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Sluggish interfacial charge transfer in Li-metal batteries limits ultrafast charging and causes side reactions. The authors design solvent molecules to enhance Li⁺ coordination, improving the charge-transfer kinetics and enabling stable high-rate cycling of Li-metal cells.

The presence of EGFR mutations and de novo MET aberrations limited response to EGFR inhibitors in patients with advance non-small cell lung cancer (NSCLC). Here, the authors report a phase 2 randomised clinical trial investigating first-line osimertinib (EGFR inhibitor) plus savolitinib (c-MET inhibitor) in patients with MET-aberrant, EGFR-mutant advanced NSCLC.

Circulating N-glycomics studies have shown alterations in multiple cancer types. Here, the authors show that blood-based glycome patterns on proteins can be used to predict liver damage and liver cancer development.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

The authors create a room-temperature super relaxor critical state in a lead-free ceramic, delivering dual-high recoverable energy density and efficiency by residing at a crossover between dynamic and static/frozen polar states.

Efficient modeling of battery electrolytes is limited by the accuracy-cost trade-off. Here, authors develop a universal machine learning potential to accurately calculate transport and solvation properties across a broad chemical space.

A ductile inorganic-rich solid–electrolyte interphase that retains its structural integrity and allows easy ion diffusion enables a long cycle life under practical conditions for lithium metal batteries.

The authors reveal that the ferroelectric to antiferroelectric phase transition in Pb(Zr_0.97Ti_0.03)O₃-1wt%Nb₂O₅ at low temperatures is an irreversible process exhibiting relaxation behavior and diffusional kinetics.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Defect formation and phase instability remain critical challenges for perovskite/organic tandem solar cells. Jiang et al. address this by designing an additive to modulate the crystallization thermodynamics of wide-bandgap perovskite, achieving a record efficiency of 22.1% in a flexible cell.

Anode-free lithium-metal and lithium–sulfur batteries offer high energy density and simplified manufacturing, but drawbacks such as lithium loss and interfacial instability limit their viability as next-generation energy storage systems. This Review examines failure mechanisms and strategies to improve performance as well as scalability challenges.

The authors reveal distinct atomic-scale mechanisms underlying phase boundary engineering formation and explain the different electrical properties of two (K, Na)NbO₃ based materials with the similar phase boundary, providing a new mechanistic insight.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Antibody-conjugated Mesenchymal stromal cells (Ac-MSC) carrying internalized therapeutic agents represent a promising therapeutic approach for the treatment of autoimmune disease. Here, an ac-MSC-based drug delivery system, consisting of anti-CD4 antibody-conjugated MSCs loaded with a RORγt inverse agonist, is engineered to achieve selective targeting of pathogenic CD4 T cells and to deliver therapeutic benefits in mouse models of psoriasis and arthritis.

Nicotinamide N-methyltransferase (NNMT) and its metabolite 1-MNA have been implicated in liver disease and stress adaptation. Here, the authors show that NNMT/1-MNA protects against hepatic ischemia-reperfusion injury by modulating the AKT/FOXO1/ANGPT2/JNK axis.

An extreme barocaloric effect in NH₄SCN aqueous solutions is enabled by pressure-induced dissolution and precipitation, but without using a separate heat-transfer liquid.

The Huayuan biota exhibits extraordinary biodiversity, illuminating the impact of the Phanerozoic mass extinction around 513 million years ago and offering critical insights into the transformation of global ecosystems in the early Cambrian.

Zhang et al. found that histone deacetylase 1 (HDAC1) condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner. Disrupting the HDAC1 condensates with resminostat restores the sensitivity to temozolomide.

The homocatenation of electron-deficient Group 13 metals to form metal-metal multiple bonds through covalent self-assembly remains extremely challenging. Here, the authors demonstrate the synthesis and characterization of N-heterocyclic carbene-stabilized digallyl digallenes which exhibit unsaturated Ga-Ga=Ga-Ga chains with trans-bent geometries.

