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Pt/CeO₂ ensemble catalysts show great potential for hydrocarbon oxidation, but the nature of active sites and interfacial evolution during reaction has been debated. Here, the authors demonstrate metallic Pt ensembles serve as the true active sites for C₃H₆ oxidation, and confirm dynamic nature of oxygen activation with the threshold temperature around 170 °C.

Viruses such as EBV use various mechanisms to avoid antiviral responses. Here the authors propose that the EBV protein BRRF2 is secreted via extracellular vesicles from NPC cells, disrupts the cGAS-STING pathway, reduces cGAS-DNA phase separation and the subsequent antiviral response.

Metal-support interactions (MSI) on catalysts are poorly understood. This work identifies valence-restrictive MSI fixing nanocluster Rh_n on CeO₂ as Rh_n²⁺, boosting H⁻ formation and enabling selective CO₂ to CH₄ hydrogenation.

Liang et al. estimate the prevalence of text modified by large language models in recent scientific papers and preprints, finding widespread use (up to 17.5% of papers in computer science).

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

Dihydrouridine (D) is an abundant RNA modification but its functions are currently unclear. Here, authors develop CRACI, a sensitive method for transcriptome-wide, single-base D mapping, identifying sites across mammalian and plant transcriptomes and identifying DUS2L as a mitochondrial D writer.

Aerogels are traditionally synthesized using reagent-induced sol-gel transitions, though it is challenging to precisely control the aerogel structure. Here the authors use electrophoresis-driven self-assembly combined with electrochemical gelation to more precisely control the aerogel structure.

Basalt clasts returned by Chang’e-6 suggest a lunar farside mantle potential temperature that is approximately 100 °C cooler than the nearside mantle, according to a petrologic study combined with thermobarometric modelling and remote sensing data.

Doping is used in p-n junction devices to partially mitigate nonradiative recombination losses. Here, authors use phosphorus dopants to reduce charge carrier trapping and electronic band tails in polycrystalline CdSeTe, achieving improved ambipolar mobilities, fill factor and solar cell efficiency.

UTe₂ is a proposed intrinsic topological superconductor, but its quasiparticle surface band has not yet been visualized. Now this is achieved using quasiparticle interference imaging, revealing the symmetry of the superconducting order parameter.

Diabetes can contribute to pancreatic cancer development as well as be a consequence of it. Here, the authors report that diabetes-induced senescence of endothelial cells promotes pancreatic cancer progression.

Circulating metabolites reflect key physiological states, but their genetic basis remains incompletely defined. Here, the authors show over 24,000 variant-metabolite associations and highlight rare coding variants and disease-linked metabolites through integrated analyses.

A soft mesh microelectrode array can seamlessly integrate in developing brains, enabling long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain development.

Polycystic ovary syndrome is a common cause of female infertility linked to metabolic and hormonal imbalances. Here, the authors show that androgen driven SLC1A5 upregulation increases glutamine uptake, leading to abnormal follicular development in PCOS via histone deacetylation.

The study shows that lunar ilmenite preserves less solar wind-generated water than silicate minerals, likely due to faster water escape. This finding suggests that ilmenite may critically influence surface water variations within the lunar Procellarum KREEP Terrane.

The dilute CO₂ electrocatalysis suffers from low selectivity in membrane electrode assembly. Here, the authors report the design of self-reinforced CO₂ concentration gradient that breaks CO₂ mass transport limit, realizing direct and selective conversion of simulated flue gas in membrane electrode assembly.

Enfortumab vedotin (EV) is the current standard treatment for advanced bladder cancer, but resistance typically develops within a year, highlighting the need for new therapies. This study demonstrates that NECTIN4-targeting CAR T cells are effective against bladder cancer, including EV-resistant cells, and their potency can be further enhanced by using rosiglitazone to boost NECTIN4 expression.

A biodegradable MgSO₄-reinforced poly (l-lactide-co-ε-caprolactone) cerebral stent was prepared by 3D-printing technique, providing efficient neuroprotection effects on ischemic brain tissues through sequential release of Mg ions.

Single-cell transcriptomic profiling of immune cells in the blood and liver of a human decedent receiving a pig liver xenograft reveals impaired adaptive immunity and monocyte features that may induce T cell exhaustion and contribute to platelet activation.

This large meta-analysis of 11 GWAS identified 7 genetic loci associated with strabismus, esotropia and exotropia. Mendelian randomisation provided genetic evidence of the causal link between maternal smoking to increased strabismus risk in offspring.

