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Catalytic multicomponent carbonylation reactions with high regio- and chemoselectivity represent one of the long-pursued goals in C1 chemistry. Here, the authors report a cobalt-catalyzed divergent radical alkene carbonylative functionalization under 1 atm of CO at 23 °C.

Excitation-dependent multicolour emission is desirable, but hard to obtain. Here, the authors report the development of a molecular symmetry breaking strategy to all excitation-dependent multicolour emissions from one chemical entity.

Dihydrouridine (D) is an abundant RNA modification but its functions are currently unclear. Here, authors develop CRACI, a sensitive method for transcriptome-wide, single-base D mapping, identifying sites across mammalian and plant transcriptomes and identifying DUS2L as a mitochondrial D writer.

Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

While copper-catalyzed asymmetric propargylic substitution has emerged as a versatile tool for constructing chiral propargylic frameworks, its application in forging cyclic chiral quaternary carbon centers remains a significant synthetic challenge. This work demonstrates a dinuclear copper-catalyzed asymmetric [3 + 2] annulation strategy between tertiary propargyl carbonates and diverse C,O-bisnucleophiles.

Efficient exchange of long-chain ligands has been challenging for high-performing perovskite quantum dot photovoltaics. Here, the authors construct alkaline environments for antisolvents to promote their hydrolysis into conductive surface capping, enabling a certified solar cell efficiency of 18.3%.

Intracellular siRNA delivery is key for RNAi therapy. Here, the authors report on bioengineered nanovesicles with tumour cell-targeting and enzyme-activated membrane fusion functions for efficient cytosolic siRNA delivery to knockdown oncogenes, leading to effective tumour gene therapy.

Using data from the UK Biobank, the authors develop a comprehensive human metabolome–phenome atlas, including a browsable web tool, to uncover unique metabolite–trait and metabolite–disease associations with time, and discuss potential causal relationships.

Here, Li et al. develop a human liver organoid model to elucidate Dengue virus infection dynamics and identify oxyresveratrol as a potential antiviral candidate, highlighting the NRF2 pathway’s crucial role in mitigating mitochondrial damage and enhancing cellular resistance.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

The decarbonization of energy systems requires access to minerals that are critical for manufacturing low-carbon technologies. Here researchers show that meeting climate targets could be impeded by material shortages, revealing the importance of diverse solutions that balance mitigation, equity and resource constraints.

While the counterion of a metal catalyst can influence the activity and selectivity of reactions, this phenomenon is rarely observed in carbonzincation reactions. Herein, the authors report increased catalytic efficiency in the iron-catalyzed alkylzincation of alkynes when the weakly coordinating bulky counterion tetrakis(3,5-bis(trifluoromethyl)phenyl)borate is added.

Catalytic methods to introduce fluorine into the backbone of small-ring heterocycles are challenging due to the problems of strain-induced ring cleavage and defluorination. Now, a copper catalyst mediates insertion of an in situ-generated difluorocarbene into oxygen heterocycles, affording ring-expanded fluorinated pharmacophores. Experimental and computational studies provide insights into the mechanism.

Using a single strategy to make a number of related intermediates is a useful strategy in the total synthesis. Here, the authors report the synthesis of a number of natural products, employing two diastereomerically complementary metal-catalyzed cyclizations as the key step to access a number of frameworks.

Zinc(I) bimetallic clusters have previously been reported, but they are not stable in air. Here, the authors synthesize octametallic Zinc(I) clusters with multi-centred zinc–zinc bonds and extensive electron delocalization over the cluster, resulting in cubic aromaticity and enhanced stability.

The systematic ferroelectric domain control in ferroelectric CuInP₂S₆ systems has remained elusive. Herein, the authors report the efficient ferroelectric domain engineering under a unipolar electric field in CuIn₂S₆ system.

CMAP is a method that maps large-scale individual cells to their precise spatial locations by integrating single-cell and spatial transcriptomics data through a divide-and-conquer strategy, supporting diverse data types and mapping scenarios.

Metal-driven anaerobic oxidation of methane and methanogenesis, mediated by a diverse microbial community, drove iron-mineral transformation and may have aided ice sheet melting, according to analysis of Sturtian iron formations from South China

The Einstein Probe has discovered a fast X-ray transient, EP240414a, associated with a broad-lined type Ic supernova. Its unusually soft spectrum and weak jet add to the diversity of stellar deaths and suggest a previously unknown Wolf–Rayet star explosion mechanism.

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

In this phase 3 trial, first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma with anti-PD-1 finotonlimab plus cisplatin plus 5-fluorouracil (C5F) prolonged overall survival compared with placebo plus C5F.

