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The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Pathological mechanisms underlying the onset and progression of PTSD (post-traumatic stress disorder) are not fully understood. Here authors show that stress-induced Sgk1 upregulation in basolateral amygdala neurons projecting to the hippocampus as a key mechanism underlying the delayed PTSD-like avoidance behavior in mice.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Robotic grippers struggle to handle fragile and varied objects across environments. Here, the authors introduce a liquid metal gripper that adapts its shape and stiffness for gentle, multiscale grasping and active release.

Precise transcriptional regulation is critical for cellular function and development. In this study, authors unravel a regulatory compensation mechanism that ensures stable and precise transcriptional output for SIN3A, and potentially other dosage-sensitive genes.

Nociceptive hypersensitivity and prolonged wound healing due to the interaction of peripheral neuropathy and local immune disorders hinder the regenerative repair of diabetic foot ulcer. Here, the authors report a low-intensity focused ultrasound-activated piezoelectric gel bandage with immune homeostasis modulation and neuropathic pain relief functions for comprehensive repair of diabetic wounds.

Euglenophytes evolved via secondary endosymbiosis, exemplifying plastid evolution. Here, the authors solve Euglena gracilis’ photosystem I structure, revealing specific protein organizations and structural features for far-red light absorption. This work informs the engineering of photosystem.

Conventional neuromorphic vision systems based on pixels-to-one-memristor architecture face efficiency challenge. Here, Sun et al. report an architecture employing one-pixel-to-multiple-memristor structure, mapping weight updates to voltage vectors to enhance both processing speed and energy efficiency.

Both endogenous and exogenous signaling pathways are involved in the maintenance of self-renewal and pluripotency of human embryonic stem cells (hESCs). Here, the authors uncover that endogenous VEGF signaling safeguards pluripotency and prevents extra-embryonic differentiation in primed hESCs via activation of transcription factor NANOG and suppression of BMP signaling activity.

Standard of care CD19-targeting CAR-T therapy for Relapsed-Refractory Diffuse Large B Cell Lymphoma (r/r DLBCL) faces frequent resistance often driven by regulatory T cell (Treg) activation. This study identifies Timosaponin AIII (TAIII) as A2AR inhibitor for enhanced CAR-T activity while depleting CAR-Treg formation.

This work enables seamless fiber-to-fiber and fiber-to-chip mode-field conversions and establishes a universal multi-dimensional parallel communication architecture for next-generation high-capacity data transmission and management.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Sluggish interfacial charge transfer in Li-metal batteries limits ultrafast charging and causes side reactions. The authors design solvent molecules to enhance Li⁺ coordination, improving the charge-transfer kinetics and enabling stable high-rate cycling of Li-metal cells.

A ductile inorganic-rich solid–electrolyte interphase that retains its structural integrity and allows easy ion diffusion enables a long cycle life under practical conditions for lithium metal batteries.

Isobaric labeling enables simultaneous measurement of multiple samples, reducing analysis time and eliminating potential run-to-run variation. Here, the authors report that TMT-Integrator, now built into FragPipe, improves multiplex proteomics by speeding analysis, increasing protein and phosphosite coverage, and delivering robust results across diverse datasets and workflows.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

This Comment discusses the common practice of measuring selectivity from the change of feed composition, which faces critical challenges of severe error propagation and loss of mechanistic insight. These limitations can be overcome by evaluating selectivity from the receiving solution.

Nicotinamide N-methyltransferase (NNMT) and its metabolite 1-MNA have been implicated in liver disease and stress adaptation. Here, the authors show that NNMT/1-MNA protects against hepatic ischemia-reperfusion injury by modulating the AKT/FOXO1/ANGPT2/JNK axis.

Benralizumab (an anti-IL-5 receptor α antibody), compared to placebo, significantly reduced the risk of first flare in patients with hypereosinophilic syndrome.

Researchers created a moiré superlattice in Sb₂Te₃/FeTe bilayers, producing spatially modulated superconducting gaps directly imaged with Josephson scanning tunnelling microscopy and spectroscopy, tunable by replacing Sb₂Te₃ with Bi₂Te₃.