A lightweight and high-strength Ti₃C₂T_x aerogel is prepared by air-drying methods for multi-spatiotemporal infrared information management.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Wolbachia affects host reproduction and nutrition, but the underlying mechanisms are unclear. This study suggests Wolbachia enhances ovarian development in Laodelphax striatellus via riboflavin synthesis, driving ATP production and ovarian maturation.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Affinity-proteomics platforms often yield poorly correlated measurements. Here, the authors show that protein-altering variants drive a portion of inter-platform inconsistency and that accounting for genetic variants can improve concordance of protein measures and phenotypic associations across ancestries.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

This study identifies S100B as a regulator of communication between pulmonary neuroendocrine cells and macrophages during airway repair, revealing an S100B-arginase-1 pathway that may be leveraged to enhance lung regeneration.

Alloying layers boost the longevity of lithium metal batteries. Here, authors combine nuclear magnetic resonance and impedance spectroscopy to provide insights, revealing enhanced interfacial transport and diminished dead lithium formation as the origins of improved reversibility with Li-Sn alloys.

Developing new transformations of bulky chemicals is an important approach to expand the horizons of current chemistry. Instead of traditional hydroarylation of dienes, the authors herein demonstrate a nickel-catalyzed arylative telomerization of isoprene with high chemo- and regioselectivities.

Endocytosis of TFR1 plays a crucial role in extracelluar iron uptake. Here the authors revealed that PKCβII facilitates the endocytosis of TFR1 and increases cellular iron levels through the phosphorylation of AAK1, thus promoting ferroptosis of tumor cells.

Conductive films with a coherent gradient nanolayered architecture that consists of alternating stacked silver and aluminium layers can suppress crack nucleation and propagation, leading to increased resistance to mechanical cyclic fatigue.

Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention.

TransBrain translates brain phenotypes between mouse and human via homology mapping, thus making it possible to capitalize on the wealth of knowledge about the mouse brain and gain insights into the human brain.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Glass sulfide electrolytes are promising materials for solid-state Li metal batteries, yet limited understanding hinders their progress. Here, the authors decipher the dissolution process of halogen dopants in glass and introduce a synthetic strategy to increase halogen dopant’s dissolution capacity.

Colonic smooth muscle cell (CSMC) hypertrophy and hyperplasia have been described in human ulcerative colitis (UC) and animal models. Here the authors show that mice lacking smooth muscle (SM) 22a develop spontaneous colitis which has RSAD2-driven mitochondrial dysfunction and inflammation in CSMC and show dependence on RSAD2 for colitis alleviation.

Chaperone-mediated autophagy (CMA) is often dysregulated in cancer, but its mechanisms remain unclear. This study reveals that MST4- mediated LAMP2A phosphorylation regulates CMA by stabilizing lysosomal LAMP2A, thereby promoting GBM tumorigenicity and immune evasion.

In this Resource paper the authors provide a multiomic single-cell atlas of mouse eosinophil heterogeneity across various organs and use fate-mapping methods to look at the dynamics of residency.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

Dysregulation in the proteasome pathway contributes to the pathogenesis of head and neck squamous cell carcinoma (HNSCC). Here the authors identify that Casein kinase 2 (CK2) mediates phosphorylation of Proteasome activator 28 subunit gamma (PA28γ), which promotes tumor formation and progression in HNSCC mouse models.

This study shows that TE, an inferotemporal (IT) cortex subregion, displays stronger neural plasticity than TEO, another IT subregion, during learning of a challenging visual categorization task in primates, to which both areas contribute.

Solid polymer electrolytes suffer from limited ionic conductivity and poor interfacial stability for lithium batteries. Here, authors propose a fluorinated ether diluent to reduce the dipole-dipole interaction of ionic solvate with the polymer matrix and induce the formation of aggregates.

Although Mn-site doping in LiMn₂O₄ mitigates Mn³⁺ -induced Jahn-Teller distortion responsible for cathode degradation in Li-ion batteries, this strategy faces inherent trade-offs, with low-valent doping weakening oxygen bonding and high-valent doping increasing the Mn³⁺ content. To address these limitations, the authors propose dual-lanthanide (La³⁺/Ce³⁺) co-doping and show that La³⁺ -Ce³⁺ cooperation mitigates Mn dissolution while stabilizing the spinel framework, with Ce ions additionally boosting conductivity.

High-voltage positive electrodes in sulfide all-solid-state lithium batteries face challenges due to the low oxidation stability of sulfide electrolytes. Here, authors propose a Li₂ZrF₆ coating on LiCoO₂ to suppress interfacial reactions and enhance the long-term battery cycling performance.