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Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Landfalling tropical cyclones generally accelerate as they approach coastlines due to changes in surface roughness and thermal properties, according to numerical modelling simulations and global observations.

Optomechanical crystals are promising building blocks for quantum networks but suffer from thermal mechanical noise. Here the authors demonstrate on-demand conversion of single phonons into high-purity telecom photons with low thermal noise and MHz-scale narrow bandwidth using a quasi-2D optomechanical system.

Numerical modeling combined with a global rock database shows that the Fe³⁺/ΣFe ratio in MORB mantle sources has doubled since the early Archean, suggesting a potential link between mantle redox evolution and Earth’s tectonic activity.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Wu and colleagues present the efficacy and safety results from the phase 3 SCORES trial evaluating suvemcitug plus chemotherapy in persons with platinum-refractory or resistant recurrent ovarian cancer.

Duan and Kaushik et al. reveal the structural basis of how Escherichia coli and Thermus thermophilus RNA polymerases initiate transcription from Np₄A alarmones producing Np₄-capped transcripts. The caps form various interactions with a polymerase during initial steps, influencing capping efficiency.

Morkovin’s hypothesis establishes a comparison between incompressible and compressible flows and is essential for understanding supersonic and hypersonic turbulence. In this work, the authors present the measurements of wall-normal fluctuations that support the hypothesis proposed in 1962.

Tools to identify who will develop Crohn’s disease in the future are limited. Here, the authors develop and validate a proteomics-based model that predicts disease onset up to 16 years before clinical diagnosis.

This study identifies 245 genetic loci associated with head-to-body ratios using 38,202 bone density scan images from the UK Biobank, revealing genetic links to skeletal and brain development, disease susceptibility, and human evolutionary adaptation.

Despite recent advances with trappedion-based platforms, achieving quantum networks with link efficiency greater than unity on metropolitan scales is still a challenge. Here, the authors demonstrate a multiplexed quantum network generating heralded entanglement at a rate faster than local decoherence.

Understanding the mechanisms underlying the survival of drug tolerant persister cells following chemotherapy remains elusive. Here, multi-omics analysis and experimental approaches show that the germ-cell-specific H3K4 methyltransferase PRDM9 promotes metabolic rewiring in glioblastoma stem cells.

In this study, the authors present an fMRI‑based signature of corticospinal connections, which predicts individual pain sensitivity, generalizes to patient cohorts, and tracks changes after brain stimulation, suggesting a biomarker to guide personalized pain care.

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

Monolayer amorphous carbon (a-C) has attracted attention due to its structural and electronic properties, but its synthesis has so far required the use of metal substrates. Here, the authors report the Te-assisted growth of large-scale 2D a-C patterns on various insulating substrates, confirming their insulating properties in quantum tunnelling devices.

Current estimates of dissolved CO₂ in subduction-zone fluids based on thermodynamic models rely on a very sparse experimental data base. Here, the authors show that experimental graphite-saturated COH fluids interacting with silicates at 1–3 GPa and 800 °C display unpredictably high CO₂ contents.

Here the authors reveal how replication stress in BRCA2-deficient cells triggers a mutagenic cycle of APOBEC3B upregulation, uracil accumulation at stalled forks, and DNA damage, uncovering a self-reinforcing loop that fuels genomic instability.

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

An analysis of rare genetic variants identifies three genes—MAP1A, ANO8 and ANK2—that have a role in attention deficit hyperactivity disorder (ADHD) and investigates the potential underlying biological mechanisms.

Although climate warming after the 1950s is clear in many studies, records suggest an earlier onset to industrial impacts. This study combines observational data with simulations and finds a weakening of temperature seasonality, attributable to human influence, over the Northern Hemisphere since the late nineteenth century.

To realize long-distance quantum communication it is required to have individually addressable quantum memories with programmable access to many cells. Here the authors report DLCZ-type quantum memories with 225 individually accessible memory cells in a macroscopic atomic ensemble

Quantum teleportation offers superior performance in transmitting information over classical methods but is often hindered by environmental noise. To address this issue, the authors introduce a teleportation protocol with finite-dimensional embezzling catalysts to achieve arbitrarily high fidelity, with only negligible changes to the catalytic systems.

Quantum entanglement is demonstrated in a system of massive micromechanical oscillators coupled to a microwave-frequency electromagnetic cavity by driving the devices into a steady state that is entangled.

Azoxy products have rarely been synthesized using enzyme catalysts. Herein, the authors report that fungal unspecific peroxygenases are promising catalysts for synthesizing azoxy products from simple aniline starting materials.

The high performance of two-dimensional (2D) channel membranes is generally achieved by preparing ultrathin or forming short channels with less tortuous transport through self-assembly of small flakes. Here, the authors report the construction of vertical channels in graphene oxide membranes based on a substrate template with asymmetric pores demonstrating high flux and metal ion rejection.

