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Advances have been made in thin-film piezoelectrics; however, the linearity of electric-field-induced strain with frequency and temperature still requires improvement. Here, by growing interlocked monoclinic and tetragonal polar nanoregions in (K,Na)NbO₃ thin films, highly linear strains of up to 1.1% are reported at frequencies up to 10⁵ Hz.

Acute lung injury (ALI) carries high mortality with limited treatment. Here, the authors show in mice a brain-lung circuit wherein CRH neurons activation in the paraventricular nucleus of the hypothalamus (PVN) attenuates ALI by limiting neutrophil hyperactivation.

Developing high-current-density catalysts is key to efficient water splitting. Here, the authors report a single-atom Ru-doped amorphous Ni–Mo oxide that dynamically self-reconstructs to retain high activity at industrial current densities in an anion-exchange membrane water electrolyzer.

Mercury accumulates in the deep sea, but its ecological impact remains unclear. This study reveals distinct patterns of mercury-transforming processes in deep-sea sediments, uncovering potential novel taxa and pathways.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Terahertz control of polar skyrmions—topological textures of electric dipoles—is key for fast optoelectronics. Now, ultrafast excitation of polar skyrmions is achieved across two orders of magnitude of temperature in an oxide heterostructure.

WISDEM is a hybrid detector for simultaneous EEG and fMRI recordings without artifacts or crosstalk, which allows access to neural activity at high temporal and spatial resolution, respectively, as demonstrated in rats.

In this study, the authors combine interpolation techniques and deep learning methods, introducing Interpolating Neural Networks (INNs) to model complex systems with high accuracy and low computational cost.

The authors present evidence based on satellite observations that the local cooling effect of potential forestation in Europe has intensified over the past two decades, driven by the reduced winter snow cover and declining summer soil moisture under global warming.

Vaginal infections influence about 75% of adult women worldwide each year. Here, the authors report a strategy to treat vaginal infection by restoring the homeostasis of the vaginal mucosal barrier through in situ formation of a living-synthetic therapeutic coating.

High-density multimodal soft bioelectronic fibres provide a platform for minimally invasive implantable electronics, where diverse sensing and stimulation functionalities can be effectively integrated.

Biomolecular phase separation arises from collective molecular interactions and is emerging as a key theme for biological function. Here the authors propose a broadly applicable method to quantify these interactions based on compositional and energetic parameters.

This study establishes a molecular classification of keloids based on fibroblast differentiation via integrated single-cell/bulk RNA-seq, offering novel insights into pathogenesis and enabling precision clinical management with therapeutic avenues.

Iron carbide catalysts—especially the Fe₇C₃; phase—show great promise for efficient CO₂ hydrogenation to olefins. Here, the authors report the first stable, nearly pure Fe₇C₃ catalyst for CO₂-to-olefins conversion, overturning conventional models that posit the necessity of Fe₅C₂–Fe₃O₄ coexistence.

Using single-cell metabolomics techniques, Chen and colleagues reveal that an aldehyde-dehydrogenase-2-dependent γ-aminobutyric acid synthesis pathway in hippocampal pyramidal neurons suppresses their excitability during long-term potentiation and learning, linking neuronal metabolism to synaptic plasticity and behavioral adaptability.

The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

A brain space-time-coding metasurface platform is proposed by integrating visual stimulation for brain–computer interfaces with dynamic electromagnetic wave manipulations, enabling physical-layer secure wireless communication and mind-driven device control.

Understanding brain function requires integrating neuronal structure, activity, and genes. Here, authors developed an optogenetic tool they name Pisces, to enable complete labeling of individual neurons’ morphology with functional and molecular profiling, allowing multimodal single-cell analysis in vivo in zebrafish.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

The mechanisms linking neuropsychiatric and metabolic disorders remain unclear. The authors show a pancreas–hippocampus feedback loop whereby metabolic and circadian factors drive behavioral fluctuations, with potential relevance for bipolar disorder.

