deficits in APP/PS1 mice.

A globally interconnected solar-wind power system can meet future electricity demand while lowering costs, enhancing resilience, and supporting a stable, sustainable transition to net-zero emissions.

Anaerobic ammonium oxidation (anammox) bacteria, a game-changer in biological wastewater nitrogen removal, are showing promise in real-world applications. Now, researchers report a strategy for rapidly producing valuable anammox seeds from sewage sludge, a by-product of wastewater treatment that requires careful management and disposal.

Zero-dimensional metal halides exhibit intriguing photophysical properties; however, developing their general design principles remains challenging. Now it has been shown that two-dimensional perovskites can be converted into zero-dimensional octahedral metal halides through solvent incorporation. The resulting materials feature near-unity photoluminescence quantum yields. Structural rigidity and the choice of metal cation are key parameters to tune the exciton recombination dynamics.

Capturing and valorizing H₂S from waste gas is key for sulfur recovery. Here, the authors report an electrochemical deep oxidation method that converts H₂S from polluted natural gas into value-added sulfate-containing products (K₂SO₄ or H₂SO₄) using in-situ generated H₂O₂ at cathode.

cpDistiller is a deep learning framework that corrects complex technical effects in Cell Painting data, enhancing gene function analysis with or without scRNA-seq integration, and demonstrating potential for drug discovery.

Coherent electrical manipulation of long-lived, multimode mechanical resonators is crucial for several applications. Here the authors report the integration of a high quality cubic SiC-membrane mechanical resonator with a 3D microwave cavity, enabling long-lived phononic memory and tunable light slowing.

Secondary organic aerosols in Beijing are driven by emissions from outside of the city, with seasonally different emission sources, according to molecular chemical characterization of particulate air pollution.

Mesothelin (MSLN)-targeted therapeutic strategy has potential in cancer therapy. Here this group identifies a MSLN-targeting DARPin M7 with specific binding affinity to the protease-sensitive C-terminal region of MSLN, the developed DARPin-drug conjugates demonstrate enhanced tumor control and improved survival benefits in preclinical pancreatic cancer models.

Here the authors propose an atomic-scale electron avalanche breakdown model to investigate the dynamic behaviors of excited electrons under extremely high electric fields in various dielectrics ranging from simple oxides to perovskites.

Simultaneous oxidation of soot and CH₄ is challenging in dual-fuel engines. This study introduces a Ru-Pd/3D macromesoporous Ce-Zr oxide catalyst, significantly enhancing oxidation via cooperative Ru (NO activation) and Pd (CH₄ activation) sites.

In Chinese residential buildings sector, avoid, shift and improve measures in demand-side solution will mitigate 47% of cumulative CO2 emissions and 16% of cost before 2060, and reduce the uncertainty of achieving carbon neutrality target.