Preliminary results from an investigator-initiated clinical trial showed that an AAV-OTOF gene therapy was safe and led to hearing improvements in ten patients with congenital deafness with 6–12 months of follow-up, including in a teenager and a young adult, expanding the age range from previous trials.

Although transition metal-catalyzed C–H bond functionalization is a widely used method in organic synthesis, many methods rely on metals of low abundance. Here, the authors report a copper-catalyzed, asymmetric C–H arylation using diaryliodonium salts.

Huang et al. demonstrate that somatostatin (Sst)-expressing primary afferents are pruriceptors. In spinal cord, they show that Sst potentiates itch by disinhibition involving dynorphin-expressing spinal neurons and that Sst also suppresses pain.

Foundation models hold transformative promise for oncology, yet their clinical implementation remains limited, largely owing to their current model design as narrow specialists optimized for static tasks, whereas clinical oncology requires generalist systems capable of integrating multimodal data, capturing disease evolution over time and considering patient perspectives. Design along these requirements is essential to integrating foundation models as trusted partners in cancer care.

Timely identification and treatment of cerebral lesions in high-risk neonates are crucial. Here, the authors present a deep learning system that extracts multiple standard views from neonatal cranial ultrasound videos and diagnoses severe cerebral lesions with high accuracy, outperforming junior radiologists.

Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local immune response and lead to beneficial scar tissue formation.

Asymmetric hydrophosphorylation of unsaturated compounds is a straightforward and atom-economic approach to obtaining chiral organophosphorus compounds. Herein, the authors describe a Pd-catalzyed ligand controlled regiodivergent and enantioselective hydrophosphorylation of styrenes.

The authors present DIGIT, a Bayesian imaging method that maps quantum emitters to lattice sites, achieving 0.178 Å precision and a new exponential scaling law, enabling massively parallel, sub-ångström localization in quantum and biological systems.

The role of human glioma IDH1 mutations in regulation of antiviral response is unclear. Here, the authors show that D2HG produced by mutant IDH1 inhibits IFN antiviral responses in glioma cells, which confers sensitivity to oncolytic virotherapy.

Cao et al. provide a comprehensive immune landscape of sepsis, delineating anatomical-specific and age-dependent programs.

With only a few known useful room-temperature multiferroics, other ways of achieving materials showing magnetism as well as electrical polarization are sought. The discovery that the ferroelectric BaTiO₃ also shows magnetism at room temperature at the interface with iron or cobalt marks a new approach to achieving multiferroic properties.

Two-dimensional transition metal dichalcogenide diodes with defect-free van der Waals contacts allows minimization of the extrinsic interfacial disorder-dominated recombination and access to the intrinsic excitonic behaviour in two-dimensional semiconductor devices.

It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality behaviours. Here we report a simulation of how improvements in four risk factors, namely smoking, alcohol use, physical activity and diet, could affect mortality. We show that in the ideal scenario, that is, all people who currently smokers quit smoking, excessive alcohol userswas reduced to moderate intake, people under 65 increased moderate physical activity by one hour and those aged 65 and older increased by half an hour per day, and all participants ate 200 g more fresh fruits and 50 g more fish/seafood per day, life expectancy at age 30 would increase by 4.83 and 5.39 years for men and women, respectively. In a more moderate risk reduction scenario referred to as the practical scenario, where improvements in each lifestyle factor were approximately halved, the gains in life expectancy at age 30 could be half those of the ideal scenario. However, the validity of these estimates in practise may be influenced by population-wide adherence to lifestyle recommendations. Our findings suggest that the current policy targets set by the Healthy China Initiative could be adjusted dynamically, and a greater increase in life expectancy would be achieved.

Macroscopic mechanical systems typically respond linearly to external force, and generating nonlinearity is challenging. Here, the authors generate nonlinearity in a macroscopic mechanical resonator by linking it to a gold contact and exploiting the anharmonicity in the chemical bonding interactions.

Fan et al. describe DF-003, an alpha-kinase 1 (ALPK1) inhibitor that targets the root cause of the rare genetic disease ROSAH syndrome, demonstrating the ability of DF-003 to inhibit ocular inflammatory pathology in ROSAH model mice.

Two phase 2 trials, along with translational analysis of prospective cohorts and experimental analysis, indicate that immunosenescence as a mechanism of resistance to immunotherapy can be overcome with the senolytics dasatinib and quercetin in patients with head and neck squamous cell carcinoma.

Temperature-related risks among the climate-sensitive diseases in northwestern and southwestern China have been historically high, with associated hospitalization burdens projected to rise consistently.

The authors present evidence based on satellite observations that the local cooling effect of potential forestation in Europe has intensified over the past two decades, driven by the reduced winter snow cover and declining summer soil moisture under global warming.

Cell type labelling in single-cell datasets remains a major bottleneck. Here, the authors present AnnDictionary, an open-source toolkit that enables atlas-scale analysis and provides the first benchmark of LLMs for de novo cell type annotation from marker genes, showing high accuracy at low cost.