Efficient modeling of battery electrolytes is limited by the accuracy-cost trade-off. Here, authors develop a universal machine learning potential to accurately calculate transport and solvation properties across a broad chemical space.

The authors reveal distinct atomic-scale mechanisms underlying phase boundary engineering formation and explain the different electrical properties of two (K, Na)NbO₃ based materials with the similar phase boundary, providing a new mechanistic insight.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Naturalistic fMRI reveals that dynamic attitude change is tracked by dorsal anterior cingulate cortex activity and its connectivity with the default mode network, with trait-level intolerance of uncertainty modulating these neural–behavioral associations.

The glycolytic metabolite phosphoenolpyruvate (PEP) is identified as a protective factor during aging. Acting as an endogenous inhibitor of cGAS−STING, PEP reduces inflammation and improves cognition in Alzheimer’s disease mice. PEP levels correlate with healthy traits in humans.

Li, Li, Yang and Huang et al. show that ultraviolet-induced ribotoxic stress activates ZAK signaling to phosphorylate the Integrator subunit INTS12, thus promoting Integrator recruitment to CSB-bound, stalled RNA polymerase II (Pol II) and facilitating Pol II removal during efficient transcription-coupled nucleotide excision repair.

Compact Un1Cas12f1 enzyme suits AAV delivery but is limited by narrow PAMs and modest activity. Here, authors engineer evoCas12f to recognize broader NTNR/NYTR PAMs and boost editing efficiency up to 91%, enabling efficient multiplex editing, base editing, and gene activation in cells and mice.

Anode-free lithium-metal and lithium–sulfur batteries offer high energy density and simplified manufacturing, but drawbacks such as lithium loss and interfacial instability limit their viability as next-generation energy storage systems. This Review examines failure mechanisms and strategies to improve performance as well as scalability challenges.

Elucidation of fundamental pancreatic-targeted mechanisms enables the development of lipid nanoparticles for the precise delivery of nucleic acid therapeutics to the pancreas, highlighting their promising potential in the treatment of pancreatic diseases.

The intertwined electronic and geometric effects in heterogeneous catalysis have long hindered precise attribution of their individual roles. Here, the authors demonstrate a strategy to decouple electronic and geometric effects in Pd catalysts through thermally induced surface reconstruction, enabling selective alkyne hydrogenation.

Alloying layers boost the longevity of lithium metal batteries. Here, authors combine nuclear magnetic resonance and impedance spectroscopy to provide insights, revealing enhanced interfacial transport and diminished dead lithium formation as the origins of improved reversibility with Li-Sn alloys.

A lightweight and high-strength Ti₃C₂T_x aerogel is prepared by air-drying methods for multi-spatiotemporal infrared information management.

Glass sulfide electrolytes are promising materials for solid-state Li metal batteries, yet limited understanding hinders their progress. Here, the authors decipher the dissolution process of halogen dopants in glass and introduce a synthetic strategy to increase halogen dopant’s dissolution capacity.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

Electrocatalytic CO₂ reduction typically requires high-concentration CO₂ sources to reach high levels of activity. Here, molecular azobenzene-derived coordination polymers with integrated nickel catalyst capture low-concentration CO₂ and convert it to CO with high activity and single-pass conversion efficiency.

This study identifies a long non-coding RNA regulating anthocyanin biosynthesis in purple tea leaves, highlighting potential breeding targets.

Solid polymer electrolytes suffer from limited ionic conductivity and poor interfacial stability for lithium batteries. Here, authors propose a fluorinated ether diluent to reduce the dipole-dipole interaction of ionic solvate with the polymer matrix and induce the formation of aggregates.

Anode-free lithium metal battery is one of the most promising candidates for next-generation high energy density battery but suffer from poor cycle life. Here the authors present an integrated protocol to dissect and quantify the irreversible coulombic efficiencies for better understanding of the battery.