The development of three-dimensional (3D) covalent organic frameworks (COFs) with novel topologies is of both fundamental and practical interest but the construction of highly crystalline 3D COF remains challenging. Here, the authors report highly crystalline 3D COFs with pto and mhq-z topologies by rationally selecting rectangular-planar and trigonal-planar building blocks with appropriate conformational strains.

Legionella effector LtpM is found to recognize short two-residue sequons, enabling site-specific O-glucosylation with minimal perturbations to a target protein, and is used to show that O-glucose can act as a constitutively active O-linked N-acetylglucosamine mimic.

A large electronic display textile that is flexible, breathable and withstands repeated machine-washing is integrated with a keyboard and power supply to create a wearable, durable communication tool.

The oxidative intermolecular amination of C-H bonds represents a straightforward method to construct aliphatic allylic amines. However, the utilization of widely available internal alkenes remains a synthetic challenge. Here, the authors present a regioselective Cu-catalyzed oxidative allylic C-H amination of internal olefins with azodiformates.

The mechanism through which auxin regulates chilling tolerance remains unclear. Here, the authors discover a negative regulator of chilling tolerance in japonica rice, which encodes an ABCB transporter with auxin efflux function, and show its potential to increase indica rice chilling tolerance.

The positive electrode/electrolyte interface is crucial for the performance of all-solid-state lithium batteries. Here, authors use a sintering technique to form a conformal interface between high-entropy disordered rock salt electrodes and garnet-type electrolytes to reduce interfacial resistance.

Enantioenriched α-disubstituted α-ethynylamines are valuable synthons to chiral α-tertiary amines and azacycles, but their facile access remains challenging. Now, sterically confined pyridinebisoxazoline ligands have been developed to facilitate highly enantioselective Cu(I)-catalysed propargylic amination of both aliphatic and aryl ketone-derived propargylic carbonates to give α-tertiary ethynylamines. Related tandem sequences are reported to synthesize quaternary azacycles.

Oxidative carbonylation using CO/O₂ is an attractive strategy to construct carbonyl compounds, but the explosive limit of the gas mixture hampers its application. Now, this safety issue is overcome in the aminocarbonylation of alkynes by replacing the external oxidant O₂ by electrochemistry facilitating a mild and safe reaction.

Olinger, Banarjee et al. use several proteomic approaches to profile the senescent monocyte secretome and identify senescence-associated circulating proteins that associate with age- and obesity-related phenotypes in two independent aging studies.

Neonatal gyrated brains harbor an elaborate subventricular zone, termed the Arc, supporting cortical migratory streams of diverse interneurons.

Copper-catalyzed asymmetric propargylic substitution of α-tertiary propargylic electrophiles using hydrazines and hydroxylamines can access multifunctional α-tertiary hydrazines or hydroxylamines. Here the authors use a sterically confined pyridinebisoxazolines to improve yields and enantioselectivity, supported by NMR analysis and theoretical calculations.

Perovskite solar cells have been limited by the use of relatively expensive organic compounds as hole-transporting materials. Here, Qin et al.use an inorganic hole conductor, CuSCN, in a lead halide perovskite solar cell and achieve power conversion efficiencies as high as 12.4%.

The synthesis of ionic olefin linked threedimensional covalent organic frameworks (3D COFs) is challenging because of the difficulties in forming stable carbon-carbon double bonds. Here, the authors report a general synthesis of an ionic sp² carbon linked COFs and demonstrate selective capture of ReO₄⁻ ions.

Purifying C₂H₂ by removing trace CO₂ is needed but challenging due to their analogous physical properties. Herein, the authors report the pilot-scale production of a commercial resin adsorbent loaded with polyethyleneimine for the selective capture of CO₂ traces and exclusion of C₂H₂.

Cui et al. report analogue photoelectronic reservoir computing with IGZO synaptic transistors as the reservoir and TaOX-based memristor array as the output layer. A receptive field inspired encoding scheme is implemented to simplify the feature extraction for dynamic vision processing.

Metabolic processes lead to the production of bioactive gases, such as nitric oxide, which may play roles in the gut immune homeostasis. Here authors show that genomic deletion of Nos2 in mice aggravates colitis in experimental models via an Aryl-Hydrocarbon-Receptor-mediated pathway in type 3 innate lymphoid cells.

Three-dimensional (3D) reconstruction from computed tomography could significantly contribute to guiding lung cancer surgery, but requires comprehensive clinical validation. Here, the authors test the effectiveness of an AI-driven 3D reconstruction system for lung cancer surgery in a retrospective, multi-center, multi-reader, multi-case study.

Bioluminescence imaging with enhanced sensitivity, resolution and dynamic range is enabled by a camera based on quanta image sensor technology in combination with a dedicated unconventional microscope design. The capabilities of the QIScope are demonstrated in live imaging of extracellular vesicles or low-abundance proteins.