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A generative AI approach is developed for predicting materials synthesis recipes—a complex challenge in materials science. Using this approach, the authors experimentally synthesized a material using AI-generated synthesis recipes.

The bacterial genus Aeromonas includes emerging human pathogens, often misidentified as Vibrio cholerae. Here, the authors analyse genomic sequences of over 1,800 Aeromonas isolates, showing that clinical and environmental strains do not display clear differences in drug resistance or disease-causing potential.

Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.

Using a superconducting circuit analogue of an atom in front of a mirror it is possible to shape the modes of the quantum vacuum and hide the atom from the vacuum fluctuations.

Yoshioka et al. show that bacteria wrap their flagella to squeeze through near cell-width confinements, which allows symbiotic microbes to navigate constricted gut regions within insect hosts.

Greenland’s icebergs transport 450 megatonnes of sediment to its fjords each year, representing one-third of the ice sheet’s total sediment export. This ice-rafted debris builds shoals at tidewater glacier margins and provides key nutrients for marine ecosystems.

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

A completely solid-state, single-chip, microwave-frequency surface acoustic wave phonon laser can generate coherent phonons from thermal noise or resonantly amplify injected phonons using only a direct current bias field.

Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell invasive and metastasis properties through induction of cytoskeletal and transcriptional memory.

Understanding the three-dimensional nature of fracture formation and dynamics is challenging. Experiments now show that a fracture front, after originating at a particular locus in a material, propagates jump-wise and expands transversely at high speed.

De novo domestication was performed on the brassica Thlaspi arvense (pennycress) by identifying and stacking CRISPR-induced mutations to create a new intermediate oilseed crop that can be grown in the off-season, with seed compositions similar to canola (low erucic acid and reduced glucosinolate).

Frontal ring-opening metathesis polymerization (FROMP) is a promising energy-efficient approach to fabricate polymeric materials but the characteristic properties of the front are currently controlled primarily by varying the resin composition or the environmental conditions. Here, the authors present an approach to control FROMP of dicyclopentadiene using photochemical methods.

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

Resonant inelastic X-ray scattering interferometry reveals a highly entangled electronic phase in Nd₂Ir₂O₇, enabling extraction of its entanglement structure and confirming the cubic-symmetry-breaking order predicted from complementary Raman spectroscopy.

Lasing with multi-pass gain is achieved in a diamond-based X-ray cavity at the European XFEL, opening a path to next-generation X-ray science.

A self-driving catalysis laboratory, Fast-Cat, is presented for efficient high-throughput screening of high-pressure, high-temperature, gas–liquid reaction conditions using rhodium-catalyzed hydroformylation as a case study. Fast-Cat is used to Pareto map the reaction space and investigate the varying performance of several phosphorus-based hydroformylation ligands.

Bandgap gradient is a promising approach to improve the open-circuit voltage in thin film solar cells. Here, authors incorporate a Cd(O,S,Se,Te) region to realize the bandgap gradient at front interface and demonstrate Cd(Se,Te) solar cells with reduced recombination and a champion efficiency of 20.03%.

Satellite records reveal that Southern Ocean phytoplankton responds in contrasting ways to marine heatwaves and cold spells. These opposing impacts vary sharply by region, exposing distinct ecological sensitivity to climate-driven extremes.

Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of complex behavioural traits.

A soft robotic probe enables continuous in utero monitoring of fetal physiological parameters, including heart rate, blood oxygen saturation, temperature and electrocardiogram data, during open or fetoscopic surgery to provide real-time information on fetal condition and distress.

Language is often thought to be represented through hierarchically structured units. Nielsen and Christiansen find that non-hierarchical structures are present across reaction-time tasks, eye-tracked reading and natural conversation.

Kinematic measurements of the Perseus galaxy cluster reveal two drivers of gas motions: a small-scale driver in the inner core associated with black-hole feedback and a large-scale driver in the outer core powered by mergers.

The authors report the observation of diffraction-free space-time surface plasmon polaritons propagating along straight paths at metal-dielectric interfaces. This enhances the control of wavepacket propagation for nanophotonics applications.

Symmetry breaking is key to tissue formation. Now it is shown that symmetry breaking of epithelial spheroids is controlled by an interplay of collective migration with curvature and matrix remodelling.

Using two-photon microscopy with a panoramic virtual reality setup, how head direction cells in larval zebrafish integrate visual landmarks and optic flow to track orientation is revealed.

Spatio-temporally structured light can provide useful applications in laser-wakefield acceleration. Here, the authors demonstrate the generation of wakefields by means of quasi-Bessel beams focused by an axiparabola, imaged with femtosecond relativistic electron microscopy.

During cell migration, cells are polarized with distinct front vs. rear regions but whether and how polarity is transmitted to the nucleus is unclear. Here the authors show that frontally-biased endoplasmic reticulum and the nuclear membrane protein Emerin contribute to front-rear nuclear cell polarity.

High melt rates in a key location beneath the Ross Ice Shelf result from a seasonal inflow of water heated in the Ross Sea Polynya, according to in situ observations.

High-pressure measurements of the electrical conductivity of (Mg,Fe)O, used as an analogue for basal magma ocean material, indicate that the conductivity is high enough to produce a dynamo much stronger than a core-driven dynamo for super-Earths larger than 3–6 Earth masses.

Neuroimmune interactions are important in amyotrophic lateral sclerosis (ALS). Here the authors characterize the role of NK cells in mouse models of ALS, and in patient tissue.

Miyazaki et al. characterize vepafestinib, a next-generation RET inhibitor that is selective for wild-type RET and solvent front mutants. Due to a unique binding mode, it has enhanced brain penetrance and overcomes resistance to other RET inhibitors.

CFAP20 has a key role in rescuing RNA polymerase II complexes that have arrested during DNA transcription, limiting the accumulation of R-loops and preventing collisions between the transcription and replication machinery.

The authors mapped spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity, not cytoarchitecture, organizes prefrontal function.

The study shows how inherited weak zones determine whether transpression produces pushups, duplexes, or parallel faults. 3D models offer insights into the deep processes that drive deformation and seismic patterns in the Caribbean and Levant.

The loss of sea ice enhances swell-induced flexural stress in Antarctic ice shelves before large-scale calving events, according to satellite observations and swell-induced flexural stress modelling.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

This study reveals how atmospheric warming drives glacier instabilities by analyzing multi-decadal in-situ measurements in the High Arctic. Using borehole seismology, it shows that surface melt promotes crevasse opening and sliding.

An amorphous–crystalline silicon nitride nanocomposite at the buried interface of perovskite solar cells enables small-area devices with a certified power conversion efficiency of 26.37%. Modules with an area of 1,252 cm² maintain stable output for 6 months of outdoor operation.