The ability to pursue a stronger recall response on secondary antigen encounter is a hallmark for T cell immunity. Here the authors show that the histone component, H2A.Z, may contribute to CD8 T cell recall readiness by depositing to specific locations and introducing a specific epigenetic landscape in CD8 memory T cells to facilitate more prompted activation of related genes.

The decarbonization of energy systems requires access to minerals that are critical for manufacturing low-carbon technologies. Here researchers show that meeting climate targets could be impeded by material shortages, revealing the importance of diverse solutions that balance mitigation, equity and resource constraints.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

Time-dependent phosphorescence colour is desirable but challenging to achieve. Here, the authors report the use of carbon dots with varying phosphorescence colour in the core and shell.

Sepsis-associated acute kidney injury (SA-AKI) leads to significant morbidity and mortality, but early diagnosis remains challenging. Here the authors use single urinary extracellular vesicle proteomics to identify complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.

Researchers show that two kinds of crystal dislocations in gallium nitride act as distinct path for electrons and holes. The discovery explains leakage and switching losses in GaN power devices and points to defect-guided design strategies.

R9AP is a key receptor for entry of Epstein–Barr virus into human epithelial and B cells, and interacts directly with the viral glycoprotein gH/gL complex to mediate virus–host membrane fusion.

Generalized body pain and headaches are common experience after sleep disruption. How does sleep disruption lead to generalized pain is unknown. Here, authors reveal that N-arachidonoyl dopamine, an endocannabinoid, is critically implicated in pain perception after sleep disruption.

Loss of the tumor suppressor PTEN is often observed during endometrial cancer (EC) progression. Here the authors show that the deacetylase SIRT7 mediates PTEN deacetylation in an estrogen-dependent manner, leading to increased ubiquitination and degradation of PTEN to promote EC metastasis.

Developing durable catalysts for the acidic oxygen evolution reaction is crucial for proton exchange membrane water electrolyzers. Here, the authors report incorporating high-entropy atoms (Co, Ni, Cu, Mn, Sm) into RuO₂ via annealing, achieving stable operation at 1 A cm⁻² and 50 °C for 1500 h.

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

Uterine scarring is a common complication after uterine injury, but its mechanism remains unclear. Here, the authors show that sFRP2 drives uterine scarring by activating WNT5A in fibroblasts, and explore a potential therapy with lipid nanoparticle-delivered sFRP2 siRNA inhibiting scarring and improving fertility outcomes.

This study demonstrated that different types of HC-Pros from potyviruses exhibit varying capacities to inhibit HEN1. This results in distinct levels of autophagic AGO1 degradation, which in turn leads to differences in RNA silencing suppression efficiency.

This study investigates the role of 3,4-dihydroxyphenylacetaldehyde synthase (DHPAAS) in mosquito cuticle formation, a key factor in their development and survival. The findings reveal that DHPAAS is essential for abdominal integrity and egg development, with unique structural features suggesting a novel oxygen delivery mechanism.

Achieving sustainability in wireless communications is crucial yet poses significant challenges. To address this, the authors propose and demonstrate a solar-powered programmable metasurface enabling hybrid light-to-microwave wireless communications.

Room-temperature phosphorescence is usually inefficient in purely organic material. Here, the authors achieve near-unity phosphorescence efficiency with color tunability in adaptive host-guest materials through use of hyperconjugation.

The zoonotic parasite Toxoplasma has complex developmental programs to accommodate different lifestyles that are important for parasite transmission and pathogenesis. Here, the authors discover a novel chromatin remodeling complex containing SNF2L in Toxoplasma and report its crucial roles in regulating the parasite’s developmental programs.

Here, the authors perform a pan-genome-based genome-wide meta-analysis of six independent GWAS experiments in rice, demonstrating the potential of this approach to increase understanding of the genetic basis of, and genes underlying key rice traits.