Spin defects in 2D materials offer practical advantages for quantum sensing over their 3D counterparts. Here, the authors demonstrate quantum sensing under high pressure using boron vacancy centers in hBN placed inside a diamond anvil cell and use it to detect both stress gradient inside the pressure chamber and pressure-induced magnetic phase transitions.

Dual-scale chemical ordering in CoNiV-based alloys improves the synergy of strength and ductility at cryogenic temperatures, providing an approach for obtaining high-performance metallic materials for cryogenic applications.

Noble metals can promote the stable lattice oxygen of metal oxides to take part in oxidation reactions. Here, the authors report the preparation and reactivity of rhodium-aluminum oxide cluster ions, in which the rhodium ion promotes the transfer of five oxygen atoms from a nine-atom parent cluster to oxidize carbon monoxide.

Semiconductor quantum dots that simultaneously support blue and yellow emission offer a route to realizing efficient white light-emitting diodes.

Trained and validated on multimodal data from 14.5 million images from multicountry datasets, a foundation model is shown to increase diagnostic and referral accuracy of clinicians when used as an assistant in a trial involving 16 ophthalmologists and 668 patients.

Deeply-sourced volatiles are releasing from orogenic plateau regions, providing windows to plateau growth dynamics occurring at variable depths. Here the authors show that mantle-derived volatiles reveal the involvement of mantle dynamics in southeastward growth of the Tibetan Plateau.

The difluoromethyl group is a crucial fluorinated moiety, and the synthesis of chiral CF₂H-containing analogs is a powerful strategy in drug design and screening. Here, the authors report a strategy for the asymmetric construction of carbon stereocenters featuring a difluoromethyl group via nickel-catalyzed Negishi cross-coupling.

Using Pd homogeneous catalysts for direct C–H arylation is an attractive approach for synthesizing natural products and organic functional materials, but limitations in terms of cost and catalyst recovery could be alleviated by alternative heterogeneous catalytic processes. Here, the authors report a Pd single-atom/cluster cocatalyst supported on non-enzymatic browning glucose for the direct coupling of inert C-H bonds with aryl iodides that breaks the activity-stability trade-off via a Pd^II/Pd^IV catalytic cycle, and demonstrate C(sp³)-H or C(sp²)-H bond activation tunability by tailoring the structure of the catalyst support.

Helium was long thought to be unable to form stable solid compounds, until a recent discovery that helium reacts with sodium at high pressure. Here, the authors demonstrate the driving force for helium reactivity, showing that it can form new compounds under pressure without forming any local chemical bonds.

Precipitation is a key driver of plant growth. Here the authors integrate ground-based observations, remote sensing and process-based models to disentangle the relative contribution of preceding-year and current-year precipitation on plant productivity and identify its predictors across biomes.

The conversion of carbon dioxide to higher-value chemicals is an industrially important reaction. Here, the authors report a hybrid catalyst manganese oxide nanoparticle supported on mesoporous cobalt oxide, which catalyses the conversion of carbon dioxide to methanol at high yields.

High frequency microwave is crucial for communication and radar applications. The authors develop a compact Kerr comb for photonic THz generation with near quantum limited noise performance, enabling record-breaking 240 Gbps wireless communication.

Here the authors design tripeptides that form dynamic soluble dispersions and undergo phase separation upon drying to assemble into porous particles. This evaporation-driven emulsification can be harnessed to encapsulate and stabilize biomolecules.

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

Porous solids have potential applications in energy storage, gas separation and catalysis technologies. Here, the authors report a hierarchical solid with porosity spanning the micro, meso and macro ranges, which is synthesized using templating silica, and potassium ions as both templates and reactive species.

In magnetic materials, geometry-defined competing interactions between spins combined with quantum fluctuations can present the possibility of quantum liquid states which do not order even as 0K is approached. Here, the authors present an analogue built from electric dipoles on a triangular lattice.

Soil microorganisms are changing their phenology more than plants under climate warming, which could harm terrestrial ecosystem functioning, according to an analysis of a global compilation of experimental data.

In patients with advanced cancer, the development of brain metastasis (BM) often signals a worsening prognosis with limited therapeutic options. Here, the authors assemble a large, open-source neuroimaging dataset of BM and perform spatial and morphological analysis which they use to develop a framework for function-sparing brain radiotherapy design.